JP4927746B2 - 樹脂上ペプチド環化 - Google Patents

樹脂上ペプチド環化 Download PDF

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Publication number
JP4927746B2
JP4927746B2 JP2007537183A JP2007537183A JP4927746B2 JP 4927746 B2 JP4927746 B2 JP 4927746B2 JP 2007537183 A JP2007537183 A JP 2007537183A JP 2007537183 A JP2007537183 A JP 2007537183A JP 4927746 B2 JP4927746 B2 JP 4927746B2
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JP
Japan
Prior art keywords
peptide
bond
cysteine
resin
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2007537183A
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English (en)
Japanese (ja)
Other versions
JP2008517016A5 (enExample
JP2008517016A (ja
Inventor
バライ、ステファネ
ベルビッツキイ、オレグ
ツアイター、トーマス
Original Assignee
ロンザ アーゲー
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Application filed by ロンザ アーゲー filed Critical ロンザ アーゲー
Publication of JP2008517016A publication Critical patent/JP2008517016A/ja
Publication of JP2008517016A5 publication Critical patent/JP2008517016A5/ja
Application granted granted Critical
Publication of JP4927746B2 publication Critical patent/JP4927746B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007537183A 2004-10-19 2005-10-18 樹脂上ペプチド環化 Expired - Fee Related JP4927746B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04024813.0 2004-10-19
EP04024813 2004-10-19
EP05008979 2005-04-25
EP05008979.6 2005-04-25
PCT/EP2005/011182 WO2006045483A2 (en) 2004-10-19 2005-10-18 On-resin peptide cyclization

Publications (3)

Publication Number Publication Date
JP2008517016A JP2008517016A (ja) 2008-05-22
JP2008517016A5 JP2008517016A5 (enExample) 2008-09-18
JP4927746B2 true JP4927746B2 (ja) 2012-05-09

Family

ID=36096370

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007537183A Expired - Fee Related JP4927746B2 (ja) 2004-10-19 2005-10-18 樹脂上ペプチド環化

Country Status (16)

Country Link
US (1) US7994280B2 (enExample)
EP (1) EP1805203B1 (enExample)
JP (1) JP4927746B2 (enExample)
KR (2) KR101222774B1 (enExample)
CN (1) CN101111510B (enExample)
AT (1) ATE455123T1 (enExample)
AU (1) AU2005298991B2 (enExample)
BR (1) BRPI0516929A (enExample)
CA (1) CA2588098A1 (enExample)
DE (1) DE602005018952D1 (enExample)
DK (1) DK1805203T3 (enExample)
ES (1) ES2339791T3 (enExample)
IL (1) IL182575A (enExample)
PT (1) PT1805203E (enExample)
TW (1) TW200628487A (enExample)
WO (1) WO2006045483A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101538316B (zh) * 2009-01-13 2012-09-05 深圳翰宇药业股份有限公司 一种固相法制备Eptifibatide的方法
WO2013112548A1 (en) * 2012-01-23 2013-08-01 University Of South Florida Gamma-aapeptides with potent and broad-spectrum antimicrobial activity
CN108218964A (zh) * 2018-01-30 2018-06-29 江南大学 一种固相载体上酶法合成环肽方法
WO2024234959A1 (en) * 2023-05-18 2024-11-21 Versitech Limited Late-stage peptide cyclization to form disulfide mimetics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093302A2 (en) * 2002-05-03 2003-11-13 Avecia Limited Process for the synthesis of peptides amides by side-chain attachement to a solid phase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4606856A (en) * 1985-03-18 1986-08-19 Seyler Jay K [Des-1-amino, 8-glycine]calcitonin
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
CN1222537C (zh) * 2002-11-14 2005-10-12 吉尔生化（上海）有限公司 一种制备依非巴特的工艺
WO2004092202A1 (en) 2003-04-07 2004-10-28 Novetide, Ltd. Process for production of cyclic peptides
EP1756141B1 (en) 2004-06-14 2009-12-09 USV Ltd. Process for the preparation of peptides
CN100500805C (zh) * 2006-11-07 2009-06-17 武汉钢铁集团鄂城钢铁有限责任公司 除尘焦粉回配煤炼焦方法及其工艺

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093302A2 (en) * 2002-05-03 2003-11-13 Avecia Limited Process for the synthesis of peptides amides by side-chain attachement to a solid phase

Also Published As

Publication number Publication date
WO2006045483A3 (en) 2006-07-13
DK1805203T3 (da) 2010-05-17
IL182575A0 (en) 2007-07-24
KR20070084099A (ko) 2007-08-24
WO2006045483A2 (en) 2006-05-04
AU2005298991B2 (en) 2011-03-03
PT1805203E (pt) 2010-04-19
BRPI0516929A (pt) 2008-09-23
TW200628487A (en) 2006-08-16
US20080200647A1 (en) 2008-08-21
US7994280B2 (en) 2011-08-09
AU2005298991A1 (en) 2006-05-04
KR101222774B1 (ko) 2013-01-15
EP1805203A2 (en) 2007-07-11
ATE455123T1 (de) 2010-01-15
CN101111510A (zh) 2008-01-23
CA2588098A1 (en) 2006-05-04
KR101276463B1 (ko) 2013-06-19
DE602005018952D1 (de) 2010-03-04
KR20120088855A (ko) 2012-08-08
JP2008517016A (ja) 2008-05-22
ES2339791T3 (es) 2010-05-25
EP1805203B1 (en) 2010-01-13
CN101111510B (zh) 2011-09-14
IL182575A (en) 2012-07-31

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