JP2008520640A - プロバイオティクス細菌系組成物、ならびに、呼吸病態および／または呼吸器系感染の予防および／または治療、および腸機能改善へのその使用 - Google Patents
プロバイオティクス細菌系組成物、ならびに、呼吸病態および／または呼吸器系感染の予防および／または治療、および腸機能改善へのその使用 Download PDFInfo
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- JP2008520640A JP2008520640A JP2007542140A JP2007542140A JP2008520640A JP 2008520640 A JP2008520640 A JP 2008520640A JP 2007542140 A JP2007542140 A JP 2007542140A JP 2007542140 A JP2007542140 A JP 2007542140A JP 2008520640 A JP2008520640 A JP 2008520640A
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- A61K35/66—Microorganisms or materials therefrom
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
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- Pulmonology (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002189A ITMI20042189A1 (it) | 2004-11-16 | 2004-11-16 | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
| PCT/IB2005/003214 WO2006054135A1 (en) | 2004-11-16 | 2005-10-05 | Probiotic bacteria based composition and use thereof in the prevention and/or treatment of respiratory pathologies and/or infections and in the improvement of the intestinal functionality |
Publications (2)
| Publication Number | Publication Date |
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| JP2008520640A true JP2008520640A (ja) | 2008-06-19 |
| JP2008520640A5 JP2008520640A5 (cg-RX-API-DMAC10.html) | 2008-10-30 |
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|---|---|---|---|
| JP2007542140A Pending JP2008520640A (ja) | 2004-11-16 | 2005-10-05 | プロバイオティクス細菌系組成物、ならびに、呼吸病態および／または呼吸器系感染の予防および／または治療、および腸機能改善へのその使用 |
Country Status (14)
Cited By (6)
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| JP2010047485A (ja) * | 2008-08-19 | 2010-03-04 | Nisshin Seifun Group Inc | インフルエンザワクチンのアジュバント |
| JP2014517003A (ja) * | 2011-06-10 | 2014-07-17 | デュポン ニュートリション バイオサイエンシーズ エーピーエス | ビフィドバクテリウム・ラクティスｂｌ−０４による呼吸器疾患の治療 |
| WO2014119718A1 (ja) * | 2013-01-31 | 2014-08-07 | 国立大学法人香川大学 | 血糖値の上昇抑制効果を有するこんにゃく加工飲食品 |
| JP2014526242A (ja) * | 2011-09-09 | 2014-10-06 | プロバイオティカル・ソシエタ・ペル・アチオニ | 大腸菌の様々なバイオタイプおよびクロストリジウム菌の様々なバイオタイプの増殖を阻害／低減する乳酸菌および／またはビフィズス菌の株 |
| JP2015512269A (ja) * | 2012-04-10 | 2015-04-27 | シージェイ第一製糖株式会社Ｃｊ Ｃｈｅｉｌｊｅｄａｎｇ Ｃｏｒｐｏｒａｔｉｏｎ | タガトース及びプロバイオティック乳酸菌を含有するシンバイオティック食品組成物 |
| WO2020009135A1 (ja) * | 2018-07-03 | 2020-01-09 | 学校法人北里研究所 | インフルエンザの重症化を抑制するための抗インフルエンザウイルス剤 |
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| ITMI20042189A1 (it) | 2004-11-16 | 2005-02-16 | Anidral Srl | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
| WO2007079147A2 (en) | 2005-12-28 | 2007-07-12 | Advanced Bionutrition Corporation | A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| DK2068899T3 (da) | 2006-10-02 | 2015-09-28 | Dupont Nutrition Biosci Aps | Lactobacillus acidophilus til anvendelse til reducering af forekomsten og varigheden af luftvejsinfektioner |
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| CN101815509A (zh) | 2007-08-03 | 2010-08-25 | 沙克利公司 | 营养剂量单位 |
