JP2008524162A5 - - Google Patents
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- JP2008524162A5 JP2008524162A5 JP2007546063A JP2007546063A JP2008524162A5 JP 2008524162 A5 JP2008524162 A5 JP 2008524162A5 JP 2007546063 A JP2007546063 A JP 2007546063A JP 2007546063 A JP2007546063 A JP 2007546063A JP 2008524162 A5 JP2008524162 A5 JP 2008524162A5
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- Prior art keywords
- benzene
- glucopyranose
- benzyl
- acceptable salt
- physiologically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 2
- 102100037202 Sodium/myo-inositol cotransporter 2 Human genes 0.000 claims 2
- 101710090560 Sodium/myo-inositol cotransporter 2 Proteins 0.000 claims 2
- 150000001555 benzenes Chemical class 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- -1 β-D-glucopyranosyl group Chemical group 0.000 claims 2
- JGCYYBYBNLCYJL-GNADVCDUSA-N (2R,3R,4S,5S,6R)-2-[3-[(4-but-1-ynylphenyl)methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound C1=CC(C#CCC)=CC=C1CC1=CC([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1C JGCYYBYBNLCYJL-GNADVCDUSA-N 0.000 claims 1
- UWWMOLLEOLEOPV-WSGIOKLISA-N (2R,3R,4S,5S,6R)-2-[3-[(4-cyclohexyloxyphenyl)methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound CC1=CC=C([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(C=C1)=CC=C1OC1CCCCC1 UWWMOLLEOLEOPV-WSGIOKLISA-N 0.000 claims 1
- ZTWOYHRAJXMSAD-GNADVCDUSA-N (2R,3R,4S,5S,6R)-2-[3-[(4-ethynylphenyl)methyl]-4-propan-2-ylphenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound CC(C)C1=CC=C([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC1=CC=C(C#C)C=C1 ZTWOYHRAJXMSAD-GNADVCDUSA-N 0.000 claims 1
- UTPWWZOQLPABOK-GNADVCDUSA-N (2R,3R,4S,5S,6R)-2-[4-chloro-3-[(4-piperidin-4-yloxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@](O)([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OC3CCNCC3)cc2)c1 UTPWWZOQLPABOK-GNADVCDUSA-N 0.000 claims 1
- YYFWRZWPMRLPCB-QMCAAQAGSA-N (2R,3R,4S,5S,6R)-2-[4-chloro-3-[(4-prop-1-ynylphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound C1=CC(C#CC)=CC=C1CC1=CC([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl YYFWRZWPMRLPCB-QMCAAQAGSA-N 0.000 claims 1
- XDKLGPMSLDIDKQ-ZJAVEQEKSA-N (2R,3R,4S,5S,6R)-2-[4-chloro-3-[1-(4-propan-2-ylphenyl)prop-2-ynyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound C1=CC(C(C)C)=CC=C1C(C#C)C1=CC([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl XDKLGPMSLDIDKQ-ZJAVEQEKSA-N 0.000 claims 1
- DRYSFTAPMHAOPM-WXVCVYNLSA-N (2R,3R,4S,5S,6R)-2-[4-chloro-3-[1-[4-(2-hydroxyethyl)phenyl]prop-2-ynyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound C1=CC(CCO)=CC=C1C(C#C)C1=CC([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl DRYSFTAPMHAOPM-WXVCVYNLSA-N 0.000 claims 1
- TWLZSXRNDMAZJI-QMCAAQAGSA-N (2R,3R,4S,5S,6R)-2-[4-ethynyl-3-[(4-methoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound C1=CC(OC)=CC=C1CC1=CC([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1C#C TWLZSXRNDMAZJI-QMCAAQAGSA-N 0.000 claims 1
- CTQKVAMLNWHSRW-XNBWIAOKSA-N (2R,3R,4S,5S,6R)-6-(hydroxymethyl)-2-[4-methyl-3-[(4-prop-1-ynylphenyl)methyl]phenyl]oxane-2,3,4,5-tetrol Chemical compound C1=CC(C#CC)=CC=C1CC1=CC([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1C CTQKVAMLNWHSRW-XNBWIAOKSA-N 0.000 claims 1
