JP2008515890A5 - - Google Patents
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- JP2008515890A5 JP2008515890A5 JP2007535709A JP2007535709A JP2008515890A5 JP 2008515890 A5 JP2008515890 A5 JP 2008515890A5 JP 2007535709 A JP2007535709 A JP 2007535709A JP 2007535709 A JP2007535709 A JP 2007535709A JP 2008515890 A5 JP2008515890 A5 JP 2008515890A5
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- Prior art keywords
- antibody
- medicament according
- exposure
- medicament
- approximately
- Prior art date
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- 239000003814 drug Substances 0.000 claims 123
- 239000003795 chemical substances by application Substances 0.000 claims 23
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 20
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 20
- 150000003431 steroids Chemical group 0.000 claims 19
- 239000003018 immunosuppressive agent Substances 0.000 claims 16
- 206010047115 Vasculitis Diseases 0.000 claims 13
- 229940125721 immunosuppressive agent Drugs 0.000 claims 13
- 229940127089 cytotoxic agent Drugs 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 7
- 230000001086 cytosolic effect Effects 0.000 claims 6
- 239000002254 cytotoxic agent Substances 0.000 claims 6
- 231100000599 cytotoxic agent Toxicity 0.000 claims 6
- 102220517543 Calcium uniporter protein, mitochondrial_S92A_mutation Human genes 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical group ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 4
- 229940123038 Integrin antagonist Drugs 0.000 claims 4
- 102220556084 Myeloid cell surface antigen CD33_N100A_mutation Human genes 0.000 claims 4
- 102220475559 Radial spoke head 1 homolog_D56A_mutation Human genes 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 4
- 229960004397 cyclophosphamide Drugs 0.000 claims 4
- 239000000430 cytokine receptor antagonist Substances 0.000 claims 4
- 229940088597 hormone Drugs 0.000 claims 4
- 239000005556 hormone Substances 0.000 claims 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 4
- 102220241870 rs761659830 Human genes 0.000 claims 4
- 229960003444 immunosuppressant agent Drugs 0.000 claims 3
- 230000001861 immunosuppressant effect Effects 0.000 claims 3
- -1 integrin antagonist Substances 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 2
- 208000002267 Anti-neutrophil cytoplasmic antibody-associated vasculitis Diseases 0.000 claims 2
- 206010018691 Granuloma Diseases 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 claims 2
- 230000002482 anti-endothelial effect Effects 0.000 claims 2
- 230000003460 anti-nuclear Effects 0.000 claims 2
- 230000003356 anti-rheumatic effect Effects 0.000 claims 2
- 239000003435 antirheumatic agent Substances 0.000 claims 2
- 229960002170 azathioprine Drugs 0.000 claims 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 229960004630 chlorambucil Drugs 0.000 claims 2
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229940109239 creatinine Drugs 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims 2
- 229960000890 hydrocortisone Drugs 0.000 claims 2
- 229960000681 leflunomide Drugs 0.000 claims 2
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 229960004584 methylprednisolone Drugs 0.000 claims 2
- 206010063344 microscopic polyangiitis Diseases 0.000 claims 2
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 2
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 2
- 229960005205 prednisolone Drugs 0.000 claims 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 2
- 229960004618 prednisone Drugs 0.000 claims 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 2
- 229960004641 rituximab Drugs 0.000 claims 2
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61610404P | 2004-10-05 | 2004-10-05 | |
| PCT/US2005/034647 WO2006041680A2 (en) | 2004-10-05 | 2005-09-28 | Method for treating vasculitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008515890A JP2008515890A (ja) | 2008-05-15 |
| JP2008515890A5 true JP2008515890A5 (enExample) | 2008-11-06 |
Family
ID=36148785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535709A Pending JP2008515890A (ja) | 2004-10-05 | 2005-09-28 | 血管炎の治療方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20060110387A1 (enExample) |
| EP (1) | EP1812060A2 (enExample) |
| JP (1) | JP2008515890A (enExample) |
| KR (1) | KR20070100228A (enExample) |
| CN (1) | CN101087807A (enExample) |
| AR (1) | AR052219A1 (enExample) |
| AU (1) | AU2005294666A1 (enExample) |
| BR (1) | BRPI0516297A (enExample) |
| CA (1) | CA2580271A1 (enExample) |
| GT (1) | GT200500276A (enExample) |
| IL (1) | IL181922A0 (enExample) |
| NO (1) | NO20072312L (enExample) |
| PA (1) | PA8647601A1 (enExample) |
| PE (1) | PE20060934A1 (enExample) |
| RU (1) | RU2411956C2 (enExample) |
| SG (1) | SG165344A1 (enExample) |
| SV (1) | SV2006002256A (enExample) |
| TW (1) | TW200628169A (enExample) |
| WO (1) | WO2006041680A2 (enExample) |
| ZA (2) | ZA200702335B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20020027311A (ko) * | 1999-05-07 | 2002-04-13 | 제넨테크, 인크. | Ｂ 세포 표면 마커에 결합하는 길항물질을 이용한자가면역 질환의 치료 |
