JP2008517878A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008517878A5 JP2008517878A5 JP2007535791A JP2007535791A JP2008517878A5 JP 2008517878 A5 JP2008517878 A5 JP 2008517878A5 JP 2007535791 A JP2007535791 A JP 2007535791A JP 2007535791 A JP2007535791 A JP 2007535791A JP 2008517878 A5 JP2008517878 A5 JP 2008517878A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension system
- gel particles
- working substance
- liquid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000725 suspension Substances 0.000 claims 65
- 239000007788 liquid Substances 0.000 claims 24
- 239000007863 gel particle Substances 0.000 claims 22
- 239000000126 substance Substances 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 9
- 239000000178 monomer Substances 0.000 claims 8
- 238000006116 polymerization reaction Methods 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- XFCMNSHQOZQILR-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOC(=O)C(C)=C XFCMNSHQOZQILR-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 210000002808 connective tissue Anatomy 0.000 claims 3
- 239000002537 cosmetic Substances 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 3
- 210000003205 muscle Anatomy 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- 150000003077 polyols Chemical class 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims 2
- LEJBBGNFPAFPKQ-UHFFFAOYSA-N 2-(2-prop-2-enoyloxyethoxy)ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOC(=O)C=C LEJBBGNFPAFPKQ-UHFFFAOYSA-N 0.000 claims 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 2
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 claims 2
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical group C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 claims 2
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- 230000003416 augmentation Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000008207 working material Substances 0.000 claims 2
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims 1
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims 1
- OLQFXOWPTQTLDP-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCO OLQFXOWPTQTLDP-UHFFFAOYSA-N 0.000 claims 1
- RWXMAAYKJDQVTF-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl prop-2-enoate Chemical compound OCCOCCOC(=O)C=C RWXMAAYKJDQVTF-UHFFFAOYSA-N 0.000 claims 1
- ZKLMKZINKNMVKA-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CC(O)COC(C)CO ZKLMKZINKNMVKA-UHFFFAOYSA-N 0.000 claims 1
- YATYDCQGPUOZGZ-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(O)COC(C)CO YATYDCQGPUOZGZ-UHFFFAOYSA-N 0.000 claims 1
- JJBFVQSGPLGDNX-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(C)COC(=O)C(C)=C JJBFVQSGPLGDNX-UHFFFAOYSA-N 0.000 claims 1
- IPDYIFGHKYLTOM-UHFFFAOYSA-N 2-(2-prop-2-enoyloxypropoxy)propyl prop-2-enoate Chemical compound C=CC(=O)OCC(C)OCC(C)OC(=O)C=C IPDYIFGHKYLTOM-UHFFFAOYSA-N 0.000 claims 1
- JFZBUNLOTDDXNY-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)propoxy]propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(C)OCC(C)OC(=O)C(C)=C JFZBUNLOTDDXNY-UHFFFAOYSA-N 0.000 claims 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims 1
