AU2005271372B2 - Optimizing expression of active botulinum toxin type A - Google Patents

Optimizing expression of active botulinum toxin type A Download PDF

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Publication number
AU2005271372B2
AU2005271372B2 AU2005271372A AU2005271372A AU2005271372B2 AU 2005271372 B2 AU2005271372 B2 AU 2005271372B2 AU 2005271372 A AU2005271372 A AU 2005271372A AU 2005271372 A AU2005271372 A AU 2005271372A AU 2005271372 B2 AU2005271372 B2 AU 2005271372B2
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Australia
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seq
cell
open reading
reading frame
nucleic acid
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AU2005271372A
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AU2005271372A1 (en
Inventor
Kei Roger Aoki
Ester E. Fernandez-Salas
Marcella A. Gilmore
Shengwen Li
Ronald G. Miller
Iance E. Steward
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Allergan Inc
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Allergan Inc
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Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2005271372A1 publication Critical patent/AU2005271372A1/en
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Publication of AU2005271372B2 publication Critical patent/AU2005271372B2/en
Priority to AU2012211346A priority Critical patent/AU2012211346A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2005271372A 2004-08-04 2005-08-03 Optimizing expression of active botulinum toxin type A Ceased AU2005271372B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012211346A AU2012211346A1 (en) 2004-08-04 2012-08-03 Optimizing expression of active botulinum toxin type A

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59912104P 2004-08-04 2004-08-04
US60/599,121 2004-08-04
PCT/US2005/027917 WO2006017749A2 (en) 2004-08-04 2005-08-03 Optimizing expression of active botulinum toxin type a

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012211346A Division AU2012211346A1 (en) 2004-08-04 2012-08-03 Optimizing expression of active botulinum toxin type A

Publications (2)

Publication Number Publication Date
AU2005271372A1 AU2005271372A1 (en) 2006-02-16
AU2005271372B2 true AU2005271372B2 (en) 2012-05-03

Family

ID=35355531

Family Applications (1)

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AU2005271372A Ceased AU2005271372B2 (en) 2004-08-04 2005-08-03 Optimizing expression of active botulinum toxin type A

Country Status (6)

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US (2) US20080057575A1 (enExample)
EP (1) EP1773874B1 (enExample)
JP (1) JP2008508886A (enExample)
AU (1) AU2005271372B2 (enExample)
CA (1) CA2575994A1 (enExample)
WO (1) WO2006017749A2 (enExample)

