JP2008509227A5 - - Google Patents
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- Publication number
- JP2008509227A5 JP2008509227A5 JP2007527770A JP2007527770A JP2008509227A5 JP 2008509227 A5 JP2008509227 A5 JP 2008509227A5 JP 2007527770 A JP2007527770 A JP 2007527770A JP 2007527770 A JP2007527770 A JP 2007527770A JP 2008509227 A5 JP2008509227 A5 JP 2008509227A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- composition
- inflammatory
- composition according
- arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 16
- 102000013691 Interleukin-17 Human genes 0.000 claims 12
- 108050003558 Interleukin-17 Proteins 0.000 claims 12
- 208000027866 inflammatory disease Diseases 0.000 claims 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 206010040070 Septic Shock Diseases 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 208000037487 Endotoxemia Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 206010044248 Toxic shock syndrome Diseases 0.000 claims 2
- 231100000650 Toxic shock syndrome Toxicity 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 201000001178 Bacterial Pneumonia Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010013554 Diverticulum Diseases 0.000 claims 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000011200 Kawasaki disease Diseases 0.000 claims 1
- 206010023335 Keratitis interstitial Diseases 0.000 claims 1
- 208000034486 Multi-organ failure Diseases 0.000 claims 1
- 208000010718 Multiple Organ Failure Diseases 0.000 claims 1
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010000269 abscess Diseases 0.000 claims 1
- 230000010085 airway hyperresponsiveness Effects 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 210000002421 cell wall Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000007565 gingivitis Diseases 0.000 claims 1
- 208000024557 hepatobiliary disease Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000006904 interstitial keratitis Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57880504P | 2004-06-10 | 2004-06-10 | |
| US60/578,805 | 2004-06-10 | ||
| PCT/US2005/020521 WO2005123778A2 (en) | 2004-06-10 | 2005-06-10 | Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509227A JP2008509227A (ja) | 2008-03-27 |
| JP2008509227A5 true JP2008509227A5 (enExample) | 2008-07-31 |
| JP4903703B2 JP4903703B2 (ja) | 2012-03-28 |
Family
ID=35407029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527770A Expired - Fee Related JP4903703B2 (ja) | 2004-06-10 | 2005-06-10 | 可溶性ＺｃｙｔｏＲ１４、抗ＺｃｙｔｏＲ１４抗体および結合相手ならびに炎症における使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7910540B2 (enExample) |
| EP (1) | EP1765865A2 (enExample) |
| JP (1) | JP4903703B2 (enExample) |
| CN (1) | CN101001871A (enExample) |
| AU (1) | AU2005254998B2 (enExample) |
| BR (1) | BRPI0511952A (enExample) |
| CA (1) | CA2569867A1 (enExample) |
| IL (2) | IL179356A (enExample) |
| MX (1) | MXPA06014465A (enExample) |
| NO (1) | NO20070153L (enExample) |
| WO (1) | WO2005123778A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| US7324615B2 (en) * | 2003-12-15 | 2008-01-29 | Microchip Technology Incorporated | Time signal receiver and decoder |
| EP1765865A2 (en) * | 2004-06-10 | 2007-03-28 | ZymoGenetics, Inc. | Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation |
| CN101218254A (zh) * | 2005-02-14 | 2008-07-09 | 惠氏公司 | 白介素-17f抗体及其它il-17f信号传递拮抗剂和它们的用途 |
| WO2006088925A2 (en) | 2005-02-14 | 2006-08-24 | Wyeth | Use of il17-f in diagnosis and therapy of airway inflammation |
| BRPI0616589A2 (pt) | 2005-09-28 | 2011-06-28 | Zymogenetics Inc | polipeptìdeo, e, métodos para produzir um anticorpo para um polipeptìdeo, para reduzir ou inibir a inflamação e para tratar um mamìfero afligido com uma doença inflamatória |
| WO2007117762A1 (en) * | 2006-02-10 | 2007-10-18 | Zymogenetics, Inc. | Truncated il-17ra soluble receptor and methods of using in inflammation |
| WO2008039553A1 (en) * | 2006-02-10 | 2008-04-03 | Zymogenetics, Inc. | Soluble il-17rcx4 and methods of using in inflammation |
| JP2009534297A (ja) * | 2006-03-10 | 2009-09-24 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−１７ａおよびｉｌ−１７ｆの両方に結合する抗体ならびにその使用方法 |
| US7790163B2 (en) | 2006-03-10 | 2010-09-07 | Zymogenetics, Inc. | Antibodies that bind both IL-17A and IL-17F and methods of using the same |