- SFZDSAWRWKXPOH-JHXGOWNISA-N (2R,3R,4S,5S,6R)-6-(hydroxymethyl)-2-[4-methyl-3-[[4-[(3R)-oxolan-3-yl]oxyphenyl]methyl]phenyl]oxane-2,3,4,5-tetrol Chemical compound Cc1ccc(cc1Cc1ccc(O[C@@H]2CCOC2)cc1)[C@@]1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SFZDSAWRWKXPOH-JHXGOWNISA-N 0.000 claims 1
- SFZDSAWRWKXPOH-PAXOCGFSSA-N (2R,3R,4S,5S,6R)-6-(hydroxymethyl)-2-[4-methyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]oxane-2,3,4,5-tetrol Chemical compound Cc1ccc(cc1Cc1ccc(O[C@H]2CCOC2)cc1)[C@@]1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SFZDSAWRWKXPOH-PAXOCGFSSA-N 0.000 claims 1
- DCLKEZMLRVIIFD-NHTNDUFYSA-N (2r,3r,4s,5s,6r)-2-[3-[(4-cyclopentyloxyphenyl)methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound CC1=CC=C([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(C=C1)=CC=C1OC1CCCC1 DCLKEZMLRVIIFD-NHTNDUFYSA-N 0.000 claims 1
- AHPHBMNKCIWEBW-QMCAAQAGSA-N (2r,3r,4s,5s,6r)-2-[5-[(4-ethynylphenyl)methyl]-2-methoxyphenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound C1=C([C@]2(O)[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C(OC)=CC=C1CC1=CC=C(C#C)C=C1 AHPHBMNKCIWEBW-QMCAAQAGSA-N 0.000 claims 1
- 208000010444 Acidosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 201000001431 Hyperuricemia Diseases 0.000 claims 1
- 208000013016 Hypoglycemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000007976 Ketosis Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010027417 Metabolic acidosis Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 108091006269 SLC5A2 Proteins 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 102000000070 Sodium-Glucose Transport Proteins Human genes 0.000 claims 1
- 108010080361 Sodium-Glucose Transport Proteins Proteins 0.000 claims 1
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 208000018914 glucose metabolism disease Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 230000004140 ketosis Effects 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 208000013223 septicemia Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- OJQQCBQFRVDUJN-MWRXUHODSA-N tert-butyl 4-[4-[[2-chloro-5-[(2R,3R,4S,5S,6R)-2,3,4,5-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]phenoxy]piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CC1)Oc1ccc(Cc2cc(ccc2Cl)[C@@]2(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 OJQQCBQFRVDUJN-MWRXUHODSA-N 0.000 claims 1
Claims (11)
- 以下の化合物：
(1)1-メチル-2-(4-シクロペンチルオキシ-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(2)1-メチル-2-[4-((R)-テトラヒドロフラン-3-イルオキシ)-ベンジル]-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(3)1-メチル-2-[4-((S)-テトラヒドロフラン-3-イルオキシ)-ベンジル]-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(4)1-メチル-2-(4-シクロヘキシルオキシ-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(5)1-クロロ-2-[4-(1-tert-ブチルオキシカルボニルピペリジン-4-イルオキシ)-ベンジル]-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(6)1-クロロ-2-[4-(ピペリジン-4-イルオキシ)-ベンジル]-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(7)1-メトキシ-2-(β-D-グルコピラノース-1-イル)-4-(4-エチニル-ベンジル)-ベンゼン、
(10)1-クロロ-2-(4-ヒドロキシエチルエチニル-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(11)1-エチニル-2-(4-メトキシ-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(12)1-メチル-2-(4-ブチン-1-イル-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(13)1-クロロ-2-(4-プロピン-1-イル-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(14)1-メチル-2-(4-プロピン-1-イル-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(15)1-イソプロピル-2-(4-エチニル-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン、
(16)1-クロロ-2-(4-イソプロピルエチニル-ベンジル)-4-(β-D-グルコピラノース-1-イル)-ベンゼン
の中から選択されるグルコピラノシル置換ベンゼン誘導体、
又はβ-D-グルコピラノシル基の1個以上のヒドロキシル基が、(C1-18-アルキル)カルボニル、(C1-18-アルキル)オキシカルボニル、フェニルカルボニル及びフェニル-(C1-3-アルキル)-カルボニルから選択される基でアシル化されている、その誘導体、若しくは医薬的に許容しうるその塩、
或いはその互変異性体、立体異性体又はその混合物、及びその塩。 - 該β-D-グルコピラノシル基のヒドロキシル基O-6の水素原子が、(C1-8-アルキル)カルボニル、(C1-8-アルキル)オキシカルボニル及びフェニルカルボニルの中から選択される基と置き換わっていることを特徴とする請求項１に記載のグルコピラノシル置換ベンゼン誘導体、又はその医薬的に許容しうる塩。
- 請求項１又は２に記載の化合物の、無機又は有機酸との生理学的に許容しうる塩。
- 請求項１若しくは２に記載の化合物又は請求項３に記載の生理学的に許容しうる塩を含み、任意に１種以上の不活性な担体及び／又は希釈剤を一緒に含んでよい医薬組成物。
- 少なくとも１種の請求項１若しくは２に記載の化合物又は請求項３に記載の生理学的に許容しうる塩の、ナトリウム依存性グルコース共輸送体SGLTを阻害することによって影響を受けうる疾患又は状態の治療又は予防に適した医薬組成物を調製するための使用。
- 少なくとも１種の請求項１若しくは２に記載の化合物又は請求項３に記載の生理学的に許容しうる塩の、１種以上の代謝障害の治療又は予防に適した医薬組成物を調製するための使用。
- 前記代謝障害が、１型及び２型糖尿病、糖尿病の合併症、代謝性アシドーシス若しくはケトーシス、反応性低血糖症、高インスリン血症、グルコース代謝障害、インスリン抵抗性、代謝症候群、種々起源の異脂肪血症、アテローム性動脈硬化症と関連疾患、肥満症、高血圧、慢性心不全、水腫及び高尿酸血症から成る群より選択されることを特徴とする請求項６に記載の使用。
- 少なくとも１種の請求項１若しくは２に記載の化合物又は請求項３に記載の生理学的に許容しうる塩の、ナトリウム依存性グルコース共輸送体SGLT2を阻害するための医薬組成物を調製するための使用。
- 少なくとも１種の請求項１若しくは２に記載の化合物又は請求項３に記載の生理学的に許容しうる塩の、膵臓β細胞の変性を予防するため、及び／又は膵臓β細胞の機能性を改善及び／又は修復するための医薬組成物を調製するための使用。
- 少なくとも１種の請求項１若しくは２に記載の化合物又は請求項３に記載の生理学的に許容しうる塩の、利尿薬及び／又は抗高血圧薬を調製するための使用。
- 請求項１若しくは２に記載の化合物又は請求項３に記載の生理学的に許容しうる塩を、１種以上の担体及び／又は希釈剤に非化学的方法で組み入れることを特徴とする、請求項４に記載の医薬組成物の調製方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004061145A DE102004061145A1 (de) | 2004-12-16 | 2004-12-16 | Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| EP05002628 | 2005-02-09 | ||
| PCT/EP2005/056806 WO2006064033A2 (en) | 2004-12-16 | 2005-12-15 | Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008524162A JP2008524162A (ja) | 2008-07-10 |
| JP2008524162A5 true JP2008524162A5 (ja) | 2009-02-12 |
Family
ID=36588244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007546063A Withdrawn JP2008524162A (ja) | 2004-12-16 | 2005-12-15 | グルコピラノシル置換ベンゼン誘導体、該化合物を含む薬物、その使用及びその製造方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7687469B2 (ja) |
| EP (1) | EP1828216B1 (ja) |
| JP (1) | JP2008524162A (ja) |
| AT (1) | ATE407938T1 (ja) |
| CA (1) | CA2587639A1 (ja) |
| DE (1) | DE602005009745D1 (ja) |
| ES (1) | ES2314743T3 (ja) |
| TW (1) | TW200635599A (ja) |
| WO (1) | WO2006064033A2 (ja) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG151271A1 (en) | 2004-03-16 | 2009-04-30 | Boehringer Ingelheim Int | Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof |
| AR051446A1 (es) * | 2004-09-23 | 2007-01-17 | Bristol Myers Squibb Co | Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2) |
| EP1828216B1 (en) | 2004-12-16 | 2008-09-10 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| JP5264183B2 (ja) * | 2005-02-23 | 2013-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換（（ヘテロ）アリールエチニル−ベンジル）−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体２（ｓｇｌｔ２）インヒビターとしてのそれらの使用 |
| CA2605245A1 (en) | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors |
| UA91546C2 (uk) | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
| US7723309B2 (en) | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| JP5128474B2 (ja) * | 2005-07-27 | 2013-01-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル−置換（（ヘテロ）シクロアルキルエチニル−ベンジル）−ベンゼン誘導体、該化合物を含有する薬剤、それらの使用及びそれらの製造方法 |