- HXDLWJWIAHWIKI-UHFFFAOYSA-N 2-hydroxyethyl acetate Chemical compound CC(=O)OCCO HXDLWJWIAHWIKI-UHFFFAOYSA-N 0.000 claims 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 1
- GWZMWHWAWHPNHN-UHFFFAOYSA-N 2-hydroxypropyl prop-2-enoate Chemical compound CC(O)COC(=O)C=C GWZMWHWAWHPNHN-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- UXDDRFCJKNROTO-UHFFFAOYSA-N Glycerol 1,2-diacetate Chemical compound CC(=O)OCC(CO)OC(C)=O UXDDRFCJKNROTO-UHFFFAOYSA-N 0.000 claims 1
- 239000004348 Glyceryl diacetate Substances 0.000 claims 1
- 239000004347 Glyceryl monoacetate Substances 0.000 claims 1
- 229920000877 Melamine resin Polymers 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000005888 Periodontal Pocket Diseases 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- -1 allyl vinyl maleate Chemical compound 0.000 claims 1
- KGDPCYLOLUTZEO-UHFFFAOYSA-N bis(2-hydroxyethyl) 2-methylidenebutanedioate Chemical compound OCCOC(=O)CC(=C)C(=O)OCCO KGDPCYLOLUTZEO-UHFFFAOYSA-N 0.000 claims 1
- DWSNCSCTZIYPNV-UHFFFAOYSA-N bis(3-hydroxypropyl) oxalate Chemical compound OCCCOC(=O)C(=O)OCCCO DWSNCSCTZIYPNV-UHFFFAOYSA-N 0.000 claims 1
- VGSLORJPNYOXGN-SREVYHEPSA-N bis(ethenyl) (z)-2-methylbut-2-enedioate Chemical compound C=COC(=O)C(/C)=C\C(=O)OC=C VGSLORJPNYOXGN-SREVYHEPSA-N 0.000 claims 1
- BFHRUCFCIXWADD-UHFFFAOYSA-N bis(ethenyl) 2,3-dihydroxybutanedioate Chemical compound C=COC(=O)C(O)C(O)C(=O)OC=C BFHRUCFCIXWADD-UHFFFAOYSA-N 0.000 claims 1
- ZPOLOEWJWXZUSP-AATRIKPKSA-N bis(prop-2-enyl) (e)-but-2-enedioate Chemical compound C=CCOC(=O)\C=C\C(=O)OCC=C ZPOLOEWJWXZUSP-AATRIKPKSA-N 0.000 claims 1
- ZPOLOEWJWXZUSP-WAYWQWQTSA-N bis(prop-2-enyl) (z)-but-2-enedioate Chemical compound C=CCOC(=O)\C=C/C(=O)OCC=C ZPOLOEWJWXZUSP-WAYWQWQTSA-N 0.000 claims 1
- VPPSHXIFIAJKMX-UHFFFAOYSA-N bis(prop-2-enyl) 2,3-dihydroxybutanedioate Chemical compound C=CCOC(=O)C(O)C(O)C(=O)OCC=C VPPSHXIFIAJKMX-UHFFFAOYSA-N 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- PRXKHZGEIIFEBU-UHFFFAOYSA-N butane-1,4-diol;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CC(=C)C(O)=O.OCCCCO PRXKHZGEIIFEBU-UHFFFAOYSA-N 0.000 claims 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 229920006037 cross link polymer Polymers 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 210000004268 dentin Anatomy 0.000 claims 1
- 150000001991 dicarboxylic acids Chemical class 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 235000019443 glyceryl diacetate Nutrition 0.000 claims 1
- 235000019442 glyceryl monoacetate Nutrition 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- PYGSKMBEVAICCR-UHFFFAOYSA-N hexa-1,5-diene Chemical group C=CCCC=C PYGSKMBEVAICCR-UHFFFAOYSA-N 0.000 claims 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 claims 1
- OHMBHFSEKCCCBW-UHFFFAOYSA-N hexane-2,5-diol Chemical compound CC(O)CCC(C)O OHMBHFSEKCCCBW-UHFFFAOYSA-N 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 claims 1
- RIEABXYBQSLTFR-UHFFFAOYSA-N monobutyrin Chemical compound CCCC(=O)OCC(O)CO RIEABXYBQSLTFR-UHFFFAOYSA-N 0.000 claims 1
- 150000002763 monocarboxylic acids Chemical class 0.000 claims 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 claims 1
- DBSDMAPJGHBWAL-UHFFFAOYSA-N penta-1,4-dien-3-ylbenzene Chemical compound C=CC(C=C)C1=CC=CC=C1 DBSDMAPJGHBWAL-UHFFFAOYSA-N 0.000 claims 1
