JP2008532523A5 - - Google Patents
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- JP2008532523A5 JP2008532523A5 JP2008500966A JP2008500966A JP2008532523A5 JP 2008532523 A5 JP2008532523 A5 JP 2008532523A5 JP 2008500966 A JP2008500966 A JP 2008500966A JP 2008500966 A JP2008500966 A JP 2008500966A JP 2008532523 A5 JP2008532523 A5 JP 2008532523A5
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- Prior art keywords
- antibody
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- acid sequence
- cell
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 21
- 102000003735 Mesothelin Human genes 0.000 claims 11
- 108090000015 Mesothelin Proteins 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 239000012642 immune effector Substances 0.000 claims 4
- 229940121354 immunomodulator Drugs 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000003966 growth inhibitor Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66017705P | 2005-03-10 | 2005-03-10 | |
| US60/660,177 | 2005-03-10 | ||
| PCT/US2006/008598 WO2006099141A2 (en) | 2005-03-10 | 2006-03-09 | Anti-mesothelin antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290449A Division JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008532523A JP2008532523A (ja) | 2008-08-21 |
| JP2008532523A5 true JP2008532523A5 (OSRAM) | 2009-07-30 |
| JP4949373B2 JP4949373B2 (ja) | 2012-06-06 |
Family
ID=36992268
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500966A Active JP4949373B2 (ja) | 2005-03-10 | 2006-03-09 | 抗メソテリン抗体 |
| JP2011290449A Active JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
| JP2013168325A Active JP5788443B2 (ja) | 2005-03-10 | 2013-08-13 | 抗メソテリン抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290449A Active JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
| JP2013168325A Active JP5788443B2 (ja) | 2005-03-10 | 2013-08-13 | 抗メソテリン抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7592426B2 (OSRAM) |
| EP (2) | EP2322560B1 (OSRAM) |
| JP (3) | JP4949373B2 (OSRAM) |
| AU (2) | AU2006223301B2 (OSRAM) |
| CA (1) | CA2600505C (OSRAM) |
| ES (2) | ES2429340T3 (OSRAM) |
| WO (1) | WO2006099141A2 (OSRAM) |
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| CN1541226A (zh) | 2001-05-18 | 2004-10-27 | ���ָ��Ӣ��ķ�������Ϲ�˾ | CD44v6特异性的抗体 |
| EP1258255A1 (en) | 2001-05-18 | 2002-11-20 | Boehringer Ingelheim International GmbH | Conjugates of an antibody to CD44 and a maytansinoid |
| JP2005502335A (ja) | 2001-08-08 | 2005-01-27 | インサイト・ゲノミックス・インコーポレイテッド | 細胞成長、分化および細胞死関連タンパク質 |
| WO2004009782A2 (en) | 2002-07-19 | 2004-01-29 | Morphotek, Inc. | Methods for generating enhanced antibody-producing cell lines with improved growth characteristics |
| WO2005014652A1 (en) * | 2003-08-05 | 2005-02-17 | Morphotek, Inc. | A variant cell surface molecule associated with cancer |
| ES2429340T3 (es) | 2005-03-10 | 2013-11-14 | Morphotek, Inc. | Anticuerpos anti-mesotelina |
| JP2009521206A (ja) * | 2005-04-22 | 2009-06-04 | モルフォテック、インク． | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
-
2006
- 2006-03-09 ES ES10180413T patent/ES2429340T3/es active Active
- 2006-03-09 JP JP2008500966A patent/JP4949373B2/ja active Active
- 2006-03-09 CA CA2600505A patent/CA2600505C/en active Active
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- 2006-03-09 EP EP10180413.6A patent/EP2322560B1/en active Active
- 2006-03-09 WO PCT/US2006/008598 patent/WO2006099141A2/en not_active Ceased
- 2006-03-09 US US11/373,546 patent/US7592426B2/en active Active
- 2006-03-09 ES ES06737748T patent/ES2386367T3/es active Active
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