JP2008532959A - 内部寄生虫駆除剤 - Google Patents
内部寄生虫駆除剤 Download PDFInfo
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- JP2008532959A JP2008532959A JP2008500080A JP2008500080A JP2008532959A JP 2008532959 A JP2008532959 A JP 2008532959A JP 2008500080 A JP2008500080 A JP 2008500080A JP 2008500080 A JP2008500080 A JP 2008500080A JP 2008532959 A JP2008532959 A JP 2008532959A
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Classifications
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Description
活性化合物として
−エモデプシド及び
−プラジクアンテル又はエプシプランテル
並びに溶媒として1,2−イソプロピリデングリセロール
を含んでなり、
組成物の水含有量が多くても1重量%である、
組成物を提供する。
プラジクアンテル又はエプシプランテルは特に以下:
擬葉目(Pseudophyllidea)、例えば、ジフィロボスリウム亜属(裂頭条虫)(Diphyllobothrium spp.)、スピロメトラ亜属(Spirometra spp.)、シストセファルス亜属(住血吸虫属)(Schistocephalus spp.)、リグラ亜属(Ligula spp.)、ボスリジウム亜属(Bothridium spp.)、ジフロゴノポルス亜属(大複殖門条虫)(Diphlogonoporus spp.)から、
円葉類目(Cyclophillidea)、例えば、メソセストイデス亜属(Mesocestoides spp.)、アノホプロセファラ亜属(葉状条虫)(Anoplocephala spp.)、パラノプロセファラ亜属(Paranoplocephala spp.)、モニエジア亜属(拡張条虫)(Moniezia spp.)、チサノソムサ亜属(Thysanosomsa spp.)、チサニエジア亜属(Thysaniezia spp.)、アビテリナ亜属(Avitellina spp.)、スチレシア亜属(Stilesia spp.)、シットテニア亜属(Cittotaenia spp.)、アンディラ亜属(Andyra spp.)、ベリチエラ亜属(Bertiella spp.)、テニア亜属(Taenia spp.)、エキノコックス亜属(Echinococcus spp.)、ヒダチゲラ亜属(Hydatigera spp.)、ダバイネ亜属(Davainea spp.)、ライリエチナ亜属(Raillietina spp.)、ヒメノレプシス亜属(膜様条虫)(Hymenolepsis spp.)、エキノレピス亜属(Echinolepis spp.)、エキノコチレ亜属(Echinocotyle spp.)、ジオルキス亜属(Diorchis spp.)、ジピリジウム亜属(瓜実条虫)(Dipylidium spp.)、ジョイエキシエラ亜属(Joyeuxiella spp.)、ジプロピリジウム亜属(Diplopylidium spp.)から、
単生類(Monogenea)の亜綱、例えば、ギロダクチルス亜属(三代虫)(Gyrodactylus spp.)、ダクチロギルス亜属(Dactylogyrus spp.)、ポリストーマ亜属(Polystoma spp.)、から、
二世亜綱(Digenea)、例えば、ジプロストムム亜属(Diplostomum spp.)、ポストジプロストムム亜属(Posthodiplostomum spp.)、シストソマ亜属(住血吸虫属)(Schistosoma spp.)、トリコビルハルジア亜属(Trichobilharzia spp.)、オルニソビルハルジア亜属(Ornithobilharzia spp.)、アウストロビルハルジア亜属(Austrobilharizia spp.)、ギガントビルハルジア亜属(Gigantobilharzia spp.)、ロイコクロリジウム亜属(Leucochloridium spp.)、ブラキライマ亜属(Brachylaima spp.)、エキノストマ亜属(棘口吸虫属)(Echinostoma spp.)、エキノパリフィウム亜属(Echinoparyphium spp.)、エキノカスムス亜属(Echinochasmus spp.)、ヒポデレウム亜属(Hypoderaeum spp.)、ファシオラ亜属(肝蛭)(Fasciola spp.)、ファシオリデス亜属(Fasciolides spp.)、ファシオロプシス亜属(肥大吸虫)(Fasciolopsis spp.)、シクロコエルム亜属(Cyclocoelum spp.)、チフロコエルム亜属(Typhlocoelum spp.)、パランフィストムム亜属(双口吸虫属)(Paramphistomum spp.)、カリコホロン亜属(Calicophoron spp.)、コチロホロン亜属(Cotylophoron spp.)、ギガントコチレ亜属(Gigantocotyle spp.)、フィスケデリウス亜属(Fischoederius spp.)、ガストロシラクス亜属(Gastrothylacus spp.)、ノトコチルス亜属(Notocotylus spp.)、カタトロピス亜属(Catatropis spp.)、プラギオルキス亜属(Plagiorchis spp.)、プロストゴニムス亜属(Prosthogonimus spp.)、ジクロケリウム亜属(槍形吸虫属)(Dicrocoelium spp.)、ユーリトレマ亜属(膵蛭)(Eurytrema spp.)、トログロトレマ亜属(Troglotrema spp.)、パラゴニムス亜属(肺吸虫属)(Paragonimus spp.)、コリリクルム亜属(吸虫属)(Collyriclum spp.)、ナノフィエタス亜属(Nanophyetus spp.)、オピストルキス亜属(Opisthorchis spp.)、クロノルキス亜属(肝ジストマ)(Clonorchis spp.)、メトルキス亜属(Metorchis spp.)、ヘテロフィエス亜属(異形吸虫属)(Heterophyes spp.)、メタゴニムス亜属(Metagonimus spp.)の亜綱から、
