RU2414459C2 - Способ получения диарилциклоалкилпроизводных - Google Patents

Способ получения диарилциклоалкилпроизводных Download PDF

Info

Publication number
RU2414459C2
RU2414459C2 RU2007110644/04A RU2007110644A RU2414459C2 RU 2414459 C2 RU2414459 C2 RU 2414459C2 RU 2007110644/04 A RU2007110644/04 A RU 2007110644/04A RU 2007110644 A RU2007110644 A RU 2007110644A RU 2414459 C2 RU2414459 C2 RU 2414459C2
Authority
RU
Russia
Prior art keywords
compound
formula
cis
alkyl
converted
Prior art date
Application number
RU2007110644/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2007110644A (ru
Inventor
Кристоф САЛАНЬЯ (DE)
Кристоф Саланья
Франк ЦОХЕР (DE)
Франк ЦОХЕР
Андреас БУРГАРД (DE)
Андреас БУРГАРД
Бернд ЮНКЕР (DE)
Бернд ЮНКЕР
Рольф ХЕРЛЯЙН (DE)
Рольф ХЕРЛЯЙН
Томас ШТЮДЕМАНН (DE)
Томас ШТЮДЕМАНН
Клаус-Юрген МАЙЕР (DE)
Клаус-Юрген МАЙЕР
Йохен ХАХТЕЛЬ (DE)
Йохен ХАХТЕЛЬ
Вольфганг ХОЛЛА (DE)
Вольфганг ХОЛЛА
Кристоф ТАППЕРТЦХОФЕН (DE)
Кристоф Таппертцхофен
Берндт КУЛИТЦШЕР (DE)
Берндт КУЛИТЦШЕР
Стефан МЮТТИ (FR)
Стефан Мютти
Original Assignee
Санофи-Авентис Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис Дойчланд Гмбх filed Critical Санофи-Авентис Дойчланд Гмбх
Publication of RU2007110644A publication Critical patent/RU2007110644A/ru
Application granted granted Critical
Publication of RU2414459C2 publication Critical patent/RU2414459C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2007110644/04A 2004-08-23 2005-08-23 Способ получения диарилциклоалкилпроизводных RU2414459C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004040736A DE102004040736B4 (de) 2004-08-23 2004-08-23 Verfahren zur Herstellung von Diarylcycloalkylderivaten
DE102004040736.3 2004-08-23

Publications (2)

Publication Number Publication Date
RU2007110644A RU2007110644A (ru) 2008-09-27
RU2414459C2 true RU2414459C2 (ru) 2011-03-20

Family

ID=35745474

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007110644/04A RU2414459C2 (ru) 2004-08-23 2005-08-23 Способ получения диарилциклоалкилпроизводных

Country Status (27)

Country Link
US (2) US7803950B2 (enExample)
EP (1) EP1786913B1 (enExample)
JP (1) JP4991543B2 (enExample)
KR (1) KR20070048741A (enExample)
CN (1) CN101014714B (enExample)
AR (1) AR053760A1 (enExample)
AT (1) ATE520785T1 (enExample)
AU (1) AU2005276642B2 (enExample)
BR (1) BRPI0514000A (enExample)
CA (1) CA2578342A1 (enExample)
CY (1) CY1112080T1 (enExample)
DE (1) DE102004040736B4 (enExample)
DK (1) DK1786913T3 (enExample)
ES (1) ES2371762T3 (enExample)
IL (1) IL181339A0 (enExample)
MA (1) MA28796B1 (enExample)
MX (1) MX2007001872A (enExample)
NO (1) NO20071316L (enExample)
NZ (1) NZ553602A (enExample)
PL (1) PL1786913T3 (enExample)
PT (1) PT1786913E (enExample)
RU (1) RU2414459C2 (enExample)
SI (1) SI1786913T1 (enExample)
TW (1) TW200621734A (enExample)
UY (1) UY29082A1 (enExample)
WO (1) WO2006021420A2 (enExample)
ZA (1) ZA200700635B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
CN101381302B (zh) * 2007-09-07 2013-04-03 上海睿智化学研究有限公司 2-溴甲基-6-甲基苯甲酰氯/溴的制备方法
ES2601852T3 (es) * 2008-01-25 2017-02-16 Xenoport, Inc. Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003020269A1 (de) * 2001-08-31 2003-03-13 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als ppar-aktivatoren

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728899A (en) * 1995-03-27 1998-03-17 Hoechst Marion Roussel Inc. Preparation of cis-4-O-protected-2-cyclopentenol derivatives
US6884812B2 (en) * 2001-08-31 2005-04-26 Aventis Pharma Deutschland Gmbh Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals
JP2005529077A (ja) * 2002-02-25 2005-09-29 イーライ・リリー・アンド・カンパニー ペルオキシソーム増殖因子活性化受容体調節物質
US7094795B2 (en) * 2003-02-27 2006-08-22 Sanofi-Aventis Deutschland Gmbh Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives
DE10308353A1 (de) * 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308350B4 (de) * 2003-02-27 2006-06-01 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten
EP1689874A1 (fr) * 2003-10-22 2006-08-16 Rhodia Chimie Procede de fabrication de compose comprenant un groupement hydroxyle libre et un groupement hydroxyle protege par une fonction ester par reaction enzymatique
DE102004038403B4 (de) * 2004-08-07 2006-08-31 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003020269A1 (de) * 2001-08-31 2003-03-13 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als ppar-aktivatoren

