JP2008511573A5 - - Google Patents
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- Publication number
- JP2008511573A5 JP2008511573A5 JP2007528770A JP2007528770A JP2008511573A5 JP 2008511573 A5 JP2008511573 A5 JP 2008511573A5 JP 2007528770 A JP2007528770 A JP 2007528770A JP 2007528770 A JP2007528770 A JP 2007528770A JP 2008511573 A5 JP2008511573 A5 JP 2008511573A5
- Authority
- JP
- Japan
- Prior art keywords
- filtered
- tetrahydrofuran
- compound
- cooled
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0419361.1A GB0419361D0 (en) | 2004-08-31 | 2004-08-31 | Organic compounds |
| PCT/EP2005/009347 WO2006024501A1 (en) | 2004-08-31 | 2005-08-30 | Alternative synthesis of renin inhibitors and intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008511573A JP2008511573A (ja) | 2008-04-17 |
| JP2008511573A5 true JP2008511573A5 (https=) | 2008-10-09 |
Family
ID=33155811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528770A Pending JP2008511573A (ja) | 2004-08-31 | 2005-08-30 | レニン阻害剤およびその中間体の代替的製造法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7910774B2 (https=) |
| EP (2) | EP1789377B1 (https=) |
| JP (1) | JP2008511573A (https=) |
| KR (1) | KR20070045300A (https=) |
| CN (2) | CN101010281B (https=) |
| AT (1) | ATE485257T1 (https=) |
| AU (1) | AU2005279351B2 (https=) |
| BR (1) | BRPI0514742A (https=) |
| CA (1) | CA2576749C (https=) |
| DE (1) | DE602005024282D1 (https=) |
| ES (1) | ES2354986T3 (https=) |
| GB (1) | GB0419361D0 (https=) |
| MX (1) | MX2007002419A (https=) |
| PL (1) | PL1789377T3 (https=) |
| PT (1) | PT1789377E (https=) |
| RU (1) | RU2411230C2 (https=) |
| WO (1) | WO2006024501A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0511686D0 (en) | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| GB0519764D0 (en) | 2005-09-28 | 2005-11-09 | Novartis Ag | Organic compounds |
| GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
| GB2431649A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431646A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431653A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431651A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431642A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431648A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB0522789D0 (en) | 2005-11-08 | 2005-12-14 | Novartis Ag | Organic compounds |
| NZ577320A (en) * | 2006-11-07 | 2012-01-12 | Novartis Ag | CRYSTALLINE FORMS OF ALISKIREN HEMIFUMARATE N-(3-amino-2,2-dimethyl-3-oxopropyl)-2,7-di(1-methylethyl)-4-hydroxy-5-amino-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide |
| DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
| BR112012003255B1 (pt) * | 2009-08-11 | 2018-10-23 | Novartis Ag | processo de abertura de anel de lactonas e lactamas |
| US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
| CN101774986B (zh) * | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
| CN102329244A (zh) * | 2010-07-13 | 2012-01-25 | 凯瑞斯德生化(苏州)有限公司 | 一种rs-托特罗定的制备方法及中间体化合物 |
| CN102372653A (zh) * | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 二苯甲醇类衍生物、其制备方法及其在医药上的应用 |
| EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| ITMI20120354A1 (it) * | 2012-03-07 | 2013-09-08 | Friulchem Spa | Processo per la produzione di aliskirene |
| CN103044273B (zh) * | 2012-11-29 | 2014-12-24 | 珠海保税区丽珠合成制药有限公司 | 一种酒石酸托特罗定的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL88619A0 (en) * | 1987-12-15 | 1989-07-31 | Pfizer | Non-peptidic renin inhibitors |
| DE3837197A1 (de) | 1988-11-02 | 1990-05-03 | Continental Ag | Vorrichtung zum aufbereiten von unvulkanisiertem kautschuk |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| GB9523493D0 (en) * | 1995-11-16 | 1996-01-17 | British Biotech Pharm | Preparation of allyl succinate derivatives and starting materials therefore |
| AU7376301A (en) | 2000-07-05 | 2002-01-14 | Speedel Pharma Ag | Process for the preparation of substituted octanoyl amides |
| JP4853888B2 (ja) * | 2000-07-25 | 2012-01-11 | ノバルティス ファーマ アーゲー | 置換オクタノイルアミドの調製方法 |
| ES2274847T3 (es) * | 2000-12-14 | 2007-06-01 | Speedel Pharma Ag | Proceso para preparar ariloctanoil-amidas. |
| US20060154926A1 (en) * | 2002-06-11 | 2006-07-13 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
-
2004
- 2004-08-31 GB GBGB0419361.1A patent/GB0419361D0/en not_active Ceased
-
2005
- 2005-08-30 KR KR1020077004734A patent/KR20070045300A/ko not_active Abandoned
- 2005-08-30 EP EP05775930A patent/EP1789377B1/en not_active Expired - Lifetime
- 2005-08-30 AU AU2005279351A patent/AU2005279351B2/en not_active Ceased
- 2005-08-30 EP EP08158568A patent/EP1978012A1/en not_active Withdrawn
- 2005-08-30 ES ES05775930T patent/ES2354986T3/es not_active Expired - Lifetime
- 2005-08-30 PT PT05775930T patent/PT1789377E/pt unknown
- 2005-08-30 JP JP2007528770A patent/JP2008511573A/ja active Pending
- 2005-08-30 WO PCT/EP2005/009347 patent/WO2006024501A1/en not_active Ceased
- 2005-08-30 CN CN2005800292634A patent/CN101010281B/zh not_active Expired - Fee Related
- 2005-08-30 DE DE602005024282T patent/DE602005024282D1/de not_active Expired - Lifetime
- 2005-08-30 BR BRPI0514742-5A patent/BRPI0514742A/pt not_active IP Right Cessation
- 2005-08-30 MX MX2007002419A patent/MX2007002419A/es active IP Right Grant
- 2005-08-30 US US11/573,790 patent/US7910774B2/en not_active Expired - Fee Related
- 2005-08-30 AT AT05775930T patent/ATE485257T1/de active
- 2005-08-30 PL PL05775930T patent/PL1789377T3/pl unknown
- 2005-08-30 RU RU2007111752/04A patent/RU2411230C2/ru not_active IP Right Cessation
- 2005-08-30 CN CN2011103045513A patent/CN102417464A/zh active Pending
- 2005-08-30 CA CA2576749A patent/CA2576749C/en not_active Expired - Fee Related
-
2011
- 2011-02-07 US US13/022,243 patent/US8143416B2/en not_active Expired - Fee Related
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