JP2008514558A5 - - Google Patents
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- Publication number
- JP2008514558A5 JP2008514558A5 JP2007532794A JP2007532794A JP2008514558A5 JP 2008514558 A5 JP2008514558 A5 JP 2008514558A5 JP 2007532794 A JP2007532794 A JP 2007532794A JP 2007532794 A JP2007532794 A JP 2007532794A JP 2008514558 A5 JP2008514558 A5 JP 2008514558A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorophenethyl
- piperazin
- indol
- cyano
- crystal form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims 3
- WTDFFADXONGQOM-UHFFFAOYSA-N formaldehyde;hydrochloride Chemical compound Cl.O=C WTDFFADXONGQOM-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- -1 4-fluorophenethyl Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004047517A DE102004047517A1 (de) | 2004-09-28 | 2004-09-28 | Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid |
| DE102004047517.2 | 2004-09-28 | ||
| PCT/EP2005/009647 WO2006034774A1 (de) | 2004-09-28 | 2005-09-08 | Neuartige kristallform von (3-cyan-1h-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, hydrochlorid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514558A JP2008514558A (ja) | 2008-05-08 |
| JP2008514558A5 true JP2008514558A5 (enExample) | 2008-10-23 |
| JP5160892B2 JP5160892B2 (ja) | 2013-03-13 |
Family
ID=35285234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532794A Expired - Fee Related JP5160892B2 (ja) | 2004-09-28 | 2005-09-08 | （３−シアノ−１ｈ−インドール−７−イル）−［４−（４−フルオロフェネチル）ピペラジン−１−イル］メタノン塩酸塩の新規な結晶形 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7981897B2 (enExample) |
| EP (1) | EP1794121B1 (enExample) |
| JP (1) | JP5160892B2 (enExample) |
| KR (1) | KR20070057872A (enExample) |
| CN (1) | CN101027284B (enExample) |
| AR (1) | AR051043A1 (enExample) |
| AU (1) | AU2005289169B2 (enExample) |
| BR (1) | BRPI0516200A (enExample) |
| CA (1) | CA2581834A1 (enExample) |
| DE (1) | DE102004047517A1 (enExample) |
| MX (1) | MX2007003471A (enExample) |
| PE (1) | PE20060964A1 (enExample) |
| RU (1) | RU2383532C2 (enExample) |
| TW (1) | TW200616952A (enExample) |
| WO (1) | WO2006034774A1 (enExample) |
| ZA (1) | ZA200703440B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2016052B1 (en) * | 2006-05-05 | 2012-06-06 | Merck Patent GmbH | Crystalline (3-cyano-1h-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate |
| CN101437793B (zh) * | 2006-05-05 | 2012-08-22 | 默克专利股份有限公司 | 结晶的（3-氰基-1h-吲哚-7-基）-[4-（4-氟苯乙基）哌嗪-1-基]甲酮磷酸盐 |
| CA2756796C (en) * | 2007-05-11 | 2018-05-22 | Forest Laboratories Holdings Limited | Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives |
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| EP2251011B1 (en) * | 2008-02-21 | 2012-04-04 | Richter Gedeon Nyrt. | Solid preparation for oral administration |
| SI2317852T1 (sl) | 2008-07-16 | 2015-04-30 | Richter Gedeon Nyrt. | Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja |
| HU230067B1 (hu) | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| US8912197B2 (en) | 2012-08-20 | 2014-12-16 | Forest Laboratories Holdings Ltd. | Crystalline form of carbamoyl-cyclohexane derivatives |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
| DE10102944A1 (de) | 2001-01-23 | 2002-07-25 | Merck Patent Gmbh | Verfahren zur Herstellung von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon und dessen Salzen |
| DE10157673A1 (de) * | 2001-11-24 | 2003-06-05 | Merck Patent Gmbh | Verwendung von N-(Indolcarbonyl-)piperazinderivaten |
| DE10246357A1 (de) * | 2002-10-04 | 2004-04-15 | Merck Patent Gmbh | Verwendung von 5-HT2Rezeptorantagonisten |
-
2004
- 2004-09-28 DE DE102004047517A patent/DE102004047517A1/de not_active Withdrawn
-
2005
- 2005-09-08 WO PCT/EP2005/009647 patent/WO2006034774A1/de not_active Ceased
- 2005-09-08 CN CN2005800326518A patent/CN101027284B/zh not_active Expired - Fee Related
- 2005-09-08 BR BRPI0516200-9A patent/BRPI0516200A/pt not_active IP Right Cessation
- 2005-09-08 EP EP05782871.7A patent/EP1794121B1/de not_active Expired - Lifetime
- 2005-09-08 MX MX2007003471A patent/MX2007003471A/es not_active Application Discontinuation
- 2005-09-08 US US11/576,086 patent/US7981897B2/en not_active Expired - Fee Related
- 2005-09-08 CA CA002581834A patent/CA2581834A1/en not_active Abandoned
- 2005-09-08 RU RU2007116037/04A patent/RU2383532C2/ru not_active IP Right Cessation
- 2005-09-08 AU AU2005289169A patent/AU2005289169B2/en not_active Ceased
- 2005-09-08 KR KR1020077006952A patent/KR20070057872A/ko not_active Ceased
- 2005-09-08 JP JP2007532794A patent/JP5160892B2/ja not_active Expired - Fee Related
- 2005-09-23 TW TW094133161A patent/TW200616952A/zh unknown
- 2005-09-26 PE PE2005001111A patent/PE20060964A1/es not_active Application Discontinuation
- 2005-09-28 AR ARP050104084A patent/AR051043A1/es unknown
-
2007
- 2007-04-26 ZA ZA200703440A patent/ZA200703440B/xx unknown
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