JP2008514730A - Ｃｄ３０陽性リンパ腫の処置の方法 - Google Patents
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| US61528404P | 2004-10-01 | 2004-10-01 | |
| PCT/US2005/035477 WO2006039644A2 (en) | 2004-10-01 | 2005-09-30 | Methods of treating cd30 positive lymphomas |
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| JP2008514730A true JP2008514730A (ja) | 2008-05-08 |
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| JP2007534859A Pending JP2008514730A (ja) | 2004-10-01 | 2005-09-30 | Ｃｄ３０陽性リンパ腫の処置の方法 |
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| US (1) | US7790160B2 (OSRAM) |
| EP (1) | EP1802345A2 (OSRAM) |
| JP (1) | JP2008514730A (OSRAM) |
| KR (1) | KR20070083899A (OSRAM) |
| CN (1) | CN101056655A (OSRAM) |
| AU (1) | AU2005292227A1 (OSRAM) |
| BR (1) | BRPI0516727A (OSRAM) |
| CA (1) | CA2582016A1 (OSRAM) |
| IL (1) | IL182260A0 (OSRAM) |
| MX (1) | MX2007003533A (OSRAM) |
| NO (1) | NO20071714L (OSRAM) |
| WO (1) | WO2006039644A2 (OSRAM) |
| ZA (1) | ZA200703154B (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017521664A (ja) * | 2014-07-11 | 2017-08-03 | エクスプレッション、パソロジー、インコーポレイテッドＥｘｐｒｅｓｓｉｏｎ Ｐａｔｈｏｌｏｇｙ， Ｉｎｃ． | 腫瘍壊死因子レセプタースーパーファミリーメンバー８（ｃｄ３０）タンパク質のためのｓｒｍ／ｍｒｍアッセイ |
| JP2019524780A (ja) * | 2016-08-04 | 2019-09-05 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤及び抗ｃｄ３０抗体の組み合わせ |
| JP2021511806A (ja) * | 2018-02-01 | 2021-05-13 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗ｐｄ−１抗体 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1471938A4 (en) | 2002-01-09 | 2008-03-05 | Medarex Inc | HUMAN MONOCLONAL ANTIBODIES AGAINST CD30 |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| AU2005292227A1 (en) | 2004-10-01 | 2006-04-13 | Medarex, Inc. | Methods of treating CD30 positive lymphomas |
| ES2498794T3 (es) | 2005-02-18 | 2014-09-25 | Medarex, L.L.C. | Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo |
| US20090214544A1 (en) * | 2005-04-25 | 2009-08-27 | Medarex | Method of treating cd30 positive lymphomas |
| ES2396569T3 (es) * | 2006-01-17 | 2013-02-22 | Medarex, Inc. | Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo y xilosilo |
| US7910108B2 (en) * | 2006-06-05 | 2011-03-22 | Incyte Corporation | Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases |
| WO2008124197A1 (en) * | 2007-04-10 | 2008-10-16 | The Johns Hopkins University | Imaging and therapy of virus-associated tumors |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| KR101580714B1 (ko) | 2010-06-03 | 2016-01-04 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 인산화효소(ｂｔｋ)의 억제제의 용도 |
| AU2013216863B2 (en) * | 2012-02-10 | 2018-09-06 | Seagen Inc. | Detection and treatment of CD30+ cancers |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| BR112015001690A2 (pt) | 2012-07-24 | 2017-11-07 | Pharmacyclics Inc | mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk) |
| PL3508502T3 (pl) | 2013-09-20 | 2023-07-17 | Bristol-Myers Squibb Company | Kombinacja przeciwciał anty-lag-3 i przeciwciał anty-pd-1 w leczeniu raka |
| AU2014339816B2 (en) * | 2013-10-25 | 2020-05-28 | Pharmacyclics Llc | Treatment using Bruton's tyrosine kinase inhibitors and immunotherapy |
| US10335494B2 (en) * | 2013-12-06 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-CD30 antibodies |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| LT3116909T (lt) | 2014-03-14 | 2020-02-10 | Novartis Ag | Antikūno molekulės prieš lag-3 ir jų panaudojimas |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| CN106854245A (zh) * | 2016-12-28 | 2017-06-16 | 无锡傲锐东源生物科技有限公司 | 抗cd30蛋白单克隆抗体及其用途 |
| CN118356488A (zh) | 2017-05-30 | 2024-07-19 | 百时美施贵宝公司 | 包含抗lag-3抗体或抗lag-3抗体和抗pd-1或抗pd-l1抗体的组合物 |
| PT3631454T (pt) | 2017-05-30 | 2023-11-23 | Bristol Myers Squibb Co | Tratamento de tumores positivos para lag-3 |
| KR20230148203A (ko) | 2021-03-01 | 2023-10-24 | 난트바이오 인코포레이티드 | 항-cd30 단일클론성 항체 및 키메라성 항원 수용체 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6909191A (en) | 1989-11-20 | 1991-06-13 | Parker, David L. | Improved cd-30 antibodies and fragments thereof |
| US5165923A (en) | 1989-11-20 | 1992-11-24 | Imperial Cancer Research Technology | Methods and compositions for the treatment of hodgkin's disease |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6713610B1 (en) * | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| DE4200043A1 (de) | 1991-11-11 | 1993-05-13 | Stein Harald Prof Dr | Lymphoides cd30-antigen (ki-1), dessen protein- und die zugehoerige nucleotidsequenz, seine herstellung sowie mittel zur diagnose und untersuchung von tumoren |
