JP2008533471A5 - - Google Patents

Info

Publication number

JP2008533471A5

JP2008533471A5 JP2008500963A JP2008500963A JP2008533471A5 JP 2008533471 A5 JP2008533471 A5 JP 2008533471A5 JP 2008500963 A JP2008500963 A JP 2008500963A JP 2008500963 A JP2008500963 A JP 2008500963A JP 2008533471 A5 JP2008533471 A5 JP 2008533471A5

Authority

JP

Japan

Prior art keywords

hepcidin

biomarkers

subject

biomarker

ovarian cancer

Prior art date

2006-03-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 30
• 239000000090 biomarker Substances 0.000 claims 29
• XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 19
• 102000018511 hepcidin Human genes 0.000 claims 18
• 229940066919 hepcidin Drugs 0.000 claims 18
• 108060003558 hepcidin Proteins 0.000 claims 18
• 206010033128 Ovarian cancer Diseases 0.000 claims 14
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 14
• 108010071690 Prealbumin Proteins 0.000 claims 12
• 102000009190 Transthyretin Human genes 0.000 claims 12
• 101000609413 Homo sapiens Inter-alpha-trypsin inhibitor heavy chain H4 Proteins 0.000 claims 11
• 102100039457 Inter-alpha-trypsin inhibitor heavy chain H4 Human genes 0.000 claims 11
• 239000012634 fragment Substances 0.000 claims 11
• 239000000523 sample Substances 0.000 claims 11
• 102400000498 Connective tissue-activating peptide III Human genes 0.000 claims 9
• 102000004338 Transferrin Human genes 0.000 claims 9
• 108090000901 Transferrin Proteins 0.000 claims 9
• 239000003795 chemical substances by application Substances 0.000 claims 9
• 108010035886 connective tissue-activating peptide Proteins 0.000 claims 9
• 239000007787 solid Substances 0.000 claims 9
• 239000012581 transferrin Substances 0.000 claims 9
• 238000005259 measurement Methods 0.000 claims 7
• 239000012472 biological sample Substances 0.000 claims 5
• 150000001875 compounds Chemical class 0.000 claims 3
• 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims 3
• 206010014733 Endometrial cancer Diseases 0.000 claims 2
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
• 102000015736 beta 2-Microglobulin Human genes 0.000 claims 2
• 108010081355 beta 2-Microglobulin Proteins 0.000 claims 2
• 238000003745 diagnosis Methods 0.000 claims 2
• 238000004949 mass spectrometry Methods 0.000 claims 2
• 208000025661 ovarian cyst Diseases 0.000 claims 2
• 206010003445 Ascites Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 206010061818 Disease progression Diseases 0.000 claims 1
• 201000009273 Endometriosis Diseases 0.000 claims 1
• 102400001151 Hepcidin-25 Human genes 0.000 claims 1
• 101800003310 Hepcidin-25 Proteins 0.000 claims 1
• 206010038111 Recurrent cancer Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• -1 and ApoA1 Proteins 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000010836 blood and blood product Substances 0.000 claims 1
• 229940125691 blood product Drugs 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 238000007635 classification algorithm Methods 0.000 claims 1
• 210000002726 cyst fluid Anatomy 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 230000005750 disease progression Effects 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 238000003018 immunoassay Methods 0.000 claims 1
• 201000010260 leiomyoma Diseases 0.000 claims 1
• 208000015124 ovarian disease Diseases 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1