JP2008512465A - 脂肪酸酸化阻害剤としての置換ピペラジン化合物およびその使用 - Google Patents
脂肪酸酸化阻害剤としての置換ピペラジン化合物およびその使用 Download PDFInfo
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- JP2008512465A JP2008512465A JP2007531283A JP2007531283A JP2008512465A JP 2008512465 A JP2008512465 A JP 2008512465A JP 2007531283 A JP2007531283 A JP 2007531283A JP 2007531283 A JP2007531283 A JP 2007531283A JP 2008512465 A JP2008512465 A JP 2008512465A
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- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 11
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- AHZJKOKFZJYCLG-UHFFFAOYSA-K trifluoromethanesulfonate;ytterbium(3+) Chemical compound [Yb+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F AHZJKOKFZJYCLG-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60838404P | 2004-09-08 | 2004-09-08 | |
| PCT/US2005/031786 WO2006029179A2 (en) | 2004-09-08 | 2005-09-07 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512465A true JP2008512465A (ja) | 2008-04-24 |
| JP2008512465A5 JP2008512465A5 (enExample) | 2008-08-21 |
Family
ID=35884036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531283A Pending JP2008512465A (ja) | 2004-09-08 | 2005-09-07 | 脂肪酸酸化阻害剤としての置換ピペラジン化合物およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7271169B2 (enExample) |
| EP (1) | EP1789407A2 (enExample) |
| JP (1) | JP2008512465A (enExample) |
| KR (1) | KR20070051305A (enExample) |
| AU (1) | AU2005282492A1 (enExample) |
| CA (1) | CA2579621A1 (enExample) |
| WO (1) | WO2006029179A2 (enExample) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62258370A (ja) * | 1986-04-28 | 1987-11-10 | ヘキスト・アクチエンゲゼルシヤフト | ベンゾチアジノン誘導体 |
| JPH0665231A (ja) * | 1992-05-18 | 1994-03-08 | Adir | 新規チオクロマン化合物、その製造方法及びそれを含む薬学的組成物 |
| WO2003008411A1 (en) * | 2001-07-19 | 2003-01-30 | Cv Therapeutics, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
| JP2003531116A (ja) * | 2000-02-22 | 2003-10-21 | スィーヴィー セラピューティクス インコーポレイテッド | 置換ピペラジン化合物 |
| WO2004052887A2 (en) * | 2002-12-05 | 2004-06-24 | Cv Therapeutics, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
| JP2004518725A (ja) * | 2000-10-23 | 2004-06-24 | スィーヴィー セラピューティクス インコーポレイテッド | 脂肪酸の酸化防止剤としてのヘテロアリールアルキルピペラジン誘導体 |
| WO2004067506A2 (en) * | 2003-01-17 | 2004-08-12 | Cv Therapeutics Inc. | Substituted heterocyclic compounds |
| WO2004069818A1 (en) * | 2003-01-17 | 2004-08-19 | Cv Therapeutics Inc. | Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases |
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| DE2824764A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung |
| US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
| US4558129A (en) | 1983-05-18 | 1985-12-10 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade |
| US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
| US4588129A (en) * | 1983-09-06 | 1986-05-13 | Hudson Oxygen Therapy Sales Company | Nebulizer |
| EP0407780B1 (en) * | 1989-06-23 | 1996-09-11 | Syntex (U.S.A.) Inc. | Ranolazine and related piperazines used in the treatment of tissues experiencing a physical or chemical insult |
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| WO2001062749A1 (en) * | 2000-02-22 | 2001-08-30 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
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| CN1181065C (zh) * | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
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- 2005-09-07 KR KR1020077005379A patent/KR20070051305A/ko not_active Withdrawn
- 2005-09-07 AU AU2005282492A patent/AU2005282492A1/en not_active Abandoned
- 2005-09-07 JP JP2007531283A patent/JP2008512465A/ja active Pending
- 2005-09-07 CA CA002579621A patent/CA2579621A1/en not_active Abandoned
- 2005-09-07 US US11/222,452 patent/US7271169B2/en not_active Expired - Lifetime
- 2005-09-07 EP EP05795369A patent/EP1789407A2/en not_active Withdrawn
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| JPH0665231A (ja) * | 1992-05-18 | 1994-03-08 | Adir | 新規チオクロマン化合物、その製造方法及びそれを含む薬学的組成物 |
| JP2003531116A (ja) * | 2000-02-22 | 2003-10-21 | スィーヴィー セラピューティクス インコーポレイテッド | 置換ピペラジン化合物 |
| JP2004518725A (ja) * | 2000-10-23 | 2004-06-24 | スィーヴィー セラピューティクス インコーポレイテッド | 脂肪酸の酸化防止剤としてのヘテロアリールアルキルピペラジン誘導体 |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2006029179A3 (en) | 2006-05-26 |
| US7271169B2 (en) | 2007-09-18 |
| US7601721B2 (en) | 2009-10-13 |
| CA2579621A1 (en) | 2006-03-16 |
| US20060052605A1 (en) | 2006-03-09 |
| US20080070927A1 (en) | 2008-03-20 |
| KR20070051305A (ko) | 2007-05-17 |
| WO2006029179A2 (en) | 2006-03-16 |
| EP1789407A2 (en) | 2007-05-30 |
| AU2005282492A1 (en) | 2006-03-16 |
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