RU2008106460A - Антимикробный агент, взаимодействующий с системой комплемента - Google Patents
Антимикробный агент, взаимодействующий с системой комплемента Download PDFInfo
- Publication number
- RU2008106460A RU2008106460A RU2008106460/13A RU2008106460A RU2008106460A RU 2008106460 A RU2008106460 A RU 2008106460A RU 2008106460/13 A RU2008106460/13 A RU 2008106460/13A RU 2008106460 A RU2008106460 A RU 2008106460A RU 2008106460 A RU2008106460 A RU 2008106460A
- Authority
- RU
- Russia
- Prior art keywords
- iptf
- polypeptide
- compound according
- complement system
- seq
- Prior art date
Links
- 239000004599 antimicrobial Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 23
- 150000001875 compounds Chemical class 0.000 claims abstract 18
- 229920001184 polypeptide Polymers 0.000 claims abstract 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 17
- 230000004154 complement system Effects 0.000 claims abstract 12
- 241001465754 Metazoa Species 0.000 claims abstract 8
- 241000894006 Bacteria Species 0.000 claims abstract 7
- 150000001413 amino acids Chemical class 0.000 claims abstract 6
- 230000000813 microbial effect Effects 0.000 claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 4
- 239000002158 endotoxin Substances 0.000 claims abstract 4
- 208000015181 infectious disease Diseases 0.000 claims abstract 4
- 229920006008 lipopolysaccharide Polymers 0.000 claims abstract 4
- 241000233866 Fungi Species 0.000 claims abstract 2
- 241000700605 Viruses Species 0.000 claims abstract 2
- 230000009089 cytolysis Effects 0.000 claims abstract 2
- 230000034994 death Effects 0.000 claims abstract 2
- 230000014207 opsonization Effects 0.000 claims abstract 2
- 108090000190 Thrombin Proteins 0.000 claims 4
- 210000004899 c-terminal region Anatomy 0.000 claims 4
- 229960004072 thrombin Drugs 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- ZOKVLMBYDSIDKG-CSMHCCOUSA-N Lys-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN ZOKVLMBYDSIDKG-CSMHCCOUSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70204905P | 2005-07-22 | 2005-07-22 | |
| US60/702,049 | 2005-07-22 | ||
| US72251205P | 2005-09-29 | 2005-09-29 | |
| US60/722,512 | 2005-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008106460A true RU2008106460A (ru) | 2009-08-27 |
Family
ID=37683904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008106460/13A RU2008106460A (ru) | 2005-07-22 | 2006-07-24 | Антимикробный агент, взаимодействующий с системой комплемента |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090176701A1 (OSRAM) |
| EP (1) | EP1913025A2 (OSRAM) |
| JP (1) | JP2009502810A (OSRAM) |
| KR (1) | KR20080040676A (OSRAM) |
| AU (1) | AU2006272653A1 (OSRAM) |
| BR (1) | BRPI0613676A2 (OSRAM) |
| CA (1) | CA2615777A1 (OSRAM) |
| RU (1) | RU2008106460A (OSRAM) |
| WO (1) | WO2007014199A2 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009129164A1 (en) * | 2008-04-15 | 2009-10-22 | Novartis Ag | Pharmaceutical combinations of tfpi-fragments and an antibiotic |
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| CN118715235A (zh) * | 2022-01-30 | 2024-09-27 | 西湖大学 | 预防和/或治疗由分支2菌株引起的艰难梭菌感染的组合物和方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| EA200400548A1 (ru) * | 2001-10-15 | 2005-06-30 | Чирон Корпорейшн | Лечение тяжёлой пневмонии путём введения ингибитора пути тканевого фактора (tfpi) |
-
2006
- 2006-07-24 KR KR1020087001728A patent/KR20080040676A/ko not_active Withdrawn
- 2006-07-24 EP EP06800311A patent/EP1913025A2/en not_active Withdrawn
- 2006-07-24 WO PCT/US2006/028804 patent/WO2007014199A2/en not_active Ceased
- 2006-07-24 JP JP2008523045A patent/JP2009502810A/ja active Pending
- 2006-07-24 US US11/988,906 patent/US20090176701A1/en not_active Abandoned
- 2006-07-24 AU AU2006272653A patent/AU2006272653A1/en not_active Abandoned
- 2006-07-24 CA CA002615777A patent/CA2615777A1/en not_active Abandoned
- 2006-07-24 BR BRPI0613676-1A patent/BRPI0613676A2/pt not_active IP Right Cessation
- 2006-07-24 RU RU2008106460/13A patent/RU2008106460A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0613676A2 (pt) | 2011-01-25 |
| EP1913025A2 (en) | 2008-04-23 |
| WO2007014199A3 (en) | 2007-05-24 |
| WO2007014199A2 (en) | 2007-02-01 |
| JP2009502810A (ja) | 2009-01-29 |
| CA2615777A1 (en) | 2007-02-01 |
| US20090176701A1 (en) | 2009-07-09 |
| AU2006272653A1 (en) | 2007-02-01 |
| KR20080040676A (ko) | 2008-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20100811 |