| EP2004231A4 (en) | 2006-04-07 | 2013-07-10 | Nektar Therapeutics | CONJUGATES OF ANTI-TNF-ALPHA ANTIBODY |
| GB0620729D0 (en) * | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
| FR2908999B1 (fr) * | 2006-11-29 | 2012-04-27 | Biomerieux Sa | Nouveau medicament destine a l'inhibition, la prevention ou le traitement de la polyarthrite rhumatoide. |
| CA2679588A1 (en) | 2007-03-26 | 2008-10-02 | Zymogenetics, Inc. | Soluble il-17ra/rc fusion proteins and related methods |
| TW200902064A (en) * | 2007-03-28 | 2009-01-16 | Wyeth Corp | Methods and compositions for modulating IL-17F/IL-17A biological activity |
| US8460647B2 (en) * | 2007-04-20 | 2013-06-11 | Amgen Inc. | Pre-ligand assembly domain of the IL-17 receptor |
| AU2007352412B2 (en) * | 2007-04-27 | 2013-05-16 | Zymogenetics, Inc. | Antibodies that bind both IL-17A and IL-17F and methods of using the same |
| EP2170958A1 (en) * | 2007-06-13 | 2010-04-07 | Amgen Inc. | Il-17 heteromeric receptor complex |
| BRPI0813262A2 (pt) * | 2007-06-20 | 2015-04-14 | Schering Corp | Biomarcadores de destruição de articulação para terapia de doença inflamatória de articulação anti-il-17a |
| EP2182943B1 (en) * | 2007-07-23 | 2016-10-26 | Janssen Biotech, Inc. | Methods and compositions for treating fibrosis related disorders using il-17 antagonists |
| WO2009026412A1 (en) * | 2007-08-21 | 2009-02-26 | Children's Medical Center Corporation | Treatment of airway hyperreactivity |
| EP2203476B1 (en) | 2007-09-25 | 2016-10-26 | Genzyme Corporation | Compositions and methods for inhibiting interleukin pathways |
| CA2711696C (en) | 2008-01-09 | 2021-10-26 | Reza Dana | Therapeutic compositions for treatment of ocular inflammatory disorders |
| BRPI0908312A2 (pt) * | 2008-05-05 | 2015-08-18 | Novimmune Sa | '' anticorpo monoclonal totalmente humano isolado, composição farmacêutica, método de alívio de um sintoma de uma indicação clínica e método de alívio de um sintoma de uma doença autoimune, distúrbio inflamatório ou distúrbio da proliferação celular'' |
| US20130011413A1 (en) * | 2010-02-03 | 2013-01-10 | The University Of Tokyo | Method and Pharmaceutical Composition for Treatment of Intestinal Disease |
| CN102188707B (zh) * | 2011-02-25 | 2015-08-05 | 中国医学科学院基础医学研究所 | Il-17抑制剂在制备治疗流感的药物中的用途 |
| EP2809660B1 (en) | 2012-02-02 | 2016-01-20 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
| AR091116A1 (es) | 2012-05-22 | 2015-01-14 | Bristol Myers Squibb Co | Anticuerpos biespecificos y sus metodos de uso |
| WO2020219943A1 (en) * | 2019-04-26 | 2020-10-29 | Prolynx Llc | Slow-release cytokine conjugates |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684032A (en) * | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| ES2229264T5 (es) | 1995-03-23 | 2009-12-17 | Immunex Corporation | Receptor il-17. |
| US5945511A (en) | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
| US20030100051A1 (en) | 1998-05-12 | 2003-05-29 | Ruben Steven M. | 97 human secreted proteins |
| US6569645B2 (en) * | 1999-05-14 | 2003-05-27 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US6579520B2 (en) * | 1998-05-15 | 2003-06-17 | Genentech, Inc. | IL-17 related mammalian cytokine polypeptides (IL-17E) |
| US20020177188A1 (en) * | 1998-05-15 | 2002-11-28 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| WO1998049307A1 (en) | 1997-05-01 | 1998-11-05 | Zymogenetics, Inc. | Mammalian cytokine-like receptor |
| US5965704A (en) | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
| EP1015488B1 (en) | 1997-09-17 | 2009-09-09 | Human Genome Sciences, Inc. | Interleukin-17 receptor-like protein |
| US7160985B2 (en) | 1997-10-29 | 2007-01-09 | Genentech, Inc. | Pro180 polypeptide |
| US20030040471A1 (en) | 1998-04-29 | 2003-02-27 | Watson James D. | Compositions isolated from skin cells and methods for their use |
| EP1078046A4 (en) | 1998-05-12 | 2005-05-11 | Human Genome Sciences Inc | 97 HUMAN SECRETED PROTEINS |
| US7247442B1 (en) | 1998-05-12 | 2007-07-24 | Human Genome Sciences, Inc. | Antibodies to HHPEN62 polypeptide |
| ES2292242T5 (es) | 1998-05-15 | 2011-05-04 | Genentech, Inc. | Utilizaciones terapéuticas de polipéptidos homólogos de il-17. |
