HUP0402357A2 - Antihisztaminok alkalmazása megnövelt koponyán belüli nyomás akut csökkentésére és gyógyszerkészítmények előállítására - Google Patents
Antihisztaminok alkalmazása megnövelt koponyán belüli nyomás akut csökkentésére és gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0402357A2 HUP0402357A2 HU0402357A HUP0402357A HUP0402357A2 HU P0402357 A2 HUP0402357 A2 HU P0402357A2 HU 0402357 A HU0402357 A HU 0402357A HU P0402357 A HUP0402357 A HU P0402357A HU P0402357 A2 HUP0402357 A2 HU P0402357A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- het
- amino
- independently
- intracranial pressure
- Prior art date
Links
- 239000000739 antihistaminic agent Substances 0.000 title abstract 3
- 230000001154 acute effect Effects 0.000 title 1
- 230000001387 anti-histamine Effects 0.000 title 1
- 229940125715 antihistaminic agent Drugs 0.000 title 1
- 201000009941 intracranial hypertension Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001204 N-oxides Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229940122236 Histamine receptor antagonist Drugs 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000007917 intracranial administration Methods 0.000 abstract 2
- 229940124056 Histamine H1 receptor antagonist Drugs 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010022773 Intracranial pressure increased Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 125000004949 alkyl amino carbonyl amino group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- -1 amino- Chemical class 0.000 abstract 1
- 208000029028 brain injury Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940077716 histamine h2 receptor antagonists for peptic ulcer and gord Drugs 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A találmány tárgya új hisztamin receptor antagonista, és a hisztaminreceptor antagonista alkalmazása koponyán belüli nyomás (ICP)csökkentésére, különösen megnövelt koponyán belüli nyomás és/vagyszekunder iszchémia kezelésére és megelőzésére, különösen olyanesetekben, amikor az ilyen állapotokat agysérülés, közelebbről traumás(TBI) vagy nem traumás agysérülés idézi elő. Az új vegyületek (I)általános képletű vegyületek, gyógyászatilag elfogadható sav- vagybázis-addíciós sói, sztereokémiai izomer formák és N-oxid formái. Azelőnyös vegyület a 3-[2-[4-(11,12-dihidro-6-H-benzimidazo[2,1-b][3]benzazepin-6-il)-2-(fenil-metil)-1-piperidinil]-etil)-2,10-dimetil-pirimido[1,2-a)benzimidazol-4(10)-on, gyógyászatilag elfogadható sav- vagy bázisaddíciós sói,sztereokémiai izomer formái és N-oxidjai. Kiterjed a találmány akereskedelemben kapható hisztamin H1- és H2-receptor antagonisták újalkalmazására koponyán belüli nyomás (ICP) csökkentésére is. Az (I)általános képletű vegyület, gyógyászatilag elfogadható sav- vagybázisaddíciós sója, sztereokémiai izomer formája és N-oxidjai, ahol mértéke 1 vagy 2; n értéke 0, 1 vagy 2; a, b, c jelentése egymástólfüggetlenül vegyértékvonal vagy kettős kötés; X jelentése kovalenskötés vagy kétértékű 1-6 szénatomos alkán-diil-csoport, ahol egy vagytöbb -CH2- csoportot adott esetben -O-, -S-, -CO- vagy -NR7-helyettesít, Y jelentése kétértékű 1-4 szénatomos alkán-diil- vagy 2-4szénatomos alkén-diil-csoport; Z jelentése nitrogénatom, ez esetben ajelentése kettős kötés és b vegyértékvonal, vagy Z jelentése N-R7,amely esetben a jelentése vegyértékvonal és b kettős kötés és R7jelentése a fenti; R1 és R2 jelentése egymástól függetlenülhidrogénatom, hidroxil-, alkil-, alkoxi-, Ar, Ar-alkil-, di(Ar)-alkil-, Het vagy Het-alkil-csoport; -A-B-jelentése egymástólfüggetlenül az alábbi kétértékű csoportok valamelyike: -E-CR8=CR8- (a-1); -CR8=CR8-E- (a-2); -CR8=CR8-CR8=CR8- (a-3); ahol R8 jelentéseegymástól függetlenül hidrogén- vagy halogénatom, hidroxil-, - alkil-vagy alkoxicsoport; E jelentése kétértékű -O-, -S- vagy -NR7-, ahol R7jelentése a fenti; -C-D- jelentése egymástól függetlenül az alábbikétértékű csoportok valamelyike: -CR8=CR8-CR8=CR8- (b-1); -N=CR8-CR8=CR8- (b-2); -CRB=N-CR8=CR8- (b-3); -CR8=CR8-N=CR8- (b-4); -CRB=CR8-CR8=N- (b-5); ahol R8 jelentése a fenti; R3 jelentésehidrogén- vagy halogénatom, hidroxil-, alkil-, alkoxi-, Ar, Ar-alkil-,di(Ar)-alkil-, Het vagy Het-alkil-csoport; R4 jelentése hidrogénatom,alkil-, amino-, alkil-amino-, Ar-amino-, Het-amino-, alkil-karbonil-amino-, Ar-karbonil-amino-, Het-karbonil-amino-, alkil-amino-karbonil-amino-, Ar-amino-karbonil-amino-, Het-amino-karbonil-amino-, alkoxi-alkil-amino-, Ar-oxi-alkil-amino- vagy Het-oxi-alkil-amino-csoport; R5jelentése hidrogénatom vagy alkilcsoport. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01204574 | 2001-11-23 | ||
PCT/EP2002/013180 WO2003044023A1 (en) | 2001-11-23 | 2002-11-22 | The use of anti-histaminics for acute reduction of elevated intracranial pressure |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0402357A2 true HUP0402357A2 (hu) | 2005-02-28 |
HUP0402357A3 HUP0402357A3 (en) | 2009-10-28 |
HU229118B1 HU229118B1 (en) | 2013-08-28 |
Family
ID=8181317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0402357A HU229118B1 (en) | 2001-11-23 | 2002-11-22 | The use of substituted tetracyclic imidazole derivatives as anti-histaminics |
Country Status (26)
Country | Link |
---|---|
US (1) | US7732437B2 (hu) |
EP (2) | EP1451196B1 (hu) |
JP (2) | JP4505226B2 (hu) |
KR (1) | KR100967601B1 (hu) |
CN (2) | CN100478031C (hu) |
AT (2) | ATE370149T1 (hu) |
AU (1) | AU2002356715B2 (hu) |
CA (2) | CA2467097C (hu) |
CY (2) | CY1107472T1 (hu) |
DE (2) | DE60231351D1 (hu) |
DK (2) | DK1451196T3 (hu) |
ES (2) | ES2290364T3 (hu) |
HK (2) | HK1073309A1 (hu) |
HR (1) | HRP20040427B1 (hu) |
HU (1) | HU229118B1 (hu) |
IL (4) | IL162109A0 (hu) |
MX (1) | MXPA04004867A (hu) |
NO (1) | NO333656B1 (hu) |
NZ (2) | NZ550723A (hu) |
PL (1) | PL209953B1 (hu) |
PT (2) | PT1451196E (hu) |
RU (1) | RU2311418C2 (hu) |
SI (2) | SI1451196T1 (hu) |
UA (1) | UA76803C2 (hu) |
WO (1) | WO2003044023A1 (hu) |
ZA (1) | ZA200403923B (hu) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1451196T3 (da) | 2001-11-23 | 2007-11-12 | Janssen Pharmaceutica Nv | Anvendelse af substituerede tetracykliske imidazolderivater som antihistaminstoffer |
TWI290140B (en) * | 2003-08-25 | 2007-11-21 | Schering Corp | 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders |
EP2796683A4 (en) * | 2011-12-20 | 2015-05-20 | Toyota Motor Co Ltd | ERROR DETECTION DEVICE FOR AN ELECTRICALLY HEATABLE CATALYST |
US9717726B2 (en) * | 2013-03-14 | 2017-08-01 | Maregade Rx, LLC | Product and method for treating diarrhea |
EP3558296B1 (en) | 2016-12-23 | 2023-06-28 | Maregade RX, LLC | Low dose product and method for treating diarrhea |
US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595988A (en) * | 1992-12-04 | 1997-01-21 | Janssen Pharmaceutica N.V. | Triazolo(pyrrolo, thieno or furano)azepine derivatives |
TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
TW429256B (en) | 1995-12-27 | 2001-04-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives |
TW527186B (en) * | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
EP1011726B1 (en) * | 1997-09-18 | 2003-02-26 | Janssen Pharmaceutica N.V. | Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents |
EP1401838B1 (en) * | 2001-06-12 | 2014-03-26 | Janssen Pharmaceutica NV | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine |
DK1451196T3 (da) | 2001-11-23 | 2007-11-12 | Janssen Pharmaceutica Nv | Anvendelse af substituerede tetracykliske imidazolderivater som antihistaminstoffer |
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2002
- 2002-11-22 DK DK02803410T patent/DK1451196T3/da active
- 2002-11-22 IL IL16210902A patent/IL162109A0/xx unknown
- 2002-11-22 CN CNB2006100841411A patent/CN100478031C/zh not_active Expired - Fee Related
- 2002-11-22 AT AT02803410T patent/ATE370149T1/de active
- 2002-11-22 DE DE60231351T patent/DE60231351D1/de not_active Expired - Lifetime
- 2002-11-22 NZ NZ550723A patent/NZ550723A/en not_active IP Right Cessation
- 2002-11-22 WO PCT/EP2002/013180 patent/WO2003044023A1/en active Application Filing
- 2002-11-22 UA UA20040604966A patent/UA76803C2/uk unknown
- 2002-11-22 RU RU2004118838/04A patent/RU2311418C2/ru not_active IP Right Cessation
- 2002-11-22 KR KR1020047005513A patent/KR100967601B1/ko not_active IP Right Cessation
- 2002-11-22 PT PT02803410T patent/PT1451196E/pt unknown
- 2002-11-22 US US10/494,006 patent/US7732437B2/en active Active
- 2002-11-22 ES ES02803410T patent/ES2290364T3/es not_active Expired - Lifetime
- 2002-11-22 EP EP02803410A patent/EP1451196B1/en not_active Expired - Lifetime
- 2002-11-22 JP JP2003545660A patent/JP4505226B2/ja not_active Expired - Lifetime
- 2002-11-22 EP EP07107669A patent/EP1832287B1/en not_active Expired - Lifetime
- 2002-11-22 DK DK07107669T patent/DK1832287T3/da active
- 2002-11-22 SI SI200230617T patent/SI1451196T1/sl unknown
- 2002-11-22 CN CNB028230140A patent/CN100379744C/zh not_active Expired - Fee Related
- 2002-11-22 PT PT07107669T patent/PT1832287E/pt unknown
- 2002-11-22 DE DE60221891T patent/DE60221891T2/de not_active Expired - Lifetime
- 2002-11-22 MX MXPA04004867A patent/MXPA04004867A/es active IP Right Grant
- 2002-11-22 PL PL369864A patent/PL209953B1/pl unknown
- 2002-11-22 SI SI200230813T patent/SI1832287T1/sl unknown
- 2002-11-22 CA CA2467097A patent/CA2467097C/en not_active Expired - Fee Related
- 2002-11-22 NZ NZ532718A patent/NZ532718A/en not_active IP Right Cessation
- 2002-11-22 AU AU2002356715A patent/AU2002356715B2/en not_active Ceased
- 2002-11-22 HU HU0402357A patent/HU229118B1/hu not_active IP Right Cessation
- 2002-11-22 ES ES07107669T patent/ES2321987T3/es not_active Expired - Lifetime
- 2002-11-22 CA CA2690483A patent/CA2690483C/en not_active Expired - Fee Related
- 2002-11-22 AT AT07107669T patent/ATE423599T1/de active
-
2004
- 2004-05-13 HR HRP20040427AA patent/HRP20040427B1/xx not_active IP Right Cessation
- 2004-05-20 IL IL162109A patent/IL162109A/en not_active IP Right Cessation
- 2004-05-20 ZA ZA2004/03923A patent/ZA200403923B/en unknown
- 2004-06-22 NO NO20042618A patent/NO333656B1/no not_active IP Right Cessation
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2005
- 2005-07-15 HK HK05106036A patent/HK1073309A1/xx not_active IP Right Cessation
- 2005-07-15 HK HK07106604.8A patent/HK1101672A1/xx not_active IP Right Cessation
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2007
- 2007-11-14 CY CY20071101471T patent/CY1107472T1/el unknown
- 2007-12-27 IL IL188457A patent/IL188457A/en not_active IP Right Cessation
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2008
- 2008-10-30 IL IL194992A patent/IL194992A/en not_active IP Right Cessation
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2009
- 2009-02-04 JP JP2009023575A patent/JP4991770B2/ja not_active Expired - Lifetime
- 2009-05-25 CY CY20091100559T patent/CY1109108T1/el unknown
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