JP2008537537A5 - - Google Patents
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- Publication number
- JP2008537537A5 JP2008537537A5 JP2007555158A JP2007555158A JP2008537537A5 JP 2008537537 A5 JP2008537537 A5 JP 2008537537A5 JP 2007555158 A JP2007555158 A JP 2007555158A JP 2007555158 A JP2007555158 A JP 2007555158A JP 2008537537 A5 JP2008537537 A5 JP 2008537537A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- hexapeptide
- kfkwpw
- acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical group C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- SZHOJFHSIKHZHA-UHFFFAOYSA-N tridecanoic acid Chemical compound CCCCCCCCCCCCC(O)=O SZHOJFHSIKHZHA-UHFFFAOYSA-N 0.000 claims 2
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 claims 2
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- AWQSAIIDOMEEOD-UHFFFAOYSA-N 5,5-Dimethyl-4-(3-oxobutyl)dihydro-2(3H)-furanone Chemical compound CC(=O)CCC1CC(=O)OC1(C)C AWQSAIIDOMEEOD-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 239000005639 Lauric acid Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- YAQXGBBDJYBXKL-UHFFFAOYSA-N iron(2+);1,10-phenanthroline;dicyanide Chemical compound [Fe+2].N#[C-].N#[C-].C1=CN=C2C3=NC=CC=C3C=CC2=C1.C1=CN=C2C3=NC=CC=C3C=CC2=C1 YAQXGBBDJYBXKL-UHFFFAOYSA-N 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65127005P | 2005-02-09 | 2005-02-09 | |
| US60/651,270 | 2005-02-09 | ||
| PCT/US2006/004147 WO2006086321A2 (en) | 2005-02-09 | 2006-02-07 | Antimicrobial hexapeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008537537A JP2008537537A (ja) | 2008-09-18 |
| JP2008537537A5 true JP2008537537A5 (OSRAM) | 2009-04-02 |
| JP5335241B2 JP5335241B2 (ja) | 2013-11-06 |
Family
ID=36793611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555158A Active JP5335241B2 (ja) | 2005-02-09 | 2006-02-07 | 抗微生物ヘキサペプチド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7407940B2 (OSRAM) |
| EP (1) | EP1853620B1 (OSRAM) |
| JP (1) | JP5335241B2 (OSRAM) |
| KR (1) | KR101306643B1 (OSRAM) |
| CN (1) | CN101155825B (OSRAM) |
| AT (1) | ATE540969T1 (OSRAM) |
| AU (1) | AU2006212922B2 (OSRAM) |
| CA (1) | CA2597191C (OSRAM) |
| DK (1) | DK1853620T3 (OSRAM) |
| ES (1) | ES2378242T3 (OSRAM) |
| PL (1) | PL1853620T3 (OSRAM) |
| SI (1) | SI1853620T1 (OSRAM) |
| WO (1) | WO2006086321A2 (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070207112A1 (en) * | 2005-12-07 | 2007-09-06 | Grant Industries, Inc. | Anti-acne composition |
| IL172896A0 (en) * | 2005-12-29 | 2006-06-11 | Yeda Res & Dev | Cxcr4 inhibition |
| CA2822302A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Methods of impairing osteoclast differentiation |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| US7713937B2 (en) * | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
| US8906859B2 (en) * | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| ES2394377T3 (es) | 2006-11-10 | 2013-01-31 | Cara Therapeutics, Inc. | Amidas de péptidos sintéticos |
| US8236766B2 (en) * | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
| WO2008140834A2 (en) * | 2007-01-16 | 2008-11-20 | The Regents Of The University Of California | Novel antimicrobial peptides |
| KR100879220B1 (ko) | 2007-11-12 | 2009-01-19 | 아주대학교산학협력단 | 식물병원성 세균에 대한 항미생물 펩티드 ｋｃｍ２１ |
| KR100879221B1 (ko) | 2007-11-12 | 2009-01-19 | 아주대학교산학협력단 | 식물병원성 세균에 대한 항미생물 펩티드 ｋｒｓ２２ |