| WO2009021585A1 (en) * | 2007-08-13 | 2009-02-19 | Dsm Ip Assets B.V. | Probiotic bacteria for rducing the occurence of symptoms of winter infections |
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| US20090280099A1 (en) * | 2008-05-07 | 2009-11-12 | Bachman Stephen E | Nasopharyngeal inoculate of probiotics and prebiotics for treatment of respiratory infections |
| RU2373277C1 (ru) * | 2008-07-15 | 2009-11-20 | Федеральное Государственное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Штамм bifidobacterium angulatum ov-15, используемый для получения бактерийных препаратов, биологически активных добавок к пище, неферментированных пищевых продуктов, гигиенических и косметических средств |
| RU2373278C1 (ru) * | 2008-07-15 | 2009-11-20 | Федеральное Государственное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Штамм bifidobacterium pseudocatenulatum ov-2, используемый для получения бактерийных препаратов, биологически активных добавок к пище, неферментированных пищевых продуктов, гигиенических и косметических средств |
| RU2373275C1 (ru) * | 2008-07-15 | 2009-11-20 | Федеральное Государственное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Штамм bifidobacterium pseudocatenulatum ov-17, используемый для получения бактерийных препаратов, биологически активных добавок к пище, неферментированных пищевых продуктов, гигиенических и косметических средств |
| KR101001767B1 (ko) | 2008-11-04 | 2010-12-15 | 주식회사한국야쿠르트 | 항 인플루엔자 바이러스 효능을 갖는 락토바실러스 루테리 에이취와이7501 및 이를 유효성분으로 함유하는 제품 |
| US20110256179A1 (en) * | 2008-11-17 | 2011-10-20 | Essum Ab | Pharmaceutical preparation comprising a combination of streptococcus strains and lactobacillus strains |
| WO2010103132A1 (es) * | 2009-03-10 | 2010-09-16 | Hero España, S.A. | Aislamiento, identificación y caracterización de cepas con actividad probiótica a partir de heces de lactantes alimentados exclusivamente con leche materna |
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| TWI767013B (zh) | 2017-06-14 | 2022-06-11 | 英商4D製藥研究有限公司 | 包含細菌品系之組成物 |
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| EP4243846A2 (en) * | 2020-11-12 | 2023-09-20 | Synbiotics AB | Synbiotic composition |
| TW202302128A (zh) * | 2021-03-26 | 2023-01-16 | 香港中文大學 | 微生物提高疫苗效力的用途 |
| CN114657100B (zh) * | 2022-04-01 | 2023-07-25 | 江南大学 | 一株能够缓解流感病毒感染小鼠病理特征的戊糖乳杆菌及其应用 |
| CN115025132B (zh) * | 2022-06-09 | 2024-01-30 | 康永波 | 一种合生元组合物及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10167972A (ja) * | 1996-10-11 | 1998-06-23 | Takeda Shokuhin Kogyo Kk | 免疫賦活剤 |
| JP2001513990A (ja) * | 1997-08-21 | 2001-09-11 | ニュージーランド デアリー ボード | 免疫増強作用を有する乳酸菌 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6241983B1 (en) | 1994-10-28 | 2001-06-05 | Metagenics, Inc. | Bacteria-and fiber-containing composition for human gastrointestinal health |
