JP2008510761A5 - - Google Patents
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- Publication number
- JP2008510761A5 JP2008510761A5 JP2007528733A JP2007528733A JP2008510761A5 JP 2008510761 A5 JP2008510761 A5 JP 2008510761A5 JP 2007528733 A JP2007528733 A JP 2007528733A JP 2007528733 A JP2007528733 A JP 2007528733A JP 2008510761 A5 JP2008510761 A5 JP 2008510761A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- ring
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 82
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000004432 carbon atom Chemical group C* 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 13
- 125000004430 oxygen atom Chemical group O* 0.000 claims 12
- 125000006239 protecting group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 125000002252 acyl group Chemical group 0.000 claims 7
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- -1 alkaline earth metal alkoxide Chemical group 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 230000002378 acidificating effect Effects 0.000 claims 4
- 239000002585 base Substances 0.000 claims 4
- 239000006227 byproduct Substances 0.000 claims 4
- 125000003262 carboxylic acid ester group Chemical class [H]C([H])([*:2])OC(=O)C([H])([H])[*:1] 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 4
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 101710098554 Lipase B Proteins 0.000 claims 3
- 241001661345 Moesziomyces antarcticus Species 0.000 claims 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 238000004821 distillation Methods 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012038 nucleophile Substances 0.000 claims 2
- 229910000102 alkali metal hydride Inorganic materials 0.000 claims 1
- 150000008046 alkali metal hydrides Chemical class 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 150000001342 alkaline earth metals Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004040736.3 | 2004-08-23 | ||
| DE102004040736A DE102004040736B4 (de) | 2004-08-23 | 2004-08-23 | Verfahren zur Herstellung von Diarylcycloalkylderivaten |
| PCT/EP2005/009095 WO2006021420A2 (de) | 2004-08-23 | 2005-08-23 | Verfahren zur herstellung von diarylcycloalkylderivaten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008510761A JP2008510761A (ja) | 2008-04-10 |
| JP2008510761A5 true JP2008510761A5 (enExample) | 2008-10-09 |
| JP4991543B2 JP4991543B2 (ja) | 2012-08-01 |
Family
ID=35745474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528733A Expired - Fee Related JP4991543B2 (ja) | 2004-08-23 | 2005-08-23 | ジアリールシクロアルキル誘導体の製造方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7803950B2 (enExample) |
| EP (1) | EP1786913B1 (enExample) |
| JP (1) | JP4991543B2 (enExample) |
| KR (1) | KR20070048741A (enExample) |
| CN (1) | CN101014714B (enExample) |
| AR (1) | AR053760A1 (enExample) |
| AT (1) | ATE520785T1 (enExample) |
| AU (1) | AU2005276642B2 (enExample) |
| BR (1) | BRPI0514000A (enExample) |
| CA (1) | CA2578342A1 (enExample) |
| CY (1) | CY1112080T1 (enExample) |
| DE (1) | DE102004040736B4 (enExample) |
| DK (1) | DK1786913T3 (enExample) |
| ES (1) | ES2371762T3 (enExample) |
| IL (1) | IL181339A0 (enExample) |
| MA (1) | MA28796B1 (enExample) |
| MX (1) | MX2007001872A (enExample) |
| NO (1) | NO20071316L (enExample) |
| NZ (1) | NZ553602A (enExample) |
| PL (1) | PL1786913T3 (enExample) |
| PT (1) | PT1786913E (enExample) |
| RU (1) | RU2414459C2 (enExample) |
| SI (1) | SI1786913T1 (enExample) |
| TW (1) | TW200621734A (enExample) |
| UY (1) | UY29082A1 (enExample) |
| WO (1) | WO2006021420A2 (enExample) |
