JP2008538174A5 - - Google Patents

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Publication number
JP2008538174A5
JP2008538174A5 JP2007556283A JP2007556283A JP2008538174A5 JP 2008538174 A5 JP2008538174 A5 JP 2008538174A5 JP 2007556283 A JP2007556283 A JP 2007556283A JP 2007556283 A JP2007556283 A JP 2007556283A JP 2008538174 A5 JP2008538174 A5 JP 2008538174A5
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JP
Japan
Prior art keywords
lentiviral
heterologous
sequence
polypeptide
vector
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007556283A
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English (en)
Japanese (ja)
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JP2008538174A (ja
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Publication date
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Priority claimed from PCT/US2006/005431 external-priority patent/WO2006089001A2/en
Publication of JP2008538174A publication Critical patent/JP2008538174A/ja
Publication of JP2008538174A5 publication Critical patent/JP2008538174A5/ja
Pending legal-status Critical Current

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JP2007556283A 2005-02-16 2006-02-16 レンチウイルスベクターとその使用 Pending JP2008538174A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US65338605P 2005-02-16 2005-02-16
US66031005P 2005-03-10 2005-03-10
US68205905P 2005-05-18 2005-05-18
US72376805P 2005-10-05 2005-10-05
PCT/US2006/005431 WO2006089001A2 (en) 2005-02-16 2006-02-16 Lentiviral vectors and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012234688A Division JP2013059331A (ja) 2005-02-16 2012-10-24 レンチウイルスベクターとその使用

Publications (2)

Publication Number Publication Date
JP2008538174A JP2008538174A (ja) 2008-10-16
JP2008538174A5 true JP2008538174A5 (enExample) 2009-04-02

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ID=36917037

Family Applications (2)

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JP2007556283A Pending JP2008538174A (ja) 2005-02-16 2006-02-16 レンチウイルスベクターとその使用
JP2012234688A Withdrawn JP2013059331A (ja) 2005-02-16 2012-10-24 レンチウイルスベクターとその使用

Family Applications After (1)

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JP2012234688A Withdrawn JP2013059331A (ja) 2005-02-16 2012-10-24 レンチウイルスベクターとその使用

Country Status (9)

