JP2008538174A5 - - Google Patents

Download PDF

Info

Publication number
JP2008538174A5
JP2008538174A5 JP2007556283A JP2007556283A JP2008538174A5 JP 2008538174 A5 JP2008538174 A5 JP 2008538174A5 JP 2007556283 A JP2007556283 A JP 2007556283A JP 2007556283 A JP2007556283 A JP 2007556283A JP 2008538174 A5 JP2008538174 A5 JP 2008538174A5
Authority
JP
Japan
Prior art keywords
lentiviral
heterologous
sequence
polypeptide
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007556283A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008538174A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/005431 external-priority patent/WO2006089001A2/en
Publication of JP2008538174A publication Critical patent/JP2008538174A/ja
Publication of JP2008538174A5 publication Critical patent/JP2008538174A5/ja
Pending legal-status Critical Current

Links

JP2007556283A 2005-02-16 2006-02-16 レンチウイルスベクターとその使用 Pending JP2008538174A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US65338605P 2005-02-16 2005-02-16
US66031005P 2005-03-10 2005-03-10
US68205905P 2005-05-18 2005-05-18
US72376805P 2005-10-05 2005-10-05
PCT/US2006/005431 WO2006089001A2 (en) 2005-02-16 2006-02-16 Lentiviral vectors and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012234688A Division JP2013059331A (ja) 2005-02-16 2012-10-24 レンチウイルスベクターとその使用

Publications (2)

Publication Number Publication Date
JP2008538174A JP2008538174A (ja) 2008-10-16
JP2008538174A5 true JP2008538174A5 (enExample) 2009-04-02

Family

ID=36917037

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007556283A Pending JP2008538174A (ja) 2005-02-16 2006-02-16 レンチウイルスベクターとその使用
JP2012234688A Withdrawn JP2013059331A (ja) 2005-02-16 2012-10-24 レンチウイルスベクターとその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012234688A Withdrawn JP2013059331A (ja) 2005-02-16 2012-10-24 レンチウイルスベクターとその使用

Country Status (9)

