JP2008522968A5 - - Google Patents
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- Publication number
- JP2008522968A5 JP2008522968A5 JP2007544307A JP2007544307A JP2008522968A5 JP 2008522968 A5 JP2008522968 A5 JP 2008522968A5 JP 2007544307 A JP2007544307 A JP 2007544307A JP 2007544307 A JP2007544307 A JP 2007544307A JP 2008522968 A5 JP2008522968 A5 JP 2008522968A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- thioxo
- pyrrolo
- pyrimidin
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0402972A SE0402972D0 (sv) | 2004-12-06 | 2004-12-06 | Novel compounds |
| SE0402972-4 | 2004-12-06 | ||
| SE0501093-9 | 2005-05-13 | ||
| SE0501093 | 2005-05-13 | ||
| PCT/SE2005/001835 WO2006062465A1 (en) | 2004-12-06 | 2005-12-05 | Novel pyrrolo [3, 2-d] pyrimidin-4-one derivatives and their use in therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008522968A JP2008522968A (ja) | 2008-07-03 |
| JP2008522968A5 true JP2008522968A5 (enExample) | 2009-01-22 |
| JP5028270B2 JP5028270B2 (ja) | 2012-09-19 |
Family
ID=36578191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544307A Expired - Lifetime JP5028270B2 (ja) | 2004-12-06 | 2005-12-05 | 新規なピロロ［３，２−ｄ］ピリミジン−４−オン誘導体および治療でのその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US7829707B2 (enExample) |
| EP (1) | EP1824855B1 (enExample) |
| JP (1) | JP5028270B2 (enExample) |
| KR (3) | KR101412939B1 (enExample) |
| CN (1) | CN101072778B (enExample) |
| AR (1) | AR051698A1 (enExample) |
| AU (1) | AU2005312388B2 (enExample) |
| BR (1) | BRPI0518846B1 (enExample) |
| CA (1) | CA2591314C (enExample) |
| CY (1) | CY1113209T1 (enExample) |
| DK (1) | DK1824855T3 (enExample) |
| ES (1) | ES2390888T3 (enExample) |
| HR (1) | HRP20120781T1 (enExample) |
| IL (1) | IL183182A (enExample) |
| ME (1) | ME01486B (enExample) |
| MX (1) | MX2007006497A (enExample) |
| MY (1) | MY140748A (enExample) |
| NO (1) | NO20072399L (enExample) |
| NZ (1) | NZ555046A (enExample) |
| PL (1) | PL1824855T3 (enExample) |
| PT (1) | PT1824855E (enExample) |
| RS (1) | RS52490B (enExample) |
| RU (2) | RU2409578C2 (enExample) |
| SA (1) | SA05260385B1 (enExample) |
| SI (1) | SI1824855T1 (enExample) |
| TW (1) | TWI365189B (enExample) |
| UA (1) | UA89968C2 (enExample) |
| UY (1) | UY29246A1 (enExample) |
| WO (1) | WO2006062465A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| US8809310B2 (en) * | 2006-02-21 | 2014-08-19 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of multiple system atrophy |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| CN101472926A (zh) * | 2006-04-13 | 2009-07-01 | 阿斯利康(瑞典)有限公司 | 硫代黄嘌呤衍生物以及它们作为髓过氧化物酶抑制剂的用途 |
| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
| JP5201063B2 (ja) * | 2008-04-15 | 2013-06-05 | 信越化学工業株式会社 | 付加硬化型シリコーン組成物及びその硬化物 |
| ES2456515T3 (es) | 2009-03-23 | 2014-04-22 | Glenmark Pharmaceuticals S.A. | Derivados de pirimidindiona fusionados como moduladores de TRPA1 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| AU2012335220B2 (en) | 2011-11-11 | 2017-06-01 | Pfizer Inc. | 2-thiopyrimidinones |
| WO2013150115A1 (en) * | 2012-04-05 | 2013-10-10 | Basf Se | N- substituted hetero - bicyclic compounds and derivatives for combating animal pests |
| CA2876689C (en) | 2012-06-13 | 2022-04-26 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| CA2873920C (en) | 2012-06-15 | 2021-07-20 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| EP3191485A1 (en) | 2014-09-11 | 2017-07-19 | Bristol-Myers Squibb Company | Triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9616063B2 (en) * | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| CA2976790C (en) | 2015-02-20 | 2024-02-27 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| SG11201708407TA (en) | 2015-05-05 | 2017-11-29 | Pfizer | 2-thiopyrimidinones |
| WO2017040449A1 (en) * | 2015-09-03 | 2017-03-09 | Bristol-Myers Squibb Company | Triazolopyridine inhibitors of myeloperoxidase |
| WO2017040451A1 (en) * | 2015-09-03 | 2017-03-09 | Bristol-Myers Squibb Company | Triazolopyridine inhibitors of myeloperoxidase |
| WO2017160632A1 (en) * | 2016-03-14 | 2017-09-21 | Bristol-Myers Squibb Company | Triazolopyridine inhibitors of myeloperoxidase |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| SG11202000086PA (en) * | 2017-07-17 | 2020-02-27 | Astrazeneca Ab | Mpo inhibitors for use in medicine |
| US10781226B2 (en) | 2017-10-19 | 2020-09-22 | Texas State University | Photoactivatable cancer prodrug |
| KR102956194B1 (ko) | 2018-05-04 | 2026-04-23 | 인사이트 코포레이션 | Fgfr 억제제의 염 |
