JP2008538775A5 - - Google Patents
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- JP2008538775A5 JP2008538775A5 JP2008508131A JP2008508131A JP2008538775A5 JP 2008538775 A5 JP2008538775 A5 JP 2008538775A5 JP 2008508131 A JP2008508131 A JP 2008508131A JP 2008508131 A JP2008508131 A JP 2008508131A JP 2008538775 A5 JP2008538775 A5 JP 2008538775A5
- Authority
- JP
- Japan
- Prior art keywords
- present
- formula
- protecting group
- reactions
- anxiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000006239 protecting group Chemical group 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 208000011688 Generalised anxiety disease Diseases 0.000 description 2
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 208000029364 generalized anxiety disease Diseases 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 208000028173 post-traumatic stress disease Diseases 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 238000003797 solvolysis reaction Methods 0.000 description 2
- 206010013654 Drug abuse Diseases 0.000 description 1
- 208000001914 Fragile X syndrome Diseases 0.000 description 1
- 101001032845 Homo sapiens Metabotropic glutamate receptor 5 Proteins 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- -1 carboxy, hydroxy, amino Chemical group 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical class OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000019899 phobic disease Diseases 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0508318.3A GB0508318D0 (en) | 2005-04-25 | 2005-04-25 | Organic compounds |
| PCT/EP2006/003764 WO2006114260A1 (en) | 2005-04-25 | 2006-04-24 | Phenylacetylene derivatives having mglur5 receptor affinity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538775A JP2008538775A (ja) | 2008-11-06 |
| JP2008538775A5 true JP2008538775A5 (https=) | 2009-06-18 |
Family
ID=34640066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508131A Pending JP2008538775A (ja) | 2005-04-25 | 2006-04-24 | ｍＧｌｕＲ５受容体親和性を有するフェニルアセチレン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080188490A1 (https=) |
| EP (1) | EP1877364B1 (https=) |
| JP (1) | JP2008538775A (https=) |
| KR (1) | KR20070122224A (https=) |
| CN (1) | CN101163662A (https=) |
| AT (1) | ATE427927T1 (https=) |
| AU (1) | AU2006239545A1 (https=) |
| BR (1) | BRPI0610337A2 (https=) |
| CA (1) | CA2605262A1 (https=) |
| DE (1) | DE602006006170D1 (https=) |
| ES (1) | ES2323288T3 (https=) |
| GB (1) | GB0508318D0 (https=) |
| MX (1) | MX2007013238A (https=) |
| PL (1) | PL1877364T3 (https=) |
| PT (1) | PT1877364E (https=) |
| RU (1) | RU2007143507A (https=) |
| WO (1) | WO2006114260A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381083C (zh) | 2003-04-29 | 2008-04-16 | 韩力 | 一种非可燃性电子喷雾香烟 |
| CN2719043Y (zh) * | 2004-04-14 | 2005-08-24 | 韩力 | 雾化电子烟 |
| GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
| GB0508319D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| GB0508314D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| CN201067079Y (zh) * | 2006-05-16 | 2008-06-04 | 韩力 | 仿真气溶胶吸入器 |
| WO2009047303A2 (en) * | 2007-10-12 | 2009-04-16 | Novartis Ag | Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder |
| AU2008309621A1 (en) * | 2007-10-12 | 2009-04-16 | Novartis Ag | Metabotropic glutamate receptor modulators for the treatment of Parkinson's Disease |
| WO2009130900A1 (ja) * | 2008-04-24 | 2009-10-29 | 日本曹達株式会社 | オキシム誘導体、中間体化合物および植物病害防除剤 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| US20120142932A1 (en) | 2009-09-08 | 2012-06-07 | Koji Kawamura | Method for manufacturing 4-(5-methylpyridin-2-ylamino)piperidine-1-carboxylic acid derivative |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
| KR101862626B1 (ko) * | 2010-07-09 | 2018-05-31 | 레코르다티 아일랜드 리미티드 | Mglu5 대항체로서의 신 스피로헤테로사이클릭 화합물 |
| WO2013042139A1 (en) | 2011-09-23 | 2013-03-28 | Advinus Therapeutics Limited | Amide compounds, compositions and applications thereof |
| WO2014124560A1 (en) * | 2013-02-18 | 2014-08-21 | Hua Medicine (Shanghai) Ltd. | Mglur regulators |
| KR20180067030A (ko) | 2016-12-12 | 2018-06-20 | 김성갑 | 금속판에 다양한 곡면을 성형하는 방법 |
| KR20180067010A (ko) | 2016-12-12 | 2018-06-20 | 김선권 | 금속판에 다양한 곡면을 성형하는 방법 |
| WO2020032080A1 (ja) * | 2018-08-07 | 2020-02-13 | 学校法人慶應義塾 | 化合物、化合物の塩、神経機能調節物質、神経機能調節物質の評価方法、化合物の製造方法、及び化合物の塩の製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991064A (en) * | 1975-01-17 | 1976-11-09 | Warner-Lambert Company | Benzonaphthyridines |
| US5714498A (en) * | 1993-03-18 | 1998-02-03 | Merck, Sharp, & Dohme, Ltd. | Benzimidazole derivatives |
| US5576336A (en) * | 1993-03-18 | 1996-11-19 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine D4 antagonists |
| US5521297A (en) * | 1993-06-04 | 1996-05-28 | Salk Institute Biotechnology/Industrial Associates | Nucleic acids encoding human metabotropic glutamate receptors |
| JPH09512542A (ja) * | 1994-04-28 | 1997-12-16 | メルク シヤープ エンド ドーム リミテツド | Ｄ▲下４▼リセプタ拮抗剤としてのベンゾフラン誘導体 |
| DE69515177T2 (de) * | 1994-08-10 | 2000-10-05 | Merck Sharp & Dohme Ltd., Hoddesdon | Tetrahydropyridinylmethylderivate von pyrrolo[2,3-b]pyridine |
| US5688798A (en) * | 1995-10-10 | 1997-11-18 | Hoffmann-La Roche Inc. | Pyrimidine compounds |
| AUPR201600A0 (en) * | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| GB0128996D0 (en) * | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| US6806279B2 (en) * | 2001-12-17 | 2004-10-19 | Sunesis Pharmaceuticals, Inc. | Small-molecule inhibitors of interleukin-2 |
| US6995144B2 (en) * | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
| GB0508314D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| GB0508319D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
-
2005
- 2005-04-25 GB GBGB0508318.3A patent/GB0508318D0/en not_active Ceased
-
2006
- 2006-04-24 AU AU2006239545A patent/AU2006239545A1/en not_active Abandoned
- 2006-04-24 RU RU2007143507/04A patent/RU2007143507A/ru not_active Application Discontinuation
- 2006-04-24 CN CNA2006800136880A patent/CN101163662A/zh active Pending
- 2006-04-24 ES ES06724538T patent/ES2323288T3/es not_active Expired - Lifetime
- 2006-04-24 JP JP2008508131A patent/JP2008538775A/ja active Pending
- 2006-04-24 KR KR1020077024419A patent/KR20070122224A/ko not_active Withdrawn
- 2006-04-24 AT AT06724538T patent/ATE427927T1/de not_active IP Right Cessation
- 2006-04-24 EP EP06724538A patent/EP1877364B1/en not_active Expired - Lifetime
- 2006-04-24 DE DE602006006170T patent/DE602006006170D1/de not_active Expired - Lifetime
- 2006-04-24 PT PT06724538T patent/PT1877364E/pt unknown
- 2006-04-24 BR BRPI0610337-5A patent/BRPI0610337A2/pt not_active IP Right Cessation
- 2006-04-24 WO PCT/EP2006/003764 patent/WO2006114260A1/en not_active Ceased
- 2006-04-24 US US11/912,624 patent/US20080188490A1/en not_active Abandoned
- 2006-04-24 MX MX2007013238A patent/MX2007013238A/es not_active Application Discontinuation
- 2006-04-24 PL PL06724538T patent/PL1877364T3/pl unknown
- 2006-04-24 CA CA002605262A patent/CA2605262A1/en not_active Abandoned
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