JP2008540333A5 - - Google Patents
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- Publication number
- JP2008540333A5 JP2008540333A5 JP2008508218A JP2008508218A JP2008540333A5 JP 2008540333 A5 JP2008540333 A5 JP 2008540333A5 JP 2008508218 A JP2008508218 A JP 2008508218A JP 2008508218 A JP2008508218 A JP 2008508218A JP 2008540333 A5 JP2008540333 A5 JP 2008540333A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- halogen
- cycloalkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical class 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- PXACTUVBBMDKRW-UHFFFAOYSA-M 4-bromobenzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=C(Br)C=C1 PXACTUVBBMDKRW-UHFFFAOYSA-M 0.000 claims 1
- -1 COOR 7.1 Inorganic materials 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05009556 | 2005-04-30 | ||
| EP05009556.1 | 2005-04-30 | ||
| PCT/EP2006/061839 WO2006117314A2 (en) | 2005-04-30 | 2006-04-26 | Novel piperidin- substituted indoles and their use as ccr-3 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540333A JP2008540333A (ja) | 2008-11-20 |
| JP2008540333A5 true JP2008540333A5 (https=) | 2012-07-05 |
| JP5080450B2 JP5080450B2 (ja) | 2012-11-21 |
Family
ID=36809076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508218A Expired - Fee Related JP5080450B2 (ja) | 2005-04-30 | 2006-04-26 | 新規なピペリジン置換インドール |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7759365B2 (https=) |
| EP (1) | EP1994019B1 (https=) |
| JP (1) | JP5080450B2 (https=) |
| AR (1) | AR054266A1 (https=) |
| AT (1) | ATE531706T1 (https=) |
| CA (1) | CA2606550C (https=) |
| TW (1) | TW200716597A (https=) |
| WO (1) | WO2006117314A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2382037C2 (ru) * | 2003-11-17 | 2010-02-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые пиперидинзамещенные индолы или их гетеропроизводные |
| ATE524461T1 (de) * | 2006-10-27 | 2011-09-15 | Boehringer Ingelheim Int | Neue substituierte piperidylpropanthiole |
| EP2079725B1 (en) * | 2006-10-27 | 2011-12-14 | Boehringer Ingelheim International GmbH | Piperidyl-propane-thiol ccr3 modulators |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| US10568876B2 (en) | 2014-09-05 | 2020-02-25 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 |
| WO2016036638A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| EP3188730B1 (en) | 2014-09-05 | 2019-05-01 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| AU2017360939B2 (en) | 2016-11-18 | 2022-03-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 |
| EP3541376B1 (en) | 2016-11-18 | 2023-04-19 | Merck Sharp & Dohme LLC | Indole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| MX2021003904A (es) | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4359468A (en) * | 1981-02-25 | 1982-11-16 | Boehringer Ingelheim Ltd. | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
| FR2533924A1 (fr) * | 1982-10-05 | 1984-04-06 | Roussel Uclaf | Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant |
| US5322851A (en) * | 1990-07-02 | 1994-06-21 | H. Lundbeck A/S | Indole derivatives |
| DK36391D0 (da) * | 1991-03-01 | 1991-03-01 | Lundbeck & Co As H | Anvendelse af piperidylsubstituerede indolderivater til behandling af stofmisbrug |
| US5683998A (en) * | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5521197A (en) | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| AU729415B2 (en) | 1996-07-12 | 2001-02-01 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US5962473A (en) | 1996-08-16 | 1999-10-05 | Eli Lilly And Company | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F |
| AU4074897A (en) | 1996-09-18 | 1998-04-14 | Eli Lilly And Company | A method for the prevention of migraine |
| AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| TR200002182T2 (tr) * | 1998-01-27 | 2000-12-21 | Aventis Pharmaceuticals Products Inc. | İkame edilmiş aksozaherosayklil faktör xa inhibitörleri |
| WO1999046259A1 (en) * | 1998-03-09 | 1999-09-16 | H. Lundbeck A/S | 5-heteroaryl substituted indoles |
| CN1149214C (zh) * | 1998-12-04 | 2004-05-12 | 东丽株式会社 | 三唑并衍生物和含有它们作为有效组分的趋化因子抑制剂 |
| ES2165274B1 (es) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| AU5567000A (en) * | 1999-06-24 | 2001-01-09 | Toray Industries, Inc. | Alpha1b-adrenergic receptor antagonists |
| AU3789901A (en) | 1999-12-17 | 2001-06-25 | Bristol-Myers Squibb Company | Antipsychotic heterocycle compounds |
| IL153605A0 (en) * | 2000-07-21 | 2003-07-06 | Lundbeck & Co As H | Indole derivatives useful for the treatment of cns disorders |
| HK1052705B (en) | 2000-08-14 | 2006-09-29 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazole |
| GB0107907D0 (en) * | 2001-03-29 | 2001-05-23 | Smithkline Beecham Plc | Novel compounds |
| MXPA04005988A (es) * | 2001-12-19 | 2004-09-27 | Lundbeck & Co As H | 3,4-dihidro-1h-isoquinolin-2-il-derivados. |
| EP1478643A1 (en) * | 2002-02-22 | 2004-11-24 | H. Lundbeck A/S | 5-heteroaryl substituted indoles |
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| WO2004041279A1 (en) * | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Gamma-aminoamide modulators of chemokine receptor activity |
| CA2536787C (en) * | 2003-08-25 | 2012-02-21 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
| US7157471B2 (en) * | 2003-08-25 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
| RU2382037C2 (ru) * | 2003-11-17 | 2010-02-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые пиперидинзамещенные индолы или их гетеропроизводные |
-
2006
- 2006-04-26 AT AT06743381T patent/ATE531706T1/de active
- 2006-04-26 US US11/380,232 patent/US7759365B2/en active Active
- 2006-04-26 EP EP06743381A patent/EP1994019B1/en not_active Expired - Lifetime
- 2006-04-26 WO PCT/EP2006/061839 patent/WO2006117314A2/en not_active Ceased
- 2006-04-26 CA CA2606550A patent/CA2606550C/en not_active Expired - Fee Related
- 2006-04-26 JP JP2008508218A patent/JP5080450B2/ja not_active Expired - Fee Related
- 2006-04-28 TW TW095115409A patent/TW200716597A/zh unknown
- 2006-04-28 AR AR20060101713A patent/AR054266A1/es not_active Application Discontinuation
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