JP2008522001A - 感圧接着剤ヒドロゲルを製造する方法 - Google Patents
感圧接着剤ヒドロゲルを製造する方法 Download PDFInfo
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- JP2008522001A JP2008522001A JP2007544340A JP2007544340A JP2008522001A JP 2008522001 A JP2008522001 A JP 2008522001A JP 2007544340 A JP2007544340 A JP 2007544340A JP 2007544340 A JP2007544340 A JP 2007544340A JP 2008522001 A JP2008522001 A JP 2008522001A
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- Prior art keywords
- ethylenically unsaturated
- pressure sensitive
- sensitive adhesive
- precursor
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61L15/42—Use of materials characterised by their function or physical properties
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
- C08F290/14—Polymers provided for in subclass C08G
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J151/00—Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J151/00—Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
- C09J151/08—Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Materials For Medical Uses (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
- Dental Preparations (AREA)
- Polyethers (AREA)
- Jellies, Jams, And Syrups (AREA)
- Colloid Chemistry (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/004,158 US7999023B2 (en) | 2004-12-03 | 2004-12-03 | Process for making pressure sensitive adhesive hydrogels |
| PCT/US2005/036322 WO2006062573A1 (en) | 2004-12-03 | 2005-10-11 | Process for making pressure sensitive adhesive hydrogels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012204720A Division JP5543560B2 (ja) | 2004-12-03 | 2012-09-18 | 感圧接着剤ヒドロゲルを製造する方法 |
Publications (2)
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| JP2008522001A true JP2008522001A (ja) | 2008-06-26 |
| JP2008522001A5 JP2008522001A5 (https=) | 2008-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2012204720A Expired - Lifetime JP5543560B2 (ja) | 2004-12-03 | 2012-09-18 | 感圧接着剤ヒドロゲルを製造する方法 |
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| JP2012204720A Expired - Lifetime JP5543560B2 (ja) | 2004-12-03 | 2012-09-18 | 感圧接着剤ヒドロゲルを製造する方法 |
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| US (1) | US7999023B2 (https=) |
| EP (2) | EP1819797B1 (https=) |
| JP (2) | JP2008522001A (https=) |
| KR (1) | KR101134219B1 (https=) |
| CN (1) | CN101087860B (https=) |
| AT (2) | ATE489442T1 (https=) |
| AU (1) | AU2005314594A1 (https=) |
| BR (1) | BRPI0518756C8 (https=) |
| CA (1) | CA2588700C (https=) |
| DE (1) | DE602005025011D1 (https=) |
| MX (1) | MX2007006417A (https=) |
| TW (1) | TW200628578A (https=) |
| WO (1) | WO2006062573A1 (https=) |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06200224A (ja) * | 1992-12-28 | 1994-07-19 | Nitto Chem Ind Co Ltd | 高粘着性ハイドロゲル組成物 |
| US5420182A (en) * | 1994-02-01 | 1995-05-30 | Industrial Technology Research Institute | Water-retaining adhesive composition |
| WO2003025062A1 (en) * | 2001-09-18 | 2003-03-27 | Sekisui Plastics Co., Ltd. | Polymeric hydrogel |
| JP2004530008A (ja) * | 2001-03-30 | 2004-09-30 | ザ プロクター アンド ギャンブル カンパニー | 皮膚適合性ヒドロゲル接着剤 |
| JP2005533531A (ja) * | 2002-04-12 | 2005-11-10 | スリーエム イノベイティブ プロパティズ カンパニー | ゲル材料、医療用品、および方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO134790C (no) | 1968-07-09 | 1984-03-22 | Smith & Nephew | Klebende,; trykkfoelsomt, vanndamp-permeabelt produkt for bruk paa hud hos mennesker. |
| US3805769A (en) | 1971-08-27 | 1974-04-23 | R Sessions | Disposable electrode |
| US3845757A (en) | 1972-07-12 | 1974-11-05 | Minnesota Mining & Mfg | Biomedical monitoring electrode |
| US4233425A (en) | 1978-11-15 | 1980-11-11 | The Dow Chemical Company | Addition polymerizable polyethers having pendant ethylenically unsaturated urethane groups |
| US4310509A (en) | 1979-07-31 | 1982-01-12 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive having a broad spectrum antimicrobial therein |
| EP0043850B1 (en) | 1980-01-23 | 1985-06-19 | Minnesota Mining And Manufacturing Company | Method of manufacturing a dry biomedical electrode |
| US4539996A (en) | 1980-01-23 | 1985-09-10 | Minnesota Mining And Manufacturing Company | Conductive adhesive and biomedical electrode |
| US4527087A (en) | 1981-09-03 | 1985-07-02 | Tokyo Shibaura Denki Kabushiki Kaisha | Fluorescent lamp |
| AU560088B2 (en) | 1982-04-08 | 1987-03-26 | Smith & Nephew Associated Companies Plc | Surgical adhesive dressing |
| JPS59104791A (ja) * | 1982-12-04 | 1984-06-16 | Fujitsu Ltd | 半導体記憶装置 |
| US4640289A (en) | 1983-11-14 | 1987-02-03 | Minnesota Mining And Manufacturing Company | Biomedical electrode |
| US4771713A (en) | 1985-05-20 | 1988-09-20 | Kinzenbaw Jon E | Row crop planter convertible between narrow and wide row spacing |
| BR8606865A (pt) * | 1985-09-13 | 1987-11-03 | Chattan Nominees Pty Ltd | Dispositivo para colocacao no interior de uma vagina humana para recolha do fluido descarregado do utero,e instrumento para a colocacao do dispositivo |
| US4771783A (en) | 1986-08-01 | 1988-09-20 | Minnesota Mining And Manufacturing Company | Flat, conformable, biomedical electrode |
| US4715382A (en) | 1986-08-01 | 1987-12-29 | Minnesota Mining And Manufacturing Company | Flat biomedical electrode with reuseable lead wire |
| US4848353A (en) | 1986-09-05 | 1989-07-18 | Minnesota Mining And Manufacturing Company | Electrically-conductive, pressure-sensitive adhesive and biomedical electrodes |
| US4849224A (en) | 1987-11-12 | 1989-07-18 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
| US4846185A (en) | 1987-11-25 | 1989-07-11 | Minnesota Mining And Manufacturing Company | Bioelectrode having a galvanically active interfacing material |
| DE68917292T2 (de) | 1988-02-26 | 1995-02-02 | Riker Laboratories Inc | Transdermales estradiol als therapeutisches sytem. |
| CN1039609A (zh) * | 1988-07-15 | 1990-02-14 | 上海科技大学 | 紫外光动态合成水凝胶材料的方法 |
| US4855294A (en) | 1988-09-06 | 1989-08-08 | Theratech, Inc. | Method for reducing skin irritation associated with drug/penetration enhancer compositions |
| US5215087A (en) | 1988-09-22 | 1993-06-01 | Minnesota Mining And Manufacturing Company | Biomedical electrode construction |
| US5012810A (en) | 1988-09-22 | 1991-05-07 | Minnesota Mining And Manufacturing Company | Biomedical electrode construction |
| US5270358A (en) | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
| US5133356A (en) | 1991-04-16 | 1992-07-28 | Minnesota Mining And Manufacturing Company | Biomedical electrode having centrally-positioned tab construction |
| US5489624A (en) * | 1992-12-01 | 1996-02-06 | Minnesota Mining And Manufacturing Company | Hydrophilic pressure sensitive adhesives |
| DE4336299A1 (de) | 1993-10-25 | 1995-05-11 | Arbo Robotron Medizin Technolo | Gelkörper zur percutanen Verabreichung, insbesondere von Medikamenten |
| TW425403B (en) | 1997-02-04 | 2001-03-11 | Novartis Ag | Branched polyurethane (meth)acrylate prepolymers, opthal-mic mouldings derived therefrom and processes for their manufacture |
| JPH11164878A (ja) * | 1997-12-04 | 1999-06-22 | Teijin Ltd | 新規な医療用ポリマー |
| AU2001286651A1 (en) | 2000-08-22 | 2002-03-04 | Purdue Research Foundation | Microparticle composition and method |
| DE10059828A1 (de) * | 2000-12-01 | 2002-06-13 | Clariant Gmbh | Kammförmige Copolymere auf Basis von Acryloyldimethyltaurinsäure |
| US6537569B2 (en) * | 2001-02-14 | 2003-03-25 | Microvention, Inc. | Radiation cross-linked hydrogels |
| US20040068093A1 (en) | 2002-07-01 | 2004-04-08 | The Procter & Gamble Company | Polymerized hydrogel comprising low amounts of residual monomers and by-products |
