JP2008535909A - Mcp−1/ccr2関連疾患を治療するための分子およびその使用方法 - Google Patents

Mcp−1/ccr2関連疾患を治療するための分子およびその使用方法 Download PDF

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JP2008535909A
JP2008535909A JP2008506051A JP2008506051A JP2008535909A JP 2008535909 A JP2008535909 A JP 2008535909A JP 2008506051 A JP2008506051 A JP 2008506051A JP 2008506051 A JP2008506051 A JP 2008506051A JP 2008535909 A JP2008535909 A JP 2008535909A
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ccr2
mcp
molecule
amino acid
acid sequence
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JP2008535909A5 (enExample
Inventor
ナサン カリン,
ギジ ウィルドバーム,
ヤニヴ ゾハア,
リアト イザク,
ウリ ウエインベルグ,
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ラパポート ファミリー インスティテュート フォー リサーチ イン ザ メディカル サイエンシーズ
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Publication of JP2008535909A publication Critical patent/JP2008535909A/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008506051A 2005-04-15 2006-04-10 Mcp−1/ccr2関連疾患を治療するための分子およびその使用方法 Pending JP2008535909A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67147605P 2005-04-15 2005-04-15
PCT/IL2006/000454 WO2006109301A2 (en) 2005-04-15 2006-04-10 Molecules and methods of using same for treating mcp-1/ccr2 associated diseases

Publications (2)

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JP2008535909A true JP2008535909A (ja) 2008-09-04
JP2008535909A5 JP2008535909A5 (enExample) 2009-04-02

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JP2008506051A Pending JP2008535909A (ja) 2005-04-15 2006-04-10 Mcp−1/ccr2関連疾患を治療するための分子およびその使用方法

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Country Link
US (1) US8388962B2 (enExample)
EP (1) EP1871798B1 (enExample)
JP (1) JP2008535909A (enExample)
CN (1) CN101160323A (enExample)
AT (1) ATE445644T1 (enExample)
AU (1) AU2006233927A1 (enExample)
CA (1) CA2597789A1 (enExample)
DE (1) DE602006009786D1 (enExample)
ES (1) ES2333358T3 (enExample)
MX (1) MX2007010484A (enExample)
WO (1) WO2006109301A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2015020040A1 (ja) * 2013-08-06 2017-03-02 国立大学法人九州大学 有機酸重合体を有効成分とする癌細胞の生着予防又は生着抑制のための医薬

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007010484A (es) 2005-04-15 2007-10-15 Rappaport Family Inst For Res Moleculas y metodos para usarlas para tratar enfermedades asociadas con mcp-1/ccr2.
EP1989216A4 (en) * 2006-03-01 2010-03-31 Univ Michigan DIAGNOSIS AND TREATMENT OF PROSTATE CANCER
EP2193805A4 (en) 2007-08-24 2013-09-04 Univ Keio IMMUNOSUPPRESSION DETOXIFICANT WITH TUMOR CELLS AND THIS USE ANTITUMOROUS AGENT
CN102370981B (zh) * 2010-08-11 2014-07-16 中国科学院上海生命科学研究院 防治神经退行性疾病的试剂和方法
NO2776305T3 (enExample) 2014-04-23 2018-01-27
CN107362353A (zh) * 2016-05-11 2017-11-21 上海长海医院 一种去势抵抗的前列腺癌相关的药物靶点及其应用
KR102308102B1 (ko) * 2018-05-18 2021-10-07 가톨릭대학교 산학협력단 Ccr2를 유효성분으로 포함하는 골질환의 예방 또는 치료용 조성물
US20220409698A1 (en) * 2019-11-15 2022-12-29 The Catholic University Of Korea Industry-Academic Cooperation Foundation Composition for preventing or treating bone diseases comprising ccr2
KR102308099B1 (ko) * 2019-11-15 2021-10-01 가톨릭대학교 산학협력단 Soluble CCR2 발현 유도된 줄기세포를 유효성분으로 포함하는 골질환의 예방 또는 치료용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004521655A (ja) * 2001-07-26 2004-07-22 メデックスジェン カンパニー リミテッド 直列連鎖体を有する免疫接合体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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AU1679395A (en) * 1994-01-13 1995-08-01 Regents Of The University Of California, The Mammalian monocyte chemoattractant protein receptors
SE9600820D0 (sv) * 1996-03-01 1996-03-01 Pharmacia Ab Antibodies and their use
US6528625B1 (en) 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
AU2001243145A1 (en) 2000-02-09 2001-08-20 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
FR2828102B1 (fr) * 2001-03-28 2004-07-09 Ifc Sa Utilisation des lipoaminoacides dans une composition pharmaceutique comme promoteur et systeme disperse a usage pharmaceutique contenant de tels composes
ATE364050T1 (de) 2003-07-24 2007-06-15 Amgen Inc Zusammensetzungen und verfahren, die multimere und oligomere lösliche fragmente des tweak- rezeptors betreffen
IL157398A0 (en) 2003-08-14 2004-02-19 Hadasit Med Res Service Pharmaceutical compositions comprising ccr5 antagonists
GB2423472A (en) 2003-12-11 2006-08-30 Univ Yale Methods and compositions relating to ccr5 antagonist,ifn-&gammed;and il-13 induced inflammation
US20050215543A1 (en) 2004-03-24 2005-09-29 Pin-Fang Lin Methods of treating HIV infection
MX2007010484A (es) 2005-04-15 2007-10-15 Rappaport Family Inst For Res Moleculas y metodos para usarlas para tratar enfermedades asociadas con mcp-1/ccr2.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004521655A (ja) * 2001-07-26 2004-07-22 メデックスジェン カンパニー リミテッド 直列連鎖体を有する免疫接合体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2015020040A1 (ja) * 2013-08-06 2017-03-02 国立大学法人九州大学 有機酸重合体を有効成分とする癌細胞の生着予防又は生着抑制のための医薬

Also Published As

Publication number Publication date
DE602006009786D1 (de) 2009-11-26
EP1871798B1 (en) 2009-10-14
ES2333358T3 (es) 2010-02-19
CA2597789A1 (en) 2006-10-19
US8388962B2 (en) 2013-03-05
WO2006109301A3 (en) 2006-12-07
US20110033521A1 (en) 2011-02-10
MX2007010484A (es) 2007-10-15
ATE445644T1 (de) 2009-10-15
AU2006233927A1 (en) 2006-10-19
CN101160323A (zh) 2008-04-09
WO2006109301A2 (en) 2006-10-19
EP1871798A2 (en) 2008-01-02

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