JP2008506632A5 - - Google Patents
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- Publication number
- JP2008506632A5 JP2008506632A5 JP2006554374A JP2006554374A JP2008506632A5 JP 2008506632 A5 JP2008506632 A5 JP 2008506632A5 JP 2006554374 A JP2006554374 A JP 2006554374A JP 2006554374 A JP2006554374 A JP 2006554374A JP 2008506632 A5 JP2008506632 A5 JP 2008506632A5
- Authority
- JP
- Japan
- Prior art keywords
- trp
- azagly
- asn
- tyr
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004187671 | 2004-06-25 | ||
| JP2004363311 | 2004-12-15 | ||
| PCT/JP2005/012021 WO2006001499A2 (en) | 2004-06-25 | 2005-06-23 | Metastin derivatives and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008245073A Division JP4654284B2 (ja) | 2004-06-25 | 2008-09-25 | メタスチン誘導体およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008506632A JP2008506632A (ja) | 2008-03-06 |
| JP2008506632A5 true JP2008506632A5 (enExample) | 2008-11-13 |
| JP4346650B2 JP4346650B2 (ja) | 2009-10-21 |
Family
ID=34971534
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554374A Expired - Fee Related JP4346650B2 (ja) | 2004-06-25 | 2005-06-23 | メタスチン誘導体およびその用途 |
| JP2008245073A Expired - Fee Related JP4654284B2 (ja) | 2004-06-25 | 2008-09-25 | メタスチン誘導体およびその用途 |
| JP2009132363A Pending JP2009227687A (ja) | 2004-06-25 | 2009-06-01 | メタスチン誘導体およびその用途 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008245073A Expired - Fee Related JP4654284B2 (ja) | 2004-06-25 | 2008-09-25 | メタスチン誘導体およびその用途 |
| JP2009132363A Pending JP2009227687A (ja) | 2004-06-25 | 2009-06-01 | メタスチン誘導体およびその用途 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7625869B2 (enExample) |
| EP (2) | EP2113513B1 (enExample) |
| JP (3) | JP4346650B2 (enExample) |
| CN (2) | CN101863971A (enExample) |
| AR (1) | AR049938A1 (enExample) |
| AU (1) | AU2005257484A1 (enExample) |
| BR (1) | BRPI0512397A (enExample) |
| CA (1) | CA2571420A1 (enExample) |
| CL (1) | CL2008003730A1 (enExample) |
| CR (1) | CR8828A (enExample) |
| IL (1) | IL179640A0 (enExample) |
| MA (1) | MA28903B1 (enExample) |
| MX (1) | MXPA06014206A (enExample) |
| NO (1) | NO20065957L (enExample) |
| NZ (1) | NZ552029A (enExample) |
| PE (2) | PE20091567A1 (enExample) |
| RU (1) | RU2006145886A (enExample) |
| SG (1) | SG153865A1 (enExample) |
| TW (1) | TW200607816A (enExample) |
| WO (1) | WO2006001499A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1494732T1 (sl) | 2002-03-20 | 2008-08-31 | Mannking Corp | Inhalacijski aparat |
| CA2511858A1 (en) | 2002-12-26 | 2004-07-29 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| US7754220B2 (en) | 2003-03-12 | 2010-07-13 | Takeda Pharmaceutical Company Limited | Methods of inhibiting secretion of follicle-stimulating hormone and testosterone |
| EP1737573A2 (en) | 2004-04-08 | 2007-01-03 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US7625869B2 (en) | 2004-06-25 | 2009-12-01 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| KR101273120B1 (ko) | 2004-08-20 | 2013-06-13 | 맨카인드 코포레이션 | 다이케토피페라진 합성의 촉매 작용 |
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| EP2656836B1 (en) | 2005-09-14 | 2017-07-26 | MannKind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8039431B2 (en) | 2006-02-22 | 2011-10-18 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| WO2007125619A1 (ja) * | 2006-04-26 | 2007-11-08 | Kyoto University | Gpr54アゴニスト活性を有する新規化合物 |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| UA94774C2 (en) * | 2006-10-25 | 2011-06-10 | Такеда Фармасьютикал Компани Лимитед | Metastin derivatives and use thereof |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| EP2277900A4 (en) * | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| WO2009139298A1 (ja) | 2008-04-30 | 2009-11-19 | 国立大学法人京都大学 | メタスチン誘導体およびその用途 |
