JP2008517897A5 - - Google Patents
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- Publication number
- JP2008517897A5 JP2008517897A5 JP2007537410A JP2007537410A JP2008517897A5 JP 2008517897 A5 JP2008517897 A5 JP 2008517897A5 JP 2007537410 A JP2007537410 A JP 2007537410A JP 2007537410 A JP2007537410 A JP 2007537410A JP 2008517897 A5 JP2008517897 A5 JP 2008517897A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- aryl
- defined above
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 28
- 125000005842 heteroatom Chemical group 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 20
- 125000001072 heteroaryl group Chemical group 0.000 claims description 17
- 125000004429 atom Chemical group 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 12
- 125000005843 halogen group Chemical group 0.000 claims description 10
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 150000004677 hydrates Chemical class 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- -1 polyfluoroalkyl Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 101000693265 Homo sapiens Sphingosine 1-phosphate receptor 1 Proteins 0.000 claims 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04292517A EP1650186B1 (en) | 2004-10-22 | 2004-10-22 | Novel dicarboxylic acid derivatives |
| PCT/IB2005/003113 WO2006043149A2 (en) | 2004-10-22 | 2005-10-18 | Novel dicarboxylic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517897A JP2008517897A (ja) | 2008-05-29 |
| JP2008517897A5 true JP2008517897A5 (https=) | 2012-05-31 |
Family
ID=34931473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537410A Pending JP2008517897A (ja) | 2004-10-22 | 2005-10-18 | 新規なジカルボン酸誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20090264469A1 (https=) |
| EP (1) | EP1650186B1 (https=) |
| JP (1) | JP2008517897A (https=) |
| KR (1) | KR20070097418A (https=) |
| CN (1) | CN101107218A (https=) |
| AP (1) | AP2007004001A0 (https=) |
| AT (1) | ATE397582T1 (https=) |
| AU (1) | AU2005297138A1 (https=) |
| BR (1) | BRPI0516988A (https=) |
| CA (1) | CA2584610A1 (https=) |
| CY (1) | CY1108321T1 (https=) |
| DE (1) | DE602004014277D1 (https=) |
| DK (1) | DK1650186T3 (https=) |
| EA (1) | EA200700931A1 (https=) |
| ES (1) | ES2308127T3 (https=) |
| HR (1) | HRP20080431T3 (https=) |
| IL (1) | IL182678A0 (https=) |
| MX (1) | MX2007004847A (https=) |
| PL (1) | PL1650186T3 (https=) |
| PT (1) | PT1650186E (https=) |
| SI (1) | SI1650186T1 (https=) |
| WO (1) | WO2006043149A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2014653A1 (en) * | 2007-06-15 | 2009-01-14 | Bioprojet | Novel dicarboxylic acid derivatives as S1P1 receptor agonists |
| ES2360929T3 (es) * | 2007-09-20 | 2011-06-10 | Amgen Inc. | Derivados del ácido 1-(4-(4-bencilbenzamido)-bencil)azetidin-3-carboxílico y compuestos relacionados como moduladores del receptor s1p para el tratamiento de trastornos inmunitarios. |
| SI2291080T1 (sl) | 2008-05-14 | 2015-11-30 | The Scripps Research Institute | Novi modulatorji sfingosinskih fosfatnih receptorjev |
| EA019252B1 (ru) | 2008-07-23 | 2014-02-28 | Арена Фармасьютикалз, Инк. | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ (1,2,3,4-ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛ-3-ИЛ)УКСУСНОЙ КИСЛОТЫ, ПРИМЕНИМЫЕ В ЛЕЧЕНИИ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ |
| SI2342205T1 (sl) | 2008-08-27 | 2016-09-30 | Arena Pharmaceuticals, Inc. | Substituirani triciklični kislinski derivati kot agonisti S1P1 receptorja, uporabni v zdravljenju avtoimunskih in vnetnih obolenj |
| SG10201906876PA (en) | 2010-01-27 | 2019-09-27 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| SG183416A1 (en) | 2010-03-03 | 2012-09-27 | Arena Pharm Inc | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
| KR101299512B1 (ko) * | 2011-04-19 | 2013-08-22 | 전북대학교산학협력단 | 스핑고신 1-포스페이트를 유효성분으로 함유하는 관절염 질환 치료 조성물 |
| MX386419B (es) | 2015-01-06 | 2025-03-18 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
| EP3939965A1 (en) | 2015-06-22 | 2022-01-19 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in sipi receptor-associated disorders |
| RU2615765C1 (ru) * | 2016-04-11 | 2017-04-11 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Уфимский государственный нефтяной технический университет" | Способ получения диалкилциклопент-3-ен-1,1-дикарбоксилата |
| WO2018151834A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| ES2987794T3 (es) | 2018-06-06 | 2024-11-18 | Arena Pharm Inc | Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1 |