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nicolosi G. et al. "Desymmetrization of cis-1,2-Dihydroxycycloalkanes by Stereoselective Lipase Mediated Esterification" TETRAHEDRON: ASYMMETRY, 1995, Vol.6, №2, 519-524. *

Also Published As

Publication number Publication date
ATE520785T1 (de) 2011-09-15
BRPI0514000A (pt) 2008-05-20
WO2006021420B1 (de) 2007-02-08
DE102004040736B4 (de) 2007-01-11
WO2006021420A3 (de) 2006-12-21
PL1786913T3 (pl) 2012-01-31
RU2007110644A (ru) 2008-09-27
NO20071316L (no) 2007-05-22
PT1786913E (pt) 2011-10-31
WO2006021420A2 (de) 2006-03-02
NZ553602A (en) 2010-04-30
JP4991543B2 (ja) 2012-08-01
EP1786913A2 (de) 2007-05-23
EP1786913B1 (de) 2011-08-17
MX2007001872A (es) 2007-04-24
UY29082A1 (es) 2006-03-31
IL181339A0 (en) 2007-07-04
ES2371762T3 (es) 2012-01-09
US20080051583A1 (en) 2008-02-28
TW200621734A (en) 2006-07-01
CA2578342A1 (en) 2006-03-02
JP2008510761A (ja) 2008-04-10
DK1786913T3 (da) 2011-11-28
AR053760A1 (es) 2007-05-23
CN101014714A (zh) 2007-08-08
AU2005276642B2 (en) 2011-12-22
SI1786913T1 (sl) 2011-12-30
CN101014714B (zh) 2012-05-23
MA28796B1 (fr) 2007-08-01
US7803950B2 (en) 2010-09-28
DE102004040736A1 (de) 2006-03-02
CY1112080T1 (el) 2015-11-04
KR20070048741A (ko) 2007-05-09
US20070197614A1 (en) 2007-08-23
ZA200700635B (en) 2010-01-27
AU2005276642A1 (en) 2006-03-02

Similar Documents

Publication Publication Date Title
CZ329792A3 (en) Process for preparing optically pure (+)-r-2-phenoxypropionic acids esters
US20070197788A1 (en) Method for the preparation of enantiomer forms of cis-configured 3-hydroxycyclohexane carboxylic acid derivatives using hydrolases
CN103228640A (zh) 奈必洛尔的制备过程
JP3772095B2 (ja) ピラノン
RU2124506C1 (ru) Способ стереоизбирательного получения гетеробициклического спиртового энантиомера, существенно чистый спиртовой энантиомер, способ получения производного пиперазина
US7803950B2 (en) Method for the production of diarylcycloalkyl derivatives
WO2002070512A1 (en) Method for producing 2-azetidinone derivative
US5527916A (en) Pyranones
KR101399551B1 (ko) 광학적으로 활성인 사이클로펜텐온의 제조방법 및 그로부터제조된 사이클로펜텐온
JP2006519001A (ja) シス−１，３−シクロヘキサンジオール誘導体のエナンチオマー形の製造法
JPH06256278A (ja) 光学活性α−カルバモイルアルカン酸誘導体およびその製法
US7094795B2 (en) Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives
EP1283200A2 (en) Optically pure paroxetine precursors
HK1105999A (en) Method for the production of diarylcycloalkyl derivatives
JP4608938B2 (ja) 光学活性３−アルキル−３−アリールプロピオン酸及び光学活性３−アルキル−３−アリールプロピオン酸アルキルエステルの製造方法
JPWO2004092113A1 (ja) 光学活性２−アリルカルボン酸誘導体およびその製造法
HU213569B (en) Enzymatic process for the stereoselective preparation of a heterobicyclic alcohol enantiomer
JPWO1992014835A1 (ja) 光学活性３―クロロ―１―フェニル―１―プロパノール及びその誘導体の製造方法
HK1104579A (en) Method for producing the enantiomer forms of cis-configured 3-hydroxycyclohexane carboxylic acid derivatives using hydrolases
JPWO2008072764A1 (ja) 光学活性（ｒ又はｓ）−ピペリジン−３−カルボン酸化合物及び光学活性（ｓ又はｒ）−ピペリジン−３−カルボン酸アルキルエステル化合物の製造方法
JP2010207248A (ja) 光学活性３−アルキル−３−アリールプロピオン酸及び光学活性３−アルキル−３−アリールプロピオン酸アルキルエステルの製造方法
HK1088889B (en) Method for producing the enantiomeric forms of cis 1,3-cyclohexanediol derivatives

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20130824