JP2008524158A5 - - Google Patents
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- Publication number
- JP2008524158A5 JP2008524158A5 JP2007546052A JP2007546052A JP2008524158A5 JP 2008524158 A5 JP2008524158 A5 JP 2008524158A5 JP 2007546052 A JP2007546052 A JP 2007546052A JP 2007546052 A JP2007546052 A JP 2007546052A JP 2008524158 A5 JP2008524158 A5 JP 2008524158A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- pharmaceutical composition
- acute
- chronic
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical class C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 claims 3
- 206010035664 Pneumonia Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 206010006451 bronchitis Diseases 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000009610 hypersensitivity Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- JVWZQRDKIMSXFY-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[2-(2h-tetrazol-5-yl)-4-[3-(trifluoromethyl)phenyl]phenyl]urea Chemical group FC(F)(F)C1=CC=CC(C=2C=C(C(NC(=O)NC=3C=C(Cl)C=C(Cl)C=3)=CC=2)C=2NN=NN=2)=C1 JVWZQRDKIMSXFY-UHFFFAOYSA-N 0.000 claims 1
- 208000033116 Asbestos intoxication Diseases 0.000 claims 1
- 206010004485 Berylliosis Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 229920000742 Cotton Polymers 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 201000010001 Silicosis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 206010003441 asbestosis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 206010035653 pneumoconiosis Diseases 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Claims (4)
- 式ＶＩＩで表されるジフェニル尿素誘導体又は医薬として許容されるその塩
［式中、
Ｘはテトラゾリル基；
Ｒ １ は、３位でハロアルキルにより３位で置換されているフェニルを表し、
Ｒ ２ は、水素を表し；
Ｒ ３ 及びＲ ４ はハロを表す］
を含む、ヒトを含む哺乳動物の閉塞性若しくは炎症性気道疾患の治療、予防又は軽減用医薬組成物。 - 前記ジフェニル尿素誘導体がＮ−（３，５−ジクロロフェニル）−Ｎ’−［３−（１Ｈ−テトラゾール−５−イル）−３’−トリフルオロメチル−ビフェニル−４−イル］−尿素又は医薬として許容されるその塩である、請求項１に記載の医薬組成物。
- 前記閉塞性又は炎症性気道疾患が、急性又は慢性の感染性肺疾患、気道過敏症、じん肺症、アルミニウム肺症、炭肺症、石綿肺症、石症、プティロシス（ｐｔｉｌｏｓｉｓ）、鉄沈着症、ケイ肺症、タバコ症、綿肺症、サルコイドーシス、ベリリウム症、慢性の閉塞性肺疾患（ＣＯＰＤ）、気管支炎、慢性気管支炎、喘息様気管支炎、肺気腫、急性呼吸促迫症候群（ＡＲＤＳ）及び急性肺損傷（ＡＬＩ）、気道過敏症又は嚢胞性線維症の悪化、肺線維症、急性呼吸促迫症候群（ＡＲＤＳ）、肺高血圧症、炎症性肺疾患、急性又は慢性呼吸感染性疾患である、請求項１に記載の使用。
- 請求項１又は２に記載の医薬組成物、或いは請求項１又は２に記載されたジフェニル尿素誘導体の医薬として許容されるその付加塩を含む医薬組成物であって、血液脳関門透過性を増加するための医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401953 | 2004-12-17 | ||
| US63777504P | 2004-12-22 | 2004-12-22 | |
| PCT/EP2005/056766 WO2006064015A2 (en) | 2004-12-17 | 2005-12-14 | Diphenylurea derivatives useful as potassium channel activators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008524158A JP2008524158A (ja) | 2008-07-10 |
| JP2008524158A5 true JP2008524158A5 (ja) | 2009-01-29 |
Family
ID=36354109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007546052A Abandoned JP2008524158A (ja) | 2004-12-17 | 2005-12-14 | カリウムチャネル活性化剤として有用なジフェニル尿素誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20070293553A1 (ja) |
| EP (1) | EP1827411A2 (ja) |
| JP (1) | JP2008524158A (ja) |
| CN (1) | CN101287456A (ja) |
| AU (1) | AU2005315607A1 (ja) |
| CA (1) | CA2591616A1 (ja) |
| MX (1) | MX2007007029A (ja) |