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US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
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EP2218783A1 (en) 2009-02-05 2010-08-18 Merz Pharma GmbH & Co. KGaA Novel method for the manufacturing of neurotoxins
WO2010105236A1 (en) 2009-03-13 2010-09-16 Allergan, Inc. Immuno-based retargeted endopeptidase activity assays
JP2013514091A (ja) 2009-12-16 2013-04-25 アラーガン、インコーポレイテッド 組込型プロテアーゼ切断部位結合ドメインを含む改変クロストリジウム毒素
WO2011091419A2 (en) * 2010-01-25 2011-07-28 New York Universiy Recombinant derivatives of botulinum neurotoxins engineered for trafficking studies and neuronal delivery
DK2528940T3 (da) 2010-01-25 2014-07-14 Allergan Inc Fremgangsmåder til intracellulær omdannelse af enkeltkædede proteiner til deres to-kædeform
KR101920094B1 (ko) 2010-11-23 2018-11-19 알러간, 인코포레이티드 효모에서 엔테로키나아제를 생산하는 조성물과 방법
US20120244188A1 (en) 2011-03-25 2012-09-27 Allergan, Inc. Treatment of Sensory Disturbance Disorders
US20120251573A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Neuroendocrine Disorders
US20120251574A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase and Neurotoxin Combination Treatment of Multiple Medical Conditions
US20120251575A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Involuntary Movement Disorders
US20120258132A1 (en) 2011-03-29 2012-10-11 Allergan, Inc. Vagal Nerve-Based Disorders
US20120251518A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Sexual Dysfunction Disorders
US20120251519A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Smooth Muscle Disorders
US20120251515A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Cosmesis Disorders
ES2783425T3 (es) * 2011-05-17 2020-09-17 Boston Scient Neuromodulation Corp Formaciones gráficas definidas por el usuario usadas como una ayuda de visualización para la programación de estimulador
US9764009B2 (en) 2011-06-13 2017-09-19 Allergan, Inc. Treatment of psychological trauma
EP2793934B1 (en) 2011-12-23 2017-08-23 Merz Pharma GmbH & Co. KGaA Novel method for the manufacturing of di-chain proteins for use in humans
US20130171122A1 (en) 2011-12-29 2013-07-04 Allergan, Inc. Endopeptidase and neurotoxin combination treatment of bladder disorders
CN111454931A (zh) * 2012-11-21 2020-07-28 益普生生物创新有限公司 用于制备经蛋白水解处理的多肽的方法
US9315549B2 (en) 2013-01-28 2016-04-19 New York University Treatment methods using atoxic neurotoxin derivatives
US9732123B2 (en) 2013-03-15 2017-08-15 The Trustees Of The University Of Pennsylvania Mono or multivalent botulinum neurotoxin based vaccine using the heavy chain from serotypes of Clostridium botulinum
EP3113792B1 (en) 2014-03-05 2018-12-05 Merz Pharma GmbH & Co. KGaA Novel recombinant clostridial neurotoxins with increased duration of effect
WO2016094555A1 (en) 2014-12-09 2016-06-16 New York University Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
AU2015367329B2 (en) 2014-12-19 2021-02-18 Merz Pharma Gmbh & Co. Kgaa Means and methods for the determination of the biological activity of BoNT/E in cells
WO2016110662A1 (en) * 2015-01-09 2016-07-14 Ipsen Bioinnovation Limited Cationic neurotoxins
TW201718627A (zh) 2015-06-11 2017-06-01 梅茲製藥有限兩合公司 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
ES2929347T3 (es) 2016-01-20 2022-11-28 Merz Pharma Gmbh & Co Kgaa Nuevas neurotoxinas clostridiales recombinantes con aumento de la duración del efecto
ES2893838T3 (es) 2016-03-02 2022-02-10 Merz Pharma Gmbh & Co Kgaa Composición que comprende toxina botulínica
EP3290437A1 (en) 2016-08-31 2018-03-07 Merz Pharma GmbH & Co. KGaA Novel recombinant clostridial neurotoxins with decreased duration of effect
IL265109B2 (en) 2016-09-13 2024-05-01 Allergan Inc Stabilized non-protein clostridial toxin compositions
EP3312193A1 (en) 2016-10-19 2018-04-25 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with accelerated onset of effect
EP3333179A1 (en) 2016-12-07 2018-06-13 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum toxin with accelarated onset of effect
EP3335719A1 (en) 2016-12-14 2018-06-20 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with a stabilized light chain
WO2018233813A1 (en) 2017-06-20 2018-12-27 Merz Pharma Gmbh & Co. Kgaa NOVEL RECOMBINANT BOTULINUM TOXINS WITH INCREASED DURATION
US11155802B2 (en) 2017-07-06 2021-10-26 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum neurotoxins with increased duration of effect
US20210008156A1 (en) 2017-10-26 2021-01-14 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum neurotoxins with increased duration of effect
WO2019101308A1 (en) 2017-11-22 2019-05-31 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum toxin with increased duration of effect
CN111971294A (zh) * 2018-01-30 2020-11-20 儿童医学中心公司 使用芽孢杆菌系统产生肉毒神经毒素
WO2019158745A1 (de) * 2018-02-16 2019-08-22 Bontana Therapies Gmbh Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung
WO2020174079A1 (en) * 2019-02-28 2020-09-03 Proteonic Biotechnology Ip B.V. Self-immolative plasmid backbone
US20240158773A1 (en) * 2021-03-15 2024-05-16 Children's Medical Center Cprporation Engineered botulinum neurotoxin a protease domain with improved efficacy
GB202104294D0 (en) * 2021-03-26 2021-05-12 Ipsen Biopharm Ltd Clostridial neurotoxins comprising an exogenous activation loop

Citations (1)

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US20030009025A1 (en) * 1993-09-21 2003-01-09 Smith Leonard A. Recombinant vaccine against botulinum neurotoxin

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SMITH, L.A., Toxicon, 1998, Vol. 36, pages 1539-1548 *

Also Published As

Publication number Publication date
CA2575994A1 (en) 2006-02-16
EP1773874A2 (en) 2007-04-18
JP2008508886A (ja) 2008-03-27
AU2005271372A1 (en) 2006-02-16
EP1773874B1 (en) 2012-10-24
WO2006017749A2 (en) 2006-02-16
WO2006017749A3 (en) 2006-03-30
US20090023198A1 (en) 2009-01-22
US20080057575A1 (en) 2008-03-06

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired