JP2008504228A - Amp活性化プロテインキナーゼの薬理学的阻害による新規神経保護方法 - Google Patents

Amp活性化プロテインキナーゼの薬理学的阻害による新規神経保護方法 Download PDF

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Publication number
JP2008504228A
JP2008504228A JP2007505165A JP2007505165A JP2008504228A JP 2008504228 A JP2008504228 A JP 2008504228A JP 2007505165 A JP2007505165 A JP 2007505165A JP 2007505165 A JP2007505165 A JP 2007505165A JP 2008504228 A JP2008504228 A JP 2008504228A
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Prior art keywords
ampk
stroke
ischemic
pampk
hours
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Japanese (ja)
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JP2008504228A5 (https=
Inventor
ルイーズ・ディ・マックロー
ホン・リ
ジル・マクファッデン
ガブリエル・ブイ・ロネット
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Fasgen LLC
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Fasgen LLC
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Publication of JP2008504228A publication Critical patent/JP2008504228A/ja
Publication of JP2008504228A5 publication Critical patent/JP2008504228A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2007505165A 2004-03-24 2005-03-23 Amp活性化プロテインキナーゼの薬理学的阻害による新規神経保護方法 Pending JP2008504228A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55600004P 2004-03-24 2004-03-24
PCT/US2005/009797 WO2005092068A2 (en) 2004-03-24 2005-03-23 Novel method of neuroprotection by pharmacological inhibition of amp-activated protein kinase

Publications (2)

Publication Number Publication Date
JP2008504228A true JP2008504228A (ja) 2008-02-14
JP2008504228A5 JP2008504228A5 (https=) 2008-05-08

Family

ID=35056772

Family Applications (1)

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JP2007505165A Pending JP2008504228A (ja) 2004-03-24 2005-03-23 Amp活性化プロテインキナーゼの薬理学的阻害による新規神経保護方法

Country Status (11)

Country Link
US (1) US8293791B2 (https=)
EP (1) EP1734973A4 (https=)
JP (1) JP2008504228A (https=)
KR (2) KR20070085093A (https=)
CN (1) CN101132802A (https=)
AU (1) AU2005226731A1 (https=)
BR (1) BRPI0509085A (https=)
CA (1) CA2560843A1 (https=)
IL (1) IL178242A0 (https=)
MX (1) MXPA06010916A (https=)
WO (1) WO2005092068A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0509085A (pt) 2004-03-24 2007-08-21 Fasgen Llc processo de neuroproteção através da inibição farmacológica da proteìna quinase ativada por amp
KR101152607B1 (ko) 2005-12-20 2012-06-05 에스케이케미칼주식회사 6-[4-(2-피페리딘-1-일-에톡시)-페닐]-3-피리딘-4-일-피라졸로[1,5-a]피리미딘의 제조방법
US7741350B1 (en) * 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
WO2010088050A2 (en) 2009-01-28 2010-08-05 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
HK1221119A1 (zh) 2013-03-28 2017-05-26 The Trustees Of Columbia University In The City Of New York 用omega-3甘油酯再灌注促进对用於移植的供体器官的保护
KR101532211B1 (ko) * 2014-04-30 2015-06-30 세종대학교산학협력단 Ampk 억제기능에 기반한 뇌졸중 치료용 약학적 조성물 및 방법
CN119868551B (zh) * 2024-11-28 2026-04-14 四川大学华西医院 F-box蛋白48的抑制剂的新用途和治疗缺血性脑血管病的药物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002275096A (ja) * 2001-01-25 2002-09-25 Pfizer Prod Inc 併用療法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
CO5180581A1 (es) 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
US6423705B1 (en) * 2001-01-25 2002-07-23 Pfizer Inc. Combination therapy
BRPI0509085A (pt) 2004-03-24 2007-08-21 Fasgen Llc processo de neuroproteção através da inibição farmacológica da proteìna quinase ativada por amp

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002275096A (ja) * 2001-01-25 2002-09-25 Pfizer Prod Inc 併用療法

Also Published As

Publication number Publication date
KR101283416B1 (ko) 2013-07-08
KR20120078756A (ko) 2012-07-10
US8293791B2 (en) 2012-10-23
IL178242A0 (en) 2007-03-08
EP1734973A2 (en) 2006-12-27
US20090137665A1 (en) 2009-05-28
WO2005092068A2 (en) 2005-10-06
KR20070085093A (ko) 2007-08-27
AU2005226731A1 (en) 2005-10-06
EP1734973A4 (en) 2010-08-04
MXPA06010916A (es) 2007-07-25
WO2005092068A3 (en) 2007-09-20
BRPI0509085A (pt) 2007-08-21
CN101132802A (zh) 2008-02-27
CA2560843A1 (en) 2005-10-06

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