JP2008511633A - Ｃ型肝炎ウィルスｎｓ３セリンプロテアーゼの阻害因子としてのアシルスルホンアミド化合物 - Google Patents

Ｃ型肝炎ウィルスｎｓ３セリンプロテアーゼの阻害因子としてのアシルスルホンアミド化合物 Download PDF

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Publication number
JP2008511633A
JP2008511633A JP2007530123A JP2007530123A JP2008511633A JP 2008511633 A JP2008511633 A JP 2008511633A JP 2007530123 A JP2007530123 A JP 2007530123A JP 2007530123 A JP2007530123 A JP 2007530123A JP 2008511633 A JP2008511633 A JP 2008511633A
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compound
alkyl
group
heterocyclyl
cycloalkyl
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JP2007530123A
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Japanese (ja)
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JP2008511633A5 (enExample
Inventor
ムースミ サンニグラヒ，
エフ． ジョージ ヌジョロジ，
ビヨール エム． ギリジャバラバン，
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Merck Sharp & Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007530123A 2004-08-27 2005-08-25 Ｃ型肝炎ウィルスｎｓ３セリンプロテアーゼの阻害因子としてのアシルスルホンアミド化合物 Pending JP2008511633A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60523404P 2004-08-27 2004-08-27
PCT/US2005/030249 WO2006026352A1 (en) 2004-08-27 2005-08-25 Acylsulfonamide compounds as inhibitors of hepatitis c virus ns3 serine protease

Publications (2)

Publication Number Publication Date
JP2008511633A true JP2008511633A (ja) 2008-04-17
JP2008511633A5 JP2008511633A5 (enExample) 2008-09-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007530123A Pending JP2008511633A (ja) 2004-08-27 2005-08-25 Ｃ型肝炎ウィルスｎｓ３セリンプロテアーゼの阻害因子としてのアシルスルホンアミド化合物

Country Status (8)

Country Link
US (1) US7550559B2 (enExample)
EP (1) EP1797111B1 (enExample)
JP (1) JP2008511633A (enExample)
CN (1) CN101068828A (enExample)
AT (1) ATE513844T1 (enExample)
CA (1) CA2577812A1 (enExample)
MX (1) MX2007002371A (enExample)
WO (1) WO2006026352A1 (enExample)

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US20060046956A1 (en) 2006-03-02
US7550559B2 (en) 2009-06-23
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