- 210000002379 periodontal ligament Anatomy 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 230000008467 tissue growth Effects 0.000 claims 1
- 150000003628 tricarboxylic acids Chemical class 0.000 claims 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 1
- XHDRYKHQTDSTRY-UHFFFAOYSA-N tris(2-hydroxyethyl) 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound OCCOC(=O)CC(O)(C(=O)OCCO)CC(=O)OCCO XHDRYKHQTDSTRY-UHFFFAOYSA-N 0.000 claims 1
- NZHHDFRSEQSGLN-ZRDIBKRKSA-N tris(prop-2-enyl) (e)-prop-1-ene-1,2,3-tricarboxylate Chemical compound C=CCOC(=O)C\C(C(=O)OCC=C)=C/C(=O)OCC=C NZHHDFRSEQSGLN-ZRDIBKRKSA-N 0.000 claims 1
- KJWHEZXBZQXVSA-UHFFFAOYSA-N tris(prop-2-enyl) phosphite Chemical compound C=CCOP(OCC=C)OCC=C KJWHEZXBZQXVSA-UHFFFAOYSA-N 0.000 claims 1
- 229960000834 vinyl ether Drugs 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/960,461 US7811605B2 (en) | 2002-11-06 | 2004-10-06 | Method of formation of shape-retentive aggregates of gel particles and their uses |
| PCT/US2005/035905 WO2006041967A1 (en) | 2004-10-06 | 2005-10-06 | Method of formation of the shape-retentive aggregates of gel particles and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517878A JP2008517878A (ja) | 2008-05-29 |
| JP2008517878A5 true JP2008517878A5 (cg-RX-API-DMAC7.html) | 2008-11-06 |
Family
ID=36148658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535791A Pending JP2008517878A (ja) | 2004-10-06 | 2005-10-06 | ゲル粒子の形状保持凝集塊の形成の方法とその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7811605B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1814522A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008517878A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20070083927A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101065109A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005294311B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0516095A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2583341A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL182410A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007004169A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ554458A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2395276C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006041967A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200703563B (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7811605B2 (en) * | 2002-11-06 | 2010-10-12 | Uluru Inc. | Method of formation of shape-retentive aggregates of gel particles and their uses |
| US7351430B2 (en) * | 2002-11-06 | 2008-04-01 | Uluru Inc. | Shape-retentive hydrogel particle aggregates and their uses |
| DE10300271A1 (de) * | 2003-01-08 | 2004-07-22 | Mnemoscience Gmbh | Photosensitive polymere Netzwerke |
| AU2006330627A1 (en) * | 2005-12-16 | 2007-07-05 | University Of Kansas | Nanoclusters for delivery of therapeutics |
| US8668676B2 (en) * | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
| US7504366B2 (en) * | 2006-08-16 | 2009-03-17 | Halliburton Energy Services, Inc. | Subterranean treatment fluids, friction reducing copolymers, and associated methods |
| US7910135B2 (en) * | 2006-10-13 | 2011-03-22 | Uluru Inc. | Hydrogel wound dressing and biomaterials formed in situ and their uses |
