JP2008502651A5 - - Google Patents
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- Publication number
- JP2008502651A5 JP2008502651A5 JP2007515944A JP2007515944A JP2008502651A5 JP 2008502651 A5 JP2008502651 A5 JP 2008502651A5 JP 2007515944 A JP2007515944 A JP 2007515944A JP 2007515944 A JP2007515944 A JP 2007515944A JP 2008502651 A5 JP2008502651 A5 JP 2008502651A5
- Authority
- JP
- Japan
- Prior art keywords
- tetramethyl
- piperidine
- disorder
- phenoxy
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 208000002193 Pain Diseases 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 206010012289 Dementia Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 206010034912 Phobia Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 208000019906 panic disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 208000030814 Eating disease Diseases 0.000 claims 3
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 235000014632 disordered eating Nutrition 0.000 claims 3
- 208000019899 phobic disease Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- -1 trifluoromethoxy, cyano, hydroxy, amino Chemical group 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010013654 Drug abuse Diseases 0.000 claims 2
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 206010043269 Tension headache Diseases 0.000 claims 2
- 208000008548 Tension-Type Headache Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000001881 impotence Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- RKMGAJGJIURJSJ-UHFFFAOYSA-N 2,2,6,6-Tetramethylpiperidine Substances CC1(C)CCCC(C)(C)N1 RKMGAJGJIURJSJ-UHFFFAOYSA-N 0.000 claims 1
- LCULDGORJZRIBF-UHFFFAOYSA-N 2,2,6,6-tetramethyl-4-(2,3,4-trichlorophenoxy)piperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Cl)C(Cl)=C1Cl LCULDGORJZRIBF-UHFFFAOYSA-N 0.000 claims 1
- MCTGZWHLAUFQMK-UHFFFAOYSA-N 2,2,6,6-tetramethyl-4-(2,4,5-trichlorophenoxy)piperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC(Cl)=C(Cl)C=C1Cl MCTGZWHLAUFQMK-UHFFFAOYSA-N 0.000 claims 1
- IURBEPNJIZNFTI-UHFFFAOYSA-N 2,2,6,6-tetramethyl-4-[4-(trifluoromethyl)phenoxy]piperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(C(F)(F)F)C=C1 IURBEPNJIZNFTI-UHFFFAOYSA-N 0.000 claims 1
- OOUMMYJVOJNKMT-UHFFFAOYSA-N 2,2,6,6-tetramethyl-4-naphthalen-1-yloxypiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=CC2=CC=CC=C12 OOUMMYJVOJNKMT-UHFFFAOYSA-N 0.000 claims 1
- RLXOJODVMIWGIG-UHFFFAOYSA-N 2,2,6,6-tetramethyl-n-(2-naphthalen-1-yloxyphenyl)piperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC=CC=C1OC1=CC=CC2=CC=CC=C12 RLXOJODVMIWGIG-UHFFFAOYSA-N 0.000 claims 1
- NHCJIOXLACYZGF-UHFFFAOYSA-N 2-[4-(3,4-dichlorophenoxy)-2,2,6,6-tetramethylpiperidin-1-yl]acetonitrile Chemical compound C1C(C)(C)N(CC#N)C(C)(C)CC1OC1=CC=C(Cl)C(Cl)=C1 NHCJIOXLACYZGF-UHFFFAOYSA-N 0.000 claims 1
- ZSMSGPANWYJSDF-UHFFFAOYSA-N 4-(2,2,6,6-tetramethylpiperidin-4-yl)oxyphenol Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(O)C=C1 ZSMSGPANWYJSDF-UHFFFAOYSA-N 0.000 claims 1
- QYKMXNVTTLDZRT-UHFFFAOYSA-N 4-(2,4-dichlorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Cl)C=C1Cl QYKMXNVTTLDZRT-UHFFFAOYSA-N 0.000 claims 1
- RZKSXFJQJRINNE-UHFFFAOYSA-N 4-(2,5-dichlorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC(Cl)=CC=C1Cl RZKSXFJQJRINNE-UHFFFAOYSA-N 0.000 claims 1
- QUIHPAAKYUAPST-UHFFFAOYSA-N 4-(2-chloro-5-fluorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC(F)=CC=C1Cl QUIHPAAKYUAPST-UHFFFAOYSA-N 0.000 claims 1
- IHNYEZOKKMPVJC-UHFFFAOYSA-N 4-(3,4-dichlorophenoxy)-1,2,2,6,6-pentamethylpiperidine Chemical compound C1C(C)(C)N(C)C(C)(C)CC1OC1=CC=C(Cl)C(Cl)=C1 IHNYEZOKKMPVJC-UHFFFAOYSA-N 0.000 claims 1