| DE602006017566D1 (de) * | 2005-08-30 | 2010-11-25 | Boehringer Ingelheim Pharma | Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür |
| JP5345846B2 (ja) | 2005-09-08 | 2013-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−（４−エチニル−ベンジル）−ベンゼンの結晶形態、その製造方法及び薬剤製造のためのそれらの使用 |
| AR056195A1 (es) * | 2005-09-15 | 2007-09-26 | Boehringer Ingelheim Int | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos |
| CA2634701C (en) * | 2005-12-21 | 2014-07-29 | Decode Genetics Ehf | Biaryl substituted nitrogen containing heterocycle inhibitors of lta4h for treating inflammation |
| EP1989191B1 (en) * | 2006-02-15 | 2011-07-20 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture |
| PE20080697A1 (es) | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| CA2656847A1 (en) * | 2006-08-15 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture |
| CA2664095A1 (en) * | 2006-09-21 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted difluorobenzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| EP2086991A1 (en) * | 2006-10-27 | 2009-08-12 | Boehringer Ingelheim International GmbH | CRYSTALLINE FORM OF 4-(ß-D-GLUCOPYRANOS-1-YL)-1-METHYL-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS |
| EP2079753A1 (en) | 2006-11-06 | 2009-07-22 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted benzyl-benzonitrile derivatives, medicaments containing such compounds, their use and process for their manufacture |
| CA2676620A1 (en) | 2007-01-26 | 2008-07-31 | Boehringer Ingelheim International Gmbh | Methods for preventing and treating neurodegenerative disorders |
| CA2679310A1 (en) | 2007-02-21 | 2008-08-28 | Boehringer Ingelheim International Gmbh | Tetrasubstituted glucopyranosylated benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| CN101652377A (zh) * | 2007-04-02 | 2010-02-17 | 泰拉科斯有限公司 | 苄基化糖苷衍生物及其用法 |
| CL2008002427A1 (es) | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
| JP4809931B2 (ja) | 2007-08-23 | 2011-11-09 | セラコス・インコーポレイテッド | ベンジルベンゼン誘導体およびその使用方法 |
| PE20091211A1 (es) * | 2007-11-30 | 2009-09-14 | Boehringer Ingelheim Int | Derivados de pirazolopirimidina como moduladores de pde9a |
| UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| PL2324002T3 (pl) | 2008-08-22 | 2017-03-31 | Theracos Sub, Llc | Sposoby otrzymywania inhibitorów sglt2 |
| PE20110288A1 (es) * | 2008-08-28 | 2011-05-26 | Pfizer | Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol |
| PE20110383A1 (es) | 2008-09-08 | 2011-07-15 | Boehringer Ingelheim Int | Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a) |
| AP2011005780A0 (en) | 2009-02-13 | 2011-08-31 | Boehringer Ingelheim Int | Pharmaceutical composition comprising glucopyranosyl diphenylmethane derivatives, pharmaceutical dosage form thereof, process for their preparation and uses thereof for improved glycemic control in a patient. |
| PL2395983T3 (pl) | 2009-02-13 | 2020-09-07 | Boehringer Ingelheim International Gmbh | Kompozycja farmaceutyczna zawierająca inhibitor sglt2, inhibitor dpp-iv i ewentualnie dalszy środek przeciwcukrzycowy oraz jej zastosowania |
| AU2016213789B2 (en) * | 2009-02-13 | 2018-01-18 | Boehringer Ingelheim International Gmbh | SGLT-2 inhibitor for treating type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance or hyperglycemia |