| CA3086027C (en) | 2008-06-13 | 2022-05-17 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CA2728523C (en) | 2008-06-20 | 2020-03-10 | Mannkind Corporation | An interactive apparatus and method for real-time profiling of inhalation efforts |
| WO2010013762A1 (ja) | 2008-07-30 | 2010-02-04 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| PE20110939A1 (es) * | 2008-12-29 | 2012-01-19 | Takeda Pharmaceutical | Agente preventivo/terapeutico contra el cancer |
| WO2010137022A1 (en) | 2009-05-27 | 2010-12-02 | Yeda Research And Development Co. Ltd | Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| MA33910B1 (fr) | 2009-12-22 | 2013-01-02 | Takeda Pharmaceutcal Company Ltd | Formulation à libération prolongée |
| RU2571331C1 (ru) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| CA2806670A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| JP6133270B2 (ja) | 2011-04-01 | 2017-05-24 | マンカインド コーポレイション | 薬剤カートリッジのためのブリスター包装 |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| EP2755690B1 (en) | 2011-08-04 | 2020-04-01 | Merck Sharp & Dohme B.V. | Kisspeptide-pentasaccharide conjugates |
| JP6018640B2 (ja) * | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム |
| WO2013136338A1 (en) | 2012-03-14 | 2013-09-19 | Yeda Research And Development Co. Ltd At The Weizmann Institute Of Science | Modified kisspeptin peptides and uses thereof |
| ES2624294T3 (es) | 2012-07-12 | 2017-07-13 | Mannkind Corporation | Sistemas de suministro de fármacos en polvo seco |
| EP3249054A1 (en) | 2012-12-20 | 2017-11-29 | Biomatrica, INC. | Formulations and methods for stabilizing pcr reagents |
| JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
| BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
| WO2015112703A1 (en) * | 2014-01-22 | 2015-07-30 | The Johns Hopkins University | Compositions and methods for treating diabetes |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| JP6661554B2 (ja) | 2014-06-10 | 2020-03-11 | バイオマトリカ,インク. | 周囲温度における血小板の安定化 |
| CN113588501B (zh) | 2015-12-08 | 2024-12-17 | 生物马特里卡公司 | 降低红细胞沉降速率 |
| MA46353A (fr) | 2016-09-30 | 2019-08-07 | Myovant Sciences Gmbh | Méthodes de traitement de l'infertilité féminine |
| US11427615B2 (en) | 2017-07-05 | 2022-08-30 | Xdcexplorer (Shanghai) Co., Ltd. | Peptide compound and application thereof, and composition containing peptide compound |
| CN108752233B (zh) * | 2018-07-18 | 2020-10-16 | 河北师范大学 | 小分子凝胶因子、凝胶材料及制备方法和应用 |
| EP4146629A4 (en) * | 2020-05-08 | 2024-10-23 | The Feinstein Institutes for Medical Research | Dimers for use in synthesis of peptidomimetics |
| WO2025217074A1 (en) | 2024-04-08 | 2025-10-16 | Radionetics Oncology, Inc. | Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1524747A (en) * | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| FR2488253A1 (fr) * | 1980-08-08 | 1982-02-12 | Roques Bernard | Nouveaux peptides et leur application en therapeutique |
| IL74827A (en) | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
| MX9100717A (es) * | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JPH09169735A (ja) | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | キノリン誘導体、その製造法および用途 |
| DE69623655T2 (de) | 1995-10-19 | 2003-04-24 | Takeda Chemical Industries, Ltd. | Chinolinderivate als gnrh antagonisten |
| WO1997040071A1 (en) | 1996-04-19 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CA2283299A1 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| JP4486187B2 (ja) | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規g蛋白質共役型レセプター蛋白質、そのdnaおよびそのリガンド |
| US6528054B1 (en) | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| MXPA01013367A (es) | 1999-06-28 | 2002-07-02 | Basf Ag | Metodo para la prevencion del crecimiento tumoral. |
| US6638906B1 (en) | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
| US6838259B2 (en) | 1999-12-17 | 2005-01-04 | Takeda Chemical Industries, Ltd. | Process for producing kiss-1 peptide |
| JP2001231581A (ja) * | 1999-12-17 | 2001-08-28 | Takeda Chem Ind Ltd | KiSS−1ペプチドの製造法 |
| CA2404233A1 (en) | 2000-03-29 | 2001-10-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| EP1273658A4 (en) | 2000-03-30 | 2004-08-11 | Takeda Chemical Industries Ltd | NEW PROTEIN, THEIR DNA AND METHOD FOR THE PRODUCTION THEREOF |
| US7834141B1 (en) | 2000-03-31 | 2010-11-16 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy |
| RU2311920C2 (ru) | 2000-09-20 | 2007-12-10 | Корикса Корпорейшн | Композиции и способы для лечения и диагностики рака легких |
| JP2003026601A (ja) | 2000-11-29 | 2003-01-29 | Takeda Chem Ind Ltd | 医薬組成物およびその製造法 |
| JP2002320496A (ja) | 2001-02-26 | 2002-11-05 | Takeda Chem Ind Ltd | 新規マウス型KiSS−1レセプタータンパク質およびそのDNA |
| WO2002085399A1 (fr) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Preparations contenant un peptide |
| US20040185525A1 (en) | 2001-05-17 | 2004-09-23 | Osamu Nishimura | Process for producing peptide |
| EP1428835B1 (en) | 2001-09-19 | 2007-04-18 | Takeda Pharmaceutical Company Limited | Antibody against metastin and use of the same in the diagnosis of pregnancy |
| EP1466976A4 (en) | 2002-01-11 | 2005-11-09 | Takeda Pharmaceutical | PROCESS FOR PREPARING KISS-1 PEPTIDES |
| JP2003300906A (ja) | 2002-04-12 | 2003-10-21 | Daiichi Fine Chemical Co Ltd | がん転移抑制因子の安定化 |
| AU2003272964A1 (en) | 2002-10-09 | 2004-05-04 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for hormone-dependent cancer |
| WO2004038021A1 (en) | 2002-10-25 | 2004-05-06 | Paradigm Therapeutics Limited | Gpr54 knock-out mammals and screening methods using them |
| CA2511858A1 (en) | 2002-12-26 | 2004-07-29 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| JP4804714B2 (ja) | 2002-12-26 | 2011-11-02 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| US6800611B2 (en) | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
| KR100595364B1 (ko) | 2003-02-20 | 2006-07-03 | 재단법인 목암생명공학연구소 | Lk8 단백질을 유효성분으로 포함하는 항암제 |
| US7754220B2 (en) | 2003-03-12 | 2010-07-13 | Takeda Pharmaceutical Company Limited | Methods of inhibiting secretion of follicle-stimulating hormone and testosterone |
| EP1464652A1 (en) | 2003-04-02 | 2004-10-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases |
| US20050002935A1 (en) | 2003-04-17 | 2005-01-06 | Vincent Ling | Use of B7-H3 as an immunoregulatory agent |
| US20050026224A1 (en) | 2003-04-28 | 2005-02-03 | Follettie Maximillian T. | Methods and compositions for modulating G-protein coupled receptor 54 |
| WO2004101747A2 (en) | 2003-05-07 | 2004-11-25 | The General Hospital Corporation | Identification and use of gpr54 and its ligands for reproductive disorders and contraception |
| WO2004106289A1 (en) | 2003-05-30 | 2004-12-09 | Prozymex A/S | Protease inhibitors |
| RU2333221C2 (ru) | 2003-11-03 | 2008-09-10 | Бейцзин Санбио Байотек Ко., Лтд. | Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение |
| BRPI0318594B8 (pt) | 2003-11-03 | 2021-05-25 | Beijing Sunbio Biotech Co Ltd | proteína recombinante que possui um efeito anticâncer, seu gene de codificação, seu uso, medicamento para tratar cânceres, vetor de expressão e microrganismo transgênico |
| WO2005095973A2 (en) | 2004-03-25 | 2005-10-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54) |
| JP2007533748A (ja) | 2004-04-23 | 2007-11-22 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症の処置のためのgpcr54リガンドの使用 |
| US7625869B2 (en) | 2004-06-25 | 2009-12-01 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| WO2007084211A2 (en) | 2005-11-11 | 2007-07-26 | The General Hospital Corporation | Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US20090093615A1 (en) | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090099334A1 (en) | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| ATE516300T1 (de) | 2006-03-20 | 2011-07-15 | Merck Sharp & Dohme | Neuromedin-u-rezeptoragonisten und ihre verwendung |
| WO2007109857A1 (en) | 2006-03-28 | 2007-10-04 | Biopharmica Ltd | Agent for the treatment of hormone-dependent disorders and uses thereof |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| CA2701612A1 (en) | 2007-10-05 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Neuromedin u derivative |
| EP2277900A4 (en) | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| WO2010033224A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
-
2005
- 2005-06-23 US US11/630,698 patent/US7625869B2/en not_active Expired - Fee Related
- 2005-06-23 MX MXPA06014206A patent/MXPA06014206A/es unknown
- 2005-06-23 SG SG200904360-5A patent/SG153865A1/en unknown
- 2005-06-23 CN CN200910225194A patent/CN101863971A/zh active Pending
- 2005-06-23 RU RU2006145886/04A patent/RU2006145886A/ru not_active Application Discontinuation
- 2005-06-23 EP EP09075257.7A patent/EP2113513B1/en not_active Expired - Lifetime
- 2005-06-23 AR ARP050102591A patent/AR049938A1/es unknown
- 2005-06-23 JP JP2006554374A patent/JP4346650B2/ja not_active Expired - Fee Related
- 2005-06-23 CA CA002571420A patent/CA2571420A1/en not_active Abandoned
- 2005-06-23 PE PE2009000637A patent/PE20091567A1/es not_active Application Discontinuation
- 2005-06-23 CN CN200910225195A patent/CN101845091A/zh active Pending
- 2005-06-23 PE PE2005000728A patent/PE20060371A1/es not_active Application Discontinuation
- 2005-06-23 NZ NZ552029A patent/NZ552029A/en not_active IP Right Cessation
- 2005-06-23 BR BRPI0512397-6A patent/BRPI0512397A/pt not_active IP Right Cessation
- 2005-06-23 TW TW094120917A patent/TW200607816A/zh unknown
- 2005-06-23 WO PCT/JP2005/012021 patent/WO2006001499A2/en not_active Ceased
- 2005-06-23 EP EP05755666A patent/EP1758932A2/en not_active Withdrawn
- 2005-06-23 AU AU2005257484A patent/AU2005257484A1/en not_active Abandoned
-
2006
- 2006-11-27 IL IL179640A patent/IL179640A0/en unknown
- 2006-12-21 NO NO20065957A patent/NO20065957L/no not_active Application Discontinuation
- 2006-12-22 CR CR8828A patent/CR8828A/es not_active Application Discontinuation
- 2006-12-28 MA MA29567A patent/MA28903B1/fr unknown
-
2008
- 2008-09-25 JP JP2008245073A patent/JP4654284B2/ja not_active Expired - Fee Related
- 2008-10-01 US US12/286,671 patent/US8778871B2/en active Active
- 2008-12-15 CL CL2008003730A patent/CL2008003730A1/es unknown
-
2009
- 2009-06-01 JP JP2009132363A patent/JP2009227687A/ja active Pending
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