AR051043A1 - Forma cristalina de clorhidrato de (3-cian-1h-indol-7il)-[4-(4-fluorofenetil)-piperazin-1-il]-metanona - Google Patents

Forma cristalina de clorhidrato de (3-cian-1h-indol-7il)-[4-(4-fluorofenetil)-piperazin-1-il]-metanona

Info

Publication number
AR051043A1
AR051043A1 ARP050104084A ARP050104084A AR051043A1 AR 051043 A1 AR051043 A1 AR 051043A1 AR P050104084 A ARP050104084 A AR P050104084A AR P050104084 A ARP050104084 A AR P050104084A AR 051043 A1 AR051043 A1 AR 051043A1
Authority
AR
Argentina
Prior art keywords
piperazin
indol
fluorofenetil
metanona
cian
Prior art date
Application number
ARP050104084A
Other languages
English (en)
Inventor
Dr Bathe Andreas
Helfert Bernd
Knierieme Ralf
Dr Saal Christoph
Dr Keiner Ronald
Original Assignee
Merck Patent Ges Mit Beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung
Publication of AR051043A1 publication Critical patent/AR051043A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente se refiere a una forma cristalina B hasta ahora desconocida de clorhidrato de (3-cian-1H-indol-7-il)-[4-(4-fluorofenetil)-piperazin-1-il]-metanona, a procedimientos para su preparación, así como a su uso para la preparación de un medicamento.
ARP050104084A 2004-09-28 2005-09-28 Forma cristalina de clorhidrato de (3-cian-1h-indol-7il)-[4-(4-fluorofenetil)-piperazin-1-il]-metanona AR051043A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004047517A DE102004047517A1 (de) 2004-09-28 2004-09-28 Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid

Publications (1)

Publication Number Publication Date
AR051043A1 true AR051043A1 (es) 2006-12-13

Family

ID=35285234

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104084A AR051043A1 (es) 2004-09-28 2005-09-28 Forma cristalina de clorhidrato de (3-cian-1h-indol-7il)-[4-(4-fluorofenetil)-piperazin-1-il]-metanona

Country Status (16)

Country Link
US (1) US7981897B2 (es)
EP (1) EP1794121B1 (es)
JP (1) JP5160892B2 (es)
KR (1) KR20070057872A (es)
CN (1) CN101027284B (es)
AR (1) AR051043A1 (es)
AU (1) AU2005289169B2 (es)
BR (1) BRPI0516200A (es)
CA (1) CA2581834A1 (es)
DE (1) DE102004047517A1 (es)
MX (1) MX2007003471A (es)
PE (1) PE20060964A1 (es)
RU (1) RU2383532C2 (es)
TW (1) TW200616952A (es)
WO (1) WO2006034774A1 (es)
ZA (1) ZA200703440B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2388000T3 (es) * 2006-05-05 2012-10-05 Merck Patent Gmbh Fosfato de (3-ciano-1H-indol-7-il)-[4-(4-fluorofenetil)piperazin-1-il]metanona cristalino
CN101437793B (zh) * 2006-05-05 2012-08-22 默克专利股份有限公司 结晶的（3-氰基-1h-吲哚-7-基）-[4-（4-氟苯乙基）哌嗪-1-基]甲酮磷酸盐
WO2008141135A1 (en) * 2007-05-11 2008-11-20 Forest Laboratories Holdings Limited Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
ATE552002T1 (de) * 2008-02-21 2012-04-15 Richter Gedeon Nyrt Feste zubereitung zur oralen verabreichung
CN102118970A (zh) 2008-07-16 2011-07-06 吉瑞工厂 包含多巴胺受体配体的药物制剂
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
US8912197B2 (en) 2012-08-20 2014-12-16 Forest Laboratories Holdings Ltd. Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19934433A1 (de) 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
DE10102944A1 (de) * 2001-01-23 2002-07-25 Merck Patent Gmbh Verfahren zur Herstellung von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon und dessen Salzen
DE10157673A1 (de) 2001-11-24 2003-06-05 Merck Patent Gmbh Verwendung von N-(Indolcarbonyl-)piperazinderivaten
DE10246357A1 (de) * 2002-10-04 2004-04-15 Merck Patent Gmbh Verwendung von 5-HT2Rezeptorantagonisten

Also Published As

Publication number Publication date
BRPI0516200A (pt) 2008-08-26
RU2007116037A (ru) 2008-11-10
PE20060964A1 (es) 2006-10-02
EP1794121A1 (de) 2007-06-13
US7981897B2 (en) 2011-07-19
JP5160892B2 (ja) 2013-03-13
JP2008514558A (ja) 2008-05-08
CA2581834A1 (en) 2006-04-06
RU2383532C2 (ru) 2010-03-10
AU2005289169A1 (en) 2006-04-06
CN101027284A (zh) 2007-08-29
US20070259885A1 (en) 2007-11-08
WO2006034774A1 (de) 2006-04-06
EP1794121B1 (de) 2013-12-25
CN101027284B (zh) 2010-09-29
DE102004047517A1 (de) 2006-03-30
ZA200703440B (en) 2008-08-27
MX2007003471A (es) 2007-05-10
TW200616952A (en) 2006-06-01
AU2005289169B2 (en) 2011-07-14
KR20070057872A (ko) 2007-06-07

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