の内部寄生虫を抑制する。
エノプリダ目(Enoplida)、例えば、トリクリス亜属(鞭虫)(Trichuris spp.)、カピラリア亜属(毛細線虫)(Capillaria spp.)、トリコモソイデス亜属(Trichomosoides spp.)、トリキネラ亜属(旋毛虫属)(Trichinella spp.)、から、
桿線虫目(Rhabditia)、例えば、ミクロネマ亜属(Micronema spp.)、ストロンギロイデス亜属(Strongyloides spp.)、から、
円虫目(Strongylida)、例えば、ストロニルス亜属(円虫)(Stronylus spp.)、トリオドントホルス亜属(Triodontophorus spp.)、エソファゴドンタス亜属(Oesophagodontus spp.)、トリコネマ亜属(Trichonema spp.)、ギアロセファルス亜属(Gyalocephalus spp.)、シリンドロファリンクス亜属(Cylindropharynx spp.)、ポテリオストムム亜属(Poteriostomum spp.)、シクロコセルクス亜属(Cyclococercus spp.)、シリコステファヌス亜属(Cylicostephanus spp.)、エソファゴストムム亜属(腸結節虫属)(Oesophagostomum spp.)、シャベルチア亜属(Chabertia spp.)、ステファヌルス亜属(豚腎虫)(Stephanurus spp.)、アンシロストマ亜属(ズビニ鉤虫)(Ancylostoma spp.)、ウンシナリア亜属(Uncinaria spp.)、ブノストムム亜属(Bunostomum spp.)、から、
グロボセファルス亜属(Globocephalus spp.)、シンガムス亜属(交合線虫)(Syngamus spp.)、シアストーマ亜属(Cyathostoma spp.)、メタストロンギルス亜属(肺虫)(Metastrongylus spp.)、ジクチオカウルス亜属(Dictyocaulus spp.)、ミュエレリウス亜属(Muellerius spp.)、プロトストロンギルス亜属(Protostrongylus spp.)、ネオストロンギルス亜属(Neostrongylus spp.)、シストカウルス亜属(Cystocaulus spp.)、ニューモストロンギルス亜属(Pneumostrongylus spp.)、スピコカウルス亜属(Spicocaulus spp.)、エラホストロンギルス亜属(Elaphostrongylus spp.)、パレラホストロンギルス亜属(Parelaphostrongylus spp.)、クレノソマ亜属(Crenosoma spp.)、パラクレノソマ亜属(Parelaphostrongylus spp.)、アンギオストロンギルス亜属(住血線虫)(Angiostrongylus spp.)、エルロストギルス亜属(Aelurosutrongylus spp.)、フィラロイデス亜属(Filaroides spp.)、パラフィラロイデス亜属(Parafilaroides spp.)、トリコストロンギルス亜属(毛様線虫)(Trichostrongylus spp.)、ヘモンクス亜属(捻転胃虫)(Haemonchus spp.)、オステルタジア亜属(Ostertagia spp.)、マルシャラジア亜属(Marshallagia spp.)、クーペリア亜属(Cooperia spp.)、ネマトジルス亜属(線虫)(Nematodirus spp.)、ヒオストロンギルス亜属(Hyostrongylus spp.)、オベリスコイデス亜属(Obeliscoides spp.)、アミドストムム亜属(Amidostomum spp.)、オルラヌス亜属(Ollulanus spp.)、
オキシウリダ目(Oxyurida)、例えば、オキシウリス亜属(ウマギョウチュウ)(Oxyuris spp.)、エンテロビウス亜属(ギョウチュウ)(Enterobius spp.)、パッサルルス亜属(Passalurus spp.)、シファシア亜属(Syphacia spp.)、アスピキュルリス亜属(Aspiculuris spp.)、ヘテラキス亜属(Heterakis spp.)、から、
回虫目(Ascaridia)、例えば、アスカリス亜属(カイチュウ)(Ascaris spp.)、トキソアスカリス亜属(Toxascaris spp.)、トキソカラ亜属(イヌ回虫)(Toxocara spp.)、パラスカリス亜属(ウマ回虫)(Parascaris spp.)、アニサキス亜属(Anisakis spp.)、アスカリジア亜属(回虫)(Ascaridia spp.)、から、
スピルリダ目(旋尾線虫類)(Spirurida)、例えば、グナトストマ亜属(顎口虫)(Gnathostoma spp.)、フィサロプテラ亜属(Physaloptera spp.)、テラジア亜属(Thelazia spp.)、ゴンギロネマ亜属(Gongylonema spp.)、ハブロネマ亜属(Habronema spp.)、パラブロネマ亜属(Parabronema spp.)、ドラスキア亜属(Draschia)spp.、ドラクンクルス亜属(メディナ虫)(Dracunculus spp.)、から、
フィラリイダ目(Filariida)、例えば、ステファノフィラリア亜属(Stephanofilaria spp.)、パラフィラリア亜属(Parafilaria spp.)、セタリア亜属(Setaria spp.)、ロア亜属(Loa spp.)、ジロフィラリア亜属(イヌ糸状虫)(Dirofilaria spp.)、リトモソイデス亜属(Litomosoides spp.)、ブルギア亜属(Brugia spp.)、ウケレリア亜属(糸状虫)(Wuchereria spp.)、オンコセルカ亜属(Onchocerca spp.)、から、
ギガントリンキダ目(Gigentorhynchida)、例えば、フィリコリス亜属(Filicollis spp.)、モニリホルミス亜属(Moniliforumis spp.)、マクラカントリンクス亜属(Macracanthorhynchus spp.)、プロステノルキス亜属(Prosthenorchis spp.)、から
の内部寄生虫を抑制する。
7.94gのプラジクアンテル、
1.98gのエモデプシド、
87.58gの1,2−イソプロピリデングリセロール、
2.00gの乳酸、
0.50gのブチル化ヒドロキシアニイソール
を含んでなる。
Claims (7)
- 活性化合物として、
−エモデプシド及び
−プラジクアンテル又はエプシプランテル
並びに溶媒として1,2−イソプロピリデングリセロール
を含んでなり、
組成物の水含有量が多くても1重量%である
組成物。 - 活性化合物として、エモデプシド及びプラジクアンテルを含んでなることを特徴とする請求項1に従う組成物。
- 使用される溶媒が少なくとも60容量%の1,2−イソプロピリデングリセロールを含んでなることを特徴とする、前記請求項のいずれかに従う組成物。
- 唯一の溶媒として1,2−イソプロピリデングリセロールを含んでなることを特徴とする、前記請求項のいずれかに従う組成物。
- 活性化合物を溶媒及び適当な場合は更なる補助剤と混合することを特徴とする、請求項1〜4のいずれかに従う組成物の調製方法。
- 多くても1重量%の水含有量を有し且つ内部寄生虫を抑制するための外用に適した、溶媒として1,2−イソプロピリデングリセロールを含んでなる組成物を調製するためのエモデプシド及びプラジクアンテル又はエプシプランテルの使用。
- 内部寄生虫を抑制するための請求項1〜4のいずれかに従う組成物の使用。
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DE102005011779A DE102005011779A1 (de) | 2005-03-11 | 2005-03-11 | Endoparasitizide Mittel |
DE102005011779.1 | 2005-03-11 | ||
PCT/EP2006/001759 WO2006094664A1 (de) | 2005-03-11 | 2006-02-27 | Endoparasitizide mittel |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012520244A (ja) * | 2009-03-10 | 2012-09-06 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 抗原生動物性トリアジンおよび駆虫性シクロデプシペプチドを含有する油性製剤 |
JP2015502377A (ja) * | 2011-12-21 | 2015-01-22 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 非晶質エモデプシド含有製剤 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004055316A1 (de) * | 2004-11-16 | 2006-05-18 | Bayer Healthcare Ag | Verhinderung vertikaler Endoparasiten-Infektionen |
DE102005011779A1 (de) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
EP3480195A1 (en) | 2017-11-07 | 2019-05-08 | Bayer Animal Health GmbH | Method for the synthesis of cyclic depsipeptides |
SG11202003272UA (en) | 2017-11-07 | 2020-05-28 | Bayer Animal Health Gmbh | Method for the synthesis of cyclic depsipeptides |
CA3147171A1 (en) * | 2019-08-14 | 2021-02-18 | Vetoquinol Sa | Compositions comprising tigolaner for controlling parasites |
CN111346046B (zh) * | 2020-03-06 | 2021-07-09 | 安徽农业大学 | 一种含莫西菌素注射用缓释凝胶制剂及制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6396127A (ja) * | 1986-10-11 | 1988-04-27 | バイエル・アクチエンゲゼルシヤフト | 蠕虫病の経皮用駆除剤 |
JPH07223951A (ja) * | 1994-01-11 | 1995-08-22 | Bayer Ag | 内寄生性生物防除剤である組成物 |
JP2003523397A (ja) * | 2000-02-22 | 2003-08-05 | バイエル アクチェンゲゼルシャフト | 殺内部寄生虫剤 |
WO2004089239A2 (en) * | 2003-04-04 | 2004-10-21 | Merial Ltd. | Topical anthelmintic veterinary formulations |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2362539C2 (de) * | 1973-12-17 | 1986-05-07 | Merck Patent Gmbh, 6100 Darmstadt | 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