| SG10201600204YA (en) * | 2009-02-13 | 2016-02-26 | Boehringer Ingelheim Int | SGLT-2 Inhibitor For Treating Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Impaired Glucose Tolerance Or Hyperglycemia |
| UY32427A (es) | 2009-02-13 | 2010-09-30 | Boheringer Ingelheim Internat Gmbh | Composicion farmaceutica, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma |
| CA2757231A1 (en) * | 2009-03-31 | 2010-10-07 | Boehringer Ingelheim International Gmbh | 1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| TW201118099A (en) * | 2009-08-12 | 2011-06-01 | Boehringer Ingelheim Int | New compounds for the treatment of CNS disorders |
| KR101811997B1 (ko) | 2009-09-30 | 2017-12-26 | 베링거 인겔하임 인터내셔날 게엠베하 | １클로로４（베타ｄ글루코피라노스１일）２（４（（ｓ）테트라하이드로푸란３일옥시）벤질）벤젠의 결정형의 제조방법 |
| IN2012DN02751A (ja) * | 2009-09-30 | 2015-09-18 | Boehringer Ingelheim Int | |
| US10610489B2 (en) | 2009-10-02 | 2020-04-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof |
| NZ599945A (en) | 2009-11-02 | 2014-05-30 | Pfizer | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| WO2011070592A2 (en) | 2009-12-09 | 2011-06-16 | Panacea Biotec Ltd. | Novel sugar derivatives |
| WO2011120923A1 (en) | 2010-03-30 | 2011-10-06 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising an sglt2 inhibitor and a ppar- gamma agonist and uses thereof |
| WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
| PL2595980T3 (pl) | 2010-07-22 | 2015-03-31 | Gilead Sciences Inc | Sposoby i związki do leczenia infekcji wirusowych Paramyxoviridae |
| PL2603511T3 (pl) | 2010-08-12 | 2017-08-31 | Boehringer Ingelheim Int | Pochodne 6-cykloalkilo-1,5-dihydropirazolo[3,4-d]pirymidyn-4-onu i ich zastosowanie jako inhibitorów PDE9A |
| JP2013224263A (ja) * | 2010-08-19 | 2013-10-31 | Taisho Pharmaceutical Co Ltd | ４−イソプロピルフェニルグルシトール化合物 |
| WO2012041898A1 (en) | 2010-09-29 | 2012-04-05 | Celon Pharma Sp. Z O.O. | Combination of sglt2 inhibitor and a sugar compound for the treatment of diabetes |
| EP2635268A1 (en) | 2010-11-02 | 2013-09-11 | Boehringer Ingelheim International GmbH | Pharmaceutical combinations for the treatment of metabolic disorders |
| US20120283169A1 (en) | 2010-11-08 | 2012-11-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US20130035281A1 (en) | 2011-02-09 | 2013-02-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
| CN102757415B (zh) * | 2011-04-25 | 2015-07-29 | 北京普禄德医药科技有限公司 | 一种钠依赖性葡萄糖转运蛋白抑制剂及其制备方法和用途 |
| JP5835598B2 (ja) | 2011-06-03 | 2015-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 神経弛緩剤で治療されている患者において代謝性障害を治療するためのｓｇｌｔ−２阻害剤 |
| US20130035298A1 (en) | 2011-07-08 | 2013-02-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| JP2014530186A (ja) | 2011-09-13 | 2014-11-17 | パナセア バイオテック リミテッド | 新規ｓｇｌｔ阻害剤 |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
| KR20150014488A (ko) | 2012-05-09 | 2015-02-06 | 베링거 인겔하임 인터내셔날 게엠베하 | 대사 장애의 치료를 위한 약제학적 병용물 |
| EP4245765A3 (en) | 2013-04-04 | 2024-03-20 | Boehringer Ingelheim Vetmedica GmbH | Treatment of metabolic disorders in equine animals |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| ES2702174T3 (es) | 2013-04-05 | 2019-02-27 | Boehringer Ingelheim Int | Usos terapéuticos de empagliflozina |
| PT2986304T (pt) | 2013-04-18 | 2022-02-25 | Boehringer Ingelheim Int | Composição farmacêutica, métodos para o tratamento e suas utilizações |
| CN104447893B (zh) * | 2013-09-25 | 2018-01-23 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物及其在医药上的应用 |
| WO2015051484A1 (en) | 2013-10-12 | 2015-04-16 | Theracos, Inc. | Preparation of hydroxy-benzylbenzene derivatives |
| DK3082829T3 (da) | 2013-12-17 | 2021-05-03 | Boehringer Ingelheim Vetmedica Gmbh | Sglt2-inhibitorer til behandlingen af metaboliske lidelser i kattedyr |
| DK3096765T3 (en) | 2014-01-23 | 2019-03-04 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of metabolic disorders in dogs |
| ES2811261T3 (es) | 2014-04-01 | 2021-03-11 | Boehringer Ingelheim Vetmedica Gmbh | Tratamiento de trastornos metabólicos en animales equinos |
| WO2016046150A1 (en) | 2014-09-25 | 2016-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals |
| TWI687432B (zh) | 2014-10-29 | 2020-03-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
| AU2016310535B2 (en) | 2015-08-27 | 2021-08-19 | Boehringer Ingelheim Vetmedica Gmbh | Liquid pharmaceutical compositions comprising SGLT-2 inhibitors |
| ES2918585T3 (es) | 2015-09-16 | 2022-07-19 | Gilead Sciences Inc | Métodos para el tratamiento de infecciones por el virus Arenaviridae |
| EP3362055B1 (en) | 2015-10-15 | 2023-01-18 | Boehringer Ingelheim International GmbH | Sglt-2 inhibitor for use in the treatment of a metabolic myopathy |
| EP3595672B1 (en) | 2017-03-14 | 2023-09-06 | Gilead Sciences, Inc. | Compounds for use in methods of treating feline coronavirus infections |
| EP3606527A1 (en) | 2017-04-03 | 2020-02-12 | Coherus Biosciences, Inc. | Ppar-gamma agonist for treatment of progressive supranuclear palsy |
| ES2938859T3 (es) | 2017-05-01 | 2023-04-17 | Gilead Sciences Inc | Una forma cristalina de (S)-2-etilbutilo 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato |
| EP3651734A1 (en) | 2017-07-11 | 2020-05-20 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| KR102204439B1 (ko) | 2018-05-14 | 2021-01-18 | 에이치케이이노엔 주식회사 | Sglt-2 억제제 및 dpp-iv 억제제를 포함하는 약제학적 조성물 |
| WO2020039394A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | New drug combinations |
| US20220259247A1 (en) * | 2019-07-26 | 2022-08-18 | Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. | Sglts/dpp4 inhibitor and application thereof |
| BR112022010385A2 (pt) | 2019-11-28 | 2022-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Uso de inibidores de sglt-2 na secagem de mamíferos não humanos |
| JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ， インコーポレイテッド | ＳＡＲＳ ＣｏＶ－２感染を治療するための方法 |
| EP4106744A1 (en) | 2020-02-17 | 2022-12-28 | Boehringer Ingelheim Vetmedica GmbH | Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in felines |
| AU2021230562A1 (en) | 2020-03-06 | 2022-09-22 | Vertex Pharmaceuticals Incorporated | Methods of treating APOL-1 dependent focal segmental glomerulosclerosis |
| TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
| KR20220164784A (ko) | 2020-04-06 | 2022-12-13 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형 |
| EP4157272A1 (en) | 2020-05-29 | 2023-04-05 | Gilead Sciences, Inc. | Remdesivir treatment methods |
| TWI819321B (zh) | 2020-06-24 | 2023-10-21 | 美商基利科學股份有限公司 | 1'-氰基核苷類似物及其用途 |
| TW202228722A (zh) | 2020-08-27 | 2022-08-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
| WO2022051316A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a sglt-2 inhibitor |
| KR20240041966A (ko) | 2021-07-28 | 2024-04-01 | 베링거잉겔하임베트메디카게엠베하 | 고양이를 제외한 비인간 포유류, 특히 개에서 심장 질환의 예방 및/또는 치료를 위한 sglt-2 억제제의 용도 |
| CN117715639A (zh) | 2021-07-28 | 2024-03-15 | 勃林格殷格翰动物保健有限公司 | Sglt-2抑制剂用于预防和/或治疗非人哺乳动物中的肾脏病的用途 |
| WO2023129595A1 (en) | 2021-12-30 | 2023-07-06 | Newamsterdam Pharma B.V. | Obicetrapib and sglt2 inhibitor combination |
| EP4320128A1 (en) | 2022-03-02 | 2024-02-14 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| WO2023227492A1 (en) | 2022-05-25 | 2023-11-30 | Boehringer Ingelheim Vetmedica Gmbh | Aqueous pharmaceutical compositions comprising sglt-2 inhibitors |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58164502A (ja) | 1982-03-26 | 1983-09-29 | Chugai Pharmaceut Co Ltd | 除草用組成物 |
| US4786755A (en) * | 1985-06-03 | 1988-11-22 | Warner-Lambert Company | Diphenic acid monoamides |
| US4602023A (en) * | 1985-06-03 | 1986-07-22 | Warner-Lambert Company | Diphenic acid monoamides |
| AU6024998A (en) | 1997-01-15 | 1998-08-07 | Glycomed Incorporated | Aryl c-glycoside compounds and sulfated esters thereof |
| JPH11124392A (ja) | 1997-10-21 | 1999-05-11 | Sankyo Co Ltd | Ｃ−グリコシル化されたアリールスズ化合物 |
| PH12000002657B1 (en) * | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| US6515117B2 (en) * | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| JP4456768B2 (ja) | 2000-02-02 | 2010-04-28 | 壽製薬株式会社 | Ｃ−配糖体を含有する薬剤 |
| US6627611B2 (en) * | 2000-02-02 | 2003-09-30 | Kotobuki Pharmaceutical Co Ltd | C-glycosides and preparation of thereof as antidiabetic agents |
| US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| EA005994B1 (ru) * | 2000-09-29 | 2005-08-25 | Киссеи Фармасьютикал Ко., Лтд. | Производные глюкопиранозилоксибензилбензола и содержащие их лекарственные композиции |
| AU2002223127A1 (en) | 2000-11-30 | 2002-06-11 | Kissei Pharmaceutical Co., Ltd. Intellectual Property | Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
| TWI255817B (en) | 2001-02-14 | 2006-06-01 | Kissei Pharmaceutical | Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof |
| US6936590B2 (en) * | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| EP1385856B1 (en) | 2001-04-11 | 2006-02-22 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
| TWI254635B (en) | 2002-08-05 | 2006-05-11 | Yamanouchi Pharma Co Ltd | Azulene derivative and salt thereof |
| DE10258008B4 (de) | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258007B4 (de) | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| EP1581543A4 (en) | 2003-01-03 | 2008-03-19 | Bristol Myers Squibb Co | METHODS FOR PRODUCING SGLT2 GLYCOSIS C-ARYL INHIBITORS |
| US7164015B2 (en) | 2003-02-27 | 2007-01-16 | Bristol-Myers Squibb Company | Non-cryogenic process for forming glycosides |
| TWI310033B (en) * | 2003-03-14 | 2009-05-21 | Yamanouchi Pharma Co Ltd | C-glycoside derivatives or salts thereof |
| JP2004359630A (ja) | 2003-06-06 | 2004-12-24 | Yamanouchi Pharmaceut Co Ltd | ジフルオロジフェニルメタン誘導体及びその塩 |
| SI1651658T2 (sl) | 2003-08-01 | 2020-12-31 | Mitsubishi Tanabe Pharma Corporation | Nove spojine, ki imajo inhibitorno aktivnost proti transporterju, ki je odvisen od natrija |
| WO2005012318A2 (en) | 2003-08-01 | 2005-02-10 | Janssen Pharmaceutica Nv | Substituted fused heterocyclic c-glycosides |
| US7375090B2 (en) * | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
| US7371732B2 (en) * | 2003-12-22 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture |
| WO2005085265A1 (ja) | 2004-03-04 | 2005-09-15 | Kissei Pharmaceutical Co., Ltd. | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
| AU2005219779B2 (en) | 2004-03-04 | 2011-04-14 | Kissei Pharmaceutical Co., Ltd. | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof |
| SG151271A1 (en) * | 2004-03-16 | 2009-04-30 | Boehringer Ingelheim Int | Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof |
| US7393836B2 (en) * | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| DE102004034690A1 (de) * | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
| CA2574451A1 (en) * | 2004-07-27 | 2006-02-02 | Boehringer Ingelheim International Gmbh | D-glucopyranosyl phenyl-substituted cyclene, medicaments containing these compounds, their use, and method for the production thereof |
| WO2006018150A1 (de) * | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| AR051446A1 (es) * | 2004-09-23 | 2007-01-17 | Bristol Myers Squibb Co | Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2) |
| DE102004048388A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| EP1828216B1 (en) | 2004-12-16 | 2008-09-10 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| JP5264183B2 (ja) | 2005-02-23 | 2013-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換（（ヘテロ）アリールエチニル−ベンジル）−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体２（ｓｇｌｔ２）インヒビターとしてのそれらの使用 |
| CA2605245A1 (en) * | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors |
| US7723309B2 (en) * | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
| UA91546C2 (uk) * | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| WO2007000445A1 (en) * | 2005-06-29 | 2007-01-04 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| JP5128474B2 (ja) * | 2005-07-27 | 2013-01-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル−置換（（ヘテロ）シクロアルキルエチニル−ベンジル）−ベンゼン誘導体、該化合物を含有する薬剤、それらの使用及びそれらの製造方法 |
| DE602006017566D1 (de) | 2005-08-30 | 2010-11-25 | Boehringer Ingelheim Pharma | Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür |
| JP5345846B2 (ja) * | 2005-09-08 | 2013-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−（４−エチニル−ベンジル）−ベンゼンの結晶形態、その製造方法及び薬剤製造のためのそれらの使用 |
| AR056195A1 (es) * | 2005-09-15 | 2007-09-26 | Boehringer Ingelheim Int | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos |
| EP1989191B1 (en) * | 2006-02-15 | 2011-07-20 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture |
| PE20080697A1 (es) * | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
-
2005
- 2005-12-15 EP EP05821489A patent/EP1828216B1/en not_active Not-in-force
- 2005-12-15 CA CA002587639A patent/CA2587639A1/en not_active Withdrawn
- 2005-12-15 US US11/304,284 patent/US7687469B2/en active Active
- 2005-12-15 DE DE602005009745T patent/DE602005009745D1/de active Active
- 2005-12-15 ES ES05821489T patent/ES2314743T3/es active Active
- 2005-12-15 AT AT05821489T patent/ATE407938T1/de active
- 2005-12-15 TW TW094144456A patent/TW200635599A/zh unknown
- 2005-12-15 WO PCT/EP2005/056806 patent/WO2006064033A2/en active IP Right Grant
- 2005-12-15 JP JP2007546063A patent/JP2008524162A/ja not_active Withdrawn
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