Country Link
US (1) US20080254008A1 (enExample)
EP (2) EP2573185A3 (enExample)
JP (2) JP2008538174A (enExample)
KR (1) KR20070114157A (enExample)
AU (1) AU2006214278C1 (enExample)
CA (1) CA2597928A1 (enExample)
MX (1) MX2007010008A (enExample)
NO (1) NO20074654L (enExample)
WO (1) WO2006089001A2 (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
CA2646536A1 (en) 2006-04-06 2007-10-11 Boehringer Ingelheim International Gmbh Thiazolyl dihydro-indazoles
EP2082043A4 (en) * 2006-10-10 2010-03-24 Viromed Co Ltd EXPRESSION VECTORS WITH IMPROVED SAFETY
JP2010512782A (ja) * 2006-12-20 2010-04-30 ジ チャン ユウ, Hivのnc蛋白質発現用ベクター及びこれを利用したnc蛋白質の生産方法
WO2010045659A1 (en) 2008-10-17 2010-04-22 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
WO2010051521A1 (en) * 2008-10-31 2010-05-06 Lentigen Corporation Cell therapy product for the treatment of hiv infection
CN102438658A (zh) * 2009-03-13 2012-05-02 莱蒂恩公司 非整合型逆转录病毒载体疫苗
US20120027725A1 (en) * 2009-11-30 2012-02-02 Galvin Jeffrey A Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules to treat liver cancer
WO2011087855A1 (en) * 2009-12-22 2011-07-21 Columbia University Method for evaluating inhibitory polynucleotide efficiency and efficacy
DK2717922T3 (en) * 2011-06-10 2019-01-07 Bluebird Bio Inc GENERATIVE VECTORS FOR ADDRENOLEUCODYSTROPHY AND ADDRENOMYELONE EUROPE
PT2790737T (pt) 2011-12-12 2019-02-28 Childrens Hospital Philadelphia Sistema de produção de vetores lentivirais a grande escala comercial e vetores produzidos pelo mesmo
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
JP7060324B2 (ja) 2013-12-20 2022-04-26 ザ・ブロード・インスティテュート・インコーポレイテッド ネオ抗原ワクチンによる併用療法
EP3137100B1 (en) 2014-04-15 2023-12-20 University Of Virginia Patent Foundation Isolated t cell receptors and methods of use therefor
US10982189B2 (en) * 2014-07-11 2021-04-20 Celgene Corporation Methods of improving vector transduction efficiency into T lymphocytes
EA201790551A1 (ru) 2014-09-07 2017-07-31 Селекта Байосайенсиз, Инк. Способы и композиции для ослабления иммунных ответов к пропускающему экзон вирусному трансферному вектору
US20170247762A1 (en) 2014-10-27 2017-08-31 The Board Institute Inc. Compositions, methods and use of synthetic lethal screening
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
EP3234130B1 (en) 2014-12-19 2020-11-25 The Broad Institute, Inc. Methods for profiling the t-cell- receptor repertoire
JP6913032B2 (ja) 2015-05-20 2021-08-04 ザ・ブロード・インスティテュート・インコーポレイテッド 共通ネオ抗原
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US12533338B2 (en) * 2015-09-30 2026-01-27 Vycellix, Inc. Enhanced gene delivery to natural killer cells, hematopoietic stem cells and macrophages
WO2017059241A1 (en) 2015-10-02 2017-04-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lentiviral protein delivery system for rna-guided genome editing
WO2017079269A1 (en) 2015-11-04 2017-05-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Igf2bp1 and/or igf2bp3 for treatment
RU2639539C2 (ru) * 2015-12-29 2017-12-21 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий
IL297238B2 (en) 2016-01-15 2024-08-01 American Gene Tech Int Inc Methods and preparations for gamma-delta T-cell activation
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
JP7153332B2 (ja) 2016-02-08 2022-10-14 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Hivワクチン接種および免疫療法
ES2911448T3 (es) 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
SG11201808196UA (en) 2016-03-31 2018-10-30 Neon Therapeutics Inc Neoantigens and methods of their use
AU2017254477A1 (en) 2016-04-18 2018-11-01 Jennifer G. ABELIN Improved HLA epitope prediction
WO2017213697A1 (en) 2016-06-08 2017-12-14 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
CA3028982A1 (en) 2016-07-08 2018-01-11 American Gene Technologies International Inc. Hiv pre-immunization and immunotherapy
WO2018017882A1 (en) 2016-07-21 2018-01-25 American Gene Technologies International Inc. Viral vectors for treating parkinson's disease
WO2018071295A1 (en) * 2016-10-10 2018-04-19 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for inducible production of anti-inflammatory cytokines
JP2020506890A (ja) 2017-01-07 2020-03-05 セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. 合成ナノキャリアにカップリングした免疫抑制剤のパターン化された投与
EP3574116A1 (en) 2017-01-24 2019-12-04 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
CN110809716B (zh) 2017-02-12 2023-07-07 百欧恩泰美国公司 基于hla的方法和组合物及其用途
CN110506060B (zh) 2017-03-30 2024-05-07 昆士兰大学 嵌合分子及其用途
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
US12559769B2 (en) 2017-06-16 2026-02-24 American Gene Technologies International Inc. Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells
WO2019017940A1 (en) * 2017-07-19 2019-01-24 Rubius Therapeutics, Inc. COMPOSITIONS AND METHODS ASSOCIATED WITH MULTIMODAL THERAPEUTIC CELLULAR SYSTEMS FOR THE TREATMENT OF INFECTIOUS DISEASE
WO2019040994A1 (en) 2017-09-01 2019-03-07 The Australian National University IMMUNOREGULATOR MOLECULES AND USES THEREOF
GB201715052D0 (en) * 2017-09-19 2017-11-01 Oxford Genetics Ltd Vectors
WO2019075360A1 (en) 2017-10-13 2019-04-18 Selecta Biosciences, Inc. METHODS AND COMPOSITIONS FOR MITIGATING ANTI-VECTOR VIRAL TRANSFER IGM RESPONSES
FI3633040T3 (fi) * 2017-12-22 2023-08-03 Oxford Biomedica Ltd Retrovirusvektori
RU2697797C2 (ru) * 2017-12-28 2019-08-19 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Генетическая конструкция для индукции пролиферации периферических моноцитов in vitro
JP2021515037A (ja) 2018-02-26 2021-06-17 アントルクス,インコーポレーテッド 寛容原性リポソーム及びその使用方法
WO2020018715A1 (en) 2018-07-17 2020-01-23 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
US20210268049A1 (en) * 2018-08-16 2021-09-02 Immvira Co., Limited Methods and compositions for treatment of solid cancers and microbial infection
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
EP3876952A4 (en) 2018-11-05 2022-08-24 American Gene Technologies International Inc. VECTOR SYSTEM FOR EXPRESSING REGULATORY RNA
CA3120576A1 (en) 2018-11-26 2020-06-04 Massachusetts Institute Of Technology Compositions and methods for immune tolerance
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
CA3124457A1 (en) 2018-12-21 2020-06-25 Biontech Us Inc. Method and systems for prediction of hla class ii-specific epitopes and characterization of cd4+ t cells
CN113518825A (zh) * 2018-12-23 2021-10-19 美国杰特贝林生物制品有限公司 Wiskott-aldrich综合征的造血干细胞基因疗法
CN109735568A (zh) * 2019-01-28 2019-05-10 贵州大学 稳定表达fgf-1蛋白细胞株的构建方法
CA3138525A1 (en) 2019-04-28 2020-11-05 Selecta Biosciences, Inc. Methods for treatment of subjects with preexisting immunity to viral transfer vectors
CA3141863A1 (en) 2019-05-28 2020-12-03 Selecta Biosciences, Inc. Methods and compositions for attenuated anti-viral transfer vector immune response
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
JP7854946B2 (ja) 2020-05-26 2026-05-07 ディオニス セラピューティクス インコーポレイテッド 核酸人工ミニプロテオームライブラリー
JP2023528476A (ja) * 2020-06-02 2023-07-04 バイオピーエルエックス,インコーポレイティド 組み換え微生物においてゲノムに安定に組み込むための方法
JP2023540098A (ja) 2020-09-03 2023-09-21 チェン アーヴィン エス.ワイ. 可溶性アルカリホスファターゼ構築物及び可溶性アルカリホスファターゼ構築物をコードするポリヌクレオチドを含む発現ベクター
JP2024501482A (ja) 2020-12-14 2024-01-12 ビオンテック ユーエス インコーポレイテッド がん免疫療法のための組織特異的抗原
TWI758171B (zh) 2021-04-28 2022-03-11 沛爾生技醫藥股份有限公司 慢病毒包裝系統及使用其以提高宿主細胞之慢病毒產量的方法
WO2023009510A1 (en) * 2021-07-30 2023-02-02 The Trustees Of Princeton University Compositions and methods for transfer using cer1
US20230141563A1 (en) 2021-10-12 2023-05-11 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
WO2023076733A1 (en) 2021-11-01 2023-05-04 Dana-Farber Cancer Institute, Inc. Biologically selected nucleic acid artificial mini-proteome libraries
WO2023114918A1 (en) 2021-12-16 2023-06-22 Ludwig Institute For Cancer Research Ltd Antisense transfer vectors and methods of use thereof
US20230357437A1 (en) 2022-03-09 2023-11-09 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
WO2024015892A1 (en) 2022-07-13 2024-01-18 The Broad Institute, Inc. Hla-ii immunopeptidome methods and systems for antigen discovery
WO2024129696A1 (en) 2022-12-12 2024-06-20 Retromer Therapeutics Corp. Aav and lentiviral constructs comprising a sorl1 mini-gene for use in treating neurodegenerative diseases
CN116656616B (zh) * 2023-01-03 2024-05-28 生物岛实验室 一种制备外泌体的方法及其应用
WO2024178386A1 (en) 2023-02-24 2024-08-29 Aarhus Universitet Methods of treating endosomal trafficking diseases
US12531162B1 (en) * 2023-05-31 2026-01-20 Northeastern University Multi-dimensional phenotypic space for genotype to phenotype mapping and intelligent design of cancer drug therapies using a deep learning net
WO2025097055A2 (en) 2023-11-02 2025-05-08 The Broad Institute, Inc. Compositions and methods of use of t cells in immunotherapy
US12562256B2 (en) * 2023-11-07 2026-02-24 New York University Systems, methods and computer-accessible medium for identifying target pairs for CAR-T therapy

