JP2011528559A5 - - Google Patents

Info

Publication number

JP2011528559A5

JP2011528559A5 JP2011519076A JP2011519076A JP2011528559A5 JP 2011528559 A5 JP2011528559 A5 JP 2011528559A5 JP 2011519076 A JP2011519076 A JP 2011519076A JP 2011519076 A JP2011519076 A JP 2011519076A JP 2011528559 A5 JP2011528559 A5 JP 2011528559A5

Authority

JP

Japan

Prior art keywords

gpbp

polypeptide

seq

amino acid

acid sequence

Prior art date

2009-07-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 102100035437 Ceramide transfer protein Human genes 0.000 claims 37
• 101710119334 Ceramide transfer protein Proteins 0.000 claims 37
• 229920001184 polypeptide Polymers 0.000 claims 24
• 102000004196 processed proteins & peptides Human genes 0.000 claims 24
• 108090000765 processed proteins & peptides Proteins 0.000 claims 24
• 238000000034 method Methods 0.000 claims 20
• 230000004481 post-translational protein modification Effects 0.000 claims 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
• 238000004255 ion exchange chromatography Methods 0.000 claims 7
• 102000001708 Protein Isoforms Human genes 0.000 claims 6
• 108010029485 Protein Isoforms Proteins 0.000 claims 6
• 210000002700 urine Anatomy 0.000 claims 5
• 208000023275 Autoimmune disease Diseases 0.000 claims 3
• 238000001641 gel filtration chromatography Methods 0.000 claims 3
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 2
• 229910052921 ammonium sulfate Inorganic materials 0.000 claims 2
• 235000011130 ammonium sulphate Nutrition 0.000 claims 2
• 230000009918 complex formation Effects 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 238000003259 recombinant expression Methods 0.000 claims 2
• 238000002965 ELISA Methods 0.000 claims 1
• 206010018364 Glomerulonephritis Diseases 0.000 claims 1
• 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 238000004587 chromatography analysis Methods 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 238000000684 flow cytometry Methods 0.000 claims 1
• 201000008269 immune-complex glomerulonephritis Diseases 0.000 claims 1
• 238000010166 immunofluorescence Methods 0.000 claims 1
• 230000001376 precipitating effect Effects 0.000 claims 1
• 238000005185 salting out Methods 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 230000002485 urinary effect Effects 0.000 claims 1
• 238000005406 washing Methods 0.000 claims 1