JP2009502810A5 - - Google Patents
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- Publication number
- JP2009502810A5 JP2009502810A5 JP2008523045A JP2008523045A JP2009502810A5 JP 2009502810 A5 JP2009502810 A5 JP 2009502810A5 JP 2008523045 A JP2008523045 A JP 2008523045A JP 2008523045 A JP2008523045 A JP 2008523045A JP 2009502810 A5 JP2009502810 A5 JP 2009502810A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- amino acids
- infection
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 208000015181 infectious disease Diseases 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 7
- 230000000813 microbial effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 3
- 208000027096 gram-negative bacterial infections Diseases 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 101000653189 Homo sapiens Tissue factor pathway inhibitor Proteins 0.000 claims 1
- 230000004154 complement system Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70204905P | 2005-07-22 | 2005-07-22 | |
| US72251205P | 2005-09-29 | 2005-09-29 | |
| PCT/US2006/028804 WO2007014199A2 (en) | 2005-07-22 | 2006-07-24 | Tfpi fragments as anti-microbial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009502810A JP2009502810A (ja) | 2009-01-29 |
| JP2009502810A5 true JP2009502810A5 (OSRAM) | 2009-04-30 |
Family
ID=37683904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008523045A Pending JP2009502810A (ja) | 2005-07-22 | 2006-07-24 | 補体系と相互作用する抗微生物剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090176701A1 (OSRAM) |
| EP (1) | EP1913025A2 (OSRAM) |
| JP (1) | JP2009502810A (OSRAM) |
| KR (1) | KR20080040676A (OSRAM) |
| AU (1) | AU2006272653A1 (OSRAM) |
| BR (1) | BRPI0613676A2 (OSRAM) |
| CA (1) | CA2615777A1 (OSRAM) |
| RU (1) | RU2008106460A (OSRAM) |
| WO (1) | WO2007014199A2 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009129164A1 (en) * | 2008-04-15 | 2009-10-22 | Novartis Ag | Pharmaceutical combinations of tfpi-fragments and an antibiotic |
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| CN118715235A (zh) * | 2022-01-30 | 2024-09-27 | 西湖大学 | 预防和/或治疗由分支2菌株引起的艰难梭菌感染的组合物和方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| HUP0501111A2 (en) * | 2001-10-15 | 2007-12-28 | Chiron Corp | Treatment of severe pneumonia by administration of tissue factor pathway inhibitor |
-
2006
- 2006-07-24 AU AU2006272653A patent/AU2006272653A1/en not_active Abandoned
- 2006-07-24 WO PCT/US2006/028804 patent/WO2007014199A2/en not_active Ceased
- 2006-07-24 US US11/988,906 patent/US20090176701A1/en not_active Abandoned
- 2006-07-24 CA CA002615777A patent/CA2615777A1/en not_active Abandoned
- 2006-07-24 BR BRPI0613676-1A patent/BRPI0613676A2/pt not_active IP Right Cessation
- 2006-07-24 EP EP06800311A patent/EP1913025A2/en not_active Withdrawn
- 2006-07-24 JP JP2008523045A patent/JP2009502810A/ja active Pending
- 2006-07-24 KR KR1020087001728A patent/KR20080040676A/ko not_active Withdrawn
- 2006-07-24 RU RU2008106460/13A patent/RU2008106460A/ru not_active Application Discontinuation
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