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US5981276A (en) 1990-06-20 1999-11-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US5817491A (en) 1990-09-21 1998-10-06 The Regents Of The University Of California VSV G pseusdotyped retroviral vectors
WO1994016060A1 (en) * 1993-01-11 1994-07-21 The Trustees Of The University Of Pennsylvania Mutants of hiv for supression of hiv infection
US6051427A (en) 1993-06-11 2000-04-18 Cell Genesys, Inc. Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
US5591264A (en) 1994-03-22 1997-01-07 Sony Corporation Spin coating device
US5750396A (en) 1995-05-08 1998-05-12 St. Judes Children's Research Hospital Stable virus packaging cell lines
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5888767A (en) 1996-11-27 1999-03-30 The Johns Hopkins University School Of Medicine Method of using a conditionally replicating viral vector to express a gene
US5885806A (en) 1995-11-28 1999-03-23 The Johns Hopkins University School Of Medicine Methods to prepare conditionally replicating viral vectors
US6924123B2 (en) 1996-10-29 2005-08-02 Oxford Biomedica (Uk) Limited Lentiviral LTR-deleted vector
US6207455B1 (en) * 1997-05-01 2001-03-27 Lung-Ji Chang Lentiviral vectors
US6531123B1 (en) * 1997-05-01 2003-03-11 Lung-Ji Chang Lentiviral vectors
ATE298371T1 (de) 1997-09-24 2005-07-15 Univ California Nicht-primaten lentivirale vektoren und verpackungssysteme
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6218181B1 (en) 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
WO2000040741A2 (en) * 1999-01-07 2000-07-13 The Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services, The National Institutes Of Health Lentivirus vector system
US7262049B2 (en) * 1999-03-16 2007-08-28 Dana-Farber Cancer Institute, Inc. Pseudotyped lentiviral vectors and uses thereof
US6358739B1 (en) 1999-04-12 2002-03-19 Modex Therapeutiques, S.A. Transiently immortalized cells
ATE376059T1 (de) * 2000-06-23 2007-11-15 Wyeth Corp Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps)
AU2001270252B2 (en) * 2000-07-03 2007-02-08 Catalent Pharma Solutions, Llc Expression vectors
JP2004524805A (ja) * 2000-07-03 2004-08-19 ギャラ デザイン インコーポレイテッド 複数の組み込みベクターを含む宿主細胞
AU2001286540A1 (en) 2000-08-24 2002-03-04 Sierra Sciences, Inc. Methods and compositions for modulating telomerase reverse transcriptase (tert) expression
US6627442B1 (en) 2000-08-31 2003-09-30 Virxsys Corporation Methods for stable transduction of cells with hiv-derived viral vectors
US7211247B2 (en) * 2001-04-09 2007-05-01 University Of Southern California Lentivirus vectors for gene transfer to alveolar epithelial cells
US20030167500A1 (en) * 2001-12-21 2003-09-04 Ram Ramabhadran Methods and compositions for generating a genetically modified animal using lentiviral vectors
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US8592197B2 (en) * 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
ATE478965T1 (de) * 2004-07-21 2010-09-15 Dana Farber Cancer Inst Inc Lentivirusvektoren und deren verwendung

