JP2008508886A5 - - Google Patents

Download PDF

Info

Publication number
JP2008508886A5
JP2008508886A5 JP2007525034A JP2007525034A JP2008508886A5 JP 2008508886 A5 JP2008508886 A5 JP 2008508886A5 JP 2007525034 A JP2007525034 A JP 2007525034A JP 2007525034 A JP2007525034 A JP 2007525034A JP 2008508886 A5 JP2008508886 A5 JP 2008508886A5
Authority
JP
Japan
Prior art keywords
seq
reading frame
open reading
active bont
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007525034A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008508886A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/027917 external-priority patent/WO2006017749A2/en
Publication of JP2008508886A publication Critical patent/JP2008508886A/ja
Publication of JP2008508886A5 publication Critical patent/JP2008508886A5/ja
Pending legal-status Critical Current

Links

JP2007525034A 2004-08-04 2005-08-03 活性ボツリヌス毒素ａ型の発現の最適化 Pending JP2008508886A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59912104P 2004-08-04 2004-08-04
PCT/US2005/027917 WO2006017749A2 (en) 2004-08-04 2005-08-03 Optimizing expression of active botulinum toxin type a

Publications (2)

Publication Number Publication Date
JP2008508886A JP2008508886A (ja) 2008-03-27
JP2008508886A5 true JP2008508886A5 (enExample) 2008-09-18

Family

ID=35355531

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007525034A Pending JP2008508886A (ja) 2004-08-04 2005-08-03 活性ボツリヌス毒素ａ型の発現の最適化

Country Status (6)

Country Link
US (2) US20080057575A1 (enExample)
EP (1) EP1773874B1 (enExample)
JP (1) JP2008508886A (enExample)
AU (1) AU2005271372B2 (enExample)
CA (1) CA2575994A1 (enExample)
WO (1) WO2006017749A2 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7514088B2 (en) 2005-03-15 2009-04-07 Allergan, Inc. Multivalent Clostridial toxin derivatives and methods of their use
US20080057575A1 (en) * 2004-08-04 2008-03-06 Allergan, Inc. Optimizing Expression of Active Botulinum Toxin Type A
CA2588758C (en) 2004-11-22 2017-01-03 New York University Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof
AU2006339490B2 (en) 2005-09-19 2011-12-08 Allergan, Inc. Clostridial toxin activatable clostridial toxins
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
JP2009538622A (ja) * 2006-05-30 2009-11-12 ダウ グローバル テクノロジーズ インコーポレイティド コドン最適化法
CA2693958A1 (en) 2007-06-14 2008-12-18 Emergent Biosolutions, Inc. Chemically modified peptides with improved immunogenicity
RU2535003C2 (ru) 2008-12-10 2014-12-10 Аллерган, Инк. Фармацевтические композиции токсина клостридий
EP2218783A1 (en) 2009-02-05 2010-08-18 Merz Pharma GmbH & Co. KGaA Novel method for the manufacturing of neurotoxins
WO2010105236A1 (en) 2009-03-13 2010-09-16 Allergan, Inc. Immuno-based retargeted endopeptidase activity assays
JP2013514091A (ja) 2009-12-16 2013-04-25 アラーガン、インコーポレイテッド 組込型プロテアーゼ切断部位結合ドメインを含む改変クロストリジウム毒素
WO2011091419A2 (en) * 2010-01-25 2011-07-28 New York Universiy Recombinant derivatives of botulinum neurotoxins engineered for trafficking studies and neuronal delivery
DK2528940T3 (da) 2010-01-25 2014-07-14 Allergan Inc Fremgangsmåder til intracellulær omdannelse af enkeltkædede proteiner til deres to-kædeform
KR101920094B1 (ko) 2010-11-23 2018-11-19 알러간, 인코포레이티드 효모에서 엔테로키나아제를 생산하는 조성물과 방법
US20120244188A1 (en) 2011-03-25 2012-09-27 Allergan, Inc. Treatment of Sensory Disturbance Disorders
US20120251573A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Neuroendocrine Disorders
US20120251574A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase and Neurotoxin Combination Treatment of Multiple Medical Conditions
US20120251575A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Involuntary Movement Disorders
US20120258132A1 (en) 2011-03-29 2012-10-11 Allergan, Inc. Vagal Nerve-Based Disorders
US20120251518A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Sexual Dysfunction Disorders
US20120251519A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Smooth Muscle Disorders
US20120251515A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Cosmesis Disorders
ES2783425T3 (es) * 2011-05-17 2020-09-17 Boston Scient Neuromodulation Corp Formaciones gráficas definidas por el usuario usadas como una ayuda de visualización para la programación de estimulador
US9764009B2 (en) 2011-06-13 2017-09-19 Allergan, Inc. Treatment of psychological trauma
EP2793934B1 (en) 2011-12-23 2017-08-23 Merz Pharma GmbH & Co. KGaA Novel method for the manufacturing of di-chain proteins for use in humans
US20130171122A1 (en) 2011-12-29 2013-07-04 Allergan, Inc. Endopeptidase and neurotoxin combination treatment of bladder disorders
CN111454931A (zh) * 2012-11-21 2020-07-28 益普生生物创新有限公司 用于制备经蛋白水解处理的多肽的方法
US9315549B2 (en) 2013-01-28 2016-04-19 New York University Treatment methods using atoxic neurotoxin derivatives
US9732123B2 (en) 2013-03-15 2017-08-15 The Trustees Of The University Of Pennsylvania Mono or multivalent botulinum neurotoxin based vaccine using the heavy chain from serotypes of Clostridium botulinum
EP3113792B1 (en) 2014-03-05 2018-12-05 Merz Pharma GmbH & Co. KGaA Novel recombinant clostridial neurotoxins with increased duration of effect
WO2016094555A1 (en) 2014-12-09 2016-06-16 New York University Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
AU2015367329B2 (en) 2014-12-19 2021-02-18 Merz Pharma Gmbh & Co. Kgaa Means and methods for the determination of the biological activity of BoNT/E in cells
WO2016110662A1 (en) * 2015-01-09 2016-07-14 Ipsen Bioinnovation Limited Cationic neurotoxins
TW201718627A (zh) 2015-06-11 2017-06-01 梅茲製藥有限兩合公司 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
ES2929347T3 (es) 2016-01-20 2022-11-28 Merz Pharma Gmbh & Co Kgaa Nuevas neurotoxinas clostridiales recombinantes con aumento de la duración del efecto
ES2893838T3 (es) 2016-03-02 2022-02-10 Merz Pharma Gmbh & Co Kgaa Composición que comprende toxina botulínica
EP3290437A1 (en) 2016-08-31 2018-03-07 Merz Pharma GmbH & Co. KGaA Novel recombinant clostridial neurotoxins with decreased duration of effect
IL265109B2 (en) 2016-09-13 2024-05-01 Allergan Inc Stabilized non-protein clostridial toxin compositions
EP3312193A1 (en) 2016-10-19 2018-04-25 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with accelerated onset of effect
EP3333179A1 (en) 2016-12-07 2018-06-13 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum toxin with accelarated onset of effect
EP3335719A1 (en) 2016-12-14 2018-06-20 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with a stabilized light chain
WO2018233813A1 (en) 2017-06-20 2018-12-27 Merz Pharma Gmbh & Co. Kgaa NOVEL RECOMBINANT BOTULINUM TOXINS WITH INCREASED DURATION
US11155802B2 (en) 2017-07-06 2021-10-26 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum neurotoxins with increased duration of effect
US20210008156A1 (en) 2017-10-26 2021-01-14 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum neurotoxins with increased duration of effect
WO2019101308A1 (en) 2017-11-22 2019-05-31 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum toxin with increased duration of effect
CN111971294A (zh) * 2018-01-30 2020-11-20 儿童医学中心公司 使用芽孢杆菌系统产生肉毒神经毒素
WO2019158745A1 (de) * 2018-02-16 2019-08-22 Bontana Therapies Gmbh Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung
WO2020174079A1 (en) * 2019-02-28 2020-09-03 Proteonic Biotechnology Ip B.V. Self-immolative plasmid backbone
US20240158773A1 (en) * 2021-03-15 2024-05-16 Children's Medical Center Cprporation Engineered botulinum neurotoxin a protease domain with improved efficacy
GB202104294D0 (en) * 2021-03-26 2021-05-12 Ipsen Biopharm Ltd Clostridial neurotoxins comprising an exogenous activation loop

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2003383A1 (en) * 1988-11-23 1990-05-23 Sushil G. Devare Synthetic dna derived recombinant hiv antigens
UA48104C2 (uk) * 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
US7214787B1 (en) * 1993-09-21 2007-05-08 United States Of America As Represented By The Secretary Of The Army Recombinant vaccine against botulinum neurotoxin
US7037680B2 (en) * 1993-09-21 2006-05-02 The United States Of America As Represented By The Secretary Of The Army Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
CN1176658A (zh) * 1994-10-24 1998-03-18 蛇药制品有限公司 治疗和预防艰难梭菌疾病的疫苗和抗毒素
US6114148C1 (en) * 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
EP1020517A4 (en) * 1997-07-11 2004-11-17 Chugai Pharmaceutical Co Ltd Gene originating in human chondrocyte
US6277622B1 (en) * 1997-08-11 2001-08-21 The University Of Sydney Synthetic polynucleotides
US6218188B1 (en) * 1997-11-12 2001-04-17 Mycogen Corporation Plant-optimized genes encoding pesticidal toxins
US6214602B1 (en) * 1998-08-28 2001-04-10 Promega Corporation Host cells for expression of clostridial toxins and proteins
EP1180999A4 (en) * 1999-05-12 2005-03-30 Us Army Medical Res And Materi RECOMBINANT VACCINE AGAINST BOTULINUM NEUROTOXIN
US6399857B1 (en) * 1999-09-22 2002-06-04 Paradigm Genetics, Inc. Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species
EP1322338A4 (en) * 2000-10-04 2005-04-13 Univ Pennsylvania COMPOSITIONS AND METHODS OF USING A CAPSID PROTEIN FROM VARIOUS FLAVIVIRUS AND PESTIVIRUS
DE60336736D1 (de) * 2002-07-16 2011-05-26 VGX Pharmaceuticals LLC Codon-optimierte synthetische plasmide
US20080057575A1 (en) * 2004-08-04 2008-03-06 Allergan, Inc. Optimizing Expression of Active Botulinum Toxin Type A

Similar Documents

Publication Publication Date Title
Shi et al. The low molecular mass subunits of the photosynthetic supracomplex, photosystem II
Pfeifer Distribution, formation and regulation of gas vesicles
JP2009148257A5 (enExample)
Von Caemmerer C4 photosynthesis in a single C3 cell is theoretically inefficient but may ameliorate internal CO2 diffusion limitations of C3 leaves
Manzoor et al. Genome-guided analysis and whole transcriptome profiling of the mesophilic syntrophic acetate oxidising bacterium Syntrophaceticus schinkii
CO5680484A2 (es) Moleculas de ligando gitr y relacionadas con ligando gitr y anticuerpos y usos de estas
JP2010279377A5 (enExample)
EA200900512A1 (ru) Метаболическая инженерия сбраживающих арабинозу дрожжевых клеток
WO2005069762A3 (en) Bacillus licheniformis chromosome
JP2011516063A5 (enExample)
JP2009502127A5 (enExample)
Reznicek et al. Improved xylose uptake in Saccharomyces cerevisiae due to directed evolution of galactose permease Gal2 for sugar co‐consumption
GEP201606544B (en) Excision of transgenes in genetically modified organisms
HUE031212T2 (en) Preparation of isobutanol by fermentation with yeast
JP2006526394A5 (enExample)
EP2543726A8 (en) Reduced genome E. coli
JP2007175057A5 (enExample)
JP2010539988A5 (enExample)
EP4449858A3 (en) Compositions and methods for enhancing resistance to northern leaf blight in maize
WO2010147462A3 (en) Novel stringent selectable markers
WO2007118790A3 (en) Active potassium channel transporters (akt) and their use to create stress tolerant plants
JP2010530223A5 (enExample)
WO2005077117A3 (en) Transgenic corn seed with enhanced amino acid content
WO2013058654A3 (en) Methods for producing cinnamolide and/or drimendiol
WO2007020198A3 (en) Nucleic acid sequences encoding proteins associated with abiotic stress response and plant cells and plants with increased tolerance to environmental stress