- WMBGSNGCTXWNAL-UHFFFAOYSA-N 4-(3,4-dichlorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Cl)C(Cl)=C1 WMBGSNGCTXWNAL-UHFFFAOYSA-N 0.000 claims 1
- WJPZZJGQMUEKDD-UHFFFAOYSA-N 4-(3-bromo-4-chlorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Cl)C(Br)=C1 WJPZZJGQMUEKDD-UHFFFAOYSA-N 0.000 claims 1
- MWSDEOAIPFHYFO-UHFFFAOYSA-N 4-(3-chloro-4-fluorophenoxy)-1,2,2,6,6-pentamethylpiperidine Chemical compound C1C(C)(C)N(C)C(C)(C)CC1OC1=CC=C(F)C(Cl)=C1 MWSDEOAIPFHYFO-UHFFFAOYSA-N 0.000 claims 1
- IQVZVIOUZNOTGR-UHFFFAOYSA-N 4-(3-chloro-4-fluorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(F)C(Cl)=C1 IQVZVIOUZNOTGR-UHFFFAOYSA-N 0.000 claims 1
- GEEUVJGRVRIWDT-UHFFFAOYSA-N 4-(4-bromo-3-chlorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Br)C(Cl)=C1 GEEUVJGRVRIWDT-UHFFFAOYSA-N 0.000 claims 1
- BLFCOKICYVRNOU-UHFFFAOYSA-N 4-(4-chloro-3-fluorophenoxy)-1,2,2,6,6-pentamethylpiperidine Chemical compound C1C(C)(C)N(C)C(C)(C)CC1OC1=CC=C(Cl)C(F)=C1 BLFCOKICYVRNOU-UHFFFAOYSA-N 0.000 claims 1
- PXQGBETVFHGWJF-UHFFFAOYSA-N 4-(4-chlorophenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Cl)C=C1 PXQGBETVFHGWJF-UHFFFAOYSA-N 0.000 claims 1
- JAUBPQRKTICTCA-UHFFFAOYSA-N 4-(4-methoxyphenoxy)-2,2,6,6-tetramethylpiperidine Chemical compound C1=CC(OC)=CC=C1OC1CC(C)(C)NC(C)(C)C1 JAUBPQRKTICTCA-UHFFFAOYSA-N 0.000 claims 1
- ROWKXROIWYNFFF-UHFFFAOYSA-N 4-[4-chloro-3-(trifluoromethyl)phenoxy]-1,2,2,6,6-pentamethylpiperidine Chemical compound C1C(C)(C)N(C)C(C)(C)CC1OC1=CC=C(Cl)C(C(F)(F)F)=C1 ROWKXROIWYNFFF-UHFFFAOYSA-N 0.000 claims 1
- GGTIYJFYUYCJQS-UHFFFAOYSA-N 4-[4-chloro-3-(trifluoromethyl)phenoxy]-2,2,6,6-tetramethylpiperidine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Cl)C(C(F)(F)F)=C1 GGTIYJFYUYCJQS-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
- 208000027534 Emotional disease Diseases 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 206010029216 Nervousness Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 201000001880 Sexual dysfunction Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000011962 Substance-induced mood disease Diseases 0.000 claims 1
- 231100000395 Substance-induced mood disorder Toxicity 0.000 claims 1
- 206010043903 Tobacco abuse Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000031674 Traumatic Acute Stress disease Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 208000026345 acute stress disease Diseases 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 208000025748 atypical depressive disease Diseases 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000001272 cocaine abuse Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 210000001097 facial muscle Anatomy 0.000 claims 1
- 208000029364 generalized anxiety disease Diseases 0.000 claims 1
- 210000002816 gill Anatomy 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 206010020765 hypersomnia Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000000938 luteal effect Effects 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 230000007074 memory dysfunction Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000013465 muscle pain Diseases 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- QOVTZYVVCOIIBT-UHFFFAOYSA-N n-(2,3-dimethoxyphenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound COC1=CC=CC(NC2CC(C)(C)NC(C)(C)C2)=C1OC QOVTZYVVCOIIBT-UHFFFAOYSA-N 0.000 claims 1
- NLCWQNJAKKLPFS-UHFFFAOYSA-N n-(2,4-dichlorophenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC=C(Cl)C=C1Cl NLCWQNJAKKLPFS-UHFFFAOYSA-N 0.000 claims 1
- ZCSKMPUCIIYYFX-UHFFFAOYSA-N n-(2,5-dichlorophenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC(Cl)=CC=C1Cl ZCSKMPUCIIYYFX-UHFFFAOYSA-N 0.000 claims 1