| AUPN881396A0 (en) † | 1996-03-20 | 1996-04-18 | Arnott's Biscuits Limited | Enhancement of microbial colonization of the gastrointestinal tract |
| EP0904784A1 (en) † | 1997-09-22 | 1999-03-31 | N.V. Nutricia | Probiotic nutritional preparation |
| NL1010770C2 (nl) † | 1998-12-09 | 2000-06-13 | Nutricia Nv | Preparaat dat oligosacchariden en probiotica bevat. |
| WO2001097821A1 (en) | 2000-06-19 | 2001-12-27 | Mucoprotec Pty Ltd | Immunotherapy or treating bacterial or viral infection at mucosal surfaces with probiotics, and compositions therefor. |
| FI110668B (fi) | 2000-06-20 | 2003-03-14 | Aboatech Ab Oy | Probioottien käyttö atooppisten sairauksien primaariseen ehkäisyyn |
| GB2369777B (en) | 2000-10-05 | 2004-10-27 | St Ivel Ltd | Food products with antimicrobial lactic acid bacteria |
| FI109602B (fi) * | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
| DE20202562U1 (de) * | 2002-02-19 | 2002-05-23 | Orthomol pharmazeutische Vertriebs GmbH, 40764 Langenfeld | Mikronährstoffkombinationsprodukt mit Pro- und Prebiotika |
| ITMI20020399A1 (it) | 2002-02-28 | 2003-08-28 | Ct Sperimentale Del Latte S P | Composizioni dietetiche e/o farmaceutiche per uso umano e/o animale abase di preparati microbici probiotici |
| US20050074442A1 (en) | 2002-03-13 | 2005-04-07 | Natarajan Ranganathan | Compositions and methods for augmenting kidney function |
| WO2004009031A2 (en) | 2002-07-22 | 2004-01-29 | Agtech Products, Inc. | Lactobacillus strains and uses therefor |
| BRPI0418986A (pt) | 2004-08-05 | 2007-12-11 | Anidral Srl | cepas bacterianas bifidobacterium produtoras de ácido fólico, formulações e seus usos |
| ITMI20042189A1 (it) | 2004-11-16 | 2005-02-16 | Anidral Srl | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
| EP2269465A1 (en) | 2006-05-03 | 2011-01-05 | Probiotical S.p.a. | Compositions comprising Bifidobacterium adolescentis |
| ITMI20072260A1 (it) | 2007-12-03 | 2009-06-04 | Anidral Srl | Una composizione a base di batteri probiotici in associazione con un prebiotico e suo uso nella prevenzione e/o nel trattamento di patologie e/o infezioni respiratorie e nel miglioramento della funzionalita intestinale. |
-
2004
- 2004-11-16 IT IT002189A patent/ITMI20042189A1/it unknown
-
2005
- 2005-10-05 DK DK05793656.9T patent/DK1773361T4/da active
- 2005-10-05 JP JP2007542140A patent/JP2008520640A/ja active Pending
- 2005-10-05 RU RU2007106038/10A patent/RU2418063C2/ru active
- 2005-10-05 PT PT05793656T patent/PT1773361E/pt unknown
- 2005-10-05 CN CN2005800327953A patent/CN101031313B/zh not_active Expired - Fee Related
- 2005-10-05 US US11/719,027 patent/US9233130B2/en active Active
- 2005-10-05 ES ES05793656T patent/ES2329390T5/es not_active Expired - Lifetime
- 2005-10-05 BR BRPI0517273A patent/BRPI0517273B8/pt not_active IP Right Cessation
- 2005-10-05 WO PCT/IB2005/003214 patent/WO2006054135A1/en not_active Ceased
- 2005-10-05 PL PL05793656T patent/PL1773361T5/pl unknown