| ZA (1) | ZA200700635B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050232972A1 (en) * | 2004-04-15 | 2005-10-20 | Steven Odrich | Drug delivery via punctal plug |
| CN101381302B (zh) * | 2007-09-07 | 2013-04-03 | 上海睿智化学研究有限公司 | 2-溴甲基-6-甲基苯甲酰氯/溴的制备方法 |
| TWI380812B (zh) * | 2008-01-25 | 2013-01-01 | Xenoport Inc | （３ｓ）-胺甲基-５-甲基己酸前藥之晶形及使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728899A (en) * | 1995-03-27 | 1998-03-17 | Hoechst Marion Roussel Inc. | Preparation of cis-4-O-protected-2-cyclopentenol derivatives |
| UA76773C2 (uk) * | 2001-08-31 | 2006-09-15 | Санофі-Авентіс Дойчланд Гмбх | Діарилциклоалкільні похідні, спосіб їх одержання і їх застосування як ppar-активаторів |
| US6884812B2 (en) * | 2001-08-31 | 2005-04-26 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals |
| WO2003072100A1 (en) * | 2002-02-25 | 2003-09-04 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| US7094795B2 (en) * | 2003-02-27 | 2006-08-22 | Sanofi-Aventis Deutschland Gmbh | Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives |
| DE10308353A1 (de) * | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308350B4 (de) * | 2003-02-27 | 2006-06-01 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten |
| US20080039635A1 (en) * | 2003-10-22 | 2008-02-14 | Rhodia-Chimie | Method for the Production of a Compound, Comprising a Free Hydroxyl Group and a Hydroxyl Group Which is Protected by an Ester Function by Enzymatic Reaction |
| DE102004038403B4 (de) * | 2004-08-07 | 2006-08-31 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten |
-
2004
- 2004-08-23 DE DE102004040736A patent/DE102004040736B4/de not_active Expired - Fee Related
-
2005
- 2005-08-22 TW TW094128546A patent/TW200621734A/zh unknown
- 2005-08-22 AR ARP050103522A patent/AR053760A1/es not_active Application Discontinuation
- 2005-08-23 ES ES05782434T patent/ES2371762T3/es not_active Expired - Lifetime
- 2005-08-23 PT PT05782434T patent/PT1786913E/pt unknown
- 2005-08-23 MX MX2007001872A patent/MX2007001872A/es active IP Right Grant
- 2005-08-23 RU RU2007110644/04A patent/RU2414459C2/ru not_active IP Right Cessation
- 2005-08-23 KR KR1020077004449A patent/KR20070048741A/ko not_active Ceased
- 2005-08-23 SI SI200531403T patent/SI1786913T1/sl unknown
- 2005-08-23 BR BRPI0514000-5A patent/BRPI0514000A/pt not_active IP Right Cessation
- 2005-08-23 JP JP2007528733A patent/JP4991543B2/ja not_active Expired - Fee Related
- 2005-08-23 WO PCT/EP2005/009095 patent/WO2006021420A2/de not_active Ceased
- 2005-08-23 DK DK05782434.4T patent/DK1786913T3/da active
- 2005-08-23 UY UY29082A patent/UY29082A1/es unknown
- 2005-08-23 CA CA002578342A patent/CA2578342A1/en not_active Abandoned
- 2005-08-23 AU AU2005276642A patent/AU2005276642B2/en not_active Ceased
- 2005-08-23 EP EP05782434A patent/EP1786913B1/de not_active Expired - Lifetime
- 2005-08-23 AT AT05782434T patent/ATE520785T1/de active
- 2005-08-23 NZ NZ553602A patent/NZ553602A/en not_active IP Right Cessation
- 2005-08-23 CN CN200580028364XA patent/CN101014714B/zh not_active Expired - Fee Related
- 2005-08-23 PL PL05782434T patent/PL1786913T3/pl unknown
-
2007
- 2007-01-23 ZA ZA200700635A patent/ZA200700635B/xx unknown
- 2007-02-08 MA MA29674A patent/MA28796B1/fr unknown
- 2007-02-14 IL IL181339A patent/IL181339A0/en unknown
- 2007-02-20 US US11/676,721 patent/US7803950B2/en not_active Expired - Fee Related
- 2007-03-12 NO NO20071316A patent/NO20071316L/no not_active Application Discontinuation
- 2007-10-31 US US11/930,244 patent/US20080051583A1/en not_active Abandoned
-
2011
- 2011-11-17 CY CY20111101110T patent/CY1112080T1/el unknown
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