CA1194791A (en) * | 1981-05-08 | 1985-10-08 | John M. Ballany | Parasiticidal pour-on compositions |
DE3472678D1 (de) * | 1983-07-18 | 1988-08-18 | Beecham Group Plc | Benzazepine and benzoxazepine derivatives |
NO176766C (no) * | 1989-02-07 | 1995-05-24 | Meiji Seika Kaisha | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet |
DK0634408T3 (da) * | 1992-03-17 | 2002-04-22 | Fujisawa Pharmaceutical Co | Depsipeptidderivater, fremstilling og anvendelse deraf |
DE4317458A1 (de) * | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
DE4317432A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
DE4317457A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
NZ260018A (en) * | 1994-03-03 | 1995-10-26 | Bomac Lab Ltd | Benzimidazole compositions and anthelmintic compositions |
DE19520275A1 (de) * | 1995-06-02 | 1996-12-05 | Bayer Ag | Endoparasitizide Mittel |
DE19601263A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Anthelmintische Paste |
DE19628776A1 (de) * | 1996-07-17 | 1998-01-22 | Bayer Ag | Oral applizierbare Granulate von Hexahydropyrazinderivaten |
US6340672B1 (en) * | 2000-02-16 | 2002-01-22 | Phoenix Scientific, Inc. | Parasiticidal formulation and a method of making this formulation |
DE60118132T2 (de) * | 2000-10-10 | 2006-10-19 | Wyeth | Anthelmintika |
US6893652B2 (en) * | 2001-08-27 | 2005-05-17 | Wyeth | Endoparasiticidal gel composition |
US7001889B2 (en) * | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
DE10358525A1 (de) * | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
DE102004001558A1 (de) * | 2004-01-10 | 2005-08-18 | Bayer Healthcare Ag | Arzneimittel zur topischen Applikation bei Tieren |
DE102005011779A1 (de) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6396127A (ja) * | 1986-10-11 | 1988-04-27 | バイエル・アクチエンゲゼルシヤフト | 蠕虫病の経皮用駆除剤 |
JPH07223951A (ja) * | 1994-01-11 | 1995-08-22 | Bayer Ag | 内寄生性生物防除剤である組成物 |
JP2003523397A (ja) * | 2000-02-22 | 2003-08-05 | バイエル アクチェンゲゼルシャフト | 殺内部寄生虫剤 |
WO2004089239A2 (en) * | 2003-04-04 | 2004-10-21 | Merial Ltd. | Topical anthelmintic veterinary formulations |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012520244A (ja) * | 2009-03-10 | 2012-09-06 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 抗原生動物性トリアジンおよび駆虫性シクロデプシペプチドを含有する油性製剤 |
JP2015502377A (ja) * | 2011-12-21 | 2015-01-22 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 非晶質エモデプシド含有製剤 |
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US7763583B2 (en) | Endoparasiticidal compositions for topical application | |
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