JP2008503712A5 - - Google Patents

Download PDF

Info

Publication number
JP2008503712A5
JP2008503712A5 JP2007515968A JP2007515968A JP2008503712A5 JP 2008503712 A5 JP2008503712 A5 JP 2008503712A5 JP 2007515968 A JP2007515968 A JP 2007515968A JP 2007515968 A JP2007515968 A JP 2007515968A JP 2008503712 A5 JP2008503712 A5 JP 2008503712A5
Authority
JP
Japan
Prior art keywords
acid sequence
group
seq
polypeptide
nos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007515968A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008503712A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2005/052875 external-priority patent/WO2005124342A2/en
Publication of JP2008503712A publication Critical patent/JP2008503712A/ja
Publication of JP2008503712A5 publication Critical patent/JP2008503712A5/ja
Pending legal-status Critical Current

Links

JP2007515968A 2004-06-21 2005-06-21 骨関節炎治療の方法及び手段 Pending JP2008503712A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58156804P 2004-06-21 2004-06-21
PCT/EP2005/052875 WO2005124342A2 (en) 2004-06-21 2005-06-21 Methods and means for treatment of osteoarthritis

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011171061A Division JP2012021995A (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段
JP2011171363A Division JP5595989B2 (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段

Publications (2)

Publication Number Publication Date
JP2008503712A JP2008503712A (ja) 2008-02-07
JP2008503712A5 true JP2008503712A5 (enExample) 2008-07-31

Family

ID=35510369

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007515968A Pending JP2008503712A (ja) 2004-06-21 2005-06-21 骨関節炎治療の方法及び手段
JP2011171061A Pending JP2012021995A (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段
JP2011171363A Expired - Fee Related JP5595989B2 (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2011171061A Pending JP2012021995A (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段
JP2011171363A Expired - Fee Related JP5595989B2 (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段

Country Status (5)

Country Link
US (4) US20070004658A1 (enExample)
EP (3) EP2386856B1 (enExample)
JP (3) JP2008503712A (enExample)
ES (2) ES2427136T3 (enExample)
WO (1) WO2005124342A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008503712A (ja) 2004-06-21 2008-02-07 ガラパゴス・ナムローゼ・フェンノートシャップ 骨関節炎治療の方法及び手段
US8673268B2 (en) 2004-10-15 2014-03-18 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US7485468B2 (en) 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
ES2310469B1 (es) * 2007-03-08 2009-11-16 Consejo Superior Investig. Cientificas Uso compuestos inhibidores actividad snail1 en elaboracion composiciones farmaceuticas utiles para tratamiento de condrodisplasias, procedimiento identificacion compuestos inhibidores, dichas composiciones farmaceuticas, procedimiento diagnostico condrodisplasias y aplicaciones.
US20100034898A1 (en) * 2007-03-12 2010-02-11 Thomas Joseph Lally Cartilage simulating bio-material composition and method
HRP20140405T1 (hr) 2007-06-20 2014-06-20 Galapagos N.V. Molekularni ciljevi i metode za identificiranje spojeva za lijeäśenje degenerativnih bolesti kostiju i zglobova
US8501449B2 (en) 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
RU2405490C1 (ru) * 2009-06-29 2010-12-10 Анатолий Дмитриевич Олейник Способ превентивного лечения рецидива болевого синдрома при хирургических вмешательствах на поясничных межпозвонковых дисках
CN103547580B (zh) 2011-03-22 2016-12-07 阿迪维纳斯疗法有限公司 取代的稠合三环化合物、其组合物及医药用途
AR086042A1 (es) 2011-04-28 2013-11-13 Galapagos Nv Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
IN2015DN02008A (enExample) 2012-09-21 2015-08-14 Advinus Therapeutics Ltd
IN2013MU02611A (enExample) 2013-08-07 2015-06-12 Cadila Healthcare Ltd
GB201401086D0 (en) 2014-01-23 2014-03-12 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201402070D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Pharmaceutical compositions for the treatment of inflammatory disorders
KR101710127B1 (ko) 2014-08-29 2017-02-27 한화제약주식회사 야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민
GB201512733D0 (en) * 2015-07-20 2015-08-26 Genagon Therapeutics Ab Therapeutic agents for treating conditions associated with elevated GDF15
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
EP3775896B1 (en) * 2018-04-03 2023-06-07 Sanofi Lateral flow immunoassay strip device
GB201808575D0 (en) 2018-05-24 2018-07-11 Galapagos Nv Methods for the treatment of psoriatic arthrits

