JP2008506632A5 - - Google Patents

Download PDF

Info

Publication number
JP2008506632A5
JP2008506632A5 JP2006554374A JP2006554374A JP2008506632A5 JP 2008506632 A5 JP2008506632 A5 JP 2008506632A5 JP 2006554374 A JP2006554374 A JP 2006554374A JP 2006554374 A JP2006554374 A JP 2006554374A JP 2008506632 A5 JP2008506632 A5 JP 2008506632A5
Authority
JP
Japan
Prior art keywords
trp
azagly
asn
tyr
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006554374A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008506632A (ja
JP4346650B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2005/012021 external-priority patent/WO2006001499A2/en
Publication of JP2008506632A publication Critical patent/JP2008506632A/ja
Publication of JP2008506632A5 publication Critical patent/JP2008506632A5/ja
Application granted granted Critical
Publication of JP4346650B2 publication Critical patent/JP4346650B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006554374A 2004-06-25 2005-06-23 メタスチン誘導体およびその用途 Expired - Fee Related JP4346650B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004187671 2004-06-25
JP2004363311 2004-12-15
PCT/JP2005/012021 WO2006001499A2 (en) 2004-06-25 2005-06-23 Metastin derivatives and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008245073A Division JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途

Publications (3)

Publication Number Publication Date
JP2008506632A JP2008506632A (ja) 2008-03-06
JP2008506632A5 true JP2008506632A5 (enExample) 2008-11-13
JP4346650B2 JP4346650B2 (ja) 2009-10-21

Family

ID=34971534

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2006554374A Expired - Fee Related JP4346650B2 (ja) 2004-06-25 2005-06-23 メタスチン誘導体およびその用途
JP2008245073A Expired - Fee Related JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途
JP2009132363A Pending JP2009227687A (ja) 2004-06-25 2009-06-01 メタスチン誘導体およびその用途

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008245073A Expired - Fee Related JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途
JP2009132363A Pending JP2009227687A (ja) 2004-06-25 2009-06-01 メタスチン誘導体およびその用途

Country Status (20)

Country Link
US (2) US7625869B2 (enExample)
EP (2) EP2113513B1 (enExample)
JP (3) JP4346650B2 (enExample)
CN (2) CN101863971A (enExample)
AR (1) AR049938A1 (enExample)
AU (1) AU2005257484A1 (enExample)
BR (1) BRPI0512397A (enExample)
CA (1) CA2571420A1 (enExample)
CL (1) CL2008003730A1 (enExample)
CR (1) CR8828A (enExample)
IL (1) IL179640A0 (enExample)
MA (1) MA28903B1 (enExample)
MX (1) MXPA06014206A (enExample)
NO (1) NO20065957L (enExample)
NZ (1) NZ552029A (enExample)
PE (2) PE20091567A1 (enExample)
RU (1) RU2006145886A (enExample)
SG (1) SG153865A1 (enExample)
TW (1) TW200607816A (enExample)
WO (1) WO2006001499A2 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
KR20050090420A (ko) 2002-12-26 2005-09-13 다케다 야쿠힌 고교 가부시키가이샤 메타스틴 유도체 및 이의 용도
CA2518541C (en) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Gonadal function improving agents
CN101035620B (zh) 2004-04-08 2012-01-04 生物马特里卡公司 用于生命科学的样品存储和样品管理的综合
WO2006001499A2 (en) * 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
BRPI0514293B1 (pt) 2004-08-23 2022-07-19 Mannkind Corporation Sistema microparticulado para distribuição de droga
DK1928423T3 (en) 2005-09-14 2016-02-29 Mannkind Corp A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
CA2643464C (en) 2006-02-22 2018-09-04 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US8183212B2 (en) * 2006-04-26 2012-05-22 Kyoto University Compound having GPR54 agonistic activity
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
CN101528772B (zh) * 2006-10-25 2013-03-13 武田药品工业株式会社 Metastin衍生物及其用途
WO2011163272A1 (en) 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
EP2277900A4 (en) 2008-04-24 2011-08-03 Takeda Pharmaceutical METASTINE DERIVATIVE AND ITS USE
US8592379B2 (en) 2008-04-30 2013-11-26 Kyoto University Metastin derivative and use thereof
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN106039494B (zh) 2008-06-13 2019-12-24 曼金德公司 干粉吸入器和用于药物输送的系统
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
JP5698977B2 (ja) 2008-07-30 2015-04-08 武田薬品工業株式会社 メタスチン誘導体およびその用途
UY32367A (es) * 2008-12-29 2010-07-30 Takeda Pharmaceutical Agente preventivo/terapéutico contra el cáncer
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010137022A1 (en) 2009-05-27 2010-12-02 Yeda Research And Development Co. Ltd Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities
MA33910B1 (fr) 2009-12-22 2013-01-02 Takeda Pharmaceutcal Company Ltd Formulation à libération prolongée
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
MY180552A (en) 2011-04-01 2020-12-02 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2755690B1 (en) 2011-08-04 2020-04-01 Merck Sharp & Dohme B.V. Kisspeptide-pentasaccharide conjugates
JP6018640B2 (ja) * 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
CN104350064A (zh) 2012-03-14 2015-02-11 耶达研究及发展有限公司 修饰的吻素肽和其用途
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
EP2934572A4 (en) 2012-12-20 2016-11-23 Biomatrica Inc FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
JP6143270B2 (ja) * 2013-01-31 2017-06-07 学校法人東京薬科大学 マイオスタチン阻害ペプチド
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015112703A1 (en) * 2014-01-22 2015-07-30 The Johns Hopkins University Compositions and methods for treating diabetes
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
CN113826612B (zh) 2014-06-10 2022-11-22 生物马特里卡公司 在环境温度下稳定凝血细胞
BR112018011639A2 (pt) 2015-12-08 2018-11-27 Biomatrica Inc redução de taxa de sedimentação de eritrócitos
IL311335A (en) 2016-09-30 2024-05-01 Sumitomo Pharma Switzerland Gmbh Methods for treating female infertility
WO2019007383A1 (zh) 2017-07-05 2019-01-10 凯惠科技发展(上海)有限公司 一种肽类化合物、其应用及含其的组合物
CN108752233B (zh) * 2018-07-18 2020-10-16 河北师范大学 小分子凝胶因子、凝胶材料及制备方法和应用
EP4146629A4 (en) * 2020-05-08 2024-10-23 The Feinstein Institutes for Medical Research Dimers for use in synthesis of peptidomimetics

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
IL74827A (en) 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
MX9100717A (es) * 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JPH09169735A (ja) 1995-10-19 1997-06-30 Takeda Chem Ind Ltd キノリン誘導体、その製造法および用途
AU7333496A (en) 1995-10-19 1997-05-07 Takeda Chemical Industries Ltd. Quinoline derivatives as gnrh antagonists
JP2000510453A (ja) 1996-04-19 2000-08-15 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン遊離特性を有する化合物
CA2283299A1 (en) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
JP4486187B2 (ja) 1998-10-27 2010-06-23 武田薬品工業株式会社 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド
US6528054B1 (en) 1998-12-28 2003-03-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
WO2001000228A1 (de) 1999-06-28 2001-01-04 Basf Aktiengesellschaft Verfahren zur verhinderung von tumorwachstum
US6638906B1 (en) 1999-12-13 2003-10-28 Nobex Corporation Amphiphilic polymers and polypeptide conjugates comprising same
AU1889101A (en) 1999-12-17 2001-06-25 Takeda Chemical Industries Ltd. Process for producing kiss-1 peptide
JP2001231581A (ja) * 1999-12-17 2001-08-28 Takeda Chem Ind Ltd ＫｉＳＳ−１ペプチドの製造法
CZ20023567A3 (cs) 2000-03-29 2003-11-12 Corixa Corporation Sloučeniny a způsoby pro terapii a diagnostiku karcinomu plic
EP1273658A4 (en) 2000-03-30 2004-08-11 Takeda Chemical Industries Ltd NEW PROTEIN, THEIR DNA AND METHOD FOR THE PRODUCTION THEREOF
US7834141B1 (en) 2000-03-31 2010-11-16 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
RU2311920C2 (ru) 2000-09-20 2007-12-10 Корикса Корпорейшн Композиции и способы для лечения и диагностики рака легких
JP2003026601A (ja) 2000-11-29 2003-01-29 Takeda Chem Ind Ltd 医薬組成物およびその製造法
JP2002320496A (ja) 2001-02-26 2002-11-05 Takeda Chem Ind Ltd 新規マウス型ＫｉＳＳ−１レセプタータンパク質およびそのＤＮＡ
WO2002085399A1 (fr) 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Preparations contenant un peptide
CN1509336A (zh) 2001-05-17 2004-06-30 株式会社岛津制作所 肽的制备方法
ATE360034T1 (de) 2001-09-19 2007-05-15 Takeda Pharmaceutical Antikörper gegen metastin und dessen verwendung zur diagnose von schwangerschaft
CA2472423A1 (en) 2002-01-11 2003-07-24 Takeda Chemical Industries, Ltd. Process for producing kiss-1 peptide
JP2003300906A (ja) 2002-04-12 2003-10-21 Daiichi Fine Chemical Co Ltd がん転移抑制因子の安定化
JPWO2004035089A1 (ja) 2002-10-09 2006-02-09 協和醗酵工業株式会社 ホルモン依存性癌の治療剤
MXPA05004380A (es) 2002-10-25 2005-11-23 Paradigm Therapeutics Ltd Mamiferos gpr54 knock out y metodos de investigacion que los utilizan.
JP4804714B2 (ja) 2002-12-26 2011-11-02 武田薬品工業株式会社 メタスチン誘導体およびその用途
KR20050090420A (ko) 2002-12-26 2005-09-13 다케다 야쿠힌 고교 가부시키가이샤 메타스틴 유도체 및 이의 용도
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
KR100595364B1 (ko) 2003-02-20 2006-07-03 재단법인 목암생명공학연구소 Ｌｋ8 단백질을 유효성분으로 포함하는 항암제
CA2518541C (en) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Gonadal function improving agents
EP1464652A1 (en) 2003-04-02 2004-10-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases
US20050002935A1 (en) 2003-04-17 2005-01-06 Vincent Ling Use of B7-H3 as an immunoregulatory agent
US20050026224A1 (en) 2003-04-28 2005-02-03 Follettie Maximillian T. Methods and compositions for modulating G-protein coupled receptor 54
WO2004101747A2 (en) 2003-05-07 2004-11-25 The General Hospital Corporation Identification and use of gpr54 and its ligands for reproductive disorders and contraception
WO2004106289A1 (en) 2003-05-30 2004-12-09 Prozymex A/S Protease inhibitors
RU2333221C2 (ru) 2003-11-03 2008-09-10 Бейцзин Санбио Байотек Ко., Лтд. Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение
CA2544473C (en) 2003-11-03 2013-08-13 Beijing Sunbio Biotech Co., Ltd. A recombinant protein having an anti-cancer effect, its encoding gene and uses thereof
WO2005095973A2 (en) 2004-03-25 2005-10-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54)
EP1750513A4 (en) 2004-04-23 2009-07-22 Serono Lab USE OF GPCR54 LIGANDS FOR THE TREATMENT OF BARRENESS
WO2006001499A2 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
WO2007084211A2 (en) 2005-11-11 2007-07-26 The General Hospital Corporation Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US20090099334A1 (en) 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
RU2008141280A (ru) 2006-03-20 2010-04-27 Мерк энд Ко., Инк. (US) Агонисты рецептора нейромедина u и их применение
WO2007109857A1 (en) 2006-03-28 2007-10-04 Biopharmica Ltd Agent for the treatment of hormone-dependent disorders and uses thereof
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
US20100286035A1 (en) 2007-10-05 2010-11-11 Takeda Pharmaceutical Company Limited Neuromedin u derivative
EP2277900A4 (en) 2008-04-24 2011-08-03 Takeda Pharmaceutical METASTINE DERIVATIVE AND ITS USE
EP2340047A1 (en) 2008-09-19 2011-07-06 Nektar Therapeutics Polymer conjugates of kiss1 peptides

Similar Documents

Publication Publication Date Title
JP2008506632A5 (enExample)
FIC20253005I1 (fi) Seladelpaarin L-lysiinisuola, erityisesti seladelpaari-L-lysiinidihydraatti
JP2010501534A5 (enExample)
NO2018037I1 (no) Simeprevir, eller salt derav, innbefattende natrium-simeprevir
JP2007522220A5 (enExample)
JP2005518413A5 (enExample)
NL300703I2 (nl) Simeprevir, of een farmaceutisch aanvaardbaar zout daarvan, waaronder simeprevirnatrium.
JP2010500116A5 (enExample)
JP2008514563A5 (enExample)
JP2006524283A5 (enExample)
JP2006503588A5 (enExample)
JP2009520682A5 (enExample)
SI1725218T1 (sl) Farmacevtski sestavek, ki obsega pimobendan
NO20053762D0 (no) Kondensert furanforbindelse.
JP2007520206A5 (enExample)
JP2004149545A5 (enExample)
JP2007119504A5 (enExample)
ATE531717T1 (de) Neue kristalline form eines pyridazinoä4,5- büindolderivats
DK1611884T3 (da) Plaster, indeholdende diclofenac
JP2006339594A5 (enExample)
JP2003160581A5 (enExample)
NL1031335A1 (nl) Gesubstitueerde N-sulfonylaminofenylethyl-2-fenoxyaceetamideverbindingen.
JP2006518752A5 (enExample)
NL1030382A1 (nl) Gesubstitueerde N-sulfonylaminobenzyl-2-fenoxyaceetamide verbindingen.
JP2009215399A5 (enExample)