| JP2010512225A (ja) * | 2006-12-12 | 2010-04-22 | ボーシュ アンド ローム インコーポレイティド | 規則性ポリマーシステムおよび眼内レンズ |
| US20080228268A1 (en) * | 2007-03-15 | 2008-09-18 | Uluru, Inc. | Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis |
| US8747872B2 (en) * | 2007-05-02 | 2014-06-10 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| US20080287633A1 (en) * | 2007-05-18 | 2008-11-20 | Drumheller Paul D | Hydrogel Materials |
| US20110009520A1 (en) * | 2008-03-20 | 2011-01-13 | Figuly Garret D | Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same |
| EP2641567A1 (en) | 2008-06-30 | 2013-09-25 | Allergan, Inc. | Fillable prosthetic implant with gel-like properties |
| US8557288B2 (en) * | 2008-08-15 | 2013-10-15 | Washington University | Hydrogel microparticle formation in aqueous solvent for biomedical applications |
| CA2734252A1 (en) | 2008-08-20 | 2010-02-25 | Allergan, Inc. | Self-sealing shell for inflatable prostheses |
| US8636797B2 (en) | 2010-02-05 | 2014-01-28 | Allergan, Inc. | Inflatable prostheses and methods of making same |
| AU2011213037A1 (en) | 2010-02-05 | 2012-08-16 | Allergan, Inc. | Inflatable prostheses and methods of making same |
| WO2011119262A1 (en) | 2010-03-26 | 2011-09-29 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
| WO2012103182A1 (en) | 2011-01-28 | 2012-08-02 | Cerulean Pharma Inc. | Method for fabricating nanoparticles |
| KR101860485B1 (ko) * | 2011-11-03 | 2018-07-02 | (주)아모레퍼시픽 | 미세 유화 입자를 포함하는 미용 티슈, 그 제조방법 및 사용방법 |
| HK1206374A1 (en) * | 2012-03-14 | 2016-01-08 | 麦德医像公司 | Smart polymer materials with excess reactive molecules |
| WO2016140716A1 (en) | 2015-03-02 | 2016-09-09 | The Trustees Of Columbia University In The City Of New York | Injectable microtissue systems, devices, and methods |
| CA3112634A1 (en) | 2018-09-13 | 2020-03-19 | Allergan, Inc. | Tissue expansion device |
| USD896383S1 (en) | 2018-09-13 | 2020-09-15 | Allergan, Inc. | Tissue expansion device |
| CN113336536B (zh) * | 2021-05-31 | 2022-11-15 | 大连理工大学 | 一种无机非金属纳米颗粒组装的水凝胶材料及其在增材制造技术中的应用 |
| WO2025166277A1 (en) * | 2024-02-02 | 2025-08-07 | Slingshot Biosciences, Inc. | Synthetic cell mimics with modified surface charges |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3822089A (en) | 1968-09-25 | 1974-07-02 | Akademie Ved | Contact lens blank or replica made from anhydrous, sparingly cross-linked hydrophilic copolymers |
| CS153762B1 (cg-RX-API-DMAC7.html) | 1969-01-14 | 1974-03-29 | ||
| JPS492189B1 (cg-RX-API-DMAC7.html) | 1970-10-28 | 1974-01-18 | ||
| CS163469B1 (cg-RX-API-DMAC7.html) | 1972-05-22 | 1975-09-15 | ||
| US3948841A (en) | 1972-05-22 | 1976-04-06 | Karel Dusek | Process for producing transparent gels with improved mechanical and sorption properties from copolymers of 2-hydroxyethyl methacrylate and amides of acrylic or methacrylic acid |
| US3963685A (en) | 1974-05-13 | 1976-06-15 | Abrahams Robert A | Alcohol soluble hydrophilic polymer via aqueous polymerization |
| JPS5340038A (en) | 1976-09-27 | 1978-04-12 | Japan Exlan Co Ltd | Preparation of microhydrogel |
| US4272518A (en) | 1979-07-10 | 1981-06-09 | Moro Daniel G | Plastic wound bandage |
| DK171937B1 (da) | 1981-06-12 | 1997-08-18 | British Tech Group | Fremgangsmåde til fremstilling af partikelformige hydrogeler |
| JPS58331A (ja) | 1981-06-23 | 1983-01-05 | Nec Corp | プレス部品打抜き方法 |
| JPS5911602B2 (ja) | 1982-12-28 | 1984-03-16 | 東レ株式会社 | 診断用微粒子 |
| US5122544A (en) * | 1988-05-31 | 1992-06-16 | Nalco Chemical Company | Process for producing improved superabsorbent polymer aggregates from fines |
| US5840293A (en) | 1988-11-16 | 1998-11-24 | Advanced Polymer Systems, Inc. | Ionic beads for controlled release and adsorption |
| US4962133A (en) | 1989-09-05 | 1990-10-09 | Dow Corning Corporation | Method of making highly adsorptive copolymers |
| US5468811A (en) | 1989-11-02 | 1995-11-21 | National Patent Development Corporation | Hydrophilic composite polymer articles formed from a settable paste comprising a mixture of hydrophilic polymer and unsaturated monomer |
| US5045266A (en) | 1989-11-02 | 1991-09-03 | National Patent Development Corporation | Process of making a hearing aid earmold in situ |
| US5091443A (en) * | 1990-02-07 | 1992-02-25 | Becton, Dickinson And Company | Composition for gelling liquids |
| AU651654B2 (en) | 1992-01-14 | 1994-07-28 | Endo Pharmaceuticals Solutions Inc. | Manufacture of water-swellable hydrophilic articles and drug delivery devices |
| US5266325A (en) | 1990-09-28 | 1993-11-30 | Hydro Med Science Division Of National Patent Development Corp. | Preparation of homogeneous hydrogel copolymers |
| IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| JP2993801B2 (ja) | 1992-07-09 | 1999-12-27 | 株式会社日本触媒 | 粒子状含水ゲル状重合体および吸水性樹脂の製造方法 |
| JP2977907B2 (ja) | 1994-05-06 | 1999-11-15 | ファイザー・インコーポレーテッド | アジスロマイシンの放出調節された剤形 |
| US5840338A (en) | 1994-07-18 | 1998-11-24 | Roos; Eric J. | Loading of biologically active solutes into polymer gels |
| US5632774A (en) | 1995-01-17 | 1997-05-27 | Babian; Hamik | In-the-shell hydration to make implant filler material and prosthesis employing same |
| JP3156955B2 (ja) | 1995-07-12 | 2001-04-16 | 大日精化工業株式会社 | 連結されたミクロゲル粒子の製造方法及びそれで処理された物品 |
| AU676971B1 (en) | 1995-08-24 | 1997-03-27 | Dainichiseika Color & Chemicals Mfg. Co. Ltd. | Production process of connected microgel particles and articles treated with connected microgel particles |
| DE19601764A1 (de) | 1996-01-19 | 1997-07-24 | Hoechst Ag | Verfahren zur Herstellung hydrophiler, hochquellfähiger Hydrogele |
| AU7178698A (en) | 1996-11-15 | 1998-06-03 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
| EP1015042A1 (en) | 1997-09-19 | 2000-07-05 | Reprogenesis, Inc | Improved hydrogel for tissue engineering |
| US5945457A (en) | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
| US6521431B1 (en) | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
| JP2002284882A (ja) | 2001-03-27 | 2002-10-03 | Mitsubishi Chemicals Corp | 高吸水性ポリマーの製造方法 |
| JP4883844B2 (ja) | 2001-04-05 | 2012-02-22 | 住友精化株式会社 | カルボキシル基含有重合体粒子 |
| JP4490095B2 (ja) * | 2001-06-29 | 2010-06-23 | メドグラフト マイクロテック インコーポレイテッド | 生体分解性の注入可能な移植物およびそれに関連する製造方法ならびに使用方法 |
| WO2003022910A1 (en) | 2001-09-08 | 2003-03-20 | Access Pharmaceuticals, Inc. | Synthesis and uses of polymer gel nanoparticle networks |
| IL145576A0 (en) | 2001-09-24 | 2002-06-30 | A prosthesis for physical implant | |