| GB0724951D0 (en) * | 2007-12-20 | 2008-01-30 | Lytix Biopharma As | Compounds |
| WO2009146885A2 (en) * | 2008-06-02 | 2009-12-10 | Spiderbiotech S.R.L. | Lipidated antibacterial peptides |
| GB0818074D0 (en) * | 2008-10-02 | 2008-11-05 | Lytix Biopharma As | Treatment of biofilms |
| GB0818072D0 (en) | 2008-10-02 | 2008-11-05 | Lytix Biopharma As | Compounds |
| GB0918579D0 (en) | 2009-10-22 | 2009-12-09 | Imp Innovations Ltd | Gadd45beta targeting agents |
| BR112012011780A2 (pt) * | 2009-11-23 | 2019-09-24 | Palatin Technologies, Inc | peptídeo linear,composição farmacêutica,métodopara tratamento de umadoença,indicação,condição ou sídrome mediadsa por receptor de melanocortina emum mamífero humano ou não humano e método para tratamento de uma condição responsiva ás alterações em função de receptor de melanocortina em um mamifero humano ou não humano |
| WO2013086003A1 (en) * | 2011-12-05 | 2013-06-13 | The Ohio State University | Antimicrobial agent, bacterial strain, biosynthesis, and methods of use |
| CN104136626B (zh) * | 2012-03-01 | 2017-05-03 | 诺沃—诺迪斯克有限公司 | N‑末端修饰的寡肽及其用途 |
| WO2014012165A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| FR3002452B1 (fr) * | 2013-02-28 | 2016-02-12 | Dermaconcept Jmc | Composition dermatologique antimicrobienne topique |
| TWI577697B (zh) * | 2013-11-28 | 2017-04-11 | 國立清華大學 | 耐高鹽及抗蛋白之抗菌胜肽及其製造方法 |
| WO2016114390A1 (ja) | 2015-01-16 | 2016-07-21 | 株式会社マンダム | クレンジングローション、シート化粧料、及び美容方法 |
| US9738684B2 (en) | 2015-06-29 | 2017-08-22 | Council Of Scientific & Industrial Research | N-terminally modified linear and branched polyamine conjugated peptidomimetics as antimicrobials agents |
| KR101855170B1 (ko) * | 2015-11-18 | 2018-05-08 | (주)노바셀테크놀로지 | 신규 항균 펩타이드 및 그의 용도 |
| CN109942713A (zh) * | 2018-12-28 | 2019-06-28 | 广州医科大学 | 新型抗菌肽及其应用 |
| KR102170236B1 (ko) * | 2019-03-19 | 2020-10-29 | (주)노바셀테크놀로지 | 신규 다중 기능성 펩타이드 및 그의 용도 |
| WO2020225255A1 (en) | 2019-05-06 | 2020-11-12 | Université De Genève | Antimicrobial tailored chitosan |
| CN110950932B (zh) * | 2020-01-09 | 2023-04-18 | 福州大学 | 一种修饰肽的制备及其应用 |
| KR102220323B1 (ko) * | 2020-05-15 | 2021-02-26 | (주)노바셀테크놀로지 | 신규 다중 기능성 펩타이드 및 그의 용도 |
| KR102429281B1 (ko) * | 2020-05-25 | 2022-08-05 | (주)노바셀테크놀로지 | 신규 안구건조증 치료용 약학적 조성물 |
| KR102486996B1 (ko) * | 2020-09-04 | 2023-01-10 | 서울대학교병원 | 펩타이드 및 이를 포함하는 피부 주름 개선용 조성물 및 대사성 질환 치료용 조성물 |
| CN111925422B (zh) * | 2020-09-17 | 2021-05-18 | 张雪山 | 抗菌肽及其在制备药物或化妆品中的应用 |
| CN113248572B (zh) * | 2021-04-30 | 2023-04-11 | 重庆理工大学 | 一种抗多重耐药菌环肽及其应用 |
| CZ309857B6 (cs) * | 2022-03-31 | 2023-12-20 | Contipro A.S. | Hexapeptid, kompozice zahrnující tento hexapeptid a jejich topické použití |
| CN116332777A (zh) * | 2023-02-20 | 2023-06-27 | 华中科技大学 | 二芳基苯甲胺类化合物、制备及作为载体合成多肽的应用 |
| CN116041422B (zh) * | 2023-03-31 | 2023-06-16 | 四川大学 | 自组装抗菌肽及其组合物、药物载体、载药体系和用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4520016A (en) * | 1980-06-17 | 1985-05-28 | Kabigen Ab | Bacteriolytic proteins |
| US4355104A (en) * | 1980-06-17 | 1982-10-19 | Kabigen Ab | Bacteriolytic proteins |
| KR970006154B1 (ko) * | 1987-07-06 | 1997-04-24 | 루이지아나 스테이트 유니버시티 아그리컬춰럴 앤드 메카니칼 컬리지 | 용해성 펩티드에 의한 진핵 병원체와 신생물의 억제 및 섬유아세포와 임파구의 자극 |
| CA1327311C (en) * | 1987-07-06 | 1994-03-01 | Jesse M. Jaynes | Therapeutic antimicrobial polypeptides, their use and methods for preparation |
