JP2008509132A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008509132A5 JP2008509132A5 JP2007524466A JP2007524466A JP2008509132A5 JP 2008509132 A5 JP2008509132 A5 JP 2008509132A5 JP 2007524466 A JP2007524466 A JP 2007524466A JP 2007524466 A JP2007524466 A JP 2007524466A JP 2008509132 A5 JP2008509132 A5 JP 2008509132A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- day
- pharmaceutical composition
- treatment
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 claims 4
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 4
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 4
- 229960001109 policosanol Drugs 0.000 claims 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 4
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 239000006014 omega-3 oil Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- QOEHNLSDMADWEF-UHFFFAOYSA-N I-Dotriacontanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO QOEHNLSDMADWEF-UHFFFAOYSA-N 0.000 claims 2
- DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 230000002402 anti-lipaemic effect Effects 0.000 claims 2
- 210000000748 cardiovascular system Anatomy 0.000 claims 2
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 2
- 229940110767 coenzyme Q10 Drugs 0.000 claims 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229930014626 natural product Natural products 0.000 claims 2
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 claims 2
- 229960000903 pantethine Drugs 0.000 claims 2
- 235000008975 pantethine Nutrition 0.000 claims 2
- 239000011581 pantethine Substances 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- 239000011669 selenium Substances 0.000 claims 2
- 229910052711 selenium Inorganic materials 0.000 claims 2
- 229960002855 simvastatin Drugs 0.000 claims 2
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 2
- UZSAQAWEIQNGJT-UHFFFAOYSA-N tetracontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO UZSAQAWEIQNGJT-UHFFFAOYSA-N 0.000 claims 2
- TYWMIZZBOVGFOV-UHFFFAOYSA-N tetracosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCO TYWMIZZBOVGFOV-UHFFFAOYSA-N 0.000 claims 2
- REZQBEBOWJAQKS-UHFFFAOYSA-N triacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO REZQBEBOWJAQKS-UHFFFAOYSA-N 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- 235000008100 Ginkgo biloba Nutrition 0.000 claims 1
- 244000194101 Ginkgo biloba Species 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 1
- 240000000111 Saccharum officinarum Species 0.000 claims 1
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- 229960005110 cerivastatin Drugs 0.000 claims 1
- SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 ecocontanol Chemical compound 0.000 claims 1
- 229960003765 fluvastatin Drugs 0.000 claims 1
- DDJYKWPDLSFXPT-UHFFFAOYSA-N hexacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO DDJYKWPDLSFXPT-UHFFFAOYSA-N 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 229960002965 pravastatin Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 229960000672 rosuvastatin Drugs 0.000 claims 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 1
- 229940091258 selenium supplement Drugs 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM2004A000395 | 2004-08-03 | ||
| IT000395A ITRM20040395A1 (it) | 2004-08-03 | 2004-08-03 | Composizione comprendente statine e acidi grassi omega 3. |
| PCT/IT2005/000414 WO2006013602A1 (en) | 2004-08-03 | 2005-07-19 | Composition containing statins and omega-3 fatty acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509132A JP2008509132A (ja) | 2008-03-27 |
| JP2008509132A5 true JP2008509132A5 (enExample) | 2008-09-04 |
| JP5103179B2 JP5103179B2 (ja) | 2012-12-19 |
Family
ID=35124288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524466A Expired - Fee Related JP5103179B2 (ja) | 2004-08-03 | 2005-07-19 | スタチンおよびオメガ−３脂肪酸を含む組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8853229B2 (enExample) |
| EP (1) | EP1773312B1 (enExample) |
| JP (1) | JP5103179B2 (enExample) |
| KR (1) | KR101355122B1 (enExample) |
| CN (1) | CN1993119B (enExample) |
| AU (1) | AU2005268402B2 (enExample) |
| BR (1) | BRPI0514026A (enExample) |
| CA (1) | CA2573000C (enExample) |
| CY (1) | CY1115416T1 (enExample) |
| DK (1) | DK1773312T3 (enExample) |
| EA (1) | EA014444B1 (enExample) |
| ES (1) | ES2481169T3 (enExample) |
| IL (1) | IL180602A (enExample) |
| IT (1) | ITRM20040395A1 (enExample) |
| MX (1) | MX2007001009A (enExample) |
| NZ (1) | NZ552396A (enExample) |
| PL (1) | PL1773312T3 (enExample) |
| PT (1) | PT1773312E (enExample) |
| SI (1) | SI1773312T1 (enExample) |
| WO (1) | WO2006013602A1 (enExample) |
| ZA (1) | ZA200701816B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005271413A1 (en) | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel statin pharmaceutical compositions and related methods of treatment |
| DE102004063638A1 (de) * | 2004-12-31 | 2006-07-13 | Biosyn Arzneimittel Gmbh | Selen-haltige Medikamente zur Prophylaxe oder Therapie von endothelialen Gefäßerkrankungen |
| US20060211763A1 (en) * | 2005-03-08 | 2006-09-21 | Abdel Fawzy | Treatment with Statin and Omega-3 Fatty Acids and a Combination Product Thereof |
| WO2007042272A2 (en) * | 2005-10-14 | 2007-04-19 | Dsm Ip Assets B.V. | Use of a nutraceutical composition comprising resveratrol for the treatment of age-related diseases |
| US8784886B2 (en) | 2006-03-09 | 2014-07-22 | GlaxoSmithKline, LLC | Coating capsules with active pharmaceutical ingredients |
| US20080085911A1 (en) | 2006-10-10 | 2008-04-10 | Reliant Pharmaceuticals, Inc. | Statin and omega-3 fatty acids for reduction of apo-b levels |
| EP3578177A1 (en) | 2008-09-02 | 2019-12-11 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| ITFI20080243A1 (it) * | 2008-12-15 | 2010-06-16 | Valpharma Sa | Formulazioni per la somministrazione orale di acidi grassi omega polienoici in combinazione con statine di origine naturale o semi-sintetica. |
| ES2769926T3 (es) | 2009-02-10 | 2020-06-29 | Amarin Pharmaceuticals Ie Ltd | Ester etílico del ácido eicosapentaenoico para tratar la hipertrigliceridemia |
| MX2011011517A (es) | 2009-04-29 | 2012-06-19 | Amarin Corp Plc | Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo. |
| CN102458109B (zh) | 2009-04-29 | 2015-02-11 | 阿马里纳制药公司 | 稳定的药物组合物和使用其的方法 |
| CA2765329C (en) * | 2009-06-12 | 2018-01-02 | Calanus As | Oil composition, formulations comprising the oil composition, and the use thereof to reduce accumulation of visceral fat, improve glucose tolerance, and prevent or treat obesity related diseases and disorders |
| LT2443246T (lt) | 2009-06-15 | 2018-03-26 | Amarin Pharmaceuticals Ireland Limited | Kompozicijos ir būdai, skirti trigliceridų sumažinimui, nepakeliant ldl-c lygio subjekte, kartu taikant statino terapiją |
| US20110071176A1 (en) | 2009-09-23 | 2011-03-24 | Amarin Pharma, Inc. | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| CN102665698A (zh) | 2009-12-23 | 2012-09-12 | 迪菲安特制药有限责任公司 | 可用于治疗心血管疾病的联合组合物 |
| US8557236B2 (en) * | 2010-02-09 | 2013-10-15 | Vascure Natural LLC | Cardiovascular support supplement and compositions and methods thereof |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| AU2011336856A1 (en) | 2010-11-29 | 2013-07-04 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| EP3036999B1 (en) | 2010-12-20 | 2019-04-24 | Hill's Pet Nutrition, Inc. | Pet food compositions for inducing a satiety response |
| AU2015201809B2 (en) * | 2010-12-20 | 2016-09-29 | Hill's Pet Nutrition, Inc. | Pet food compositions for inducing a satiety response |
| KR101310710B1 (ko) * | 2011-03-23 | 2013-09-27 | 한미약품 주식회사 | 오메가-3 지방산 에스테르 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 경구용 복합 조성물 |
| US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| WO2013103958A1 (en) | 2012-01-06 | 2013-07-11 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
| AU2013240427B2 (en) * | 2012-03-30 | 2017-08-03 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions |
| EP2875359A4 (en) * | 2012-03-30 | 2015-08-19 | Charles R Drew University Of Medicine And Science | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLISM SYNDROME DISEASES |
| BR112014032905B1 (pt) | 2012-06-29 | 2022-02-22 | Amarin Pharmaceuticals Ireland Limited | Uso de éster etílico do ácido eicosapentaenóico para redução do risco de morte cardiovascular, revascularização coronária e/ou angina instável em um indivíduo em terapia com estatina |
| US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| WO2015003246A1 (en) * | 2013-07-09 | 2015-01-15 | Mcmaster University | Combination of a statin with an inflammasome inhibitor |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| RU2554806C1 (ru) * | 2014-07-29 | 2015-06-27 | государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) | Способ коррекции повышенного уровня тревоги и депрессии у пациентов с артериальной гипертонией на фоне сахарного диабета 2 типа |
| CN104922160A (zh) * | 2015-05-22 | 2015-09-23 | 舟山三合生物科技有限公司 | 他汀与Omega-3脂肪酸和辅酶Q10复配的组合物及其应用 |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| ITUA20162575A1 (it) | 2016-04-13 | 2017-10-13 | S&R Farm S P A | Composizione farmaceutica o nutraceutica per l’uso nel trattamento della sindrome dell’ovaio policistico o di malattie o disturbi correlati ad essa |
| WO2018213663A1 (en) | 2017-05-19 | 2018-11-22 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
| EP3810104B1 (en) | 2018-04-16 | 2024-03-06 | S&R Farmaceutici S.p.A. | Mixture of resveratrol supported on magnesium hydroxide and non-supported pure resveratrol for treating female fertility |
| MA51766A (fr) | 2018-09-24 | 2020-12-16 | Amarin Pharmaceuticals Ie Ltd | Procédés de réduction du risque d'événements cardiovasculaires chez un sujet |
| CN114980973A (zh) | 2019-11-12 | 2022-08-30 | 阿马里纳药物爱尔兰有限公司 | 降低心房纤颤和/或心房扑动受试者心血管事件风险的方法 |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055638C (zh) * | 1995-07-14 | 2000-08-23 | 李江 | 富硒虫草口服液及其制备方法 |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| US20030228393A1 (en) * | 2002-05-31 | 2003-12-11 | Zhao Iris Ginron | Multi-phase food & beverage |
| CN1061259C (zh) * | 1998-11-24 | 2001-01-31 | 彭素萍 | 藜蒿中生物活性物质的富集物及用途 |
| EP1339429A4 (en) * | 2000-11-29 | 2007-03-14 | Smithkline Beecham Corp | COMPOSITION CONTAINING STATINS AND CALCIUM FOR IMPROVING CARDIOVASCULAR HEALTH |
| US20050002992A1 (en) * | 2003-06-17 | 2005-01-06 | Mccleary Edward Larry | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
| US20020182585A1 (en) | 2001-01-10 | 2002-12-05 | George Kindness | Combination and method using EDTA, cystine, zinc and selenium for anti-thrombin effect and for anti-platelet aggregation and measurement of efficacy |
| US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
| US20040018248A1 (en) * | 2001-11-29 | 2004-01-29 | Adrianne Bendich | Composition containing statins and calcium for improved cardiovascular health |
| US6855353B2 (en) * | 2002-03-08 | 2005-02-15 | Yaguang Liu | Method for producing antioxidant and prevention of cancer |
| AU2003266287A1 (en) * | 2002-08-23 | 2004-03-11 | Dsm Ip Assets B.V. | Novel nutraceutical compositions comprising biotin |
| EP2384750A1 (en) * | 2002-09-27 | 2011-11-09 | Martek Biosciences Corporation | Improved Glycemic Control for Prediabetes and/or Diabetes Type II using Docohexaenoic Acid |
| JP2006508096A (ja) | 2002-11-07 | 2006-03-09 | ディーエスエム アイピー アセッツ ビー．ブイ． | 没食子酸エピガロカテキンを含む新規な栄養補助組成物 |
-
2004
- 2004-08-03 IT IT000395A patent/ITRM20040395A1/it unknown
-
2005
- 2005-07-19 ES ES05769486.1T patent/ES2481169T3/es not_active Expired - Lifetime
- 2005-07-19 US US11/632,953 patent/US8853229B2/en not_active Expired - Fee Related
- 2005-07-19 WO PCT/IT2005/000414 patent/WO2006013602A1/en not_active Ceased
- 2005-07-19 KR KR1020077004538A patent/KR101355122B1/ko not_active Expired - Fee Related
- 2005-07-19 PL PL05769486T patent/PL1773312T3/pl unknown
- 2005-07-19 EA EA200700240A patent/EA014444B1/ru not_active IP Right Cessation
- 2005-07-19 NZ NZ552396A patent/NZ552396A/en not_active IP Right Cessation
- 2005-07-19 JP JP2007524466A patent/JP5103179B2/ja not_active Expired - Fee Related
- 2005-07-19 AU AU2005268402A patent/AU2005268402B2/en not_active Ceased
- 2005-07-19 EP EP05769486.1A patent/EP1773312B1/en not_active Expired - Lifetime
- 2005-07-19 SI SI200531865T patent/SI1773312T1/sl unknown
- 2005-07-19 MX MX2007001009A patent/MX2007001009A/es active IP Right Grant
- 2005-07-19 PT PT57694861T patent/PT1773312E/pt unknown
- 2005-07-19 BR BRPI0514026-9A patent/BRPI0514026A/pt not_active Application Discontinuation
- 2005-07-19 CN CN2005800258385A patent/CN1993119B/zh not_active Expired - Fee Related
- 2005-07-19 CA CA2573000A patent/CA2573000C/en not_active Expired - Fee Related
- 2005-07-19 DK DK05769486.1T patent/DK1773312T3/da active
-
2007
- 2007-01-08 IL IL180602A patent/IL180602A/en not_active IP Right Cessation
- 2007-03-01 ZA ZA200701816A patent/ZA200701816B/en unknown
-
2014
- 2014-07-16 CY CY20141100583T patent/CY1115416T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008509132A5 (enExample) | ||
| KR101355122B1 (ko) | 스타틴 및 오메가 3 지방산 함유 조성물 | |
| RU2022100434A (ru) | Фармацевтические композиции, содержащие epa и сердечно-сосудистое средство, и способы их применения | |
| US20080299187A1 (en) | Substances for Reducing Occurence of Major Cardiac Events in Humans | |
| ES2542412T3 (es) | Composición útil para el tratamiento de trastornos del metabolismo de los lípidos | |
| CA2608651A1 (en) | Compositions and methods for the prevention and treatment of conditions associated with inflammation | |
| HRP20180423T1 (hr) | Pripravci i postupci za smanjivanje triglicerida bez povećavanja razina ldl-c kod subjekta koji je na istovremenoj terapiji sa statinom | |
| KR101791278B1 (ko) | 홍국 추출물 및 오메가-3 다중불포화 지방산 또는 그의 유도체를 포함하는, 주요 심장 사건의 발생을 감소시키기 위한 물질 | |
| HK1222551A1 (zh) | ω-3脂肪酸的自乳化组合物 | |
| JP2003048831A5 (enExample) | ||
| DE60005152D1 (de) | Arzneimittel, nahrungszusätze und kosmetische zubereitung enthaltend eine fettsäure und ingwer | |
| McCarty | Policosanol safely down-regulates HMG-CoA reductase–potential as a component of the Esselstyn regimen | |
| WO2008146016A3 (en) | Cyclodextrins for administering fatty acids in tablets | |
| CN103002889A (zh) | Sn-2-单酰基甘油和脂质吸收不良 | |
| JP5069448B2 (ja) | 脳卒中再発予防用組成物 | |
| WO2009059717A3 (en) | Pharmaceutical compositions containing statins and omega-3 fatty acids derivatives and their solid formulations for oral use | |
| CA2617805A1 (en) | Novel formulations comprising fenofibrate and a statin, and related methods of treatment | |
| JP2007238594A (ja) | 脳卒中再発予防用組成物 | |
| KR20140144433A (ko) | 파리유충 에탄올 추출물을 유효성분으로 포함하는 고지혈증 예방 또는 치료용 약제학적 조성물 | |
| TW200403053A (en) | A pharmaceutical composition for improving blood lipid or reducing blood homocysteine | |
| JP2006176498A5 (enExample) | ||
| CA2676583C (en) | Composition comprising red yeast rice and an omega-3 polyunsaturated fatty acid | |
| HK40040979A (en) | SELF-EMULSIFYING COMPOSITION OF ω-3 FATTY ACID | |
| HK1105871B (en) | Composition containing statins and omega-3 fatty acids | |
| Houston | Nutrition and Nutritional Supplements in the Management of Dyslipidemia—Part 2 |