CN101111510B - 树脂上肽环化 - Google Patents

树脂上肽环化 Download PDF

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Publication number
CN101111510B
CN101111510B CN2005800435892A CN200580043589A CN101111510B CN 101111510 B CN101111510 B CN 101111510B CN 2005800435892 A CN2005800435892 A CN 2005800435892A CN 200580043589 A CN200580043589 A CN 200580043589A CN 101111510 B CN101111510 B CN 101111510B
Authority
CN
China
Prior art keywords
peptide
solid phase
cysteine
resin
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800435892A
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English (en)
Chinese (zh)
Other versions
CN101111510A (zh
Inventor
S·瓦雷
O·韦尔比茨基
T·赛特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polypeptide Laboratory Ppl Holding Co
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of CN101111510A publication Critical patent/CN101111510A/zh
Application granted granted Critical
Publication of CN101111510B publication Critical patent/CN101111510B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2005800435892A 2004-10-19 2005-10-18 树脂上肽环化 Expired - Fee Related CN101111510B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04024813.0 2004-10-19
EP04024813 2004-10-19
EP05008979 2005-04-25
EP05008979.6 2005-04-25
PCT/EP2005/011182 WO2006045483A2 (en) 2004-10-19 2005-10-18 On-resin peptide cyclization

Publications (2)

Publication Number Publication Date
CN101111510A CN101111510A (zh) 2008-01-23
CN101111510B true CN101111510B (zh) 2011-09-14

Family

ID=36096370

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800435892A Expired - Fee Related CN101111510B (zh) 2004-10-19 2005-10-18 树脂上肽环化

Country Status (16)

Country Link
US (1) US7994280B2 (enExample)
EP (1) EP1805203B1 (enExample)
JP (1) JP4927746B2 (enExample)
KR (2) KR101222774B1 (enExample)
CN (1) CN101111510B (enExample)
AT (1) ATE455123T1 (enExample)
AU (1) AU2005298991B2 (enExample)
BR (1) BRPI0516929A (enExample)
CA (1) CA2588098A1 (enExample)
DE (1) DE602005018952D1 (enExample)
DK (1) DK1805203T3 (enExample)
ES (1) ES2339791T3 (enExample)
IL (1) IL182575A (enExample)
PT (1) PT1805203E (enExample)
TW (1) TW200628487A (enExample)
WO (1) WO2006045483A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101538316B (zh) * 2009-01-13 2012-09-05 深圳翰宇药业股份有限公司 一种固相法制备Eptifibatide的方法
WO2013112548A1 (en) * 2012-01-23 2013-08-01 University Of South Florida Gamma-aapeptides with potent and broad-spectrum antimicrobial activity
CN108218964A (zh) * 2018-01-30 2018-06-29 江南大学 一种固相载体上酶法合成环肽方法
WO2024234959A1 (en) * 2023-05-18 2024-11-21 Versitech Limited Late-stage peptide cyclization to form disulfide mimetics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1500805A (zh) * 2002-11-14 2004-06-02 吉尔生化（上海）有限公司 一种制备依非巴特的新工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4606856A (en) * 1985-03-18 1986-08-19 Seyler Jay K [Des-1-amino, 8-glycine]calcitonin
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
WO2003093302A2 (en) * 2002-05-03 2003-11-13 Avecia Limited Process for the synthesis of peptides amides by side-chain attachement to a solid phase
WO2004092202A1 (en) 2003-04-07 2004-10-28 Novetide, Ltd. Process for production of cyclic peptides
EP1756141B1 (en) 2004-06-14 2009-12-09 USV Ltd. Process for the preparation of peptides
CN100500805C (zh) * 2006-11-07 2009-06-17 武汉钢铁集团鄂城钢铁有限责任公司 除尘焦粉回配煤炼焦方法及其工艺

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1500805A (zh) * 2002-11-14 2004-06-02 吉尔生化（上海）有限公司 一种制备依非巴特的新工艺

Also Published As

Publication number Publication date
WO2006045483A3 (en) 2006-07-13
DK1805203T3 (da) 2010-05-17
IL182575A0 (en) 2007-07-24
KR20070084099A (ko) 2007-08-24
WO2006045483A2 (en) 2006-05-04
AU2005298991B2 (en) 2011-03-03
PT1805203E (pt) 2010-04-19
JP4927746B2 (ja) 2012-05-09
BRPI0516929A (pt) 2008-09-23
TW200628487A (en) 2006-08-16
US20080200647A1 (en) 2008-08-21
US7994280B2 (en) 2011-08-09
AU2005298991A1 (en) 2006-05-04
KR101222774B1 (ko) 2013-01-15
EP1805203A2 (en) 2007-07-11
ATE455123T1 (de) 2010-01-15
CN101111510A (zh) 2008-01-23
CA2588098A1 (en) 2006-05-04
KR101276463B1 (ko) 2013-06-19
DE602005018952D1 (de) 2010-03-04
KR20120088855A (ko) 2012-08-08
JP2008517016A (ja) 2008-05-22
ES2339791T3 (es) 2010-05-25
EP1805203B1 (en) 2010-01-13
IL182575A (en) 2012-07-31

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Granted publication date: 20110914