RU2383532C2 - Новая кристаллическая форма (3-циано-1н-индол-7-ил)-[4-(4-фторфенэтил)пиперазин-1-ил]метанона гидрохлорида - Google Patents

Новая кристаллическая форма (3-циано-1н-индол-7-ил)-[4-(4-фторфенэтил)пиперазин-1-ил]метанона гидрохлорида Download PDF

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Publication number
RU2383532C2
RU2383532C2 RU2007116037/04A RU2007116037A RU2383532C2 RU 2383532 C2 RU2383532 C2 RU 2383532C2 RU 2007116037/04 A RU2007116037/04 A RU 2007116037/04A RU 2007116037 A RU2007116037 A RU 2007116037A RU 2383532 C2 RU2383532 C2 RU 2383532C2
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RU
Russia
Prior art keywords
emd281014
fluorophenethyl
piperazin
indol
cyano
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RU2007116037/04A
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English (en)
Russian (ru)
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RU2007116037A (ru
Inventor
Андреас БАТЕ (DE)
Андреас БАТЕ
Бернд ХЕЛЬФЕРТ (DE)
Бернд ХЕЛЬФЕРТ
Ральф КНИРИМЕ (DE)
Ральф КНИРИМЕ
Кристоф ЗАЛ (DE)
Кристоф ЗАЛ
Рональд КАЙНЕР (DE)
Рональд КАЙНЕР
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Мерк Патент Гмбх
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Publication of RU2007116037A publication Critical patent/RU2007116037A/ru
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Publication of RU2383532C2 publication Critical patent/RU2383532C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
RU2007116037/04A 2004-09-28 2005-09-08 Новая кристаллическая форма (3-циано-1н-индол-7-ил)-[4-(4-фторфенэтил)пиперазин-1-ил]метанона гидрохлорида RU2383532C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004047517A DE102004047517A1 (de) 2004-09-28 2004-09-28 Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
DE102004047517.2 2004-09-28

Publications (2)

Publication Number Publication Date
RU2007116037A RU2007116037A (ru) 2008-11-10
RU2383532C2 true RU2383532C2 (ru) 2010-03-10

Family

ID=35285234

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007116037/04A RU2383532C2 (ru) 2004-09-28 2005-09-08 Новая кристаллическая форма (3-циано-1н-индол-7-ил)-[4-(4-фторфенэтил)пиперазин-1-ил]метанона гидрохлорида

Country Status (16)

Country Link
US (1) US7981897B2 (enExample)
EP (1) EP1794121B1 (enExample)
JP (1) JP5160892B2 (enExample)
KR (1) KR20070057872A (enExample)
CN (1) CN101027284B (enExample)
AR (1) AR051043A1 (enExample)
AU (1) AU2005289169B2 (enExample)
BR (1) BRPI0516200A (enExample)
CA (1) CA2581834A1 (enExample)
DE (1) DE102004047517A1 (enExample)
MX (1) MX2007003471A (enExample)
PE (1) PE20060964A1 (enExample)
RU (1) RU2383532C2 (enExample)
TW (1) TW200616952A (enExample)
WO (1) WO2006034774A1 (enExample)
ZA (1) ZA200703440B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2016052B1 (en) * 2006-05-05 2012-06-06 Merck Patent GmbH Crystalline (3-cyano-1h-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate
CN101437793B (zh) * 2006-05-05 2012-08-22 默克专利股份有限公司 结晶的（3-氰基-1h-吲哚-7-基）-[4-（4-氟苯乙基）哌嗪-1-基]甲酮磷酸盐
CA2756796C (en) * 2007-05-11 2018-05-22 Forest Laboratories Holdings Limited Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
EP2251011B1 (en) * 2008-02-21 2012-04-04 Richter Gedeon Nyrt. Solid preparation for oral administration
SI2317852T1 (sl) 2008-07-16 2015-04-30 Richter Gedeon Nyrt. Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
US8912197B2 (en) 2012-08-20 2014-12-16 Forest Laboratories Holdings Ltd. Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2114111C1 (ru) * 1991-12-19 1998-06-27 Бристоль-Мейерз Сквибб Компани 4-пиримидин- или пиридинильные производные индол-3-ил-алкилпиперазинов, фармацевтическая композиция

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
DE10102944A1 (de) 2001-01-23 2002-07-25 Merck Patent Gmbh Verfahren zur Herstellung von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon und dessen Salzen
DE10157673A1 (de) * 2001-11-24 2003-06-05 Merck Patent Gmbh Verwendung von N-(Indolcarbonyl-)piperazinderivaten
DE10246357A1 (de) * 2002-10-04 2004-04-15 Merck Patent Gmbh Verwendung von 5-HT2Rezeptorantagonisten

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2114111C1 (ru) * 1991-12-19 1998-06-27 Бристоль-Мейерз Сквибб Компани 4-пиримидин- или пиридинильные производные индол-3-ил-алкилпиперазинов, фармацевтическая композиция

Also Published As

Publication number Publication date
PE20060964A1 (es) 2006-10-02
CN101027284B (zh) 2010-09-29
DE102004047517A1 (de) 2006-03-30
JP5160892B2 (ja) 2013-03-13
EP1794121A1 (de) 2007-06-13
AR051043A1 (es) 2006-12-13
US7981897B2 (en) 2011-07-19
CN101027284A (zh) 2007-08-29
CA2581834A1 (en) 2006-04-06
WO2006034774A1 (de) 2006-04-06
BRPI0516200A (pt) 2008-08-26
EP1794121B1 (de) 2013-12-25
AU2005289169B2 (en) 2011-07-14
JP2008514558A (ja) 2008-05-08
AU2005289169A1 (en) 2006-04-06
ZA200703440B (en) 2008-08-27
TW200616952A (en) 2006-06-01
KR20070057872A (ko) 2007-06-07
RU2007116037A (ru) 2008-11-10
US20070259885A1 (en) 2007-11-08
MX2007003471A (es) 2007-05-10

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Effective date: 20110909