Similar Documents

Publication Publication Date Title
Vannucci et al. Viral vectors: a look back and ahead on gene transfer technology
JP2022091989A (ja) ウイルスベクター産生系
US20090017543A1 (en) Viral Vectors
Brinzevich et al. HIV-1 interacts with human endogenous retrovirus K (HML-2) envelopes derived from human primary lymphocytes
EP1974043B1 (en) Vectors
Steckbeck et al. C-terminal tail of human immunodeficiency virus gp41: functionally rich and structurally enigmatic
CN102438658A (zh) 非整合型逆转录病毒载体疫苗
WO1993011230A1 (en) Modified mammalian stem cell blocking viral replication
CN110462029A (zh) 无预先免疫步骤的hiv免疫疗法
Yu et al. Sendai virus‐based expression of HIV‐1 gp120: reinforcement by the V (−) version
EP4448549A2 (en) Modified paramyxoviridae fusion glycoproteins
JP6702863B2 (ja) 導入遺伝子発現用ベクター
AU2014276631B2 (en) Avian cells for improved virus production
US20240401077A1 (en) Koala retrovirus envelope gylcoproteins and uses thereof
Negre et al. Lentiviral vectors derived from simian immunodeficiency virus
Cheng et al. Coexpression of the simian immunodeficiency virus Env and Rev proteins by a recombinant human adenovirus host range mutant
Pérot et al. From viruses to genes: syncytins
US7803582B2 (en) Recombinant vector and use in gene therapy
Boulanger et al. Use of heterologous expression systems to study retroviral morphogenesis
Suzuki et al. Gene regulatable lentiviral vector system
Curran et al. Nonprimate lentiviral vectors
WO2012118092A1 (ja) 融合タンパク質
CN107988239B (zh) 一种寨卡病毒的重组基因及其制备方法和应用
Derse et al. Transcriptional regulation of equine infectious anemia virus
EP1859813A1 (en) Remedy for disease associated with apoptotic degeneration in ocular cell tissue with the use of siv-pedf vector