- BKMQASILXPDTHY-UHFFFAOYSA-N n-(2-bromo-4-chloro-5-methoxyphenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1=C(Cl)C(OC)=CC(NC2CC(C)(C)NC(C)(C)C2)=C1Br BKMQASILXPDTHY-UHFFFAOYSA-N 0.000 claims 1
- JZERIWHTWQKHKP-UHFFFAOYSA-N n-(2-chloro-5-fluorophenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC(F)=CC=C1Cl JZERIWHTWQKHKP-UHFFFAOYSA-N 0.000 claims 1
- LMSSARPMNOMFSL-UHFFFAOYSA-N n-(3,4-dichlorophenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC=C(Cl)C(Cl)=C1 LMSSARPMNOMFSL-UHFFFAOYSA-N 0.000 claims 1
- GEMHCWUYVPXNGX-UHFFFAOYSA-N n-(3,4-dichlorophenyl)-n,1,2,2,6,6-hexamethylpiperidin-4-amine Chemical compound C=1C=C(Cl)C(Cl)=CC=1N(C)C1CC(C)(C)N(C)C(C)(C)C1 GEMHCWUYVPXNGX-UHFFFAOYSA-N 0.000 claims 1
- SUEMQYXPDPITQZ-UHFFFAOYSA-N n-(3-chloro-4-fluorophenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC=C(F)C(Cl)=C1 SUEMQYXPDPITQZ-UHFFFAOYSA-N 0.000 claims 1
- MHKBXZAAAXPRHO-UHFFFAOYSA-N n-(4-chloro-2-fluorophenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC=C(Cl)C=C1F MHKBXZAAAXPRHO-UHFFFAOYSA-N 0.000 claims 1
- FOBVFFRIICNIMJ-UHFFFAOYSA-N n-(4-chloro-3-methoxyphenyl)-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1=C(Cl)C(OC)=CC(NC2CC(C)(C)NC(C)(C)C2)=C1 FOBVFFRIICNIMJ-UHFFFAOYSA-N 0.000 claims 1
- AQWHDVGMCJDQIB-UHFFFAOYSA-N n-[4-chloro-3-(trifluoromethyl)phenyl]-2,2,6,6-tetramethylpiperidin-4-amine Chemical compound C1C(C)(C)NC(C)(C)CC1NC1=CC=C(Cl)C(C(F)(F)F)=C1 AQWHDVGMCJDQIB-UHFFFAOYSA-N 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 230000000422 nocturnal effect Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 150000003053 piperidines Chemical class 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 201000000484 premenstrual tension Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 231100000872 sexual dysfunction Toxicity 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 201000001716 specific phobia Diseases 0.000 claims 1
- 230000035882 stress Effects 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400961 | 2004-06-18 | ||
| US58135904P | 2004-06-22 | 2004-06-22 | |
| PCT/EP2005/052731 WO2005123679A2 (en) | 2004-06-18 | 2005-06-14 | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008502651A JP2008502651A (ja) | 2008-01-31 |
| JP2008502651A5 true JP2008502651A5 (enExample) | 2008-06-19 |
Family
ID=37311739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515944A Abandoned JP2008502651A (ja) | 2004-06-18 | 2005-06-14 | モノアミン神経伝達物質再取込み阻害剤としての、新規アルキル置換ピペリジン誘導体及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7547788B2 (enExample) |
| EP (1) | EP1761493A2 (enExample) |
| JP (1) | JP2008502651A (enExample) |
| CN (1) | CN1960974A (enExample) |
| AR (1) | AR050341A1 (enExample) |
| CA (1) | CA2570075A1 (enExample) |
| MX (1) | MXPA06013917A (enExample) |
| TW (1) | TW200604173A (enExample) |
| WO (1) | WO2005123679A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1761493A2 (en) * | 2004-06-18 | 2007-03-14 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2006131524A1 (en) * | 2005-06-08 | 2006-12-14 | Neurosearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP2059506A1 (en) * | 2006-08-30 | 2009-05-20 | Neurosearch A/S | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2011513355A (ja) * | 2008-03-05 | 2011-04-28 | ノイロサーチ アクティーゼルスカブ | 新規な４−ベンズヒドロキシ−テトラアルキル−ピペリジン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用 |
| US8546576B2 (en) * | 2008-06-06 | 2013-10-01 | Sk Biopharmaceuticals Co., Ltd. | 3 or 4-substituted piperidine compounds |
| WO2015177193A1 (en) * | 2014-05-21 | 2015-11-26 | Solvay Specialty Polymers Usa, Llc | Stabilizer compounds |
