JP2008526836A - シブトラミンの無機酸塩 - Google Patents

シブトラミンの無機酸塩 Download PDF

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Publication number
JP2008526836A
JP2008526836A JP2007550301A JP2007550301A JP2008526836A JP 2008526836 A JP2008526836 A JP 2008526836A JP 2007550301 A JP2007550301 A JP 2007550301A JP 2007550301 A JP2007550301 A JP 2007550301A JP 2008526836 A JP2008526836 A JP 2008526836A
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JP
Japan
Prior art keywords
sibutramine
acid salt
inorganic acid
bromate
hydrogen sulfate
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Pending
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JP2007550301A
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Japanese (ja)
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JP2008526836A5 (https=
Inventor
ドンクォン リム，
ウンヨン ヤン，
ジェギョン コー，
クァンド チョイ，
ヨンシク ヨン，
ヘラン スー，
チャンジュ キム，
Original Assignee
シージェー チェイルジェダン コーポレーション
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Publication of JP2008526836A publication Critical patent/JP2008526836A/ja
Publication of JP2008526836A5 publication Critical patent/JP2008526836A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/24—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2007550301A 2005-01-06 2006-01-06 シブトラミンの無機酸塩 Pending JP2008526836A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20050001405 2005-01-06
PCT/KR2006/000073 WO2006073292A1 (en) 2005-01-06 2006-01-06 Inorganic acid salts of sibutramine

Publications (2)

Publication Number Publication Date
JP2008526836A true JP2008526836A (ja) 2008-07-24
JP2008526836A5 JP2008526836A5 (https=) 2008-11-27

Family

ID=36647751

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007550301A Pending JP2008526836A (ja) 2005-01-06 2006-01-06 シブトラミンの無機酸塩

Country Status (6)

Country Link
US (1) US7432398B2 (https=)
EP (1) EP1846359A4 (https=)
JP (1) JP2008526836A (https=)
KR (1) KR100830002B1 (https=)
CN (1) CN101098850B (https=)
WO (1) WO2006073292A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017530146A (ja) * 2014-10-09 2017-10-12 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． Ｊａｋ阻害剤の硫酸水素塩の結晶形およびその製造方法
JP2022506137A (ja) * 2018-10-31 2022-01-17 レ ラボラトワール セルヴィエ Ｂｃｌ－２阻害薬の新規な塩、関連する結晶形、その調製方法及びそれを含有する医薬組成物
JP2024520141A (ja) * 2021-06-04 2024-05-21 リペア セラピューティクス インコーポレイテッド 結晶形、それを含有する組成物、およびそれらの使用方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060080818A (ko) * 2005-01-06 2006-07-11 씨제이 주식회사 시부트라민의 술폰산염
KR20060080817A (ko) * 2005-01-06 2006-07-11 씨제이 주식회사 시부트라민의 디카복실산염
KR100814384B1 (ko) * 2006-02-10 2008-03-18 대화제약 주식회사 시부트라민 염을 함유하는 약학 조성물 및 이의 제조방법
KR100800561B1 (ko) * 2006-03-29 2008-02-04 주식회사 삼오제약 시부트라민 술포닐염의 제조방법 및 이를 포함하는비만관련 질환 예방 및 치료용 약학조성물
EP2044043B2 (en) 2006-06-16 2021-03-03 H. Lundbeck A/S 1- ý[- (2, 4-dimethylphenylsulfanyl) -phenyl]piperazine hydrobromide as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
CN102786444A (zh) * 2012-07-24 2012-11-21 上海瑞博化学有限公司 一种西布曲明类似物的磺酸盐的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021615A1 (en) * 1994-02-11 1995-08-17 Knoll Ag Use of arylcyclobutylalkylamines for the treatment of seizures and neurological disorders
WO2000056310A1 (en) * 1999-03-19 2000-09-28 Knoll Pharmaceutical Company Treatment of chronic fatigue syndrome
JP2001050883A (ja) * 1999-08-05 2001-02-23 Akashi Corp 複合機能材料試験機
JP2002523366A (ja) * 1998-08-24 2002-07-30 セプラコア インコーポレーテッド ドーパミン再取込みインヒビターを含有する組成物及びその使用方法
JP2002539251A (ja) * 1999-03-19 2002-11-19 クノール・ゲー・エム・ベー・ハー 治療薬に伴う体重増加を調節する方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52768B1 (en) 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
GB8531071D0 (en) 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB2184122B (en) 1985-12-17 1989-10-18 Boots Co Plc N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate
GB8704777D0 (en) 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (ja) 1988-03-31 1997-11-12 科研製薬株式会社 脳機能改善剤
IE61928B1 (en) 1988-11-29 1994-11-30 Boots Co Plc Treatment of obesity
US5459164A (en) 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
GB9619961D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
US6046242A (en) * 1998-11-27 2000-04-04 Basf Aktiengesellschaft Use of aryl-substituted cyclobutylalkylamines for treating urinary incontinence
BR0105486A (pt) 2001-09-27 2003-10-07 Libbs Farmaceutica Ltda Novo composto farmacêutico, seus processos de obtenção e composições farmacêuticas contendo o mesmo
JP4278652B2 (ja) 2002-10-05 2009-06-17 ハンミ ファーム． シーオー．， エルティーディー． 結晶性シブトラミンメタンスルホン酸塩半水和物を含む医薬組成物
KR100536750B1 (ko) * 2002-10-05 2005-12-16 한미약품 주식회사 시부트라민 메탄술폰산염의 결정성 반수화물을 포함하는약학 조성물
GB0310361D0 (en) * 2003-05-06 2003-06-11 Cipla Ltd Pharmaceutical compound
KR20060080818A (ko) 2005-01-06 2006-07-11 씨제이 주식회사 시부트라민의 술폰산염
KR20060080817A (ko) 2005-01-06 2006-07-11 씨제이 주식회사 시부트라민의 디카복실산염

