JP2008517016A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008517016A5 JP2008517016A5 JP2007537183A JP2007537183A JP2008517016A5 JP 2008517016 A5 JP2008517016 A5 JP 2008517016A5 JP 2007537183 A JP2007537183 A JP 2007537183A JP 2007537183 A JP2007537183 A JP 2007537183A JP 2008517016 A5 JP2008517016 A5 JP 2008517016A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cysteine
- amino acid
- solid phase
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 238000000034 method Methods 0.000 claims 10
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 9
- 235000018417 cysteine Nutrition 0.000 claims 9
- 239000007790 solid phase Substances 0.000 claims 9
- -1 butyl-sulfenyl group Chemical group 0.000 claims 6
- 239000011347 resin Substances 0.000 claims 6
- 229920005989 resin Polymers 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 4
- 150000001408 amides Chemical group 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000002148 esters Chemical group 0.000 claims 2
- 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000006664 bond formation reaction Methods 0.000 claims 1
- 125000006244 carboxylic acid protecting group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000003949 imides Chemical class 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 238000010647 peptide synthesis reaction Methods 0.000 claims 1
- 239000003880 polar aprotic solvent Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04024813.0 | 2004-10-19 | ||
| EP04024813 | 2004-10-19 | ||
| EP05008979 | 2005-04-25 | ||
| EP05008979.6 | 2005-04-25 | ||
| PCT/EP2005/011182 WO2006045483A2 (en) | 2004-10-19 | 2005-10-18 | On-resin peptide cyclization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008517016A JP2008517016A (ja) | 2008-05-22 |
| JP2008517016A5 true JP2008517016A5 (enExample) | 2008-09-18 |
| JP4927746B2 JP4927746B2 (ja) | 2012-05-09 |
Family
ID=36096370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537183A Expired - Fee Related JP4927746B2 (ja) | 2004-10-19 | 2005-10-18 | 樹脂上ペプチド環化 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7994280B2 (enExample) |
| EP (1) | EP1805203B1 (enExample) |
| JP (1) | JP4927746B2 (enExample) |
| KR (2) | KR101222774B1 (enExample) |
| CN (1) | CN101111510B (enExample) |
| AT (1) | ATE455123T1 (enExample) |
| AU (1) | AU2005298991B2 (enExample) |
| BR (1) | BRPI0516929A (enExample) |
| CA (1) | CA2588098A1 (enExample) |
| DE (1) | DE602005018952D1 (enExample) |
| DK (1) | DK1805203T3 (enExample) |
| ES (1) | ES2339791T3 (enExample) |
| IL (1) | IL182575A (enExample) |
| PT (1) | PT1805203E (enExample) |
| TW (1) | TW200628487A (enExample) |
| WO (1) | WO2006045483A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101538316B (zh) * | 2009-01-13 | 2012-09-05 | 深圳翰宇药业股份有限公司 | 一种固相法制备Eptifibatide的方法 |
| WO2013112548A1 (en) * | 2012-01-23 | 2013-08-01 | University Of South Florida | Gamma-aapeptides with potent and broad-spectrum antimicrobial activity |
| CN108218964A (zh) * | 2018-01-30 | 2018-06-29 | 江南大学 | 一种固相载体上酶法合成环肽方法 |
| WO2024234959A1 (en) * | 2023-05-18 | 2024-11-21 | Versitech Limited | Late-stage peptide cyclization to form disulfide mimetics |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4606856A (en) * | 1985-03-18 | 1986-08-19 | Seyler Jay K | [Des-1-amino, 8-glycine]calcitonin |
| US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
| WO2003093302A2 (en) * | 2002-05-03 | 2003-11-13 | Avecia Limited | Process for the synthesis of peptides amides by side-chain attachement to a solid phase |
| CN1222537C (zh) * | 2002-11-14 | 2005-10-12 | 吉尔生化（上海）有限公司 | 一种制备依非巴特的工艺 |
| WO2004092202A1 (en) | 2003-04-07 | 2004-10-28 | Novetide, Ltd. | Process for production of cyclic peptides |
| EP1756141B1 (en) | 2004-06-14 | 2009-12-09 | USV Ltd. | Process for the preparation of peptides |
| CN100500805C (zh) * | 2006-11-07 | 2009-06-17 | 武汉钢铁集团鄂城钢铁有限责任公司 | 除尘焦粉回配煤炼焦方法及其工艺 |
-
2005
- 2005-10-18 BR BRPI0516929-1A patent/BRPI0516929A/pt not_active IP Right Cessation
- 2005-10-18 KR KR1020077010506A patent/KR101222774B1/ko not_active Expired - Fee Related
- 2005-10-18 PT PT05796237T patent/PT1805203E/pt unknown
- 2005-10-18 CN CN2005800435892A patent/CN101111510B/zh not_active Expired - Fee Related
- 2005-10-18 ES ES05796237T patent/ES2339791T3/es not_active Expired - Lifetime
- 2005-10-18 US US11/665,537 patent/US7994280B2/en not_active Expired - Fee Related
- 2005-10-18 AT AT05796237T patent/ATE455123T1/de not_active IP Right Cessation
- 2005-10-18 AU AU2005298991A patent/AU2005298991B2/en not_active Ceased
- 2005-10-18 DE DE602005018952T patent/DE602005018952D1/de not_active Expired - Lifetime
- 2005-10-18 EP EP05796237A patent/EP1805203B1/en not_active Expired - Lifetime
- 2005-10-18 JP JP2007537183A patent/JP4927746B2/ja not_active Expired - Fee Related
- 2005-10-18 CA CA002588098A patent/CA2588098A1/en not_active Abandoned
- 2005-10-18 TW TW094136279A patent/TW200628487A/zh unknown
- 2005-10-18 KR KR1020127016164A patent/KR101276463B1/ko not_active Expired - Fee Related
- 2005-10-18 WO PCT/EP2005/011182 patent/WO2006045483A2/en not_active Ceased
- 2005-10-18 DK DK05796237.5T patent/DK1805203T3/da active
-
2007
- 2007-04-16 IL IL182575A patent/IL182575A/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20050267017A1 (en) | Conformationally constrained C-backbone cyclic peptides | |
| JP6011528B2 (ja) | ペプチドの製造方法 | |
| JP7641895B2 (ja) | 液相ペプチド合成のための方法およびその保護戦略 | |
| CA2382931A1 (en) | Synthesis of template-fixed .beta.-hairpin loop mimetics | |
| JPWO2016047794A1 (ja) | 疎水性ペプチドの製造法 | |
| JP2009504885A (ja) | コポリマー−１の製造方法 | |
| JP2008517016A5 (enExample) | ||
| US20040063902A1 (en) | Side chain anchored thioester and selenoester generators | |
| CN1300168C (zh) | 一种新的用于肽和小分子有机合成的基于连接剂的固体载体 | |
| JP5119159B2 (ja) | ペプチドチオエステルの製造方法 | |
| JPH04502908A (ja) | アミノ酸のトリアルキルシリルエステルおよびペプチド合成におけるその使用 | |
| US8404804B2 (en) | Methods and intermediates for chemical synthesis of polypeptides and proteins | |
| CN1832962A (zh) | 促生长素抑制素肽的制备 | |
| JP5399238B2 (ja) | 新規な担持された酸化反応物、それらの製造方法、およびその使用 | |
| CN117957021A (zh) | 用于制备聚乙二醇化肾上腺髓质素的方法、它的中间体及其用途 | |
| JP4927746B2 (ja) | 樹脂上ペプチド環化 | |
| WO2021132336A1 (ja) | ペプチドの製造方法 | |
| CN1452632A (zh) | 扩展的天然化学连接 | |
| US8034900B2 (en) | Water-soluble thioester and selenoester compounds and methods for making and using the same | |
| KR101890979B1 (ko) | 알카인을 이용한 아마이드 화합물의 제조방법 및 이를 이용한 펩타이드 제조 방법 | |
| CN1589257A (zh) | N－甲基－高半胱氨酸及其应用以及制备方法 | |
| JP6275150B2 (ja) | 二置換アミノ酸残基を含むジペプチド誘導体の製造方法 | |
| JP4016104B2 (ja) | 新規セレニルリンカー及びその用途 | |
| JP2010538063A (ja) | ポリペプチドおよび蛋白質の化学的合成のための方法および中間体 | |
| JP2024510477A (ja) | 環状化合物ライブラリおよびその構築方法 |