| US20170204060A1 (en) * | 2014-05-21 | 2017-07-20 | Solvay Specialty Polymers Usa, Llc | Piperidine-based stabilizers and polymers end-capped with the same |
| MX2016000701A (es) | 2015-01-22 | 2016-11-24 | Evonik Degussa Gmbh | Proceso para preparar un compuesto de triacetonamina n-metil sustituida. |
| MX374426B (es) | 2015-01-22 | 2025-03-06 | Evonik Operations Gmbh | Sintesis de compuestos de triacetonadiamina mediante procedimiento de aminacion reductora de triacetonadiamina y derivados de los mismos. |
| DE102016212379A1 (de) | 2016-07-07 | 2018-01-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung einer N-methylsubstituierten Triacetonaminverbindung |
| DE102016212378A1 (de) | 2016-07-07 | 2018-01-11 | Evonik Degussa Gmbh | Synthese von Triacetondiaminverbindungen durch reduktive Aminierung ausgehend von Triacetondiamin und dessen Derivaten |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3684765A (en) * | 1970-01-08 | 1972-08-15 | Sankyo Co | Stabilization of synthetic polymers |
| GB1411782A (en) | 1972-02-24 | 1975-10-29 | Wyeth John & Brother Ltd | Piperidine derivatives |
| US3907813A (en) * | 1973-09-11 | 1975-09-23 | Janssen Pharmaceutica Nv | Stereoisomeric forms of 4-anilino-3-methyl piperidines |
| US3923992A (en) * | 1974-05-23 | 1975-12-02 | Univ Mississippi | Analgetic composition and method of use |
| FR2361880A1 (fr) * | 1976-04-29 | 1978-03-17 | Science Union & Cie | Nouvelles 4-amino piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| DE3218645A1 (de) * | 1982-05-18 | 1983-11-24 | Hoechst Ag, 6230 Frankfurt | Fluoranverbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbbilder in kopiersystemen |
| JPS63206757A (ja) | 1987-02-23 | 1988-08-26 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US4939161A (en) * | 1989-05-12 | 1990-07-03 | Boc, Inc. | Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides |
| WO1991003511A1 (en) | 1989-09-09 | 1991-03-21 | Sandoz Ltd | Synthetic polyamides and their salts |
| SK281813B6 (sk) | 1996-02-22 | 2001-08-06 | Neurosearch A/S | Tropánové deriváty, spôsob ich prípravy, použitie a farmaceutická kompozícia s ich obsahom |
| JPH11348418A (ja) * | 1998-04-08 | 1999-12-21 | Seiko Epson Corp | 記録媒体および記録液 |
| US6303627B1 (en) * | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| WO2002089803A1 (fr) * | 2001-05-07 | 2002-11-14 | Sankyo Company, Limited | Composition d'ionophorese |
| BR0314821A (pt) | 2002-11-01 | 2005-08-02 | Neurosearch As | Derivado de piperidina, composição farmacêutica, uso do derivado de piperidina, e, método para tratamento, prevenção ou alìvio de uma doença ou um distúrbio ou uma condição de um corpo animal vivo |
| EP1761493A2 (en) * | 2004-06-18 | 2007-03-14 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
-
2005
- 2005-06-14 EP EP05761133A patent/EP1761493A2/en not_active Withdrawn
- 2005-06-14 MX MXPA06013917A patent/MXPA06013917A/es not_active Application Discontinuation
- 2005-06-14 JP JP2007515944A patent/JP2008502651A/ja not_active Abandoned
- 2005-06-14 CN CNA2005800172558A patent/CN1960974A/zh active Pending
- 2005-06-14 CA CA002570075A patent/CA2570075A1/en not_active Abandoned
- 2005-06-14 WO PCT/EP2005/052731 patent/WO2005123679A2/en not_active Ceased
- 2005-06-14 US US11/579,060 patent/US7547788B2/en not_active Expired - Fee Related
- 2005-06-17 TW TW094120094A patent/TW200604173A/zh unknown
- 2005-06-17 AR ARP050102507A patent/AR050341A1/es unknown
-
2009
- 2009-05-07 US US12/437,233 patent/US7915419B2/en not_active Expired - Fee Related
-
2010
- 2010-12-16 US US12/970,274 patent/US20110086880A1/en not_active Abandoned
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