JP2008510714A5 - - Google Patents
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- Publication number
- JP2008510714A5 JP2008510714A5 JP2007528011A JP2007528011A JP2008510714A5 JP 2008510714 A5 JP2008510714 A5 JP 2008510714A5 JP 2007528011 A JP2007528011 A JP 2007528011A JP 2007528011 A JP2007528011 A JP 2007528011A JP 2008510714 A5 JP2008510714 A5 JP 2008510714A5
- Authority
- JP
- Japan
- Prior art keywords
- vla
- composition
- binding antibody
- administered
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 24
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 22
- 201000006417 multiple sclerosis Diseases 0.000 claims 6
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 2
- 229960005027 natalizumab Drugs 0.000 claims 2
- 108010041012 Integrin alpha4 Proteins 0.000 claims 1
- 206010067063 Progressive relapsing multiple sclerosis Diseases 0.000 claims 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 238000009175 antibody therapy Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60347004P | 2004-08-20 | 2004-08-20 | |
| US60346804P | 2004-08-20 | 2004-08-20 | |
| US60349504P | 2004-08-20 | 2004-08-20 | |
| US61602304P | 2004-10-05 | 2004-10-05 | |
| PCT/US2005/029407 WO2006023651A2 (en) | 2004-08-20 | 2005-08-18 | Extended treatment of multiple sclerosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011253859A Division JP2012036225A (ja) | 2004-08-20 | 2011-11-21 | 多発性硬化症の長期処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008510714A JP2008510714A (ja) | 2008-04-10 |
| JP2008510714A5 true JP2008510714A5 (enExample) | 2008-08-21 |
Family
ID=35968170
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528011A Withdrawn JP2008510714A (ja) | 2004-08-20 | 2005-08-18 | 多発性硬化症の長期処置 |
| JP2011253859A Withdrawn JP2012036225A (ja) | 2004-08-20 | 2011-11-21 | 多発性硬化症の長期処置 |
| JP2012001065A Pending JP2012067139A (ja) | 2004-08-20 | 2012-01-06 | 多発性硬化症の長期処置 |
| JP2014252699A Pending JP2015052022A (ja) | 2004-08-20 | 2014-12-15 | 多発性硬化症の長期処置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011253859A Withdrawn JP2012036225A (ja) | 2004-08-20 | 2011-11-21 | 多発性硬化症の長期処置 |
| JP2012001065A Pending JP2012067139A (ja) | 2004-08-20 | 2012-01-06 | 多発性硬化症の長期処置 |
| JP2014252699A Pending JP2015052022A (ja) | 2004-08-20 | 2014-12-15 | 多発性硬化症の長期処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20090010926A1 (enExample) |
| EP (2) | EP1789086A4 (enExample) |
| JP (4) | JP2008510714A (enExample) |
| AU (1) | AU2005277343B2 (enExample) |
| CA (2) | CA2478458A1 (enExample) |
| WO (4) | WO2006023649A2 (enExample) |
Families Citing this family (38)
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| NZ581497A (en) * | 2004-12-03 | 2012-07-27 | Biogen Idec Inc | Delaying or preventing onset of multiple sclerosis by vla-4 ginding antibody |
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| AU2008266051B2 (en) | 2007-06-14 | 2014-07-31 | Biogen Ma Inc. | Antibody formulations |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| RS63744B1 (sr) | 2010-01-11 | 2022-12-30 | Biogen Ma Inc | Test za antitela protiv jc virusa |
| PT2558499T (pt) | 2010-04-16 | 2017-07-14 | Biogen Ma Inc | Anticorpos anti-vla-4 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| CN103732062A (zh) * | 2011-05-26 | 2014-04-16 | 比奥根艾迪克Ma公司 | 治疗多发性硬化以及保持和/或增加髓磷脂含量的方法 |
| ES2729945T3 (es) | 2011-05-31 | 2019-11-07 | Biogen Ma Inc | Procedimiento para valorar el riesgo de LMP |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| JP5711167B2 (ja) | 2012-02-22 | 2015-04-30 | 三ツ星ベルト株式会社 | アラミド心線及び伝動ベルト |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| JO3529B1 (ar) * | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| HK1216546A1 (zh) | 2013-05-28 | 2016-11-18 | Biogen Ma Inc. | 评估pml风险的方法 |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| EP3501510B1 (en) | 2014-02-28 | 2020-07-01 | Banner Life Sciences LLC | Controlled release enteric soft capsules of fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| MA41785A (fr) | 2015-03-20 | 2018-01-23 | Biogen Ma Inc | Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HRP20250396T1 (hr) | 2016-08-31 | 2025-05-23 | Mapi Pharma Ltd. | Depo sustavi koji sadrže glatiramer acetat |
| AU2018242998B2 (en) | 2017-03-26 | 2023-11-02 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
| US12037398B2 (en) | 2018-06-04 | 2024-07-16 | Biogen Ma Inc. | Anti-VLA-4 antibodies having reduced effector function |
| WO2021142062A1 (en) | 2020-01-10 | 2021-07-15 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
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| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4475196A (en) * | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
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-
2004
- 2004-08-23 CA CA002478458A patent/CA2478458A1/en not_active Abandoned
-
2005
- 2005-08-18 WO PCT/US2005/029403 patent/WO2006023649A2/en not_active Ceased
- 2005-08-18 WO PCT/US2005/029407 patent/WO2006023651A2/en not_active Ceased
- 2005-08-18 EP EP05804218A patent/EP1789086A4/en not_active Ceased
- 2005-08-18 JP JP2007528011A patent/JP2008510714A/ja not_active Withdrawn
- 2005-08-18 EP EP14165153.9A patent/EP2783701A3/en not_active Withdrawn
- 2005-08-18 US US11/573,823 patent/US20090010926A1/en not_active Abandoned
- 2005-08-18 US US11/573,817 patent/US20080260728A1/en not_active Abandoned
- 2005-08-18 WO PCT/US2005/029368 patent/WO2006023629A2/en not_active Ceased
- 2005-08-18 AU AU2005277343A patent/AU2005277343B2/en not_active Expired
- 2005-08-18 WO PCT/US2005/029569 patent/WO2006036371A2/en not_active Ceased
- 2005-08-18 CA CA002577188A patent/CA2577188A1/en not_active Abandoned
-
2011
- 2011-11-21 JP JP2011253859A patent/JP2012036225A/ja not_active Withdrawn
-
2012
- 2012-01-06 JP JP2012001065A patent/JP2012067139A/ja active Pending
- 2012-07-05 US US13/542,407 patent/US20120276048A1/en not_active Abandoned
-
2014
- 2014-08-08 US US14/455,301 patent/US20150030590A1/en not_active Abandoned
- 2014-12-05 US US14/561,503 patent/US20150175703A1/en not_active Abandoned
- 2014-12-15 JP JP2014252699A patent/JP2015052022A/ja active Pending