Country Link
US (1) US20080254008A1 (enExample)
EP (2) EP1858332A4 (enExample)
JP (2) JP2008538174A (enExample)
KR (1) KR20070114157A (enExample)
AU (1) AU2006214278C1 (enExample)
CA (1) CA2597928A1 (enExample)
MX (1) MX2007010008A (enExample)
NO (1) NO20074654L (enExample)
WO (1) WO2006089001A2 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
RU2008143555A (ru) 2006-04-06 2010-06-27 Бёрингер Ингельхайм Интернациональ Гмбх (De) Тиазолилдигидроиндазолы
WO2008044869A1 (en) 2006-10-10 2008-04-17 Viromed Co., Ltd. Expression vectors with improved safety
WO2008075911A1 (en) * 2006-12-20 2008-06-26 Avixgen Inc. Vector for expressing nc protein of hiv and method for producing nc protein using the same
WO2010045659A1 (en) 2008-10-17 2010-04-22 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
WO2010051521A1 (en) * 2008-10-31 2010-05-06 Lentigen Corporation Cell therapy product for the treatment of hiv infection
EP2405945A4 (en) * 2009-03-13 2012-09-12 Lentigen Corp NON-INTEGRAL RETROVIRAL VECTOR VACCINES
WO2011066578A1 (en) * 2009-11-30 2011-06-03 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules to treat liver cancer
US20120260355A1 (en) * 2009-12-22 2012-10-11 The Trustees Of Columbia University In The City Of New York Method for Evaluating Inhibitory Polynucleotide Efficiency and Efficacy
JP6143231B2 (ja) * 2011-06-10 2017-06-07 ブルーバード バイオ， インコーポレイテッド 副腎脳白質ジストロフィおよび副腎脊髄神経障害のための遺伝子療法ベクター
ES2717876T3 (es) * 2011-12-12 2019-06-26 Childrens Hospital Philadelphia Sistema de producción de un vector lentiviral a gran escala comercial y vectores así producidos
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
EP3137100B1 (en) 2014-04-15 2023-12-20 University Of Virginia Patent Foundation Isolated t cell receptors and methods of use therefor
ES2813437T3 (es) * 2014-07-11 2021-03-23 Celgene Corp Métodos para mejorar la eficiencia de la transducción vectorial en linfocitos T
WO2016037163A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses
EP3212788A2 (en) 2014-10-27 2017-09-06 The Broad Institute, Inc. Compositions, methods and use of synthetic lethal screening
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
WO2016100977A1 (en) 2014-12-19 2016-06-23 The Broad Institute Inc. Methods for profiling the t-cel- receptor repertoire
CR20200476A (es) 2015-05-20 2020-12-02 Dana Farber Cancer Inst Inc ANTÍGENOS COMPARTIDOS (Divisional 2017-0584)
EP3319631A4 (en) 2015-07-08 2019-01-09 American Gene Technologies International Inc. HIV PREMUNICATION AND IMMUNOTHERAPY
DK3356524T3 (da) * 2015-09-30 2021-11-15 Vycellix Inc Forøget genlevering til naturlige dræberceller, hæmatopoietiske stamceller og makrofager
WO2017059241A1 (en) 2015-10-02 2017-04-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lentiviral protein delivery system for rna-guided genome editing
WO2017079269A1 (en) 2015-11-04 2017-05-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Igf2bp1 and/or igf2bp3 for treatment
RU2639539C2 (ru) * 2015-12-29 2017-12-21 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий
CA3011529A1 (en) 2016-01-15 2017-07-20 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta t-cells
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
US10888613B2 (en) 2016-02-08 2021-01-12 American Gene Technologies International Inc. Method of producing cells resistant to HIV infection
ES2911448T3 (es) 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
RS67172B1 (sr) 2016-03-31 2025-09-30 Biontech Us Inc Neoantigeni i postupci za njihovu upotrebu
EP3446119A1 (en) 2016-04-18 2019-02-27 The Broad Institute Inc. Improved hla epitope prediction
EP3468617A4 (en) 2016-06-08 2020-01-22 American Gene Technologies International Inc. INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS
IL300730A (en) 2016-07-08 2023-04-01 American Gene Tech Int Inc Pre-HIV vaccine and immunotherapy
JP7176756B2 (ja) 2016-07-21 2022-11-22 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド パーキンソン病を処置するためのウイルスベクター
US11529393B2 (en) 2016-10-10 2022-12-20 The Board Of Trustees Of The Leland Stanford Junior University Mesenchymal stem cells expressing anti-inflammatory cytokines and methods of use
KR20190104194A (ko) 2017-01-07 2019-09-06 셀렉타 바이오사이언시즈, 인크. 합성 나노담체에 커플링된 면역억제제의 패턴화된 투여
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
KR102565256B1 (ko) 2017-02-12 2023-08-08 바이오엔테크 유에스 인크. Hla 기반 방법 및 조성물, 및 이들의 용도
BR112019019813A2 (pt) 2017-03-30 2020-04-22 Univ Queensland moléculas quiméricas e usos das mesmas
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
EP3654991A1 (en) * 2017-07-19 2020-05-27 Rubius Therapeutics, Inc. Compositions and methods related to multimodal therapeutic cell systems for infectious disease
EP4400174A3 (en) 2017-09-01 2024-10-23 The Francis Crick Institute Limited Immunoregulatory molecules and uses therefor
GB201715052D0 (en) * 2017-09-19 2017-11-01 Oxford Genetics Ltd Vectors
WO2019075360A1 (en) 2017-10-13 2019-04-18 Selecta Biosciences, Inc. METHODS AND COMPOSITIONS FOR MITIGATING ANTI-VECTOR VIRAL TRANSFER IGM RESPONSES
ES2951857T3 (es) 2017-12-22 2023-10-25 Oxford Biomedica Ltd Vector retroviral
RU2697797C2 (ru) * 2017-12-28 2019-08-19 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Генетическая конструкция для индукции пролиферации периферических моноцитов in vitro
CA3092372A1 (en) 2018-02-26 2019-08-29 AnTolRx, Inc. Tolerogenic liposomes and methods of use thereof
WO2020018715A1 (en) 2018-07-17 2020-01-23 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
EP3837355A4 (en) * 2018-08-16 2022-07-06 Immvira Co., Limited METHODS AND COMPOSITIONS FOR THE TREATMENT OF SOLID TUMORS AND MICROBIAL INFECTION
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
WO2020097049A1 (en) 2018-11-05 2020-05-14 American Gene Technologies International Inc. Vector system for expressing regulatory rna
JP2022513113A (ja) 2018-11-26 2022-02-07 マサチューセッツ インスティテュート オブ テクノロジー 免疫寛容のための組成物および方法
US20220062394A1 (en) 2018-12-17 2022-03-03 The Broad Institute, Inc. Methods for identifying neoantigens
MX2021007556A (es) 2018-12-21 2021-09-10 Biontech Us Inc Método y sistemas de predicción de epítopos específicos de hla de clase ii y caracterización de células t cd4+.
WO2020139796A1 (en) * 2018-12-23 2020-07-02 Csl Behring L.L.C. Haematopoietic stem cell-gene therapy for wiskott-aldrich syndrome
CN109735568A (zh) * 2019-01-28 2019-05-10 贵州大学 稳定表达fgf-1蛋白细胞株的构建方法
WO2020223205A1 (en) 2019-04-28 2020-11-05 Selecta Biosciences, Inc. Methods for treatment of subjects with preexisting immunity to viral transfer vectors
US20200390718A1 (en) 2019-05-28 2020-12-17 Selecta Biosciences, Inc. Methods and compositions for attenuated anti-viral transfer vector immune response
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
AU2021280261A1 (en) 2020-05-26 2023-01-19 Dionis Therapeutics, Inc. Nucleic acid artificial mini-proteome libraries
MX2022015299A (es) * 2020-06-02 2023-03-13 Bioplx Inc Metodos para integracion genomica estable en microorganismos recombinantes.
WO2022051555A2 (en) 2020-09-03 2022-03-10 Rampart Bioscience, Inc. Soluble alkaline phosphatase constructs and expression vectors including a polynucleotide encoding for soluble alkaline phosphatase constructs
EP4259206A4 (en) 2020-12-14 2025-07-09 Biontech Us Inc TISSUE-SPECIFIC ANTIGENS FOR CANCER IMMUNOTHERAPY
TWI758171B (zh) 2021-04-28 2022-03-11 沛爾生技醫藥股份有限公司 慢病毒包裝系統及使用其以提高宿主細胞之慢病毒產量的方法
WO2023009510A1 (en) * 2021-07-30 2023-02-02 The Trustees Of Princeton University Compositions and methods for transfer using cer1
US20230141563A1 (en) 2021-10-12 2023-05-11 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
EP4426829A1 (en) 2021-11-01 2024-09-11 Dana-Farber Cancer Institute, Inc. Biologically selected nucleic acid artificial mini-proteome libraries
US20250009802A1 (en) 2021-12-16 2025-01-09 Ludwig Institute For Cancer Research Ltd Antisense transfer vectors and methods of use thereof
WO2023172624A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
WO2024015892A1 (en) 2022-07-13 2024-01-18 The Broad Institute, Inc. Hla-ii immunopeptidome methods and systems for antigen discovery
WO2024129696A1 (en) 2022-12-12 2024-06-20 Retromer Therapeutics Corp. Aav and lentiviral constructs comprising a sorl1 mini-gene for use in treating neurodegenerative diseases
CN116656617A (zh) * 2023-01-03 2023-08-29 生物岛实验室 一种外泌体及其制备方法和应用
WO2024178386A1 (en) 2023-02-24 2024-08-29 Aarhus Universitet Methods of treating endosomal trafficking diseases
WO2025097055A2 (en) 2023-11-02 2025-05-08 The Broad Institute, Inc. Compositions and methods of use of t cells in immunotherapy