| US5861478A (en) * | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| WO1990012866A1 (en) | 1989-04-10 | 1990-11-01 | Louisiana State University And Agricultural And Mechanical College | Lytic peptides, use for growth, infection and cancer |
| WO1992017195A1 (en) * | 1991-04-08 | 1992-10-15 | Magainin Pharmaceuticals, Inc. | Novel peptide compositions and uses therefor |
| US5561107A (en) * | 1993-06-04 | 1996-10-01 | Demeter Biotechnologies, Ltd. | Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides |
| US5955573A (en) * | 1993-06-04 | 1999-09-21 | Demegen, Inc. | Ubiquitin-lytic peptide fusion gene constructs, protein products deriving therefrom, and methods of making and using same |
| AU7050294A (en) * | 1993-06-04 | 1995-01-03 | Demeter Biotechnologies, Ltd. | Method of treating pulmonary disease states with non-naturally occurring amphipathic peptides |
| AU1086595A (en) * | 1993-11-08 | 1995-05-29 | Demeter Biotechnologies, Ltd. | Methylated lysine-rich lytic peptides and method of making same by reductive alkylation |
| WO1995019370A1 (en) * | 1994-01-18 | 1995-07-20 | Magainin Pharmaceuticals Inc. | Ion-channel forming amphiphilic peptides having n-terminal modifications |
| US5789542A (en) * | 1994-04-22 | 1998-08-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Amphipathic peptides |
| IL114697A0 (en) | 1994-07-22 | 1995-11-27 | Demeter Biotech Ltd | Polypeptides comprising ubiquitin-lytic peptide fusion protein products deriving therefrom their preparation and use |
| WO1997004008A1 (en) * | 1995-07-20 | 1997-02-06 | Xoma Corporation | Anti-fungal peptides |
| EP0866805A1 (en) * | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
| US6566334B1 (en) * | 1997-02-06 | 2003-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Short amphipathic peptides with activity against bacteria and intracellular pathogens |
| US6635740B1 (en) * | 1997-03-27 | 2003-10-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Ligand/lytic peptide compositions and methods of use |
| WO2001049834A2 (en) | 2000-01-06 | 2001-07-12 | Monsanto Technology Llc | Preparation of deallergenized patatin proteins and patatin permutein proteins |
| IL153359A0 (en) * | 2000-06-16 | 2003-07-06 | Hercules Inc | Peptides, compositions and methods for the treatment of burkholderia cepacia |
| EP1402001A4 (en) * | 2001-05-04 | 2006-05-24 | Scripps Research Inst | ANTIMICROBIAL PEPTIDES AND COMPOSITIONS |
-
2006
- 2006-02-07 CA CA2597191A patent/CA2597191C/en active Active
- 2006-02-07 ES ES06720369T patent/ES2378242T3/es active Active
- 2006-02-07 CN CN200680011180.7A patent/CN101155825B/zh active Active
- 2006-02-07 PL PL06720369T patent/PL1853620T3/pl unknown
- 2006-02-07 KR KR1020077020308A patent/KR101306643B1/ko active Active
- 2006-02-07 AT AT06720369T patent/ATE540969T1/de active
- 2006-02-07 AU AU2006212922A patent/AU2006212922B2/en not_active Ceased
- 2006-02-07 EP EP06720369A patent/EP1853620B1/en active Active
- 2006-02-07 SI SI200631248T patent/SI1853620T1/sl unknown
- 2006-02-07 DK DK06720369.5T patent/DK1853620T3/da active
- 2006-02-07 JP JP2007555158A patent/JP5335241B2/ja active Active
- 2006-02-07 WO PCT/US2006/004147 patent/WO2006086321A2/en not_active Ceased
- 2006-02-08 US US11/350,192 patent/US7407940B2/en active Active
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