JP2008512465A5 - - Google Patents

Info

Publication number

JP2008512465A5

JP2008512465A5 JP2007531283A JP2007531283A JP2008512465A5 JP 2008512465 A5 JP2008512465 A5 JP 2008512465A5 JP 2007531283 A JP2007531283 A JP 2007531283A JP 2007531283 A JP2007531283 A JP 2007531283A JP 2008512465 A5 JP2008512465 A5 JP 2008512465A5

Authority

JP

Japan

Prior art keywords

compound

hydrogen

compound according

thiazol

optionally substituted

Prior art date

2005-09-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 19
• -1 2-methylbenzo-1,3-thiazol-5-yl Chemical group 0.000 claims 16
• 229910052739 hydrogen Inorganic materials 0.000 claims 9
• 239000001257 hydrogen Substances 0.000 claims 9
• 150000002431 hydrogen Chemical class 0.000 claims 6
• 125000000217 alkyl group Chemical group 0.000 claims 5
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 125000001072 heteroaryl group Chemical group 0.000 claims 2
• 208000014674 injury Diseases 0.000 claims 2
• 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
• 125000004193 piperazinyl group Chemical group 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 125000003107 substituted aryl group Chemical group 0.000 claims 2
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
• MEMHSSUPSMDUNI-OAQYLSRUSA-N 3-[[4-[(2r)-2-methoxy-3-[(2-methyl-1,3-benzothiazol-5-yl)oxy]propyl]piperazin-1-yl]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical compound C([C@H](COC=1C=C2N=C(C)SC2=CC=1)OC)N(CC1)CCN1CC(N=1)=NOC=1C1=CC=C(C(F)(F)F)C=C1 MEMHSSUPSMDUNI-OAQYLSRUSA-N 0.000 claims 1
• 206010002383 Angina Pectoris Diseases 0.000 claims 1
• 206010002388 Angina unstable Diseases 0.000 claims 1
• 206010003130 Arrhythmia supraventricular Diseases 0.000 claims 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 206010022562 Intermittent claudication Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 229910000752 Prince's Metal Inorganic materials 0.000 claims 1
• 208000007718 Stable Angina Diseases 0.000 claims 1
• 208000007814 Unstable Angina Diseases 0.000 claims 1
• 206010047281 Ventricular arrhythmia Diseases 0.000 claims 1
• 208000027418 Wounds and injury Diseases 0.000 claims 1
• 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 150000003857 carboxamides Chemical class 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 208000019622 heart disease Diseases 0.000 claims 1
• 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
• 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 230000035939 shock Effects 0.000 claims 1
• 210000002027 skeletal muscle Anatomy 0.000 claims 1
• DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1