- 2005-10-05 DE DE602005015451T patent/DE602005015451D1/de not_active Expired - Lifetime
- 2005-10-05 KR KR1020077011176A patent/KR101228608B1/ko not_active Expired - Lifetime
- 2005-10-05 EP EP05793656A patent/EP1773361B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10167972A (ja) * | 1996-10-11 | 1998-06-23 | Takeda Shokuhin Kogyo Kk | 免疫賦活剤 |
| JP2001513990A (ja) * | 1997-08-21 | 2001-09-11 | ニュージーランド デアリー ボード | 免疫増強作用を有する乳酸菌 |
Non-Patent Citations (3)
| Title |
|---|
| JPN6011059358; Ｔｏｍａｓｉｋ ＰＪ， ｅｔ ａｌ．: 'Ｐｒｏｂｉｏｔｉｃｓ ａｎｄ Ｐｒｅｂｉｏｔｉｃｓ' Ｃｅｒｅａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ． ８０， Ｎｏ． ２, 200303, ｐ． １１３-１１７ * |
| JPN6011059359; Ｈａｔａｋｋａ Ｋ， ｅｔ ａｌ．: 'Ｅｆｆｅｃｔ ｏｆ ｌｏｎｇ ｔｅｒｍ ｃｏｎｓｕｍｐｔｉｏｎ ｏｆ ｐｒｏｂｉｏｔｉｃ ｍｉｌｋ ｏｎ ｉｎｆｅｃｔｉｏｎｓ ｉｎ ｃｈｉｌｄｒｅｎ ａｔｔｅｎｄｉｎｇ ｄａｙ ｃａｒｅ ｃｅｎｔｒ' ＢＭＪ ［ｏｎｌｉｎｅ］ Ｖｏｌ． ３２２， Ｎｏ． ７２９８， ＃１３２７, 20010602, ｐ． １-５ （ｄｏｉ：１０．１１３６／ｂｍｊ．３２２．７２９８．１３２７） * |
| JPN6014037560; Ｊ．Ｎｕｔｒ． ｖｏｌ．１３４，Ｎｏ．１, 200401, ｐ１５３-１５６ |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010047485A (ja) * | 2008-08-19 | 2010-03-04 | Nisshin Seifun Group Inc | インフルエンザワクチンのアジュバント |
| JP2014517003A (ja) * | 2011-06-10 | 2014-07-17 | デュポン ニュートリション バイオサイエンシーズ エーピーエス | ビフィドバクテリウム・ラクティスｂｌ−０４による呼吸器疾患の治療 |
| JP2014526242A (ja) * | 2011-09-09 | 2014-10-06 | プロバイオティカル・ソシエタ・ペル・アチオニ | 大腸菌の様々なバイオタイプおよびクロストリジウム菌の様々なバイオタイプの増殖を阻害／低減する乳酸菌および／またはビフィズス菌の株 |
| JP2015512269A (ja) * | 2012-04-10 | 2015-04-27 | シージェイ第一製糖株式会社Ｃｊ Ｃｈｅｉｌｊｅｄａｎｇ Ｃｏｒｐｏｒａｔｉｏｎ | タガトース及びプロバイオティック乳酸菌を含有するシンバイオティック食品組成物 |
| WO2014119718A1 (ja) * | 2013-01-31 | 2014-08-07 | 国立大学法人香川大学 | 血糖値の上昇抑制効果を有するこんにゃく加工飲食品 |
| WO2020009135A1 (ja) * | 2018-07-03 | 2020-01-09 | 学校法人北里研究所 | インフルエンザの重症化を抑制するための抗インフルエンザウイルス剤 |
| CN112351693A (zh) * | 2018-07-03 | 2021-02-09 | 学校法人北里研究所 | 用于抑制流感的重症化的抗流感病毒剂 |
| JPWO2020009135A1 (ja) * | 2018-07-03 | 2021-07-15 | 学校法人北里研究所 | インフルエンザの重症化を抑制するための抗インフルエンザウイルス剤 |
| JP7756864B2 (ja) | 2018-07-03 | 2025-10-21 | 学校法人北里研究所 | インフルエンザの重症化を抑制するための抗インフルエンザウイルス剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2329390T3 (es) | 2009-11-25 |
| RU2418063C2 (ru) | 2011-05-10 |
| CN101031313A (zh) | 2007-09-05 |
| WO2006054135A1 (en) | 2006-05-26 |
| BRPI0517273A (pt) | 2008-10-07 |
| US20080107634A1 (en) | 2008-05-08 |
| RU2007106038A (ru) | 2008-10-27 |
| DE602005015451D1 (de) | 2009-08-27 |
| BRPI0517273B1 (pt) | 2020-11-03 |
| BRPI0517273B8 (pt) | 2021-05-25 |
| PL1773361T5 (pl) | 2012-12-31 |
| DK1773361T4 (da) | 2012-10-15 |
| US9233130B2 (en) | 2016-01-12 |
| ITMI20042189A1 (it) | 2005-02-16 |
| EP1773361A1 (en) | 2007-04-18 |
| DK1773361T3 (da) | 2009-11-16 |
| PL1773361T3 (pl) | 2010-05-31 |
| EP1773361B1 (en) | 2009-07-15 |
| CN101031313B (zh) | 2010-06-16 |
| PT1773361E (pt) | 2009-10-22 |
| HK1110510A1 (zh) | 2008-07-18 |
| EP1773361B2 (en) | 2012-09-26 |
| KR101228608B1 (ko) | 2013-02-01 |
| KR20070089130A (ko) | 2007-08-30 |
| ES2329390T5 (es) | 2013-02-11 |
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