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021615A1 (en) * 1994-02-11 1995-08-17 Knoll Ag Use of arylcyclobutylalkylamines for the treatment of seizures and neurological disorders
JP2002523366A (ja) * 1998-08-24 2002-07-30 セプラコア インコーポレーテッド ドーパミン再取込みインヒビターを含有する組成物及びその使用方法
WO2000056310A1 (en) * 1999-03-19 2000-09-28 Knoll Pharmaceutical Company Treatment of chronic fatigue syndrome
JP2002539251A (ja) * 1999-03-19 2002-11-19 クノール・ゲー・エム・ベー・ハー 治療薬に伴う体重増加を調節する方法
JP2001050883A (ja) * 1999-08-05 2001-02-23 Akashi Corp 複合機能材料試験機

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017530146A (ja) * 2014-10-09 2017-10-12 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． Ｊａｋ阻害剤の硫酸水素塩の結晶形およびその製造方法
JP2022506137A (ja) * 2018-10-31 2022-01-17 レ ラボラトワール セルヴィエ Ｂｃｌ－２阻害薬の新規な塩、関連する結晶形、その調製方法及びそれを含有する医薬組成物
JP2024520141A (ja) * 2021-06-04 2024-05-21 リペア セラピューティクス インコーポレイテッド 結晶形、それを含有する組成物、およびそれらの使用方法

Also Published As

Publication number Publication date
US20070191489A1 (en) 2007-08-16
KR100830002B1 (ko) 2008-05-15
WO2006073292A1 (en) 2006-07-13
CN101098850B (zh) 2010-09-15
KR20060080899A (ko) 2006-07-11
US7432398B2 (en) 2008-10-07
CN101098850A (zh) 2008-01-02
EP1846359A4 (en) 2010-03-31
EP1846359A1 (en) 2007-10-24

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