| US6746765B1 (en) * | 2003-01-23 | 2004-06-08 | Bristol-Myers Squibb Company | Hydrocolloid adhesive tape |
| MXPA05011248A (es) * | 2003-04-23 | 2005-12-14 | Wyeth Corp | Derivados de wortmanina solubles en agua. |
-
2004
- 2004-12-03 US US11/004,158 patent/US7999023B2/en active Active
-
2005
- 2005-10-11 AT AT05807673T patent/ATE489442T1/de not_active IP Right Cessation
- 2005-10-11 CN CN2005800413963A patent/CN101087860B/zh not_active Expired - Lifetime
- 2005-10-11 MX MX2007006417A patent/MX2007006417A/es unknown
- 2005-10-11 DE DE602005025011T patent/DE602005025011D1/de not_active Expired - Lifetime
- 2005-10-11 AU AU2005314594A patent/AU2005314594A1/en not_active Abandoned
- 2005-10-11 JP JP2007544340A patent/JP2008522001A/ja not_active Withdrawn
- 2005-10-11 KR KR1020077014891A patent/KR101134219B1/ko not_active Expired - Fee Related
- 2005-10-11 WO PCT/US2005/036322 patent/WO2006062573A1/en not_active Ceased
- 2005-10-11 EP EP05807673A patent/EP1819797B1/en not_active Expired - Lifetime
- 2005-10-11 EP EP10175489A patent/EP2251366B1/en not_active Expired - Lifetime
- 2005-10-11 AT AT10175489T patent/ATE541873T1/de active
- 2005-10-11 CA CA2588700A patent/CA2588700C/en not_active Expired - Fee Related
- 2005-10-11 BR BRPI0518756A patent/BRPI0518756C8/pt not_active IP Right Cessation
- 2005-11-15 TW TW094140115A patent/TW200628578A/zh unknown
-
2012
- 2012-09-18 JP JP2012204720A patent/JP5543560B2/ja not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06200224A (ja) * | 1992-12-28 | 1994-07-19 | Nitto Chem Ind Co Ltd | 高粘着性ハイドロゲル組成物 |
| US5420182A (en) * | 1994-02-01 | 1995-05-30 | Industrial Technology Research Institute | Water-retaining adhesive composition |
| JP2004530008A (ja) * | 2001-03-30 | 2004-09-30 | ザ プロクター アンド ギャンブル カンパニー | 皮膚適合性ヒドロゲル接着剤 |
| WO2003025062A1 (en) * | 2001-09-18 | 2003-03-27 | Sekisui Plastics Co., Ltd. | Polymeric hydrogel |
| JP2005533531A (ja) * | 2002-04-12 | 2005-11-10 | スリーエム イノベイティブ プロパティズ カンパニー | ゲル材料、医療用品、および方法 |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011526961A (ja) * | 2008-07-07 | 2011-10-20 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | ポリアルキレングリコールジ(メタ)アクリレートの製造方法 |
| US8716516B2 (en) | 2008-07-07 | 2014-05-06 | Evonik Röhm Gmbh | Method for producing polyalkylene glycoldi(meth)acrylates |
| CN101664563B (zh) * | 2009-09-21 | 2012-09-19 | 杭州国纳科技有限公司 | 一种抗菌水凝胶敷料的制备方法 |
| JP2013063267A (ja) * | 2011-09-15 | 2013-04-11 | Compose Element Ltd | ドレッシング材 |
| JP2013185119A (ja) * | 2012-03-09 | 2013-09-19 | Sekisui Plastics Co Ltd | 粘着性ハイドロゲル及びその用途 |
| JP2017105722A (ja) * | 2015-12-08 | 2017-06-15 | 東洋インキScホールディングス株式会社 | 皮膚貼付用粘着剤、経皮吸収性粘着剤、および経皮吸収性粘着シート |
| JPWO2021107002A1 (https=) * | 2019-11-29 | 2021-06-03 | ||
| JPWO2021106994A1 (https=) * | 2019-11-29 | 2021-06-03 | ||
| JP7683486B2 (ja) | 2019-11-29 | 2025-05-27 | 株式会社レゾナック | ポリオキシアルキレン鎖を有する化合物を含有する組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070086797A (ko) | 2007-08-27 |
| JP2013018989A (ja) | 2013-01-31 |
| WO2006062573A1 (en) | 2006-06-15 |
| BRPI0518756B8 (pt) | 2018-05-02 |
| BRPI0518756A2 (pt) | 2008-12-02 |
| US7999023B2 (en) | 2011-08-16 |
| MX2007006417A (es) | 2007-07-20 |
| EP1819797A1 (en) | 2007-08-22 |
| EP2251366B1 (en) | 2012-01-18 |
| BRPI0518756B1 (pt) | 2017-12-26 |
| AU2005314594A1 (en) | 2006-06-15 |
| JP5543560B2 (ja) | 2014-07-09 |
| ATE541873T1 (de) | 2012-02-15 |
| CN101087860B (zh) | 2010-12-01 |
| BRPI0518756C8 (pt) | 2018-12-26 |
| CN101087860A (zh) | 2007-12-12 |
| US20060122298A1 (en) | 2006-06-08 |
| CA2588700C (en) | 2014-04-01 |
| EP1819797B1 (en) | 2010-11-24 |
| DE602005025011D1 (de) | 2011-01-05 |
| KR101134219B1 (ko) | 2012-04-09 |
| EP2251366A1 (en) | 2010-11-17 |
| CA2588700A1 (en) | 2006-06-15 |
| TW200628578A (en) | 2006-08-16 |
| ATE489442T1 (de) | 2010-12-15 |
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