| JP2003261777A (ja) | 2002-03-07 | 2003-09-19 | Japan Science & Technology Corp | 高圧により形成される分子複合体 |
| US7811605B2 (en) | 2002-11-06 | 2010-10-12 | Uluru Inc. | Method of formation of shape-retentive aggregates of gel particles and their uses |
| US7351430B2 (en) | 2002-11-06 | 2008-04-01 | Uluru Inc. | Shape-retentive hydrogel particle aggregates and their uses |
| CN1522690A (zh) | 2003-02-12 | 2004-08-25 | 罗姆和哈斯公司 | 消费产品中的聚合物纳米微粒 |
-
2004
- 2004-10-06 US US10/960,461 patent/US7811605B2/en active Active
-
2005
- 2005-10-06 CN CNA2005800402244A patent/CN101065109A/zh active Pending
- 2005-10-06 JP JP2007535791A patent/JP2008517878A/ja active Pending
- 2005-10-06 ZA ZA200703563A patent/ZA200703563B/xx unknown
- 2005-10-06 CA CA002583341A patent/CA2583341A1/en not_active Abandoned
- 2005-10-06 BR BRPI0516095-2A patent/BRPI0516095A/pt not_active IP Right Cessation
- 2005-10-06 NZ NZ554458A patent/NZ554458A/en not_active IP Right Cessation
- 2005-10-06 MX MX2007004169A patent/MX2007004169A/es unknown
- 2005-10-06 RU RU2007116975/15A patent/RU2395276C2/ru not_active IP Right Cessation
- 2005-10-06 WO PCT/US2005/035905 patent/WO2006041967A1/en not_active Ceased
- 2005-10-06 EP EP05804247A patent/EP1814522A4/en not_active Withdrawn
- 2005-10-06 KR KR1020077010042A patent/KR20070083927A/ko not_active Ceased
- 2005-10-06 AU AU2005294311A patent/AU2005294311B2/en not_active Ceased
-
2007
- 2007-04-10 IL IL182410A patent/IL182410A0/en unknown
- 2007-10-30 US US11/929,531 patent/US20080063716A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008517878A5 (cg-RX-API-DMAC7.html) | ||
| JP2006514705A5 (cg-RX-API-DMAC7.html) | ||
| Kasiński et al. | Smart hydrogels–synthetic stimuli-responsive antitumor drug release systems | |
| US7351430B2 (en) | Shape-retentive hydrogel particle aggregates and their uses | |
| Kempe et al. | In situ forming implants—an attractive formulation principle for parenteral depot formulations | |
| US20080063716A1 (en) | Method of formation of shape-retentive aggregates of gel particles and their uses | |
| Ke et al. | Length effect of stimuli-responsive block copolymer prodrug filomicelles on drug delivery efficiency | |
| TW200902097A (en) | Method of formation of viscous, shape conforming gels and their uses as medical prosthesis | |
| Abou-ElNour et al. | Microparticles-in-thermoresponsive/bioadhesive hydrogels as a novel integrated platform for effective intra-articular delivery of triamcinolone acetonide | |
| JP5898828B2 (ja) | 温度敏感性ナノ運搬体 | |
| CN114080226B (zh) | 眼用组合物 | |
| CN1921888A (zh) | 盐酸坦舒洛新的口服组合物和包含该组合物的控释颗粒制剂 | |
| JP6944263B2 (ja) | シクロデキストリン誘導体修飾ハイドロゲル | |
| JP3898783B2 (ja) | 生体内分解性ヒアルロン酸架橋ゲル組成物及び生体内分解性ヒアルロン酸架橋ゲル製剤 | |
| CN114099705B (zh) | 一种基于肼屈嗪改善肿瘤微环境的纳米药物及其制备和应用 | |
| CN111450079B (zh) | 空心载药纳米胶囊及其制备方法和应用 | |
| JP5991880B2 (ja) | 粉液型歯科用接着材およびこれを用いた歯科用接着キット | |
| R Saboktakin et al. | Intelligent drug delivery systems based on modified chitosan nanoparticles | |
| JPH11246416A (ja) | 点鼻用添加剤及び点鼻薬 | |
| JP2007302566A (ja) | 皮脂吸着剤及びこれを配合した皮膚外用剤 | |
| Mojaveryazdi et al. | Modified acrylamide hydrogel nanocomposites for vaginal drug delivery system | |
| JP2010030978A (ja) | 多糖類微粒子状ゲル含有水分散体およびその製造方法ならびに多糖類微粒子状ゲル含有保湿剤と多糖類微粒子状ゲル含有眼科用組成物 |