CA2560843A1 - Novel method of neuroprotection by pharmacological inhibition of amp-activated protein kinase - Google Patents

Novel method of neuroprotection by pharmacological inhibition of amp-activated protein kinase Download PDF

Info

Publication number
CA2560843A1
CA2560843A1 CA002560843A CA2560843A CA2560843A1 CA 2560843 A1 CA2560843 A1 CA 2560843A1 CA 002560843 A CA002560843 A CA 002560843A CA 2560843 A CA2560843 A CA 2560843A CA 2560843 A1 CA2560843 A1 CA 2560843A1
Authority
CA
Canada
Prior art keywords
ampk
stroke
ischemic
pampk
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002560843A
Other languages
English (en)
French (fr)
Inventor
Louise D. McCullough
Jill Mcfadden
Gabriele V. Ronnett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Johns Hopkins University
Fasgen LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, Fasgen LLC filed Critical Johns Hopkins University
Publication of CA2560843A1 publication Critical patent/CA2560843A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002560843A 2004-03-24 2005-03-23 Novel method of neuroprotection by pharmacological inhibition of amp-activated protein kinase Abandoned CA2560843A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55600004P 2004-03-24 2004-03-24
US60/556,000 2004-03-24
PCT/US2005/009797 WO2005092068A2 (en) 2004-03-24 2005-03-23 Novel method of neuroprotection by pharmacological inhibition of amp-activated protein kinase

Publications (1)

Publication Number Publication Date
CA2560843A1 true CA2560843A1 (en) 2005-10-06

Family

ID=35056772

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002560843A Abandoned CA2560843A1 (en) 2004-03-24 2005-03-23 Novel method of neuroprotection by pharmacological inhibition of amp-activated protein kinase

Country Status (11)

Country Link
US (1) US8293791B2 (https=)
EP (1) EP1734973A4 (https=)
JP (1) JP2008504228A (https=)
KR (2) KR20070085093A (https=)
CN (1) CN101132802A (https=)
AU (1) AU2005226731A1 (https=)
BR (1) BRPI0509085A (https=)
CA (1) CA2560843A1 (https=)
IL (1) IL178242A0 (https=)
MX (1) MXPA06010916A (https=)
WO (1) WO2005092068A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0509085A (pt) 2004-03-24 2007-08-21 Fasgen Llc processo de neuroproteção através da inibição farmacológica da proteìna quinase ativada por amp
KR101152607B1 (ko) 2005-12-20 2012-06-05 에스케이케미칼주식회사 ６-[４-(２-피페리딘-1-일-에톡시)-페닐]-３-피리딘-４-일-피라졸로[１,５-ａ]피리미딘의 제조방법
US7741350B1 (en) * 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
WO2010088050A2 (en) 2009-01-28 2010-08-05 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
HK1221119A1 (zh) 2013-03-28 2017-05-26 The Trustees Of Columbia University In The City Of New York 用omega-3甘油酯再灌注促进对用於移植的供体器官的保护
KR101532211B1 (ko) * 2014-04-30 2015-06-30 세종대학교산학협력단 Ampk 억제기능에 기반한 뇌졸중 치료용 약학적 조성물 및 방법
CN119868551B (zh) * 2024-11-28 2026-04-14 四川大学华西医院 F-box蛋白48的抑制剂的新用途和治疗缺血性脑血管病的药物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
CO5180581A1 (es) 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
US6423705B1 (en) * 2001-01-25 2002-07-23 Pfizer Inc. Combination therapy
IL147696A0 (en) * 2001-01-25 2002-08-14 Pfizer Prod Inc Combination therapy
BRPI0509085A (pt) 2004-03-24 2007-08-21 Fasgen Llc processo de neuroproteção através da inibição farmacológica da proteìna quinase ativada por amp

Also Published As

Publication number Publication date
KR101283416B1 (ko) 2013-07-08
KR20120078756A (ko) 2012-07-10
US8293791B2 (en) 2012-10-23
IL178242A0 (en) 2007-03-08
EP1734973A2 (en) 2006-12-27
US20090137665A1 (en) 2009-05-28
WO2005092068A2 (en) 2005-10-06
KR20070085093A (ko) 2007-08-27
AU2005226731A1 (en) 2005-10-06
EP1734973A4 (en) 2010-08-04
MXPA06010916A (es) 2007-07-25
WO2005092068A3 (en) 2007-09-20
BRPI0509085A (pt) 2007-08-21
CN101132802A (zh) 2008-02-27
JP2008504228A (ja) 2008-02-14

Similar Documents

Publication Publication Date Title
McCullough et al. Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
Titus et al. Mitophagy for cardioprotection
Zepeda et al. Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury
Eskew et al. Cellular protection mechanisms against extracellular heme: heme-hemopexin, but not free heme, activates the N-terminal c-Jun kinase
Kuwana et al. The phosphoinositide-3 kinase γ–Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity
NO332038B1 (no) Beskyttelse, gjenoppbygging og styrking av erytropoietinresponsive celler, vev og organer.
JP2006502976A (ja) 虚血再潅流を治療する方法および組成物
Bright et al. δPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo
JP7594441B2 (ja) 凍結保存用組成物およびその使用方法
Takada et al. Cytoprotective effect of sodium orthovanadate on ischemia/reperfusion-induced injury in the rat heart involves Akt activation and inhibition of fodrin breakdown and apoptosis
Watanabe et al. Restriction of food intake prevents postinfarction heart failure by enhancing autophagy in the surviving cardiomyocytes
Baker et al. Targeting cellular energy production in neurological disorders
Hayashi et al. Beneficial effects of MET-88, a γ-butyrobetaine hydroxylase inhibitor in rats with heart failure following myocardial infarction
Willaime-Morawek et al. IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?
Kelleher et al. Energy metabolism in hypoxic astrocytes: protective mechanism of fructose-1, 6-bisphosphate
US8293791B2 (en) Method of neuroprotection by pharmacological inhibition of AMP-activated protein kinase
Jia et al. Nrf2 participates in the protective effect of exogenous mitochondria against mitochondrial dysfunction in myocardial ischaemic and hypoxic injury
ES2992725T3 (en) Glycolic acid and/or d-lactic acid for the treatment of neurodegenerative diseases
Wang et al. Salusins protect myocardium against ischemic injury by alleviating endoplasmic reticulum stress
PL209912B1 (pl) Zastosowanie inhibitora kinazy tyrozynowej w medycynie
HK1118217A (en) Novel method of neuroprotection by pharmacological inhibition of amp-activated protein kinase
US20220241235A1 (en) Composition comprising citrate and carnitine able to activate the production of the protein klotho
Schachter et al. Regional differentiation in the rat aorta: effects of cyclooxygenase inhibitors
CN117085009B (zh) 卡格列净对急性缺血性卒中的治疗作用
US20230125482A1 (en) Protein kinase c modulators

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued