JP2008508308A5 - - Google Patents

Download PDF

Info

Publication number
JP2008508308A5
JP2008508308A5 JP2007523832A JP2007523832A JP2008508308A5 JP 2008508308 A5 JP2008508308 A5 JP 2008508308A5 JP 2007523832 A JP2007523832 A JP 2007523832A JP 2007523832 A JP2007523832 A JP 2007523832A JP 2008508308 A5 JP2008508308 A5 JP 2008508308A5
Authority
JP
Japan
Prior art keywords
optionally substituted
phenyl
pyrrole
methyl
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007523832A
Other languages
English (en)
Japanese (ja)
Other versions
JP4703649B2 (ja
JP2008508308A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/026916 external-priority patent/WO2006012642A2/en
Publication of JP2008508308A publication Critical patent/JP2008508308A/ja
Publication of JP2008508308A5 publication Critical patent/JP2008508308A5/ja
Application granted granted Critical
Publication of JP4703649B2 publication Critical patent/JP4703649B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007523832A 2004-07-30 2005-07-30 薬学的因子としてのピロール誘導体 Expired - Lifetime JP4703649B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US59246904P 2004-07-30 2004-07-30
US59243904P 2004-07-30 2004-07-30
US60/592,469 2004-07-30
US60/592,439 2004-07-30
PCT/US2005/026916 WO2006012642A2 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010007511A Division JP2010077166A (ja) 2004-07-30 2010-01-15 薬学的因子としてのピロール誘導体

Publications (3)

Publication Number Publication Date
JP2008508308A JP2008508308A (ja) 2008-03-21
JP2008508308A5 true JP2008508308A5 (https=) 2010-03-04
JP4703649B2 JP4703649B2 (ja) 2011-06-15

Family

ID=35786783

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007523832A Expired - Lifetime JP4703649B2 (ja) 2004-07-30 2005-07-30 薬学的因子としてのピロール誘導体
JP2010007511A Withdrawn JP2010077166A (ja) 2004-07-30 2010-01-15 薬学的因子としてのピロール誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010007511A Withdrawn JP2010077166A (ja) 2004-07-30 2010-01-15 薬学的因子としてのピロール誘導体

Country Status (21)

Country Link
US (2) US8026237B2 (https=)
EP (1) EP1773768B8 (https=)
JP (2) JP4703649B2 (https=)
KR (1) KR101155288B1 (https=)
AU (1) AU2005266890C1 (https=)
BR (1) BRPI0513677B8 (https=)
CA (1) CA2573426C (https=)
CY (1) CY1120922T1 (https=)
DK (1) DK1773768T3 (https=)
ES (1) ES2697524T3 (https=)
HU (1) HUE041596T2 (https=)
IL (1) IL180630A (https=)
LT (1) LT1773768T (https=)
NO (1) NO344324B1 (https=)
NZ (1) NZ552632A (https=)
PL (1) PL1773768T3 (https=)
PT (1) PT1773768T (https=)
RU (1) RU2470916C2 (https=)
SG (1) SG155188A1 (https=)
SI (1) SI1773768T1 (https=)
WO (1) WO2006012642A2 (https=)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2384753T1 (sl) * 2003-08-29 2016-06-30 The Brigham And Women's Hospital, Inc. Hidantoinski derivati kot inhibitorji celične nekroze
SE0302573D0 (sv) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
DE10354060A1 (de) * 2003-11-19 2005-06-02 Merck Patent Gmbh Pyrrolderivate
US7880001B2 (en) 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
SG155188A1 (en) * 2004-07-30 2009-09-30 Exelixis Inc Pyrrole derivatives as pharmaceutical agents
MX2007003105A (es) 2004-09-24 2007-06-07 Aztrazeneca Ab Derivados de bencimidazol, composiciones que los contienen, sus preparaciones y sus usos i.
JP5133702B2 (ja) 2005-01-05 2013-01-30 アボット・ラボラトリーズ 11−β−ヒドロキシステロイドデヒドロゲナーゼ1型酵素の阻害薬
WO2006074244A2 (en) 2005-01-05 2006-07-13 Abbott Laboratories Adamantyl derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8198331B2 (en) 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
WO2006076202A1 (en) * 2005-01-10 2006-07-20 Exelixis, Inc. Heterocyclic carboxamide compounds as steroid nuclear receptors ligands
TW200745049A (en) 2006-03-23 2007-12-16 Astrazeneca Ab New crystalline forms
TW200808769A (en) 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds
SI2089367T1 (sl) 2006-10-31 2012-02-29 Pfizer Prod Inc Spojine pirazolina kot antagonisti mineralokortikoidnih receptorjev
CN101679243B (zh) * 2007-04-09 2012-09-26 第一三共株式会社 吡咯衍生物的阻转异构体
US20090099242A1 (en) * 2007-08-15 2009-04-16 Cuny Gregory D Heterocyclic inhibitors of necroptosis
JP5736098B2 (ja) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物
EP2185506A1 (en) * 2007-08-22 2010-05-19 Allergan, Inc. Pyrrole compounds having sphingosine-1-phosphate receptor agonist or antagonist biological activity
JP5411141B2 (ja) 2007-09-10 2014-02-12 カルシメディカ,インク. 細胞内カルシウムを調節する化合物
US8389567B2 (en) * 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
CA2720164A1 (en) * 2008-03-31 2009-10-08 Teva Pharmaceutical Industries Ltd. Processes for preparing sunitinib and salts thereof
GB0808282D0 (en) * 2008-05-07 2008-06-11 Medical Res Council Compounds for use in stabilizing p53 mutants
WO2010019910A1 (en) 2008-08-15 2010-02-18 N30 Pharmaceuticals, Llc Novel pyrrole inhibitors of s-nitrosoglutathione reductase as therapeutic agents
DK2315590T3 (da) 2008-08-15 2012-11-19 N30 Pharmaceuticals Inc Pyrrolinhibitorer af S-nitrosoglutathionreduktase
DK2318007T3 (da) 2008-08-15 2013-03-25 N30 Pharmaceuticals Inc Nye pyrrol-inhibitorer af s-nitrosoglutathion-reduktase som terapeutiske midler
US7906553B2 (en) 2008-08-27 2011-03-15 Calcimedica, Inc. Substituted thiophene modulators of intracellular calcium
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
CN102177137B (zh) * 2008-10-08 2015-03-18 埃克塞利希斯股份有限公司 1-苯基吡咯化合物
AU2009302371B2 (en) 2008-10-08 2015-02-12 Exelixis, Inc. Atropisomers of (hydroxyalkyl) pyrrole derivatives
CA2772760A1 (en) 2008-12-23 2010-07-01 President And Fellows Of Harvard College Small molecule inhibitors of necroptosis
WO2010107476A1 (en) * 2009-03-19 2010-09-23 Duke University Inhibiting gsnor
WO2010129208A1 (en) * 2009-05-05 2010-11-11 Merck Sharp & Dohme Corp. P38 kinase inhibiting agents
EP2253617A1 (de) * 2009-05-20 2010-11-24 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
WO2011025706A2 (en) 2009-08-26 2011-03-03 Schering Corporation Heterocyclic amide compounds as protein kinase inhibitors
WO2011034962A2 (en) * 2009-09-16 2011-03-24 Calcimedica Inc. Compounds that modulate intracellular calcium
TWI532725B (zh) * 2010-01-26 2016-05-11 賽諾菲阿凡提斯公司 經氧取代之3-雜芳醯基胺基-丙酸衍生物及其作為藥物之用途
EP2977084B1 (en) 2010-05-10 2017-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for the treatment of fluid accumulation in and/ or under the retina
JP6180930B2 (ja) 2010-06-16 2017-08-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 創傷治癒過程における再上皮化を刺激するための方法及び組成物
EP2609095A4 (en) 2010-08-27 2014-06-18 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
US20140113898A1 (en) * 2010-11-08 2014-04-24 Zalicus Pharmaceuticals Ltd. Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers
WO2013079223A1 (en) 2011-12-02 2013-06-06 Phenex Pharmaceuticals Ag Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rorϒ, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases
WO2013096744A1 (en) 2011-12-21 2013-06-27 Novira Therapeutics, Inc. Hepatitis b antiviral agents
EA038942B1 (ru) 2012-08-28 2021-11-12 Янссен Сайенсиз Айрлэнд Юси Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b
WO2014059333A1 (en) 2012-10-12 2014-04-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
HUE034820T2 (en) 2013-02-28 2018-02-28 Janssen Sciences Ireland Uc Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B
US9725452B2 (en) 2013-03-15 2017-08-08 Presidents And Fellows Of Harvard College Substituted indoles and pyrroles as RIP kinase inhibitors
EA027068B1 (ru) 2013-04-03 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b
CA2958625C (en) * 2013-04-10 2019-05-28 Daiichi Sankyo Company, Limited Crystal of pyrrole derivative and method for producing the same
EA035500B1 (ru) 2013-05-17 2020-06-25 Янссен Сайенсиз Айрлэнд Юси Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b
TWI651300B (zh) 2013-05-17 2019-02-21 健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療b型肝炎藥物的用途
EP3025711B1 (en) * 2013-07-23 2020-11-18 Daiichi Sankyo Company, Limited Medicine for preventing or treating hypertension
DK3024819T3 (en) 2013-07-25 2018-06-06 Janssen Sciences Ireland Uc GLYOXAMIDE-SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
JP6422871B2 (ja) * 2013-08-27 2018-11-14 第一三共株式会社 ピロール誘導体の製造方法及びその中間体
KR102290189B1 (ko) 2013-10-23 2021-08-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 카르복스아미드 유도체 및 b형 간염 치료용 의약으로서의 이의 용도
WO2015083130A1 (en) * 2013-12-06 2015-06-11 Aurigene Discovery Technologies Limited Fused pyridine and pyrimidine derivatives as ror gamma modulators
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
JP6553059B2 (ja) 2014-02-05 2019-07-31 ノヴィラ・セラピューティクス・インコーポレイテッド Hbv感染の治療のための併用療法
WO2015118057A1 (en) 2014-02-06 2015-08-13 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
EP3229807A4 (en) 2014-12-11 2018-10-17 President and Fellows of Harvard College Inhibitors of cellular necrosis and related methods
CN107205984B (zh) * 2015-01-26 2019-11-12 第一三共株式会社 吡咯甲酰胺的固体组合物
WO2016172496A1 (en) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
TWI623316B (zh) * 2015-12-22 2018-05-11 Taiho Pharmaceutical Co Ltd Antitumor effect enhancer derived from pyrrolopyrimidine compound
US10882841B2 (en) 2016-03-01 2021-01-05 University Of Maryland, Baltimore Wnt signaling pathway inhibitors for treatments of disease
CN108778334A (zh) 2016-03-24 2018-11-09 第三共株式会社 用于治疗肾脏疾病的药物
SG10202011827YA (en) 2016-04-15 2021-01-28 Novira Therapeutics Inc Combinations and methods comprising a capsid assembly inhibitor
US10918639B2 (en) 2016-10-11 2021-02-16 Bayer Pharma Aktiengesellschaft Combination containing SGC stimulators and mineralocorticoid receptor antagonists
CA3039735A1 (en) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Combination containing sgc activators and mineralocorticoid receptor antagonists
DK3532459T3 (da) 2016-10-26 2023-10-30 Constellation Pharmaceuticals Inc Lsd1-hæmmere og medicinske anvendelser deraf
WO2018153898A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit mineralocorticoid-rezeptor-antagonisten
DE102017008472A1 (de) 2017-09-08 2018-05-03 Bayer Pharma Aktiengesellschaft Kombination enthaltend PDE5 Inhibitoren und Mineralocorticoid-Rezeptor-Antagonisten
CA3090125A1 (en) 2018-03-14 2019-09-19 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
CN115974753A (zh) 2018-03-30 2023-04-18 正大天晴药业集团股份有限公司 含有n杂五元环化合物和用途
EA202092159A1 (ru) 2019-01-25 2020-12-15 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение
MX2021010145A (es) 2019-02-22 2021-09-14 Janssen Sciences Ireland Unlimited Co Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb.
MA55879A (fr) 2019-05-06 2022-03-16 Janssen Sciences Ireland Unlimited Co Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
WO2021058001A1 (zh) 2019-09-29 2021-04-01 正大天晴药业集团股份有限公司 N杂五元环化合物的晶型及其应用
ES3064043T3 (en) 2019-09-29 2026-04-22 Chia Tai Tianqing Pharmaceutical Group Co Ltd Crystalline forms of a capsid protein assembly inhibitor containing a pyrrole ring, and application thereof
CN112707854B (zh) 2019-10-25 2022-03-15 年衍药业(珠海)有限公司 吡咯酰胺类化合物及其用途
RU2738405C1 (ru) * 2020-05-26 2020-12-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" АМИД (Е)-2-АМИНО-4-ОКСО-5-(2-ОКСО-2-ФЕНИЛЭТИЛИДЕН)-1-(3-ЭТОКСИКАРБОНИЛ)-4,5,6-7-ТЕТРАГИДРОБЕНЗО[b]ТИОФЕН-2-ИЛ)4,5-ДИГИДРО-1Н-ПИРРОЛ-3-КАРБОНОВОЙ КИСЛОТЫ, ОБЛАДАЮЩИЙ ПРОТИВОМИКРОБНОЙ АКТИВНОСТЬЮ
CA3179059A1 (en) * 2020-06-09 2021-12-16 Anima Biotech Inc. Collagen 1 translation inhibitors and methods of use thereof
CA3216002A1 (en) 2021-04-26 2022-11-03 Jiancheng Wang Preparation method for pyrrole amide compound
CN114456098B (zh) * 2022-01-19 2024-06-14 大连理工大学 糖尿病肾病药物艾莎利酮的制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU531214B2 (en) * 1979-06-28 1983-08-11 Ciba-Geigy Ag Stabilizers for chlorinated thermoplast
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
JPH07116139B2 (ja) 1986-06-09 1995-12-13 三菱化学株式会社 ラクタム類の製造方法
DE3717068A1 (de) * 1987-05-21 1988-12-08 Basf Ag 4-substituierte 10-cyanmethylen-pyrrolo(4,3-e)-benzo-azepine
JPH04145078A (ja) * 1990-10-04 1992-05-19 Hokko Chem Ind Co Ltd ピロールジカルボン酸誘導体および除草剤
JPH10251258A (ja) * 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
DE19719585A1 (de) * 1997-05-09 1998-11-12 Hoechst Ag Substituierte Diaminocarbonsäuren
ATE295166T1 (de) * 1998-01-14 2005-05-15 Nippon Shinyaku Co Ltd Aktivatoren der kalium-kanäle
WO1999050264A1 (en) * 1998-03-30 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Quinazoline derivatives
GB9817548D0 (en) * 1998-08-12 1998-10-07 Novartis Ag Organic compounds
CN1325385A (zh) * 1998-11-09 2001-12-05 詹姆斯·布莱克基金有限公司 胃泌素和缩胆囊素受体配体
CN1230421C (zh) * 1999-02-10 2005-12-07 三菱制药株式会社 酰胺化合物及其药物用途
MY138097A (en) * 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) * 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
UA76475C2 (en) 2001-07-19 2006-08-15 Pharmacia Corp Combination of eplerenon and hmg co-a reductase inhibitor and its use for treatment and/or prophylaxis of pathologic condition in cardiovascular system
WO2003007955A2 (en) * 2001-07-20 2003-01-30 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
US6987123B2 (en) * 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
US20070010562A1 (en) 2001-08-13 2007-01-11 Ulrike Bauer Nr1h4 nuclear receptor binding compounds
WO2003015777A1 (en) 2001-08-13 2003-02-27 Lion Bioscience Ag Nr1h4 nuclear receptor binding compounds
ATE381542T1 (de) * 2001-08-13 2008-01-15 Phenex Pharmaceuticals Ag Nr1h4-kern-rezeptor-bindende verbindungen
JP2005532982A (ja) 2001-09-24 2005-11-04 バイエル・フアーマシユーチカルズ・コーポレーシヨン 肥満の処置のためのピロール誘導体の製造及び使用
DE10148328A1 (de) 2001-09-29 2003-04-10 Bayerische Motoren Werke Ag Verfahren zum Positionieren eines Kraftfahrzeug-Lenkrads
US7078430B2 (en) * 2002-07-08 2006-07-18 Ranbaxy Laboratories Limited HMG CoA-reductase inhibitors
EP1545515A1 (en) * 2002-08-12 2005-06-29 Sugen, Inc. 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
EP1398029A1 (en) * 2002-09-10 2004-03-17 LION Bioscience AG NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives
CN1485072A (zh) 2002-09-28 2004-03-31 治疗前列腺疾病的薏苡仁油软胶囊及其应用
US20040102511A1 (en) * 2002-11-21 2004-05-27 Jitendra Sattigeri Substituted pyrrole derivatives
GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
CN100395234C (zh) * 2003-01-02 2008-06-18 霍夫曼-拉罗奇有限公司 新cb1受体反激动剂
KR100674769B1 (ko) * 2003-01-02 2007-02-28 에프. 호프만-라 로슈 아게 신규 씨비 1 수용체 역작용제
SG155188A1 (en) * 2004-07-30 2009-09-30 Exelixis Inc Pyrrole derivatives as pharmaceutical agents

Similar Documents

Publication Publication Date Title
JP4703649B2 (ja) 薬学的因子としてのピロール誘導体
JP5123668B2 (ja) 医薬品としての複素環カルボキサミド化合物
JP2008508308A5 (https=)
CN101006052B (zh) 作为药用制剂的吡咯衍生物
CA2766328C (en) Isoindolin-1-one derivatives
JP6903580B2 (ja) 乳酸脱水素酵素の小分子阻害剤及びその使用方法
Zhou et al. N-Arylsulfonylsubstituted-1H indole derivatives as small molecule dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and tubulin
WO2007024744A2 (en) Heterocyclic carboxamide compounds as steroid nuclear receptor ligands
MX2007001201A (en) Pyrrole derivatives as pharmaceutical agents
HK1108878B (en) Pyrrole derivatives as pharmaceutical agents
HK1108878A (en) Pyrrole derivatives as pharmaceutical agents
Lusardi Diversity-oriented synthesis of highly-functionalized amino-pyrazoles as pharmaceutically relevant compounds