CN101014714B - 产生二芳基环烷基衍生物的方法 - Google Patents

产生二芳基环烷基衍生物的方法 Download PDF

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Publication number
CN101014714B
CN101014714B CN200580028364XA CN200580028364A CN101014714B CN 101014714 B CN101014714 B CN 101014714B CN 200580028364X A CN200580028364X A CN 200580028364XA CN 200580028364 A CN200580028364 A CN 200580028364A CN 101014714 B CN101014714 B CN 101014714B
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China
Prior art keywords
compound
alkyl
formula
cis
ring
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Expired - Fee Related
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CN200580028364XA
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English (en)
Chinese (zh)
Other versions
CN101014714A (zh
Inventor
C·萨拉尼亚
F·祖彻尔
A·伯伽德
B·容克尔
R·霍尔莱因
T·斯图德曼
C-J·迈尔
J·哈赫特尔
W·霍拉
C·塔佩尔佐芬
B·库里兹舍尔
S·穆蒂
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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Publication of CN101014714A publication Critical patent/CN101014714A/zh
Application granted granted Critical
Publication of CN101014714B publication Critical patent/CN101014714B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200580028364XA 2004-08-23 2005-08-23 产生二芳基环烷基衍生物的方法 Expired - Fee Related CN101014714B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004040736A DE102004040736B4 (de) 2004-08-23 2004-08-23 Verfahren zur Herstellung von Diarylcycloalkylderivaten
DE102004040736.3 2004-08-23
PCT/EP2005/009095 WO2006021420A2 (de) 2004-08-23 2005-08-23 Verfahren zur herstellung von diarylcycloalkylderivaten

Publications (2)

Publication Number Publication Date
CN101014714A CN101014714A (zh) 2007-08-08
CN101014714B true CN101014714B (zh) 2012-05-23

Family

ID=35745474

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CN200580028364XA Expired - Fee Related CN101014714B (zh) 2004-08-23 2005-08-23 产生二芳基环烷基衍生物的方法

Country Status (27)

Country Link
US (2) US7803950B2 (enExample)
EP (1) EP1786913B1 (enExample)
JP (1) JP4991543B2 (enExample)
KR (1) KR20070048741A (enExample)
CN (1) CN101014714B (enExample)
AR (1) AR053760A1 (enExample)
AT (1) ATE520785T1 (enExample)
AU (1) AU2005276642B2 (enExample)
BR (1) BRPI0514000A (enExample)
CA (1) CA2578342A1 (enExample)
CY (1) CY1112080T1 (enExample)
DE (1) DE102004040736B4 (enExample)
DK (1) DK1786913T3 (enExample)
ES (1) ES2371762T3 (enExample)
IL (1) IL181339A0 (enExample)
MA (1) MA28796B1 (enExample)
MX (1) MX2007001872A (enExample)
NO (1) NO20071316L (enExample)
NZ (1) NZ553602A (enExample)
PL (1) PL1786913T3 (enExample)
PT (1) PT1786913E (enExample)
RU (1) RU2414459C2 (enExample)
SI (1) SI1786913T1 (enExample)
TW (1) TW200621734A (enExample)
UY (1) UY29082A1 (enExample)
WO (1) WO2006021420A2 (enExample)
ZA (1) ZA200700635B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
CN101381302B (zh) * 2007-09-07 2013-04-03 上海睿智化学研究有限公司 2-溴甲基-6-甲基苯甲酰氯/溴的制备方法
ES2601852T3 (es) * 2008-01-25 2017-02-16 Xenoport, Inc. Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728899A (en) * 1995-03-27 1998-03-17 Hoechst Marion Roussel Inc. Preparation of cis-4-O-protected-2-cyclopentenol derivatives
US6884812B2 (en) * 2001-08-31 2005-04-26 Aventis Pharma Deutschland Gmbh Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals
AU2002333456B2 (en) * 2001-08-31 2008-07-17 Sanofi-Aventis Deutschland Gmbh Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as PPAR activators
JP2005529077A (ja) * 2002-02-25 2005-09-29 イーライ・リリー・アンド・カンパニー ペルオキシソーム増殖因子活性化受容体調節物質
US7094795B2 (en) * 2003-02-27 2006-08-22 Sanofi-Aventis Deutschland Gmbh Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives
DE10308353A1 (de) * 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308350B4 (de) * 2003-02-27 2006-06-01 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten
EP1689874A1 (fr) * 2003-10-22 2006-08-16 Rhodia Chimie Procede de fabrication de compose comprenant un groupement hydroxyle libre et un groupement hydroxyle protege par une fonction ester par reaction enzymatique
DE102004038403B4 (de) * 2004-08-07 2006-08-31 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BANNARD, ROBERT A. B. ET AL:.Utility of the dehalogenation-deetherification sequence for the proof of structure of methoxyhalocyclohexanols and methoxyhalocyclopentanols. Synthesis of the cis- and trans-2 and 3-methoxycyclohexanols and-cyclopentanols.<CANADIAN JOURNAL OF CHEMISTRY >.1967,第45卷(第21期),2605-2611. *
HARADA T ET AL.Enantiodifferentiating functionalization of cis-cycloalkane-1,2-diols and cis-endo-5-norbornen-2,3-ylenebis(methanol ) via chiral spiroacetals derived from 1-menthone.<JOURNAL OF ORGANIC CHEMISTRY>.1989,第54卷(第11期),2599-2605. *

Also Published As

Publication number Publication date
ATE520785T1 (de) 2011-09-15
BRPI0514000A (pt) 2008-05-20
WO2006021420B1 (de) 2007-02-08
DE102004040736B4 (de) 2007-01-11
WO2006021420A3 (de) 2006-12-21
PL1786913T3 (pl) 2012-01-31
RU2007110644A (ru) 2008-09-27
NO20071316L (no) 2007-05-22
PT1786913E (pt) 2011-10-31
WO2006021420A2 (de) 2006-03-02
NZ553602A (en) 2010-04-30
JP4991543B2 (ja) 2012-08-01
EP1786913A2 (de) 2007-05-23
EP1786913B1 (de) 2011-08-17
MX2007001872A (es) 2007-04-24
UY29082A1 (es) 2006-03-31
IL181339A0 (en) 2007-07-04
ES2371762T3 (es) 2012-01-09
US20080051583A1 (en) 2008-02-28
TW200621734A (en) 2006-07-01
CA2578342A1 (en) 2006-03-02
JP2008510761A (ja) 2008-04-10
DK1786913T3 (da) 2011-11-28
AR053760A1 (es) 2007-05-23
CN101014714A (zh) 2007-08-08
AU2005276642B2 (en) 2011-12-22
SI1786913T1 (sl) 2011-12-30
MA28796B1 (fr) 2007-08-01
US7803950B2 (en) 2010-09-28
DE102004040736A1 (de) 2006-03-02
CY1112080T1 (el) 2015-11-04
RU2414459C2 (ru) 2011-03-20
KR20070048741A (ko) 2007-05-09
US20070197614A1 (en) 2007-08-23
ZA200700635B (en) 2010-01-27
AU2005276642A1 (en) 2006-03-02

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