| DK0615451T3 (da) * | 1992-05-26 | 2006-04-24 | Immunex Corp | Hidtil ukendt cytokin der binder til CD30 |
| AU4953693A (en) | 1992-08-25 | 1994-03-15 | Medac Gesellschaft Fur Klinische Spezialpraparate Mbh | Antibody/radioisotope conjugate for tumor diagnosis and/or therapy |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DE4337197C1 (de) * | 1993-10-30 | 1994-08-25 | Biotest Pharma Gmbh | Verfahren zur selektiven Herstellung von Hybridomazellinien, die monoklonale Antikörper mit hoher Zytotoxizität gegen humanes CD16-Antigen produzieren, sowie Herstellung bispezifischer monoklonaler Antikörper unter Verwendung derartiger monoklonaler Antikörper und des CD30-HRS-3-Antikörpers zur Therapie menschlicher Tumore |
| AU4485696A (en) | 1995-01-18 | 1996-08-07 | Boehringer Mannheim Gmbh | Anti-cd 30 antibodies preventing proteolytic cleavage and release of membrane-bound cd 30 antigen |
| DE19543039C1 (de) | 1995-11-08 | 1996-11-21 | Medac Klinische Spezialpraep | Rekombinante Liganden für das menschliche Zellmembran-Antigen CD30 |
| EP2314625B1 (en) | 1996-12-03 | 2014-05-07 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| EP1053316A1 (de) | 1998-02-06 | 2000-11-22 | AbGen GmbH | Nukleinsäuren zur modulation zellulärer aktivierung |
| DE19937264A1 (de) | 1999-08-06 | 2001-02-15 | Deutsches Krebsforsch | F¶v¶-Antikörper-Konstrukte |
| US6652854B2 (en) | 2000-08-08 | 2003-11-25 | Immunex Corporation | Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L |
| AU2001285286A1 (en) | 2000-08-29 | 2002-03-13 | Noveon Ip Holdings Corp. | Hydrogels containing substances |
| US7090843B1 (en) | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| ES2326964T3 (es) * | 2001-10-25 | 2009-10-22 | Genentech, Inc. | Composiciones de glicoproteina. |
| EP1471938A4 (en) * | 2002-01-09 | 2008-03-05 | Medarex Inc | HUMAN MONOCLONAL ANTIBODIES AGAINST CD30 |
| EP1532175B1 (en) | 2002-03-22 | 2012-10-17 | Aprogen, Inc. | Humanized antibody and process for preparing the same |
| FR2844513B1 (fr) | 2002-09-13 | 2007-08-03 | Lab Francais Du Fractionnement | Anticorps pour adcc et induisant la production de cytokines. |
| AU2005292227A1 (en) | 2004-10-01 | 2006-04-13 | Medarex, Inc. | Methods of treating CD30 positive lymphomas |
| ES2498794T3 (es) | 2005-02-18 | 2014-09-25 | Medarex, L.L.C. | Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo |
-
2005
- 2005-09-30 AU AU2005292227A patent/AU2005292227A1/en not_active Abandoned
- 2005-09-30 MX MX2007003533A patent/MX2007003533A/es not_active Application Discontinuation
- 2005-09-30 JP JP2007534859A patent/JP2008514730A/ja active Pending
- 2005-09-30 CN CNA2005800383614A patent/CN101056655A/zh active Pending
- 2005-09-30 WO PCT/US2005/035477 patent/WO2006039644A2/en not_active Ceased
- 2005-09-30 CA CA002582016A patent/CA2582016A1/en not_active Abandoned
- 2005-09-30 BR BRPI0516727-2A patent/BRPI0516727A/pt not_active IP Right Cessation
- 2005-09-30 ZA ZA200703154A patent/ZA200703154B/xx unknown
- 2005-09-30 EP EP05816220A patent/EP1802345A2/en not_active Withdrawn
- 2005-09-30 KR KR1020077009968A patent/KR20070083899A/ko not_active Withdrawn
- 2005-09-30 US US11/241,154 patent/US7790160B2/en not_active Expired - Fee Related
-
2007
- 2007-03-28 IL IL182260A patent/IL182260A0/en unknown
- 2007-03-30 NO NO20071714A patent/NO20071714L/no not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017521664A (ja) * | 2014-07-11 | 2017-08-03 | エクスプレッション、パソロジー、インコーポレイテッドＥｘｐｒｅｓｓｉｏｎ Ｐａｔｈｏｌｏｇｙ， Ｉｎｃ． | 腫瘍壊死因子レセプタースーパーファミリーメンバー８（ｃｄ３０）タンパク質のためのｓｒｍ／ｍｒｍアッセイ |
| JP2019524780A (ja) * | 2016-08-04 | 2019-09-05 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤及び抗ｃｄ３０抗体の組み合わせ |
| JP2021511806A (ja) * | 2018-02-01 | 2021-05-13 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗ｐｄ−１抗体 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL182260A0 (en) | 2007-07-24 |
| EP1802345A2 (en) | 2007-07-04 |
| CA2582016A1 (en) | 2006-04-13 |
| MX2007003533A (es) | 2007-05-23 |
| CN101056655A (zh) | 2007-10-17 |
| US7790160B2 (en) | 2010-09-07 |
| ZA200703154B (en) | 2008-09-25 |
| KR20070083899A (ko) | 2007-08-24 |
| BRPI0516727A (pt) | 2008-09-16 |
| NO20071714L (no) | 2007-06-28 |
| US20060177442A1 (en) | 2006-08-10 |
| WO2006039644A2 (en) | 2006-04-13 |
| WO2006039644A3 (en) | 2006-08-10 |
| AU2005292227A1 (en) | 2006-04-13 |
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