JP5080453B2 - 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法 - Google Patents

非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法 Download PDF

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JP5080453B2
JP5080453B2 JP2008512759A JP2008512759A JP5080453B2 JP 5080453 B2 JP5080453 B2 JP 5080453B2 JP 2008512759 A JP2008512759 A JP 2008512759A JP 2008512759 A JP2008512759 A JP 2008512759A JP 5080453 B2 JP5080453 B2 JP 5080453B2
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core
polymer
bas
release
microcapsules
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JP2008512759A
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Japanese (ja)
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JP2008542220A (ja
JP2008542220A5 (enExample
Inventor
グスタフション，ニルス・オーベ
ヨンション，モニカ
ラークソ，ティモ
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ストラトスフィア・ファーマ・アクチボラグ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008512759A 2005-05-27 2006-05-24 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法 Expired - Fee Related JP5080453B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05011516.1 2005-05-27
EP05011516 2005-05-27
EP05028165.8 2005-12-22
EP05028165A EP1726299A3 (en) 2005-05-27 2005-12-22 Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
PCT/EP2006/004940 WO2006125620A2 (en) 2005-05-27 2006-05-24 Cores and microcapsules suitable for parenteral administration as well as process for their manufacture

Publications (3)

Publication Number Publication Date
JP2008542220A JP2008542220A (ja) 2008-11-27
JP2008542220A5 JP2008542220A5 (enExample) 2009-07-02
JP5080453B2 true JP5080453B2 (ja) 2012-11-21

Family

ID=36935013

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008512759A Expired - Fee Related JP5080453B2 (ja) 2005-05-27 2006-05-24 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法

Country Status (7)

Country Link
EP (2) EP1726299A3 (enExample)
JP (1) JP5080453B2 (enExample)
AT (1) ATE424190T1 (enExample)
CA (1) CA2609891A1 (enExample)
DE (1) DE602006005491D1 (enExample)
DK (1) DK1906928T3 (enExample)
WO (1) WO2006125620A2 (enExample)

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Publication number Priority date Publication date Assignee Title
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
GB0707612D0 (en) 2007-04-19 2007-05-30 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
BRPI0811784A2 (pt) 2007-05-23 2011-05-10 Allergan Inc colÁgeno reticulado e uso do mesmo
BRPI0811777A2 (pt) * 2007-05-23 2019-09-24 Allergan Inc partículas de ácido hialurõnico revestidas
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
CN101896204B (zh) 2007-11-16 2015-05-20 爱力根有限公司 用于治疗紫癜的组合物及方法
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
AU2009288118B2 (en) 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
EP2544652A2 (en) 2010-03-12 2013-01-16 Allergan Industrie SAS A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition.
CA2794254C (en) 2010-03-22 2018-09-04 Allergan, Inc. Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
JP6009550B2 (ja) 2011-06-03 2016-10-19 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 抗酸化物質を含む皮膚充填剤組成物
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
WO2016051219A1 (en) 2014-09-30 2016-04-07 Allergan Industrie, Sas Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
ES2774051T3 (es) 2015-02-13 2020-07-16 Allergan Ind Sas Implantes para esculpir, aumentar o corregir características faciales, tales como la barbilla
WO2025137151A2 (en) 2023-12-18 2025-06-26 The Johns Hopkins University Dendrimer compositions for the treatment of atherosclerosis, obesity, and metabolic syndromes
CN118146569B (zh) * 2024-01-24 2024-11-22 中国海洋大学 透明质酸-青蒿琥酯-聚精氨酸纳米粒、制备方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
WO1992016191A1 (en) * 1991-03-25 1992-10-01 Fujisawa Pharmaceutical Co., Ltd. Long-acting pharmaceutical preparation
DE4201179A1 (de) * 1992-01-17 1993-07-22 Alfatec Pharma Gmbh Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
KR100201352B1 (ko) * 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
SE505146C2 (sv) 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
EP0994700A4 (en) * 1997-07-18 2000-10-18 Bayer Ag METHODS FOR REMOVING SOLVENT RESIDUES FROM COMPOSITIONS FOR THE NASAL ADMINISTRATION OF ACTIVE SUBSTANCES
SE9903236D0 (sv) 1999-09-10 1999-09-10 Astra Ab Method to obtain microparticles
DE60040012D1 (de) * 1999-11-12 2008-10-02 Fibrogen Inc Rekombinantes gelatin in impstoffen
JP2004510730A (ja) * 2000-10-06 2004-04-08 ヤゴテック　アーゲー 非経口的投与可能な制御放出微粒子調製物
ATE397020T1 (de) 2000-10-06 2008-06-15 Pacira Pharmaceuticals Inc Pharmazeutisch verwendbare stärke und deren herstellungsverfahren
JP2004510724A (ja) 2000-10-06 2004-04-08 ヤゴテック　アーゲー 分子量の低下した澱粉からなる微粒子中に埋め込まれた免疫学的活性物質を含むワクチン組成物

Also Published As

Publication number Publication date
JP2008542220A (ja) 2008-11-27
WO2006125620A3 (en) 2007-08-02
EP1726299A2 (en) 2006-11-29
ATE424190T1 (de) 2009-03-15
CA2609891A1 (en) 2006-11-30
EP1726299A3 (en) 2007-04-18
EP1906928A2 (en) 2008-04-09
DE602006005491D1 (de) 2009-04-16
DK1906928T3 (da) 2009-04-20
EP1906928B1 (en) 2009-03-04
WO2006125620A2 (en) 2006-11-30

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