JP2008514621A5 - - Google Patents
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- Publication number
- JP2008514621A5 JP2008514621A5 JP2007533665A JP2007533665A JP2008514621A5 JP 2008514621 A5 JP2008514621 A5 JP 2008514621A5 JP 2007533665 A JP2007533665 A JP 2007533665A JP 2007533665 A JP2007533665 A JP 2007533665A JP 2008514621 A5 JP2008514621 A5 JP 2008514621A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cholecalciferol
- cyclopropyl
- dihydroxy
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 239000011647 vitamin D3 Substances 0.000 claims 19
- 229940021056 vitamin d3 Drugs 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 201000010099 disease Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 7
- 230000002159 abnormal effect Effects 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 208000001132 Osteoporosis Diseases 0.000 claims 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 4
- 235000005282 vitamin D3 Nutrition 0.000 claims 4
- 101000984186 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 4 Proteins 0.000 claims 3
- 102100025578 Leukocyte immunoglobulin-like receptor subfamily B member 4 Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000006371 metabolic abnormality Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 208000021959 Abnormal metabolism Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010069632 Bladder dysfunction Diseases 0.000 claims 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 1
- 206010031240 Osteodystrophy Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039984 Senile osteoporosis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- -1 Vitamin D 3 compound Chemical class 0.000 claims 1
- 230000001594 aberrant effect Effects 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 210000002449 bone cell Anatomy 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 210000003890 endocrine cell Anatomy 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000006058 immune tolerance Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 201000006409 renal osteodystrophy Diseases 0.000 claims 1
- 208000007442 rickets Diseases 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61273204P | 2004-09-24 | 2004-09-24 | |
| PCT/US2005/034213 WO2006036813A2 (en) | 2004-09-24 | 2005-09-23 | 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514621A JP2008514621A (ja) | 2008-05-08 |
| JP2008514621A5 true JP2008514621A5 (enExample) | 2008-12-18 |
Family
ID=36119461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533665A Pending JP2008514621A (ja) | 2004-09-24 | 2005-09-23 | ２０−シクロアルキル，２６，２７−アルキル／ハロアルキル−ビタミンｄ３化合物及びその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080318911A1 (enExample) |
| EP (1) | EP1797033A4 (enExample) |
| JP (1) | JP2008514621A (enExample) |
| CN (1) | CN101106985A (enExample) |
| AU (1) | AU2005289664A1 (enExample) |
| CA (1) | CA2580962A1 (enExample) |
| IL (1) | IL182145A0 (enExample) |
| WO (1) | WO2006036813A2 (enExample) |
| ZA (1) | ZA200703310B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2588453A1 (en) * | 2004-12-02 | 2006-06-08 | Abbott Laboratories | Use of a compound that activates a vitamin d receptor for reducing intimal hyperplasia, smooth muscle cell proliferation and restenosis in mammals |
| US7286295B1 (en) | 2005-11-30 | 2007-10-23 | Sandia Corporation | Microoptical compound lens |
| WO2009115398A1 (en) * | 2008-03-18 | 2009-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Vitamin d compounds for the treatment of biliary diseases |
| MX2011012330A (es) * | 2009-05-20 | 2011-12-16 | Hybrigenics Sa | Nuevos usos terapeuticos de inecalcitol. |
| PH12013500823A1 (en) * | 2010-10-25 | 2019-03-22 | Teijin Pharma Ltd | 22-yne-vitamin d3 derivative |
| EP2682386B1 (en) * | 2011-03-02 | 2016-08-17 | Nihon University | Novel vitamin d receptor modulator with partial agonist activity |
| US9370527B2 (en) | 2012-12-28 | 2016-06-21 | The Regents Of The University Of Michigan | Amelioration of intestinal fibrosis and treatment of Crohn's disease |
| CN103193695B (zh) * | 2013-04-22 | 2015-08-05 | 中国药科大学 | 3-苯基-3-吡咯基戊烷类衍生物及其医药用途 |
| JP6946182B2 (ja) | 2014-10-22 | 2021-10-06 | エクステンド バイオサイエンシズ インコーポレーテッドＥｘｔｅｎｄ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ | 治療用ビタミンｄコンジュゲート |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| CA3147182A1 (en) * | 2019-08-13 | 2021-02-18 | Tohoku University | Novel immune checkpoint inhibitors and uses thereof |
| JP2023507110A (ja) | 2019-12-19 | 2023-02-21 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | Ｉｌｔ３結合剤及びその使用方法 |
| CN113274346A (zh) * | 2021-05-25 | 2021-08-20 | 满孝勇 | 一种莫匹罗星软膏的应用 |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW403735B (en) * | 1995-11-22 | 2000-09-01 | Hoffmann La Roche | 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol |
| SG70010A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Fluorinated vitamin d3 analogs |
| EP0981523B1 (en) * | 1997-05-16 | 2005-12-07 | Woman & Infants Hospital | Cyclic ether vitamin d3 compounds, 1alpha (oh) 3-epi-vitamin d3 compounds and uses thereof |
| JP4219553B2 (ja) * | 1997-09-08 | 2009-02-04 | エフ．ホフマン−ラ ロシュ アーゲー | １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体 |
| US6331642B1 (en) * | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| JP2005503434A (ja) * | 2001-09-21 | 2005-02-03 | エフ．ホフマン−ラ ロシュ アーゲー | ３−デスオキシ−ビタミンｄ３類似体 |
| BRPI0414701A (pt) * | 2003-09-24 | 2006-11-14 | Bioxell Spa | uso de um composto de vitamina d, método de prevenção ou tratamnento de disfunção de bexiga em um paciente, composto de vitamina d, e, kit |
| EP1663249A4 (en) * | 2003-09-24 | 2006-12-20 | Bioxell Spa | 1,3-DIACYLATED, 26,27-ALKYL / HALOALKYL VITAMIN D SB 3 / SB COMPOUNDS AND APPLICATION METHOD THEREFOR |
| JP2007525533A (ja) * | 2004-03-01 | 2007-09-06 | ビオエクセル エスピーエー | 間質性膀胱炎の治療方法、並びに関連化合物及び組成物 |
-
2005
- 2005-09-23 CA CA002580962A patent/CA2580962A1/en not_active Abandoned
- 2005-09-23 JP JP2007533665A patent/JP2008514621A/ja active Pending
- 2005-09-23 US US11/663,704 patent/US20080318911A1/en not_active Abandoned
- 2005-09-23 WO PCT/US2005/034213 patent/WO2006036813A2/en not_active Ceased
- 2005-09-23 AU AU2005289664A patent/AU2005289664A1/en not_active Abandoned
- 2005-09-23 CN CNA2005800401650A patent/CN101106985A/zh active Pending
- 2005-09-23 EP EP05801186A patent/EP1797033A4/en not_active Withdrawn
-
2007
- 2007-03-22 IL IL182145A patent/IL182145A0/en unknown
- 2007-04-23 ZA ZA200703310A patent/ZA200703310B/en unknown