JP2008521870A5 - - Google Patents
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- JP2008521870A5 JP2008521870A5 JP2007543910A JP2007543910A JP2008521870A5 JP 2008521870 A5 JP2008521870 A5 JP 2008521870A5 JP 2007543910 A JP2007543910 A JP 2007543910A JP 2007543910 A JP2007543910 A JP 2007543910A JP 2008521870 A5 JP2008521870 A5 JP 2008521870A5
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- 102000010932 Interleukin-1 receptor type 1 Human genes 0.000 claims 31
- 108050001109 Interleukin-1 receptor type 1 Proteins 0.000 claims 31
- 101100268517 Mus musculus Serpina1d gene Proteins 0.000 claims 30
- 108060003951 Immunoglobulin Proteins 0.000 claims 23
- 102000018358 immunoglobulin Human genes 0.000 claims 23
- 239000005557 antagonist Substances 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 12
- 208000023504 respiratory system disease Diseases 0.000 claims 12
- 102000000589 Interleukin-1 Human genes 0.000 claims 11
- 108010002352 Interleukin-1 Proteins 0.000 claims 11
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 10
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 10
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims 9
- 208000014085 Chronic respiratory disease Diseases 0.000 claims 8
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 8
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 claims 7
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims 7
- 210000004602 germ cell Anatomy 0.000 claims 7
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 6
- 238000012377 drug delivery Methods 0.000 claims 6
- 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 4
- 108091006905 Human Serum Albumin Proteins 0.000 claims 4
- 102000007562 Serum Albumin Human genes 0.000 claims 4
- 108010071390 Serum Albumin Proteins 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 125000003827 glycol group Chemical group 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 238000007910 systemic administration Methods 0.000 claims 3
- 102000006395 Globulins Human genes 0.000 claims 2
- 108010044091 Globulins Proteins 0.000 claims 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
- 102000019223 Interleukin-1 receptor Human genes 0.000 claims 2
- 108050006617 Interleukin-1 receptor Proteins 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 206010036790 Productive cough Diseases 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 102000007238 Transferrin Receptors Human genes 0.000 claims 2
- 108010033576 Transferrin Receptors Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 2
- 210000004969 inflammatory cell Anatomy 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 210000004879 pulmonary tissue Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 230000037317 transdermal delivery Effects 0.000 claims 2
- 239000012581 transferrin Substances 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 102000046824 human IL1RN Human genes 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 229940100601 interleukin-6 Drugs 0.000 claims 1
- 229940096397 interleukin-8 Drugs 0.000 claims 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
- 230000036961 partial effect Effects 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 230000002829 reductive effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 238000013389 whole blood assay Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63236104P | 2004-12-02 | 2004-12-02 | |
| PCT/GB2005/002163 WO2005118642A2 (en) | 2004-06-01 | 2005-05-31 | Bispecific fusion antibodies with enhanced serum half-life |
| GBGB0521621.3A GB0521621D0 (en) | 2005-10-24 | 2005-10-24 | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| PCT/GB2005/004601 WO2006059108A2 (en) | 2004-12-02 | 2005-12-01 | ANTI-IL-IRl SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC USES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008521870A JP2008521870A (ja) | 2008-06-26 |
| JP2008521870A5 true JP2008521870A5 (enExample) | 2009-01-22 |
Family
ID=38792215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543910A Pending JP2008521870A (ja) | 2004-12-02 | 2005-12-01 | 抗ｉｌ−１ｒ１単一ドメイン抗体および治療使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090191217A1 (enExample) |
| EP (1) | EP1863847A2 (enExample) |
| JP (1) | JP2008521870A (enExample) |
| KR (1) | KR20070086896A (enExample) |
| CN (1) | CN101133084A (enExample) |
| AU (2) | AU2005311101B8 (enExample) |
| BR (1) | BRPI0518622A2 (enExample) |
| CA (1) | CA2588892A1 (enExample) |
| IL (1) | IL183458A0 (enExample) |
| MA (1) | MA29669B1 (enExample) |
| MX (1) | MX2007006593A (enExample) |
| NO (1) | NO20073337L (enExample) |
| WO (1) | WO2006059108A2 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| BRPI0316092B8 (pt) * | 2002-11-08 | 2021-05-25 | Ablynx Nv | anticorpos de domínio único direcionados contra o fator de necrose tumoral alfa e usos para os mesmos |
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| GB0521621D0 (en) | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| JP2009519011A (ja) * | 2005-12-01 | 2009-05-14 | ドマンティス リミテッド | インターロイキン１受容体１型に結合する非競合ドメイン抗体フォーマット |
| US20080311111A1 (en) * | 2005-12-01 | 2008-12-18 | Drew Philip D | Competitive Domain Antibody Formats That Bind Interleukin 1 Receptor Type 1 |
| LT2068889T (lt) | 2006-08-10 | 2020-02-10 | Roy C. Levitt | Anakinra, naudojama bronchiolito obliteranso sindromo gydymui |
| AU2013270447B2 (en) * | 2006-08-10 | 2016-10-13 | Onspira Therapeutics, Inc. | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| GB0621513D0 (en) | 2006-10-30 | 2006-12-06 | Domantis Ltd | Novel polypeptides and uses thereof |
| GB0724331D0 (en) * | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| CA2688433A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
| CA2698748A1 (en) * | 2007-09-11 | 2009-03-19 | Dorian Bevec | Use of a peptide as a therapeutic agent |
| WO2009033664A1 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of delta-endorphin as a therapeutic agent |
| EP2220115A2 (en) * | 2007-12-13 | 2010-08-25 | Glaxo Group Limited | Polypeptides, antibody variable domains & antagonists |
| US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| WO2009127691A1 (en) | 2008-04-17 | 2009-10-22 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| KR20110071139A (ko) * | 2008-10-21 | 2011-06-28 | 도만티스 리미티드 | Ｄｃｓｉｇｎ에 대한 결합 특이성을 갖는 리간드 |
| BRPI0919979A2 (pt) | 2008-10-29 | 2015-12-15 | Wyeth Llc | formulações de moléculas de ligação de antígeno de domínio único |
| MX2011004558A (es) | 2008-10-29 | 2011-06-01 | Wyeth Llc | Procedimientos para la purificacion de moleculas de union a antigeno de un unico dominio. |
| US8298533B2 (en) * | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
| WO2010056732A1 (en) | 2008-11-12 | 2010-05-20 | Marv Enterprises Llc | Utilization of stents for the treatment of blood borne carcinomas |
| DK2387583T3 (en) * | 2009-01-14 | 2019-01-14 | Ablynx Nv | PULMONAL ADMINISTRATION OF VARIABLE IMMUNGLOBULIN SINGLE DOMAINS AND CONSTRUCTIONS THEREOF. |
| US9216386B2 (en) * | 2009-03-17 | 2015-12-22 | Marv Enterprises, LLC | Sequential extracorporeal treatment of bodily fluids |
| US20100291106A1 (en) * | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| PT2438087T (pt) * | 2009-06-05 | 2017-08-04 | Ablynx Nv | Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório |
| CN102573790B (zh) | 2009-08-27 | 2017-03-22 | 拜欧米特生物制剂有限责任公司 | 用于产生白介素‑1受体拮抗剂的可植入装置 |
| CN102781959A (zh) | 2010-02-05 | 2012-11-14 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽 |
| KR20130086141A (ko) * | 2010-04-16 | 2013-07-31 | 메디뮨 리미티드 | Ｃｏｐｄ 악화를 치료하기 위한 조성물 및 방법 |
| US8883134B2 (en) | 2010-10-20 | 2014-11-11 | Handok Pharmaceuticals, Inc. | Human interleukin-1 receptor antagonist—hybrid Fc fusion protein |
| WO2012053828A2 (ko) * | 2010-10-20 | 2012-04-26 | 주식회사 한독약품 | 인간 인터루킨-1 수용체 길항제-하이브리드 Ｆｃ 융합단백질 |
| JP2014501515A (ja) * | 2010-12-01 | 2014-01-23 | グラクソ グループ リミテッド | 改良された抗血清アルブミン結合単一可変ドメイン |
| EP2675470A1 (en) * | 2011-02-15 | 2013-12-25 | Novo Nordisk A/S | Long-acting il-1 receptor antagonists |
| CA2837998C (en) | 2011-06-23 | 2022-03-01 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2944653A1 (en) | 2011-06-23 | 2015-11-18 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
| EP4350345A3 (en) | 2011-06-23 | 2024-07-24 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
| US20150027950A1 (en) * | 2012-03-27 | 2015-01-29 | Marv Enterprises, LLC | Treatment for atherosclerosis |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| EP3074507B1 (en) | 2013-11-26 | 2022-01-05 | Biomet Biologics, LLC | Methods of mediating macrophage phenotypes |
| KR20230145503A (ko) | 2014-05-16 | 2023-10-17 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
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| CN107206069A (zh) | 2014-10-10 | 2017-09-26 | 埃博灵克斯股份有限公司 | Rsv感染的治疗 |
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| NO2768984T3 (enExample) | 2015-11-12 | 2018-06-09 | ||
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| AU2016357460B2 (en) | 2015-11-18 | 2023-07-27 | Ablynx Nv | Improved serum albumin binders |
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| CN109313183B (zh) | 2016-06-23 | 2022-10-21 | 埃博灵克斯股份有限公司 | 免疫球蛋白单可变结构域的改进的药代动力学测定 |
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| WO2021213435A1 (zh) | 2020-04-22 | 2021-10-28 | 迈威(上海)生物科技股份有限公司 | 一种靶向人程序性死亡配体1(pd-l1)的单可变域抗体及其衍生物 |
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2005
- 2005-12-01 JP JP2007543910A patent/JP2008521870A/ja active Pending
- 2005-12-01 CN CNA2005800476534A patent/CN101133084A/zh active Pending
- 2005-12-01 BR BRPI0518622-6A patent/BRPI0518622A2/pt not_active Application Discontinuation
- 2005-12-01 CA CA002588892A patent/CA2588892A1/en not_active Abandoned
- 2005-12-01 WO PCT/GB2005/004601 patent/WO2006059108A2/en not_active Ceased
- 2005-12-01 AU AU2005311101A patent/AU2005311101B8/en not_active Ceased
- 2005-12-01 KR KR1020077015202A patent/KR20070086896A/ko not_active Ceased
- 2005-12-01 US US11/791,781 patent/US20090191217A1/en not_active Abandoned
- 2005-12-01 EP EP05818379A patent/EP1863847A2/en not_active Ceased
- 2005-12-01 MX MX2007006593A patent/MX2007006593A/es unknown
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2007
- 2007-05-28 IL IL183458A patent/IL183458A0/en unknown
- 2007-06-28 NO NO20073337A patent/NO20073337L/no not_active Application Discontinuation
- 2007-06-29 MA MA30043A patent/MA29669B1/fr unknown
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2011
- 2011-02-09 AU AU2011200544A patent/AU2011200544A1/en not_active Abandoned