| RS66310B1 (sr) | 2018-05-04 | 2025-01-31 | Incyte Corp | Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu |
| WO2020021300A1 (en) | 2018-07-24 | 2020-01-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of myeloperoxidase (mpo) inhibitors for the treatment of chemoresistant acute myeloid leukemia (aml) |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021013942A1 (en) | 2019-07-24 | 2021-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of myeloperoxidase inhibitors for the treatment of cardiovascular diseases in patients suffering from myeloproliferative neoplasms |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR20220080133A (ko) * | 2019-10-10 | 2022-06-14 | 바이오하벤 테라퓨틱스 리미티드 | 골수퍼옥시다제 저해제의 전구약물 |
| GEP20247679B (en) | 2019-10-14 | 2024-10-10 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MX2022006691A (es) | 2019-12-04 | 2022-09-19 | Incyte Corp | Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr). |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MX2022010902A (es) * | 2020-03-05 | 2022-10-07 | Biohaven Therapeutics Ltd | Metodo para tratar la esclerosis lateral amiotrofica con un inhibidor de la mieloperoxidasa. |
| US20230192700A1 (en) | 2020-03-06 | 2023-06-22 | Bayer Aktiengesellschaft | Pyrazolopyrazines acting on cancers via inhibition of cdk12 |
| CA3181917A1 (en) * | 2020-05-06 | 2021-11-11 | Biohaven Therapeutics Ltd. | Process for the preparation of verdiperstat |
| JP2023528969A (ja) | 2020-06-11 | 2023-07-06 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２ イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンのヘミ（Ｌ）－酒石酸塩形態及びそれを含む医薬組成物 |
| EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| TW202313610A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| TW202426450A (zh) | 2022-08-18 | 2024-07-01 | 瑞典商阿斯特捷利康公司 | 髓過氧化物酶抑制劑 |
| CN120265633A (zh) * | 2022-12-09 | 2025-07-04 | 深圳信立泰药业股份有限公司 | 一种吡咯并[3,2-d]嘧啶-4-酮类衍生物及其制备方法和医药用途 |
| WO2025107036A1 (en) * | 2023-11-23 | 2025-05-30 | Syntara Limited | Dual inhibitors of amine oxidases and peroxidases, and uses thereof |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
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| US3135753A (en) * | 1961-05-10 | 1964-06-02 | Burroughs Wellcome Co | Alkylthiopurines and method |
| US3652579A (en) * | 1969-06-26 | 1972-03-28 | Hoffmann La Roche | 1-methyl-2-substituted 5-nitroimidazoles |
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| SE0301232D0 (sv) | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
| SE0302756D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel Compounds |
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| SE0402591D0 (sv) | 2004-10-25 | 2004-10-25 | Astrazeneca Ab | Novel use |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
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| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| WO2007142577A1 (en) | 2006-06-05 | 2007-12-13 | Astrazeneca Ab | Pyrrolo[3,2-d]pyrimidin-4-one derivative as myeloperoxidase inhibitor |
| AR066936A1 (es) | 2007-06-13 | 2009-09-23 | Astrazeneca Ab | 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas. |
| US20090054468A1 (en) | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
-
2005
- 2005-12-02 MY MYPI20055659A patent/MY140748A/en unknown
- 2005-12-05 MX MX2007006497A patent/MX2007006497A/es active IP Right Grant
- 2005-12-05 EP EP05812036A patent/EP1824855B1/en not_active Expired - Lifetime
- 2005-12-05 UY UY29246A patent/UY29246A1/es not_active Application Discontinuation
- 2005-12-05 KR KR1020137005332A patent/KR101412939B1/ko not_active Expired - Lifetime
- 2005-12-05 US US11/720,913 patent/US7829707B2/en active Active
- 2005-12-05 CA CA2591314A patent/CA2591314C/en not_active Expired - Lifetime
- 2005-12-05 ME MEP-2012-109A patent/ME01486B/me unknown
- 2005-12-05 AR ARP050105071A patent/AR051698A1/es unknown
- 2005-12-05 PL PL05812036T patent/PL1824855T3/pl unknown
- 2005-12-05 PT PT05812036T patent/PT1824855E/pt unknown
- 2005-12-05 KR KR1020137033109A patent/KR101557715B1/ko not_active Expired - Lifetime
- 2005-12-05 BR BRPI0518846-6A patent/BRPI0518846B1/pt active IP Right Grant
- 2005-12-05 SI SI200631433T patent/SI1824855T1/sl unknown
- 2005-12-05 NZ NZ555046A patent/NZ555046A/en not_active IP Right Cessation
- 2005-12-05 HR HRP20120781TT patent/HRP20120781T1/hr unknown
- 2005-12-05 RS RS20120426A patent/RS52490B/sr unknown
- 2005-12-05 RU RU2007119307/04A patent/RU2409578C2/ru active
- 2005-12-05 WO PCT/SE2005/001835 patent/WO2006062465A1/en not_active Ceased
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