| JP2004508420A (ja) * | 2000-09-18 | 2004-03-18 | アイデック ファーマスーティカルズ コーポレイション | Ｂ細胞枯渇抗体／免疫調節性抗体の組合せを用いて自己免疫疾患を治療するための併用療法 |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| BRPI0416262B1 (pt) | 2003-11-05 | 2022-04-12 | Roche Glycart Ag | Anticorpo anti-cd20 humano tipo ii humanizado, seu método de produção, seus usos, bem como polinucleotídeo isolado, vetor de expressão e composição farmacêutica |
| SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
| EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| AU2008282152B2 (en) * | 2007-07-31 | 2013-12-19 | Regeneron Pharmaceuticals, Inc. | Human antibodies to human CD20 and method of using thereof |
| SG189772A1 (en) | 2008-04-11 | 2013-05-31 | Trubion Pharmaceuticals Inc | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| WO2010021385A1 (ja) | 2008-08-22 | 2010-02-25 | 持田製薬株式会社 | Ａｎｃａ関連血管炎治療薬 |
| TW201014605A (en) | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| MX2012002766A (es) | 2009-09-03 | 2012-04-02 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| WO2011100403A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof |
| CA2802853C (en) | 2010-06-16 | 2016-07-26 | Bruce Chandler May | Use of levocetirizine and montelukast in the treatment of influenza, common cold and inflammation |
| CA2827859A1 (en) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Biological markers and methods for predicting response to b-cell antagonists |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| WO2014164299A1 (en) | 2013-03-13 | 2014-10-09 | Inflammatory Response Research, Inc. | Use of levocetirizine and montelukast in the treatment of autoimmune disorders |
| CN105263579B (zh) | 2013-03-13 | 2020-01-10 | 炎症反应研究公司 | 左西替利嗪和孟鲁司特在治疗血管炎中的用途 |
| EP3308835B1 (en) | 2013-03-13 | 2020-01-01 | Inflammatory Response Research, Inc. | Use of levocetirizine and montelukast in the treatment of traumatic injury |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| CA2947508A1 (en) * | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| JP2017526728A (ja) | 2014-09-15 | 2017-09-14 | インフラマトリー・レスポンス・リサーチ・インコーポレイテッド | 炎症介在性状態の治療におけるレボセチリジン及びモンテルカスト |
| EP3699198B1 (en) | 2014-11-17 | 2025-03-26 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
| CN105688208A (zh) * | 2016-03-04 | 2016-06-22 | 刘文霞 | 一种用于治疗视网膜血管炎的复方颗粒及其制备方法 |
| WO2018071524A1 (en) * | 2016-10-11 | 2018-04-19 | The University Of North Carolina At Chapel Hill | Gene-specific dna methylation changes predict relapse/remission in anca-associated vasculitis patients |
| CA3089240A1 (en) * | 2018-02-07 | 2019-08-15 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating anca associated vasculitides |
| EP4545145A3 (en) * | 2018-02-23 | 2025-07-02 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
| US11819520B2 (en) | 2018-02-23 | 2023-11-21 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
| US12364715B2 (en) | 2018-02-23 | 2025-07-22 | Enzyvant Therapeutics Gmbh | Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use |
| DK3844189T3 (da) | 2018-08-31 | 2025-02-24 | Regeneron Pharma | Doseringsstrategi, der mindsker cytokinfrigivelsessyndrom for CD3/CD20-bispecifikke antistoffer |
| EP3669888B1 (en) | 2018-12-20 | 2025-09-24 | Gambro Lundia AB | Extracorporeal devices for methods for treating diseases associated with anti-neutrophil cytoplasmic antibodies |
| WO2025007943A1 (zh) * | 2023-07-06 | 2025-01-09 | 荣昌生物制药(烟台)股份有限公司 | 用taci-fc融合蛋白治疗anca相关性血管炎的方法 |
| CN119322175A (zh) * | 2024-10-18 | 2025-01-17 | 武汉塞力斯生物技术有限公司 | 一种血管炎抗体联检试剂盒 |
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-
2005
- 2005-09-28 CA CA002580271A patent/CA2580271A1/en not_active Abandoned
- 2005-09-28 ZA ZA200702335A patent/ZA200702335B/xx unknown
- 2005-09-28 EP EP05810224A patent/EP1812060A2/en not_active Withdrawn
- 2005-09-28 CN CNA2005800417165A patent/CN101087807A/zh active Pending
- 2005-09-28 US US11/238,281 patent/US20060110387A1/en not_active Abandoned
- 2005-09-28 SG SG201006432-7A patent/SG165344A1/en unknown
- 2005-09-28 KR KR1020077007778A patent/KR20070100228A/ko not_active Ceased
- 2005-09-28 RU RU2007116980/15A patent/RU2411956C2/ru not_active IP Right Cessation
- 2005-09-28 WO PCT/US2005/034647 patent/WO2006041680A2/en not_active Ceased
- 2005-09-28 BR BRPI0516297-1A patent/BRPI0516297A/pt not_active IP Right Cessation
- 2005-09-28 JP JP2007535709A patent/JP2008515890A/ja active Pending
- 2005-09-28 AU AU2005294666A patent/AU2005294666A1/en not_active Abandoned
- 2005-10-04 PA PA20058647601A patent/PA8647601A1/es unknown
- 2005-10-05 GT GT200500276A patent/GT200500276A/es unknown
- 2005-10-05 AR ARP050104207A patent/AR052219A1/es not_active Application Discontinuation
- 2005-10-05 PE PE2005001180A patent/PE20060934A1/es not_active Application Discontinuation
- 2005-10-05 SV SV2005002256A patent/SV2006002256A/es unknown
- 2005-10-05 TW TW094134821A patent/TW200628169A/zh unknown
-
2006
- 2006-09-28 US US11/536,571 patent/US20070025987A1/en not_active Abandoned
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2007
- 2007-03-14 IL IL181922A patent/IL181922A0/en unknown
- 2007-05-04 NO NO20072312A patent/NO20072312L/no not_active Application Discontinuation
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2008
- 2008-05-20 ZA ZA200804339A patent/ZA200804339B/en unknown
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