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US5981276A (en) 1990-06-20 1999-11-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US5817491A (en) 1990-09-21 1998-10-06 The Regents Of The University Of California VSV G pseusdotyped retroviral vectors
WO1994016060A1 (en) * 1993-01-11 1994-07-21 The Trustees Of The University Of Pennsylvania Mutants of hiv for supression of hiv infection
US6051427A (en) 1993-06-11 2000-04-18 Cell Genesys, Inc. Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
US5591264A (en) 1994-03-22 1997-01-07 Sony Corporation Spin coating device
US5750396A (en) 1995-05-08 1998-05-12 St. Judes Children's Research Hospital Stable virus packaging cell lines
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5885806A (en) 1995-11-28 1999-03-23 The Johns Hopkins University School Of Medicine Methods to prepare conditionally replicating viral vectors
US5888767A (en) 1996-11-27 1999-03-30 The Johns Hopkins University School Of Medicine Method of using a conditionally replicating viral vector to express a gene
US6924123B2 (en) 1996-10-29 2005-08-02 Oxford Biomedica (Uk) Limited Lentiviral LTR-deleted vector
US6207455B1 (en) * 1997-05-01 2001-03-27 Lung-Ji Chang Lentiviral vectors
US6531123B1 (en) * 1997-05-01 2003-03-11 Lung-Ji Chang Lentiviral vectors
JP2001517433A (ja) 1997-09-24 2001-10-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非霊長類レンチウイルスベクターおよびパッケージングシステム
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6218181B1 (en) 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
AU2495300A (en) * 1999-01-07 2000-07-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Lentivirus vector system
US7262049B2 (en) * 1999-03-16 2007-08-28 Dana-Farber Cancer Institute, Inc. Pseudotyped lentiviral vectors and uses thereof
US6358739B1 (en) 1999-04-12 2002-03-19 Modex Therapeutiques, S.A. Transiently immortalized cells
EP1294892B1 (en) * 2000-06-23 2007-10-17 Wyeth Holdings Corporation Assembly of wild-type and chimeric influenza virus-like particles (vlps)
EP1297168A2 (en) * 2000-07-03 2003-04-02 Gala Design, Inc. Expression vectors
KR100868594B1 (ko) * 2000-07-03 2008-11-13 갈라 디자인, 인크. 다수의 통합 벡터를 함유하는 숙주 세포
US6686159B2 (en) 2000-08-24 2004-02-03 Sierra Sciences, Inc. Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
US6627442B1 (en) 2000-08-31 2003-09-30 Virxsys Corporation Methods for stable transduction of cells with hiv-derived viral vectors
US7211247B2 (en) * 2001-04-09 2007-05-01 University Of Southern California Lentivirus vectors for gene transfer to alveolar epithelial cells
AU2002367024A1 (en) * 2001-12-21 2003-07-30 Tranzyme, Inc. Methods and compositions for generating a genetically modified animal using lentiviral vectors
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US8592197B2 (en) * 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
EP1784506B1 (en) * 2004-07-21 2010-08-25 Dana-Farber Cancer Institute, Inc. Lentiviral vectors and uses thereof

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