GB0419361D0 - Organic compounds - Google Patents

Organic compounds

Info

Publication number
GB0419361D0
GB0419361D0 GBGB0419361.1A GB0419361A GB0419361D0 GB 0419361 D0 GB0419361 D0 GB 0419361D0 GB 0419361 A GB0419361 A GB 0419361A GB 0419361 D0 GB0419361 D0 GB 0419361D0
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxy
organic compounds
halogen
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0419361.1A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Priority to GBGB0419361.1A priority Critical patent/GB0419361D0/en
Publication of GB0419361D0 publication Critical patent/GB0419361D0/en
Priority to PT05775930T priority patent/PT1789377E/pt
Priority to MX2007002419A priority patent/MX2007002419A/es
Priority to AU2005279351A priority patent/AU2005279351B2/en
Priority to CA2576749A priority patent/CA2576749C/en
Priority to KR1020077004734A priority patent/KR20070045300A/ko
Priority to PL05775930T priority patent/PL1789377T3/pl
Priority to EP05775930A priority patent/EP1789377B1/en
Priority to RU2007111752/04A priority patent/RU2411230C2/ru
Priority to JP2007528770A priority patent/JP2008511573A/ja
Priority to PCT/EP2005/009347 priority patent/WO2006024501A1/en
Priority to BRPI0514742-5A priority patent/BRPI0514742A/pt
Priority to AT05775930T priority patent/ATE485257T1/de
Priority to EP08158568A priority patent/EP1978012A1/en
Priority to DE602005024282T priority patent/DE602005024282D1/de
Priority to CN2005800292634A priority patent/CN101010281B/zh
Priority to ES05775930T priority patent/ES2354986T3/es
Priority to CN2011103045513A priority patent/CN102417464A/zh
Priority to US11/573,790 priority patent/US7910774B2/en
Priority to US13/022,243 priority patent/US8143416B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GBGB0419361.1A 2004-08-31 2004-08-31 Organic compounds Ceased GB0419361D0 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GBGB0419361.1A GB0419361D0 (en) 2004-08-31 2004-08-31 Organic compounds
US11/573,790 US7910774B2 (en) 2004-08-31 2005-08-30 Alternative synthesis of renin inhibitors and intermediates thereof
RU2007111752/04A RU2411230C2 (ru) 2004-08-31 2005-08-30 Альтернативные способы синтеза ингибиторов ренина и их промежуточных соединений
PCT/EP2005/009347 WO2006024501A1 (en) 2004-08-31 2005-08-30 Alternative synthesis of renin inhibitors and intermediates thereof
AU2005279351A AU2005279351B2 (en) 2004-08-31 2005-08-30 Alternative synthesis of renin inhibitors and intermediates thereof
CA2576749A CA2576749C (en) 2004-08-31 2005-08-30 Alternative synthesis of renin inhibitors and intermediates thereof
KR1020077004734A KR20070045300A (ko) 2004-08-31 2005-08-30 레닌 억제제의 대안적 합성 및 그의 중간체
PL05775930T PL1789377T3 (pl) 2004-08-31 2005-08-30 Alternatywny sposób otrzymywania inhibitorów reniny i ich związków pośrednich
EP05775930A EP1789377B1 (en) 2004-08-31 2005-08-30 Alternative synthesis of renin inhibitors and intermediates thereof
PT05775930T PT1789377E (pt) 2004-08-31 2005-08-30 Síntese alternativa de inibidores de renina e seus intermediários
JP2007528770A JP2008511573A (ja) 2004-08-31 2005-08-30 レニン阻害剤およびその中間体の代替的製造法
MX2007002419A MX2007002419A (es) 2004-08-31 2005-08-30 Sintesis alternativa de inhibidores de renina e intermediarios de los mismos.
BRPI0514742-5A BRPI0514742A (pt) 2004-08-31 2005-08-30 sintese alternativa de inibidores de renina e intermediários destes
AT05775930T ATE485257T1 (de) 2004-08-31 2005-08-30 Alternative synthese von renin-inhibitoren und zwischenprodukte davon
EP08158568A EP1978012A1 (en) 2004-08-31 2005-08-30 Alternative synthesis of renin inhibitors and intermediates thereof
DE602005024282T DE602005024282D1 (de) 2004-08-31 2005-08-30 Alternative synthese von renin-inhibitoren und zwischenprodukte davon
CN2005800292634A CN101010281B (zh) 2004-08-31 2005-08-30 肾素抑制剂的替代合成方法及其中间体
ES05775930T ES2354986T3 (es) 2004-08-31 2005-08-30 Síntesis alternativa de inhibiodores de renina e intermedios de los mismos.
CN2011103045513A CN102417464A (zh) 2004-08-31 2005-08-30 肾素抑制剂的替代合成方法及其中间体
US13/022,243 US8143416B2 (en) 2004-08-31 2011-02-07 Alternative synthesis of renin inhibitors and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0419361.1A GB0419361D0 (en) 2004-08-31 2004-08-31 Organic compounds

Publications (1)

Publication Number Publication Date
GB0419361D0 true GB0419361D0 (en) 2004-10-06

Family

ID=33155811

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0419361.1A Ceased GB0419361D0 (en) 2004-08-31 2004-08-31 Organic compounds

Country Status (17)

Country Link
US (2) US7910774B2 (https=)
EP (2) EP1789377B1 (https=)
JP (1) JP2008511573A (https=)
KR (1) KR20070045300A (https=)
CN (2) CN101010281B (https=)
AT (1) ATE485257T1 (https=)
AU (1) AU2005279351B2 (https=)
BR (1) BRPI0514742A (https=)
CA (1) CA2576749C (https=)
DE (1) DE602005024282D1 (https=)
ES (1) ES2354986T3 (https=)
GB (1) GB0419361D0 (https=)
MX (1) MX2007002419A (https=)
PL (1) PL1789377T3 (https=)
PT (1) PT1789377E (https=)
RU (1) RU2411230C2 (https=)
WO (1) WO2006024501A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0511686D0 (en) 2005-06-08 2005-07-13 Novartis Ag Organic compounds
GB0519764D0 (en) 2005-09-28 2005-11-09 Novartis Ag Organic compounds
GB0521083D0 (en) * 2005-10-17 2005-11-23 Novartis Ag Organic compounds
GB2431649A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431646A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431653A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431651A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431642A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431648A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB0522789D0 (en) 2005-11-08 2005-12-14 Novartis Ag Organic compounds
NZ577320A (en) * 2006-11-07 2012-01-12 Novartis Ag CRYSTALLINE FORMS OF ALISKIREN HEMIFUMARATE N-(3-amino-2,2-dimethyl-3-oxopropyl)-2,7-di(1-methylethyl)-4-hydroxy-5-amino-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
SI2189442T1 (sl) 2008-11-20 2015-03-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek in intermediati za pripravo aliskirena
BR112012003255B1 (pt) * 2009-08-11 2018-10-23 Novartis Ag processo de abertura de anel de lactonas e lactamas
US8203005B2 (en) 2009-10-29 2012-06-19 Carbo Design Llc Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren
CN101774986B (zh) * 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 一种制备阿利克伦及其中间体的方法
CN102329244A (zh) * 2010-07-13 2012-01-25 凯瑞斯德生化(苏州)有限公司 一种rs-托特罗定的制备方法及中间体化合物
CN102372653A (zh) * 2010-08-10 2012-03-14 江苏恒瑞医药股份有限公司 二苯甲醇类衍生物、其制备方法及其在医药上的应用
EP2551260A1 (en) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemical process for opening ring compounds
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
ITMI20120354A1 (it) * 2012-03-07 2013-09-08 Friulchem Spa Processo per la produzione di aliskirene
CN103044273B (zh) * 2012-11-29 2014-12-24 珠海保税区丽珠合成制药有限公司 一种酒石酸托特罗定的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL88619A0 (en) * 1987-12-15 1989-07-31 Pfizer Non-peptidic renin inhibitors
DE3837197A1 (de) 1988-11-02 1990-05-03 Continental Ag Vorrichtung zum aufbereiten von unvulkanisiertem kautschuk
MY119161A (en) 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
GB9523493D0 (en) * 1995-11-16 1996-01-17 British Biotech Pharm Preparation of allyl succinate derivatives and starting materials therefore
AU7376301A (en) 2000-07-05 2002-01-14 Speedel Pharma Ag Process for the preparation of substituted octanoyl amides
JP4853888B2 (ja) * 2000-07-25 2012-01-11 ノバルティス ファーマ アーゲー 置換オクタノイルアミドの調製方法
ES2274847T3 (es) * 2000-12-14 2007-06-01 Speedel Pharma Ag Proceso para preparar ariloctanoil-amidas.
US20060154926A1 (en) * 2002-06-11 2006-07-13 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides

Also Published As

Publication number Publication date
JP2008511573A (ja) 2008-04-17
BRPI0514742A (pt) 2008-06-24
KR20070045300A (ko) 2007-05-02
CA2576749A1 (en) 2006-03-09
DE602005024282D1 (de) 2010-12-02
EP1789377B1 (en) 2010-10-20
ATE485257T1 (de) 2010-11-15
WO2006024501A1 (en) 2006-03-09
US7910774B2 (en) 2011-03-22
CN102417464A (zh) 2012-04-18
PT1789377E (pt) 2011-01-25
AU2005279351A1 (en) 2006-03-09
US20110137044A1 (en) 2011-06-09
ES2354986T3 (es) 2011-03-21
CA2576749C (en) 2012-10-16
US8143416B2 (en) 2012-03-27
EP1978012A1 (en) 2008-10-08
CN101010281A (zh) 2007-08-01
RU2411230C2 (ru) 2011-02-10
AU2005279351B2 (en) 2009-04-23
US20070208055A1 (en) 2007-09-06
RU2007111752A (ru) 2008-10-10
CN101010281B (zh) 2011-12-21
MX2007002419A (es) 2007-04-23
PL1789377T3 (pl) 2011-04-29
EP1789377A1 (en) 2007-05-30

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)