| CN112955431A (zh) | 2018-09-06 | 2021-06-11 | 艾尼纳制药公司 | 可用于治疗自身免疫性病症和炎性病症的化合物 |
| WO2024064726A1 (en) * | 2022-09-21 | 2024-03-28 | Bristol-Myers Squibb Company | Process for the preparation of tert-butyl (2-azabicyclo[2.2.1]heptan-4-yl)carbamate and related compounds |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE599916A (https=) * | 1960-02-05 | |||
| US3325360A (en) * | 1963-11-25 | 1967-06-13 | Carter Prod Inc | Pyrimidine-di-one pharmaceutical compositions having anti-inflammatory activity |
| US4464531A (en) * | 1981-04-20 | 1984-08-07 | Sumitomo Chemical Company, Limited | 4-Carbamoylimidazolium-5-olate derivatives |
| US5482971A (en) * | 1993-10-01 | 1996-01-09 | American Cyanamid Company | Beta3 -adrenergic agents and their use in pharmaceutical compositions |
| US5480908A (en) * | 1993-12-13 | 1996-01-02 | American Cyanamid Company | β3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions |
| US5488064A (en) * | 1994-05-02 | 1996-01-30 | Bristol-Myers Squibb Company | Benzo 1,3 dioxole derivatives |
| WO1996001260A1 (en) * | 1994-07-01 | 1996-01-18 | Dainippon Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivative, ester thereof, salt thereof, and intermediate for synthesis of these compounds |
| AU1619197A (en) * | 1996-02-07 | 1997-08-28 | Banyu Pharmaceutical Co., Ltd. | Cyclic amic acid derivatives |
| EP0801060A1 (en) * | 1996-04-09 | 1997-10-15 | Pfizer Inc. | Heterocyclic Beta-3 Adrenergenic Agonists |
| US5914339A (en) * | 1996-05-14 | 1999-06-22 | American Home Products Corporation | Substituted 1,3-benzodioxoles |
| JPH10245369A (ja) * | 1997-03-03 | 1998-09-14 | Ajinomoto Co Inc | セリン誘導体の製造方法 |
| US6124361A (en) * | 1997-12-31 | 2000-09-26 | Pfizer Inc | Bicyclo[3.1.0]hexanes and related compounds |
| WO1999061424A1 (en) * | 1998-05-26 | 1999-12-02 | Warner-Lambert Company | Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel |
| WO2000015604A1 (fr) * | 1998-09-11 | 2000-03-23 | Kyorin Pharmaceutical Co., Ltd. | Derives de diesters maloniques et leur procede d'obtention |
| JP4316787B2 (ja) * | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| ATE448193T1 (de) * | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß |
| US20050070506A1 (en) * | 2002-01-18 | 2005-03-31 | Doherty George A. | Selective s1p1/edg1 receptor agonists |
| KR20080103117A (ko) * | 2002-09-24 | 2008-11-26 | 노파르티스 아게 | 탈수초성 장애의 치료에 있어서의 스핑고신-1-포스페이트 수용체 아고니스트 |
| WO2004035538A1 (en) * | 2002-10-15 | 2004-04-29 | Merck & Co., Inc. | Process for making azetidine-3-carboxylic acid |
| JP4516430B2 (ja) * | 2002-12-20 | 2010-08-04 | メルク・シャープ・エンド・ドーム・コーポレイション | １−（アミノ）インダン並びに（１，２−ジヒドロ−３−アミノ）−ベンゾフラン、ベンゾチオフェン及びインドール |
| TW200505834A (en) * | 2003-03-18 | 2005-02-16 | Sankyo Co | Sulfamide derivative and the pharmaceutical composition thereof |
-
2004
- 2004-10-22 AT AT04292517T patent/ATE397582T1/de active
- 2004-10-22 DE DE602004014277T patent/DE602004014277D1/de not_active Expired - Lifetime
- 2004-10-22 EP EP04292517A patent/EP1650186B1/en not_active Expired - Lifetime
- 2004-10-22 SI SI200430828T patent/SI1650186T1/sl unknown
- 2004-10-22 DK DK04292517T patent/DK1650186T3/da active
- 2004-10-22 ES ES04292517T patent/ES2308127T3/es not_active Expired - Lifetime
- 2004-10-22 PT PT04292517T patent/PT1650186E/pt unknown
- 2004-10-22 PL PL04292517T patent/PL1650186T3/pl unknown
-
2005
- 2005-10-18 KR KR1020077011042A patent/KR20070097418A/ko not_active Ceased
- 2005-10-18 EA EA200700931A patent/EA200700931A1/ru unknown
- 2005-10-18 MX MX2007004847A patent/MX2007004847A/es active IP Right Grant
- 2005-10-18 JP JP2007537410A patent/JP2008517897A/ja active Pending
- 2005-10-18 AP AP2007004001A patent/AP2007004001A0/xx unknown
- 2005-10-18 US US11/577,792 patent/US20090264469A1/en not_active Abandoned
- 2005-10-18 BR BRPI0516988-7A patent/BRPI0516988A/pt not_active IP Right Cessation
- 2005-10-18 AU AU2005297138A patent/AU2005297138A1/en not_active Abandoned
- 2005-10-18 CN CNA2005800405350A patent/CN101107218A/zh active Pending
- 2005-10-18 WO PCT/IB2005/003113 patent/WO2006043149A2/en not_active Ceased
- 2005-10-18 CA CA002584610A patent/CA2584610A1/en not_active Abandoned
-
2007
- 2007-04-19 IL IL182678A patent/IL182678A0/en unknown
-
2008
- 2008-09-03 HR HR20080431T patent/HRP20080431T3/xx unknown
- 2008-09-04 CY CY20081100957T patent/CY1108321T1/el unknown
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