| US20020182673A1 (en) | 1998-05-15 | 2002-12-05 | Genentech, Inc. | IL-17 homologous polypedies and therapeutic uses thereof |
| US20030166132A1 (en) | 1998-08-26 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20030009013A1 (en) | 1998-12-30 | 2003-01-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US7507404B2 (en) | 1999-03-08 | 2009-03-24 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20030199041A1 (en) | 1999-07-07 | 2003-10-23 | Presnell Scott R. | Interleukin-17 receptor homologue |
| DE60034564T2 (de) * | 1999-07-07 | 2007-12-27 | Zymogenetics, Inc., Seattle | Menschlicher cytokinrezeptor |
| ES2333772T3 (es) | 1999-12-23 | 2010-03-01 | Genentech, Inc. | Polipeptidos homologos de il-17 y il-17r y sus utilizaciones terapeuticas. |
| US20040048249A1 (en) | 2000-01-21 | 2004-03-11 | Tang Y. Tom | Novel nucleic acids and secreted polypeptides |
| AU2001247306A1 (en) | 2000-03-08 | 2001-09-17 | Human Genome Sciences, Inc. | Immune system-related polynucleotides, polypeptides, and antibodies |
| US20040197306A1 (en) | 2000-05-24 | 2004-10-07 | Gorman Daniel M. | Mammalian receptor proteins; related reagents and methods |
| US20030092881A1 (en) * | 2000-05-24 | 2003-05-15 | Gorman Daniel M. | Mammalian receptor proteins; related reagents and methods |
| AU2001260847A1 (en) | 2000-05-24 | 2001-12-03 | Genesis Research And Development Corporation Limited | Compositions isolated from skin cells and methods for their use |
| US20020146763A1 (en) | 2000-07-06 | 2002-10-10 | Zeren Gao | Murine cytokine receptor |
| WO2002038764A2 (en) | 2000-11-10 | 2002-05-16 | The Regents Of The University Of California | Il-17 receptor-like protein, uses thereof, and modulation of catabolic activity of il-17 cytokines on bone and cartilage |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US6681210B2 (en) | 2001-09-04 | 2004-01-20 | Andrew Jeffrey Kelly | Modular service payroll system |
| US20040097447A1 (en) * | 2002-11-16 | 2004-05-20 | Isis Pharmaceuticals Inc. | Modulation of interleukin 22 receptor expression |
| DK1641822T3 (da) | 2003-07-08 | 2013-07-22 | Genentech Inc | Heterologe il-17-a/f-polypeptider og terapeutiske anvendelser deraf. |
| EP1765865A2 (en) | 2004-06-10 | 2007-03-28 | ZymoGenetics, Inc. | Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation |
| CN101218254A (zh) | 2005-02-14 | 2008-07-09 | 惠氏公司 | 白介素-17f抗体及其它il-17f信号传递拮抗剂和它们的用途 |
| BRPI0616589A2 (pt) | 2005-09-28 | 2011-06-28 | Zymogenetics Inc | polipeptìdeo, e, métodos para produzir um anticorpo para um polipeptìdeo, para reduzir ou inibir a inflamação e para tratar um mamìfero afligido com uma doença inflamatória |
| US20070249533A1 (en) | 2005-09-28 | 2007-10-25 | Levin Steven D | Il-17a and il-17f antagonists and methods of using the same |
| WO2008039553A1 (en) | 2006-02-10 | 2008-04-03 | Zymogenetics, Inc. | Soluble il-17rcx4 and methods of using in inflammation |
| CA2679588A1 (en) | 2007-03-26 | 2008-10-02 | Zymogenetics, Inc. | Soluble il-17ra/rc fusion proteins and related methods |
-
2005
- 2005-06-10 EP EP05785507A patent/EP1765865A2/en not_active Withdrawn
- 2005-06-10 MX MXPA06014465A patent/MXPA06014465A/es active IP Right Grant
- 2005-06-10 BR BRPI0511952-9A patent/BRPI0511952A/pt not_active IP Right Cessation
- 2005-06-10 CN CNA2005800271040A patent/CN101001871A/zh active Pending
- 2005-06-10 US US11/150,533 patent/US7910540B2/en active Active
- 2005-06-10 WO PCT/US2005/020521 patent/WO2005123778A2/en not_active Ceased
- 2005-06-10 CA CA002569867A patent/CA2569867A1/en not_active Abandoned
- 2005-06-10 AU AU2005254998A patent/AU2005254998B2/en not_active Ceased
- 2005-06-10 JP JP2007527770A patent/JP4903703B2/ja not_active Expired - Fee Related
-
2006
- 2006-10-04 US US11/538,574 patent/US20070048826A1/en not_active Abandoned
- 2006-10-04 US US11/538,579 patent/US20070048257A1/en not_active Abandoned
- 2006-11-16 IL IL179356A patent/IL179356A/en not_active IP Right Cessation
-
2007
- 2007-01-09 NO NO20070153A patent/NO20070153L/no not_active Application Discontinuation
-
2010
- 2010-10-21 IL IL208859A patent/IL208859A/en not_active IP Right Cessation
-
2011
- 2011-01-27 US US13/015,304 patent/US8268773B2/en not_active Expired - Lifetime
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