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
EP1251170A3 (en) 1992-07-17 2002-10-30 Ribozyme Pharmaceuticals, Inc. Method and reagent for treatment of NF-kappaB dependent animal diseases
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US20050043234A1 (en) * 1996-10-16 2005-02-24 Deisher Theresa A. Novel FGF homologs
US6413776B1 (en) 1998-06-12 2002-07-02 Galapagos Geonomics N.V. High throughput screening of gene function using adenoviral libraries for functional genomics applications
ATE283840T1 (de) 1999-01-29 2004-12-15 Chugai Pharmaceutical Co Ltd Chondrogonese promotoren und indolin-2-on derivate
US6706267B1 (en) * 1999-09-14 2004-03-16 Arkion Life Sciences Llc Glucosamine and egg for reducing inflammation
US7332337B2 (en) 2000-05-16 2008-02-19 Galapagos Nv Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
WO2001087930A2 (en) * 2000-05-18 2001-11-22 Bayer Aktiengesellschaft Human galanin receptor-like g protein coupled receptor
DE60138403D1 (de) 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
WO2002070744A2 (en) 2001-03-07 2002-09-12 Galapagos Genomics B.V. Adenoviral library assay for e2f regulatory genes and methods and compositions for screening compounds
US20040138285A1 (en) 2001-04-27 2004-07-15 Makoto Okazaki Chondrogenesis promoters
US20030068779A1 (en) * 2001-05-09 2003-04-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
HU229910B1 (hu) * 2001-05-11 2014-12-29 Amgen Inc Thousand Oaks A TALL-1-hez kötõdõ peptidek és rokon molekulák
KR20020096368A (ko) * 2001-06-19 2002-12-31 주식회사 티지 바이오텍 연골세포의 분화촉진, 연골세포의 탈분화 억제 또는탈분화된 연골세포의 재분화 촉진제, 그것의 스크리닝방법 및 그것을 이용한 연골세포의 제조방법
WO2003018799A2 (en) 2001-08-22 2003-03-06 Galapagos Genomics N.V. Modulators of bone homeostasis identified in a high-throughput screen
US20030198627A1 (en) 2001-09-01 2003-10-23 Gert-Jan Arts siRNA knockout assay method and constructs
WO2003072827A1 (en) * 2001-10-31 2003-09-04 Children's Hospital Medical Center Method for diagnosis and treatment of rheumatoid arthritis
JP2005523688A (ja) * 2002-01-18 2005-08-11 ブリストル−マイヤーズ　スクイブ　カンパニー タンパク質チロシンキナーゼおよび／またはタンパク質チロシンキナーゼ経路と相互作用する化合物の活性を予測するためのポリヌクレオチドおよびポリペプチドの同定
JP2004000209A (ja) * 2002-04-26 2004-01-08 Sumitomo Pharmaceut Co Ltd 軟骨障害マーカー及びその利用
EP1604202A2 (en) * 2003-03-11 2005-12-14 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with phosphodiesterase 1a (pde1a)
WO2004094636A1 (en) 2003-04-24 2004-11-04 Galapagos Genomics N.V. Effective sirna knock-down constructs
AU2003300239A1 (en) * 2003-12-29 2005-07-21 Galapagos Genomics N.V. Modulators of bone homeostasis identified in a high-throughput screen
JP2008503712A (ja) * 2004-06-21 2008-02-07 ガラパゴス・ナムローゼ・フェンノートシャップ 骨関節炎治療の方法及び手段

Similar Documents

Publication Publication Date Title
Zhu et al. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3
JP2007534725A5 (enExample)
JP2008516593A5 (enExample)
US20130331433A1 (en) Mirna modulators of thermogenesis
WO2019051424A2 (en) COMPOSITIONS AND METHODS FOR CONDITIONAL GENE EXPRESSION MEDIATED BY A CHIMERIC LIGAND RECEPTOR (CLR)
WO2019018441A1 (en) ATLAS OF HEAVY AND ILLUMINATED HEAVY BARRIER TISSUE CELLS
JP2011515653A (ja) 神経変性疾患の治療に有用な標的配列及びそれらの同定方法
JP6437467B2 (ja) 線維化疾患治療において有用な分子標的及び化合物、並びにこれらの同定方法
Bonnet et al. Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases
US20230059921A1 (en) Methods and compositions for diagnostically-responsive ligand-targeted delivery of therapeutic agents
US12194010B2 (en) Methods and compositions to prevent and treat disorders associated with mutations in the ODC1 gene
JP2016522675A (ja) 上皮間葉移行に関連した疾患の治療において有用な分子標的及び前記標的のインヒビター
JP2010538244A (ja) 骨及び関節の変性疾患の治療に有用な分子標的及び化合物並びにその同定方法
CA3150095A1 (en) Engineering of immune cells for ex vivo cell therapy applications
EP3914071A1 (en) Human genomic construct reporter cells and mouse models to screen therapeutics against microglia-expressed disease associated genes
JP2008502355A5 (enExample)
KR20230023612A (ko) 조작된 올리고뉴클레오티드를 사용한 표적화된 억제
US20240201168A1 (en) Composition for diagnosis or treatment of anticancer drug resistance
Steitz et al. Characterization of two mRNA· rRNA complexes implicated in the initiation of protein biosynthesis
CN108136019A (zh) 外来体分泌抑制剂
US20250283164A1 (en) Rna-binding by transcription factors
JP2005507648A5 (enExample)
Bai et al. Pathogenic TDP‐43 accelerates the generation of toxic exon1 HTT in Huntington's disease knock‐in mice
KR20220056847A (ko) 조작된 종양선택적 단백질 발현
JP2007533989A5 (enExample)