| WO (1) | WO2006064015A2 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1638948T3 (da) * | 2003-06-17 | 2009-02-02 | Neurosearch As | Diphenylurinstofderivater og deres anvendelse som chloridkanalblokkere |
| WO2006089871A2 (en) * | 2005-02-23 | 2006-08-31 | Neurosearch A/S | Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias |
| EP2121640A1 (en) * | 2007-01-18 | 2009-11-25 | NeuroSearch AS | Novel semicarbazide and carbonylhydrazide derivatives useful as potassium channel modulators |
| EP2146971A1 (en) * | 2007-05-08 | 2010-01-27 | NeuroSearch A/S | Novel benzamidine derivatives useful as potassium channel modulators |
| JP2010526850A (ja) | 2007-05-15 | 2010-08-05 | ノイロサーチ アクティーゼルスカブ | カリウムチャネル調節剤として有用な、新規な芳香族複素環式カルボン酸アミド誘導体 |
| EP2493468A1 (en) * | 2009-10-30 | 2012-09-05 | Sanofi | Amino-benzoic acid derivatives for use in the treatment of dihydrogenase-related disorders |
| SI3622953T1 (sl) | 2016-05-17 | 2021-05-31 | Scandion Oncology A/S | Kombinirano zdravljenje raka |
| JP7111359B2 (ja) * | 2018-02-08 | 2022-08-02 | 国立大学法人東北大学 | 植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法 |
| WO2023114868A1 (en) * | 2021-12-14 | 2023-06-22 | Trustees Of Tufts College | Use of hyperpolarizing agents alone and in combination with other therapeutic agents for treating cancers including glioblastoma |
| TW202337446A (zh) * | 2022-01-28 | 2023-10-01 | 韓商鐘根堂股份有限公司 | 用於預防或治療肺動脈高血壓之組合物 |
| CN117229258B (zh) * | 2022-06-07 | 2024-07-19 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050080112A1 (en) * | 2001-06-22 | 2005-04-14 | Madsen Lars Siim | Compounds for use in disorders associated with mast cell or basophil acitvity |
| US20060160856A1 (en) * | 2002-09-05 | 2006-07-20 | Dahl Bjarne H | Diarylurea derivatives and their use as chloride channel blockers |
| DE60327652D1 (de) * | 2002-11-21 | 2009-06-25 | Neurosearch As | Diarylureidoderivate und deren medizinische verwendung |
| DK1638948T3 (da) * | 2003-06-17 | 2009-02-02 | Neurosearch As | Diphenylurinstofderivater og deres anvendelse som chloridkanalblokkere |
| WO2005023238A1 (en) * | 2003-09-04 | 2005-03-17 | Poseidon Pharmaceuticals A/S | Erg channel openers for the treatment of hyperexcitability-related neuronal diseases |
| EP1663192B1 (en) * | 2003-09-04 | 2008-12-03 | NeuroSearch A/S | hERG1 CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS |
-
2005
- 2005-12-14 JP JP2007546052A patent/JP2008524158A/ja not_active Abandoned
- 2005-12-14 EP EP05826448A patent/EP1827411A2/en not_active Withdrawn
- 2005-12-14 US US11/791,340 patent/US20070293553A1/en not_active Abandoned
- 2005-12-14 CA CA002591616A patent/CA2591616A1/en not_active Abandoned
- 2005-12-14 CN CNA2005800420666A patent/CN101287456A/zh active Pending
- 2005-12-14 WO PCT/EP2005/056766 patent/WO2006064015A2/en active Application Filing
- 2005-12-14 AU AU2005315607A patent/AU2005315607A1/en not_active Abandoned
- 2005-12-14 MX MX2007007029A patent/MX2007007029A/es not_active Application Discontinuation
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